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Protein

Heat shock protein 26

Gene

Hsp26

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • myosin binding Source: FlyBase
  • unfolded protein binding Source: FlyBase

GO - Biological processi

  • chaperone-mediated protein folding Source: FlyBase
  • cold acclimation Source: FlyBase
  • determination of adult lifespan Source: FlyBase
  • protein refolding Source: FlyBase
  • response to heat Source: FlyBase

Keywordsi

Biological processStress response

Enzyme and pathway databases

ReactomeiR-DME-3371571 HSF1-dependent transactivation
R-DME-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 26
Gene namesi
Name:Hsp26
ORF Names:CG4183
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0001225 Hsp26

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001259651 – 208Heat shock protein 26Add BLAST208

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei44Phosphoserine1 Publication1
Modified residuei52Phosphoserine1 Publication1
Modified residuei58Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP02517
PRIDEiP02517

PTM databases

iPTMnetiP02517

Expressioni

Gene expression databases

BgeeiFBgn0001225
ExpressionAtlasiP02517 differential
GenevisibleiP02517 DM

Interactioni

GO - Molecular functioni

  • myosin binding Source: FlyBase
  • unfolded protein binding Source: FlyBase

Protein-protein interaction databases

BioGridi64470, 62 interactors
DIPiDIP-18379N
IntActiP02517, 21 interactors
MINTiP02517
STRINGi7227.FBpp0076224

Structurei

3D structure databases

ProteinModelPortaliP02517
SMRiP02517
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 179sHSPPROSITE-ProRule annotationAdd BLAST109

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3591 Eukaryota
ENOG410YERS LUCA
InParanoidiP02517
OMAiPLGTQQR
OrthoDBiEOG091G0USC
PhylomeDBiP02517

Family and domain databases

Gene3Di2.60.40.790, 1 hit
InterProiView protein in InterPro
IPR002068 A-crystallin/Hsp20_dom
IPR001436 Alpha-crystallin/HSP
IPR031107 HSP20
IPR008978 HSP20-like_chaperone
PANTHERiPTHR11527 PTHR11527, 1 hit
PfamiView protein in Pfam
PF00011 HSP20, 1 hit
PRINTSiPR00299 ACRYSTALLIN
SUPFAMiSSF49764 SSF49764, 1 hit
PROSITEiView protein in PROSITE
PS01031 SHSP, 1 hit

Sequencei

Sequence statusi: Complete.

P02517-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSTLLSLV DELQEPRSPI YELGLGLHPH SRYVLPLGTQ QRRSINGCPC
60 70 80 90 100
ASPICPSSPA GQVLALRREM ANRNDIHWPA TAHVGKDGFQ VCMDVAQFKP
110 120 130 140 150
SELNVKVVDD SILVEGKHEE RQDDHGHIMR HFVRRYKVPD GYKAEQVVSQ
160 170 180 190 200
LSSDGVLTVS IPKPQAVEDK SKERIIQIQQ VGPAHLNVKA NESEVKGKEN

GAPNGKDK
Length:208
Mass (Da):22,994
Last modified:November 1, 1990 - v2
Checksum:i75781CB2C309E33C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35L → LL (PubMed:6285380).Curated1
Sequence conflicti192E → D (PubMed:6285380).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01099 Genomic DNA Translation: AAA28636.1
X03890 Genomic DNA Translation: CAA27526.1
AE014296 Genomic DNA Translation: AAF50288.1
AY069419 mRNA Translation: AAL39564.1
PIRiA02920 HHFF26
C20647
RefSeqiNP_001287000.1, NM_001300071.1
NP_523997.1, NM_079273.3
UniGeneiDm.907

Genome annotation databases

EnsemblMetazoaiFBtr0076496; FBpp0076224; FBgn0001225
FBtr0346539; FBpp0312157; FBgn0001225
GeneIDi39075
KEGGidme:Dmel_CG4183

Similar proteinsi

Entry informationi

Entry nameiHSP26_DROME
AccessioniPrimary (citable) accession number: P02517
Secondary accession number(s): Q9VSX3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1990
Last modified: March 28, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health