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Protein

Heat shock protein 27

Gene

Hsp27

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • unfolded protein binding Source: FlyBase

GO - Biological processi

  • behavioral response to starvation Source: FlyBase
  • chaperone-mediated protein folding Source: FlyBase
  • defense response to bacterium Source: FlyBase
  • defense response to fungus Source: FlyBase
  • determination of adult lifespan Source: FlyBase
  • protein refolding Source: FlyBase
  • response to heat Source: FlyBase

Keywordsi

Biological processStress response

Enzyme and pathway databases

ReactomeiR-DME-3371571 HSF1-dependent transactivation
R-DME-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 27
Gene namesi
Name:Hsp27
ORF Names:CG4466
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0001226 Hsp27

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001259661 – 213Heat shock protein 27Add BLAST213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei58Phosphoserine1 Publication1
Modified residuei75Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP02518
PRIDEiP02518

PTM databases

iPTMnetiP02518

Expressioni

Gene expression databases

BgeeiFBgn0001226
ExpressionAtlasiP02518 differential
GenevisibleiP02518 DM

Interactioni

GO - Molecular functioni

  • unfolded protein binding Source: FlyBase

Protein-protein interaction databases

BioGridi64473, 37 interactors
DIPiDIP-18749N
IntActiP02518, 16 interactors
MINTiP02518
STRINGi7227.FBpp0076182

Structurei

3D structure databases

ProteinModelPortaliP02518
SMRiP02518
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 182sHSPPROSITE-ProRule annotationAdd BLAST112

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3591 Eukaryota
ENOG410YERS LUCA
InParanoidiP02518
OMAiSPYERSH
OrthoDBiEOG091G0USC
PhylomeDBiP02518

Family and domain databases

Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR002068 A-crystallin/Hsp20_dom
IPR001436 Alpha-crystallin/HSP
IPR031107 HSP20
IPR008978 HSP20-like_chaperone
PANTHERiPTHR11527 PTHR11527, 1 hit
PfamiView protein in Pfam
PF00011 HSP20, 1 hit
PRINTSiPR00299 ACRYSTALLIN
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS01031 SHSP, 1 hit

Sequencei

Sequence statusi: Complete.

P02518-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIIPLLHLA RELDHDYRTD WGHLLEDDFG FGVHAHDLFH PRRLLLPNTL
60 70 80 90 100
GLGRRRYSPY ERSHGHHNQM SRRASGGPNA LLPAVGKDGF QVCMDVSQFK
110 120 130 140 150
PNELTVKVVD NTVVVEGKHE EREDGHGMIQ RHFVRKYTLP KGFDPNEVVS
160 170 180 190 200
TVSSDGVLTL KAPPPPSKEQ AKSERIVQIQ QTGPAHLSVK APAPEAGDGK
210
AENGSGEKME TSK
Length:213
Mass (Da):23,617
Last modified:November 1, 1990 - v2
Checksum:iE08B39801A181F39
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40H → N (PubMed:6285380).Curated1
Sequence conflicti66H → P (PubMed:6285380).Curated1
Sequence conflicti94M → I (PubMed:6285380).Curated1
Sequence conflicti143 – 147FDPNE → LTPTK (PubMed:6285380).Curated5
Sequence conflicti161K → R (PubMed:6285380).Curated1
Sequence conflicti167 – 170SKEQ → GRER (PubMed:6285380).Curated4
Sequence conflicti178Q → R (PubMed:6285380).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01101 Genomic DNA Translation: AAA28638.1
X03891 Genomic DNA Translation: CAA27527.1
AE014296 Genomic DNA Translation: AAF50285.1
AY118471 mRNA Translation: AAM49840.1
PIRiA02921 HHFF27
D20647
RefSeqiNP_001287001.1, NM_001300072.1
NP_524000.1, NM_079276.4
UniGeneiDm.2803

Genome annotation databases

EnsemblMetazoaiFBtr0076454; FBpp0076182; FBgn0001226
FBtr0346541; FBpp0312159; FBgn0001226
GeneIDi39078
KEGGidme:Dmel_CG4466

Similar proteinsi

Entry informationi

Entry nameiHSP27_DROME
AccessioniPrimary (citable) accession number: P02518
Secondary accession number(s): Q9VSX6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1990
Last modified: March 28, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health