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Protein

Alpha-crystallin A chain

Gene

CRYAA

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May contribute to the transparency and refractive index of the lens.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi79Zinc 1By similarity1
Metal bindingi100Zinc 2By similarity1
Metal bindingi102Zinc 2By similarity1
Metal bindingi107Zinc 1By similarity1
Metal bindingi115Zinc 1By similarity1

GO - Molecular functioni

  • identical protein binding Source: AgBase
  • metal ion binding Source: UniProtKB-KW
  • structural constituent of eye lens Source: UniProtKB-KW
  • unfolded protein binding Source: AgBase

GO - Biological processi

  • negative regulation of apoptotic process Source: AgBase
  • negative regulation of intracellular transport Source: AgBase
  • protein homooligomerization Source: AgBase
  • visual perception Source: AgBase
Complete GO annotation...

Keywords - Molecular functioni

Eye lens protein

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-crystallin A chain
Gene namesi
Name:CRYAA
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: AgBase
  • extracellular exosome Source: AgBase
  • nucleus Source: AgBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001258931 – 173Alpha-crystallin A chainAdd BLAST173

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1
Glycosylationi162O-linked (GlcNAc)By similarity1

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

PaxDbiP02504.

Expressioni

Gene expression databases

BgeeiENSGALG00000016199.
ExpressionAtlasiP02504. differential.

Interactioni

Subunit structurei

Heteropolymer composed of three CRYAA and one CRYAB subunits. Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens (By similarity).By similarity

GO - Molecular functioni

  • identical protein binding Source: AgBase
  • unfolded protein binding Source: AgBase

Protein-protein interaction databases

STRINGi9031.ENSGALP00000035906.

Structurei

3D structure databases

ProteinModelPortaliP02504.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
GeneTreeiENSGT00760000119238.
HOGENOMiHOG000233954.
HOVERGENiHBG054766.
InParanoidiP02504.
KOiK09541.
OMAiGPKVQSG.
OrthoDBiEOG091G0USC.
PhylomeDBiP02504.
TreeFamiTF105049.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR012274. Alpha-crystallin_A.
IPR003090. Alpha-crystallin_N.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PTHR11527:SF36. PTHR11527:SF36. 1 hit.
PfamiPF00525. Crystallin. 1 hit.
PF00011. HSP20. 1 hit.
[Graphical view]
PIRSFiPIRSF036514. Sm_HSP_B1. 1 hit.
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P02504-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDITIQHPWF KRALGPLIPS RLFDQFFGEG LLEYDLLPLF SSTISPYYRQ
60 70 80 90 100
SLFRSVLESG ISEVRSDRDK FTIMLDVKHF SPEDLSVKII DDFVEIHGKH
110 120 130 140 150
SERQDDHGYI SREFHRRYRL PANVDQSAIT CSLSSDGMLT FSGPKVPSNM
160 170
DPSHSERPIP VSREEKPTSA PSS
Length:173
Mass (Da):19,787
Last modified:July 1, 1989 - v2
Checksum:i327AAFCA3D79B399
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17627 Genomic DNA. Translation: AAA48722.1.
PIRiA27309. CYCHAA.
RefSeqiNP_001025968.1. NM_001030797.2.
UniGeneiGga.32115.

Genome annotation databases

EnsembliENSGALT00000064401; ENSGALP00000054560; ENSGALG00000016199.
GeneIDi418546.
KEGGigga:418546.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17627 Genomic DNA. Translation: AAA48722.1.
PIRiA27309. CYCHAA.
RefSeqiNP_001025968.1. NM_001030797.2.
UniGeneiGga.32115.

3D structure databases

ProteinModelPortaliP02504.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000035906.

Proteomic databases

PaxDbiP02504.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000064401; ENSGALP00000054560; ENSGALG00000016199.
GeneIDi418546.
KEGGigga:418546.

Organism-specific databases

CTDi1409.

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
GeneTreeiENSGT00760000119238.
HOGENOMiHOG000233954.
HOVERGENiHBG054766.
InParanoidiP02504.
KOiK09541.
OMAiGPKVQSG.
OrthoDBiEOG091G0USC.
PhylomeDBiP02504.
TreeFamiTF105049.

Miscellaneous databases

PROiP02504.

Gene expression databases

BgeeiENSGALG00000016199.
ExpressionAtlasiP02504. differential.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiIPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR012274. Alpha-crystallin_A.
IPR003090. Alpha-crystallin_N.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
[Graphical view]
PANTHERiPTHR11527. PTHR11527. 1 hit.
PTHR11527:SF36. PTHR11527:SF36. 1 hit.
PfamiPF00525. Crystallin. 1 hit.
PF00011. HSP20. 1 hit.
[Graphical view]
PIRSFiPIRSF036514. Sm_HSP_B1. 1 hit.
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiPS01031. HSP20. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRYAA_CHICK
AccessioniPrimary (citable) accession number: P02504
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 1, 1989
Last modified: November 30, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.