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P02521 (ARLY1_CHICK) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Delta-1 crystallin
Alternative name(s):
Delta crystallin I
Gene names
Name:ASL1
OrganismGallus gallus (Chicken)
Taxonomic identifier9031 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length466 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Delta crystallin, the principal crystallin in embryonic lens, is found only in birds and reptiles.

Subunit structure

Homotetramer.

Tissue specificity

Eye lens. Ref.3 Ref.4

Post-translational modification

The N-terminus is blocked.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   Molecular functionEye lens protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Molecular functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: InterPro

structural constituent of eye lens

Traceable author statement. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed
Chain2 – 466465Delta-1 crystallin
PRO_0000137719

Amino acid modifications

Modified residue21Blocked amino end (Ala) Ref.3

Natural variations

Natural variant3451V → A.

Experimental info

Sequence conflict1181V → L in CAA25260. Ref.3
Sequence conflict1291I → T in CAA25260. Ref.3
Sequence conflict2741S → F in CAA25260. Ref.3
Sequence conflict3481G → E in CAA25260. Ref.3
Sequence conflict4431T → H in AAA48728. Ref.4
Sequence conflict446 – 4472SS → AA in CAA25260. Ref.3
Sequence conflict446 – 4472SS → AA in AAA48728. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P02521 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 712A904F8CC430C5

FASTA46650,796
        10         20         30         40         50         60 
MATEGDKLLG GRFVGSTDPI MEILSSSIST EQRLTEVDIQ ASMAYAKALE KASILTKTEL 

        70         80         90        100        110        120 
EKILSGLEKI SEESSKGVLV MTQSDEDIQT AIERRLKELI GDIAGKLQTG RSRNEQVVTD 

       130        140        150        160        170        180 
LKLLLKSSIS VISTHLLQLI KTLVERAAIE IDIIMPGYTH LQKALPIRWS QFLLSHAVAL 

       190        200        210        220        230        240 
TRDSERLGEV KKRITVLPLG SGALAGNPLE IDRELLRSEL DMTSITLNSI DAISERDFVV 

       250        260        270        280        290        300 
ELISVATLLM IHLSKLAEDL IIFSTTEFGF VTLSDAYSTG SSLLPQKKNP DSLELIRSKA 

       310        320        330        340        350        360 
GRVFGRLAAI LMVLKGIPST FSKDLQEDKE AVLDVVDTLT AVLQVATGVI STLQVNKENM 

       370        380        390        400        410        420 
EKALTPELLS TDLALYLVRK GMPIRQAQTA SGKAVHLAET KGITINNLTL EDLKSISPLF 

       430        440        450        460 
ASDVSQVFSV VNSVEQYTAV GGTAKSSVTA QIEQLRELLK KQKEQA

« Hide

References

[1]"The complete sequence of the chicken delta 1 crystallin gene and its 5' flanking region."
Nickerson J.M., Wawrousek E.F., Hawkins J.W., Wakil A.S., Wistow G.J., Thomas G., Norman B.L., Piatigorsky J.
J. Biol. Chem. 260:9100-9105(1985) [PubMed: 3839507] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Nucleotide sequence of a chicken delta-crystallin gene."
Ohno M., Sakamoto H., Yasuda K., Okada T.S., Shimura Y.
Nucleic Acids Res. 13:1593-1606(1985) [PubMed: 2987831] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"The nucleotide sequence of a complete chicken delta-crystallin cDNA."
Yasuda K., Nakajima N., Isobe T., Okada T.S., Shimura Y.
EMBO J. 3:1397-1402(1984) [PubMed: 6547670] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-447, TISSUE SPECIFICITY, BLOCKAGE OF N-TERMINUS.
Tissue: Lens.
[4]"Sequence of a complete chicken delta-crystallin cDNA."
Nickerson J.M., Piatigorsky J.
Proc. Natl. Acad. Sci. U.S.A. 81:2611-2615(1984) [PubMed: 6585817] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-447, TISSUE SPECIFICITY.
Tissue: Lens.
[5]"Structural and functional evidence for differential promoter activity of the two linked delta-crystallin genes in the chicken."
Borras T., Nickerson J.M., Chepelinsky A.B., Piatigorsky J.
EMBO J. 4:445-452(1985) [PubMed: 4018032] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-4.
Strain: White leghorn.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M10806 Genomic DNA. Translation: AAA48726.1.
X02222 Genomic DNA. Translation: CAA26144.1.
X00626 mRNA. Translation: CAA25260.1.
L29393 Genomic DNA. Translation: AAL58666.1.
J00843 mRNA. Translation: AAA48728.1.
X02187 Genomic DNA. Translation: CAA26128.1.
IPIIPI00575563.
PIRCYCHD. A25712.
RefSeqNP_990832.1. NM_205501.1.
UniGeneGga.4293.

3D structure databases

ProteinModelPortalP02521.
SMRP02521. Positions 18-462.
ModBaseSearch...

Protein-protein interaction databases

STRINGP02521.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSGALT00000039936; ENSGALP00000039143; ENSGALG00000002558.
GeneID396498.
KEGGgga:396498.

Organism-specific databases

CTD396498.

Phylogenomic databases

eggNOGveNOG06663.
GeneTreeENSGT00390000014045.
HOGENOMHBG539632.
HOVERGENHBG004281.
InParanoidP02521.
OMADPIMEIL.
OrthoDBEOG418BN7.
PhylomeDBP02521.

Family and domain databases

InterProIPR009049. Argininosuccinate_lyase.
IPR003031. D_crystallin.
IPR000362. Fumarate_lyase.
IPR008948. L-Aspartase-like.
IPR022761. Lyase1_N.
[Graphical view]
PANTHERPTHR11444:SF3. argH. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00838. ArgH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY1_CHICK
AccessionPrimary (citable) accession number: P02521
Secondary accession number(s): Q90814
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: September 21, 2011
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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