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P02518

- HSP27_DROME

UniProt

P02518 - HSP27_DROME

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Protein

Heat shock protein 27

Gene

Hsp27

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. behavioral response to starvation Source: FlyBase
  2. defense response to bacterium Source: FlyBase
  3. defense response to fungus Source: FlyBase
  4. determination of adult lifespan Source: FlyBase
  5. imaginal disc-derived wing morphogenesis Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

Stress response

Enzyme and pathway databases

ReactomeiREACT_247767. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_252605. VEGFA-VEGFR2 Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 27
Gene namesi
Name:Hsp27
ORF Names:CG4466
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0001226. Hsp27.

Subcellular locationi

GO - Cellular componenti

  1. microtubule associated complex Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 213213Heat shock protein 27PRO_0000125966Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei58 – 581Phosphoserine1 Publication
Modified residuei75 – 751Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP02518.
PRIDEiP02518.

Expressioni

Gene expression databases

BgeeiP02518.

Interactioni

Protein-protein interaction databases

BioGridi64473. 31 interactions.
DIPiDIP-18749N.
IntActiP02518. 4 interactions.
MINTiMINT-749799.
STRINGi7227.FBpp0076182.

Structurei

3D structure databases

ProteinModelPortaliP02518.
SMRiP02518. Positions 88-165.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG256133.
GeneTreeiENSGT00760000119238.
InParanoidiP02518.
OMAiRKYTLPK.
OrthoDBiEOG7WHHBK.
PhylomeDBiP02518.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. a-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
PIRSFiPIRSF036514. Sm_HSP_B1. 1 hit.
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P02518-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSIIPLLHLA RELDHDYRTD WGHLLEDDFG FGVHAHDLFH PRRLLLPNTL
60 70 80 90 100
GLGRRRYSPY ERSHGHHNQM SRRASGGPNA LLPAVGKDGF QVCMDVSQFK
110 120 130 140 150
PNELTVKVVD NTVVVEGKHE EREDGHGMIQ RHFVRKYTLP KGFDPNEVVS
160 170 180 190 200
TVSSDGVLTL KAPPPPSKEQ AKSERIVQIQ QTGPAHLSVK APAPEAGDGK
210
AENGSGEKME TSK
Length:213
Mass (Da):23,617
Last modified:November 1, 1990 - v2
Checksum:iE08B39801A181F39
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti40 – 401H → N(PubMed:6285380)Curated
Sequence conflicti66 – 661H → P(PubMed:6285380)Curated
Sequence conflicti94 – 941M → I(PubMed:6285380)Curated
Sequence conflicti143 – 1475FDPNE → LTPTK(PubMed:6285380)Curated
Sequence conflicti161 – 1611K → R(PubMed:6285380)Curated
Sequence conflicti167 – 1704SKEQ → GRER(PubMed:6285380)Curated
Sequence conflicti178 – 1781Q → R(PubMed:6285380)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01101 Genomic DNA. Translation: AAA28638.1.
X03891 Genomic DNA. Translation: CAA27527.1.
AE014296 Genomic DNA. Translation: AAF50285.1.
AY118471 mRNA. Translation: AAM49840.1.
PIRiA02921. HHFF27.
D20647.
RefSeqiNP_001287001.1. NM_001300072.1.
NP_524000.1. NM_079276.4.
UniGeneiDm.2803.

Genome annotation databases

EnsemblMetazoaiFBtr0076454; FBpp0076182; FBgn0001226.
GeneIDi39078.
KEGGidme:Dmel_CG4466.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01101 Genomic DNA. Translation: AAA28638.1 .
X03891 Genomic DNA. Translation: CAA27527.1 .
AE014296 Genomic DNA. Translation: AAF50285.1 .
AY118471 mRNA. Translation: AAM49840.1 .
PIRi A02921. HHFF27.
D20647.
RefSeqi NP_001287001.1. NM_001300072.1.
NP_524000.1. NM_079276.4.
UniGenei Dm.2803.

3D structure databases

ProteinModelPortali P02518.
SMRi P02518. Positions 88-165.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 64473. 31 interactions.
DIPi DIP-18749N.
IntActi P02518. 4 interactions.
MINTi MINT-749799.
STRINGi 7227.FBpp0076182.

Proteomic databases

PaxDbi P02518.
PRIDEi P02518.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0076454 ; FBpp0076182 ; FBgn0001226 .
GeneIDi 39078.
KEGGi dme:Dmel_CG4466.

Organism-specific databases

CTDi 39078.
FlyBasei FBgn0001226. Hsp27.

Phylogenomic databases

eggNOGi NOG256133.
GeneTreei ENSGT00760000119238.
InParanoidi P02518.
OMAi RKYTLPK.
OrthoDBi EOG7WHHBK.
PhylomeDBi P02518.

Enzyme and pathway databases

Reactomei REACT_247767. AUF1 (hnRNP D0) destabilizes mRNA.
REACT_252605. VEGFA-VEGFR2 Pathway.

Miscellaneous databases

GenomeRNAii 39078.
NextBioi 811805.

Gene expression databases

Bgeei P02518.

Family and domain databases

Gene3Di 2.60.40.790. 1 hit.
InterProi IPR002068. a-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR008978. HSP20-like_chaperone.
[Graphical view ]
Pfami PF00011. HSP20. 1 hit.
[Graphical view ]
PIRSFi PIRSF036514. Sm_HSP_B1. 1 hit.
PRINTSi PR00299. ACRYSTALLIN.
SUPFAMi SSF49764. SSF49764. 1 hit.
PROSITEi PS01031. HSP20. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence analysis of the Drosophila small heat shock gene cluster at locus 67B."
    Southgate R., Ayme A., Voellmy R.
    J. Mol. Biol. 165:35-57(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Four small Drosophila heat shock proteins are related to each other and to mammalian alpha-crystallin."
    Ingolia T.D., Craig E.A.
    Proc. Natl. Acad. Sci. U.S.A. 79:2360-2364(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Ovary.
  6. "An integrated chemical, mass spectrometric and computational strategy for (quantitative) phosphoproteomics: application to Drosophila melanogaster Kc167 cells."
    Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A., Eng J.K., Aebersold R., Tao W.A.
    Mol. Biosyst. 3:275-286(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-75, IDENTIFICATION BY MASS SPECTROMETRY.
  7. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-58, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiHSP27_DROME
AccessioniPrimary (citable) accession number: P02518
Secondary accession number(s): Q9VSX6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1990
Last modified: November 26, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3