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Protein

Heat shock protein 26

Gene

Hsp26

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • myosin binding Source: FlyBase

GO - Biological processi

  • cold acclimation Source: FlyBase
  • determination of adult lifespan Source: FlyBase
  • response to heat Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

Stress response

Enzyme and pathway databases

ReactomeiR-DME-3371571. HSF1-dependent transactivation.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 26
Gene namesi
Name:Hsp26
ORF Names:CG4183
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0001225. Hsp26.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: FlyBase
  • microtubule associated complex Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208Heat shock protein 26PRO_0000125965Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei44 – 441Phosphoserine1 Publication
Modified residuei52 – 521Phosphoserine1 Publication
Modified residuei58 – 581Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP02517.
PRIDEiP02517.

PTM databases

iPTMnetiP02517.

Expressioni

Gene expression databases

BgeeiP02517.
ExpressionAtlasiP02517. differential.
GenevisibleiP02517. DM.

Interactioni

GO - Molecular functioni

  • myosin binding Source: FlyBase

Protein-protein interaction databases

BioGridi64470. 49 interactions.
DIPiDIP-18379N.
IntActiP02517. 1 interaction.
MINTiMINT-996909.
STRINGi7227.FBpp0076224.

Structurei

3D structure databases

ProteinModelPortaliP02517.
SMRiP02517. Positions 89-160.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
InParanoidiP02517.
OMAiQQRRSIN.
OrthoDBiEOG7WHHBK.
PhylomeDBiP02517.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P02517-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSTLLSLV DELQEPRSPI YELGLGLHPH SRYVLPLGTQ QRRSINGCPC
60 70 80 90 100
ASPICPSSPA GQVLALRREM ANRNDIHWPA TAHVGKDGFQ VCMDVAQFKP
110 120 130 140 150
SELNVKVVDD SILVEGKHEE RQDDHGHIMR HFVRRYKVPD GYKAEQVVSQ
160 170 180 190 200
LSSDGVLTVS IPKPQAVEDK SKERIIQIQQ VGPAHLNVKA NESEVKGKEN

GAPNGKDK
Length:208
Mass (Da):22,994
Last modified:November 1, 1990 - v2
Checksum:i75781CB2C309E33C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti35 – 351L → LL (PubMed:6285380).Curated
Sequence conflicti192 – 1921E → D (PubMed:6285380).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01099 Genomic DNA. Translation: AAA28636.1.
X03890 Genomic DNA. Translation: CAA27526.1.
AE014296 Genomic DNA. Translation: AAF50288.1.
AY069419 mRNA. Translation: AAL39564.1.
PIRiA02920. HHFF26.
C20647.
RefSeqiNP_001287000.1. NM_001300071.1.
NP_523997.1. NM_079273.3.
UniGeneiDm.907.

Genome annotation databases

EnsemblMetazoaiFBtr0076496; FBpp0076224; FBgn0001225.
FBtr0346539; FBpp0312157; FBgn0001225.
GeneIDi39075.
KEGGidme:Dmel_CG4183.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01099 Genomic DNA. Translation: AAA28636.1.
X03890 Genomic DNA. Translation: CAA27526.1.
AE014296 Genomic DNA. Translation: AAF50288.1.
AY069419 mRNA. Translation: AAL39564.1.
PIRiA02920. HHFF26.
C20647.
RefSeqiNP_001287000.1. NM_001300071.1.
NP_523997.1. NM_079273.3.
UniGeneiDm.907.

3D structure databases

ProteinModelPortaliP02517.
SMRiP02517. Positions 89-160.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi64470. 49 interactions.
DIPiDIP-18379N.
IntActiP02517. 1 interaction.
MINTiMINT-996909.
STRINGi7227.FBpp0076224.

PTM databases

iPTMnetiP02517.

Proteomic databases

PaxDbiP02517.
PRIDEiP02517.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0076496; FBpp0076224; FBgn0001225.
FBtr0346539; FBpp0312157; FBgn0001225.
GeneIDi39075.
KEGGidme:Dmel_CG4183.

Organism-specific databases

CTDi39075.
FlyBaseiFBgn0001225. Hsp26.

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
InParanoidiP02517.
OMAiQQRRSIN.
OrthoDBiEOG7WHHBK.
PhylomeDBiP02517.

Enzyme and pathway databases

ReactomeiR-DME-3371571. HSF1-dependent transactivation.

Miscellaneous databases

ChiTaRSiHsp26. fly.
GenomeRNAii39075.
NextBioi811790.
PROiP02517.

Gene expression databases

BgeeiP02517.
ExpressionAtlasiP02517. differential.
GenevisibleiP02517. DM.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence analysis of the Drosophila small heat shock gene cluster at locus 67B."
    Southgate R., Ayme A., Voellmy R.
    J. Mol. Biol. 165:35-57(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Four small Drosophila heat shock proteins are related to each other and to mammalian alpha-crystallin."
    Ingolia T.D., Craig E.A.
    Proc. Natl. Acad. Sci. U.S.A. 79:2360-2364(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Berkeley.
    Tissue: Embryo.
  6. "Phosphoproteome analysis of Drosophila melanogaster embryos."
    Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.
    J. Proteome Res. 7:1675-1682(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-44; SER-52 AND SER-58, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Embryo.

Entry informationi

Entry nameiHSP26_DROME
AccessioniPrimary (citable) accession number: P02517
Secondary accession number(s): Q9VSX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1990
Last modified: May 11, 2016
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.