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Protein

Heat shock protein 23

Gene

Hsp23

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • actin binding Source: FlyBase

GO - Biological processi

  • chaperone-mediated protein folding Source: FlyBase
  • cold acclimation Source: FlyBase
  • protein refolding Source: FlyBase
  • response to heat Source: FlyBase
  • response to hypoxia Source: FlyBase
Complete GO annotation...

Keywords - Biological processi

Stress response

Enzyme and pathway databases

ReactomeiR-DME-3371571. HSF1-dependent transactivation.
R-DME-4420097. VEGFA-VEGFR2 Pathway.
R-DME-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.

Names & Taxonomyi

Protein namesi
Recommended name:
Heat shock protein 23
Gene namesi
Name:Hsp23
ORF Names:CG4463
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0001224. Hsp23.

Subcellular locationi

GO - Cellular componenti

  • microtubule associated complex Source: FlyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 186186Heat shock protein 23PRO_0000125964Add
BLAST

Proteomic databases

PaxDbiP02516.
PRIDEiP02516.

Expressioni

Gene expression databases

BgeeiFBgn0001224.
ExpressionAtlasiP02516. differential.
GenevisibleiP02516. DM.

Interactioni

GO - Molecular functioni

  • actin binding Source: FlyBase

Protein-protein interaction databases

BioGridi64472. 53 interactions.
DIPiDIP-18765N.
IntActiP02516. 3 interactions.
MINTiMINT-956485.
STRINGi7227.FBpp0301282.

Structurei

3D structure databases

ProteinModelPortaliP02516.
SMRiP02516. Positions 71-141.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
GeneTreeiENSGT00760000119238.
InParanoidiP02516.
OMAiQDNGNDK.
OrthoDBiEOG091G0USC.
PhylomeDBiP02516.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P02516-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANIPLLLSL ADDLGRMSMV PFYEPYYCQR QRNPYLALVG PMEQQLRQLE
60 70 80 90 100
KQVGASSGSS GAVSKIGKDG FQVCMDVSHF KPSELVVKVQ DNSVLVEGNH
110 120 130 140 150
EEREDDHGFI TRHFVRRYAL PPGYEADKVA STLSSDGVLT IKVPKPPAIE
160 170 180
DKGNERIVQI QQVGPAHLNV KENPKEAVEQ DNGNDK
Length:186
Mass (Da):20,629
Last modified:November 1, 1990 - v2
Checksum:i3C6EDCDA1719B5A0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti31 – 333QRN → RRI (PubMed:6285380).Curated
Sequence conflicti81 – 811K → E (PubMed:6285380).Curated
Sequence conflicti88 – 881K → G (PubMed:6285380).Curated
Sequence conflicti95 – 951L → V (PubMed:6285380).Curated
Sequence conflicti173 – 1731N → S (PubMed:6285380).Curated
Sequence conflicti182 – 1821N → G (PubMed:6285380).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01100 Genomic DNA. Translation: AAA28637.1.
V00210 Genomic DNA. Translation: CAA23494.1.
X03889 Genomic DNA. Translation: CAA27525.1.
AE014296 Genomic DNA. Translation: AAF50286.1.
AY061081 mRNA. Translation: AAL28629.1.
PIRiA02919. HHFF23.
B20647.
RefSeqiNP_001246694.1. NM_001259765.2.
NP_523999.1. NM_079275.4.
UniGeneiDm.2552.

Genome annotation databases

EnsemblMetazoaiFBtr0076453; FBpp0076181; FBgn0001224.
FBtr0309504; FBpp0301282; FBgn0001224.
GeneIDi39077.
KEGGidme:Dmel_CG4463.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01100 Genomic DNA. Translation: AAA28637.1.
V00210 Genomic DNA. Translation: CAA23494.1.
X03889 Genomic DNA. Translation: CAA27525.1.
AE014296 Genomic DNA. Translation: AAF50286.1.
AY061081 mRNA. Translation: AAL28629.1.
PIRiA02919. HHFF23.
B20647.
RefSeqiNP_001246694.1. NM_001259765.2.
NP_523999.1. NM_079275.4.
UniGeneiDm.2552.

3D structure databases

ProteinModelPortaliP02516.
SMRiP02516. Positions 71-141.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi64472. 53 interactions.
DIPiDIP-18765N.
IntActiP02516. 3 interactions.
MINTiMINT-956485.
STRINGi7227.FBpp0301282.

Proteomic databases

PaxDbiP02516.
PRIDEiP02516.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0076453; FBpp0076181; FBgn0001224.
FBtr0309504; FBpp0301282; FBgn0001224.
GeneIDi39077.
KEGGidme:Dmel_CG4463.

Organism-specific databases

CTDi39077.
FlyBaseiFBgn0001224. Hsp23.

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
GeneTreeiENSGT00760000119238.
InParanoidiP02516.
OMAiQDNGNDK.
OrthoDBiEOG091G0USC.
PhylomeDBiP02516.

Enzyme and pathway databases

ReactomeiR-DME-3371571. HSF1-dependent transactivation.
R-DME-4420097. VEGFA-VEGFR2 Pathway.
R-DME-450408. AUF1 (hnRNP D0) binds and destabilizes mRNA.

Miscellaneous databases

ChiTaRSiHsp23. fly.
GenomeRNAii39077.
PROiP02516.

Gene expression databases

BgeeiFBgn0001224.
ExpressionAtlasiP02516. differential.
GenevisibleiP02516. DM.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PfamiPF00011. HSP20. 1 hit.
[Graphical view]
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHSP23_DROME
AccessioniPrimary (citable) accession number: P02516
Secondary accession number(s): Q9VSX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1990
Last modified: September 7, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.