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Protein

Alpha-crystallin A chain

Gene

CRYAA

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May contribute to the transparency and refractive index of the lens.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi79Zinc 1By similarity1
Metal bindingi100Zinc 2By similarity1
Metal bindingi102Zinc 2By similarity1
Metal bindingi107Zinc 1By similarity1
Metal bindingi115Zinc 1By similarity1

GO - Molecular functioni

  • identical protein binding Source: AgBase
  • metal ion binding Source: UniProtKB-KW
  • structural constituent of eye lens Source: UniProtKB-KW
  • unfolded protein binding Source: AgBase

GO - Biological processi

  • negative regulation of apoptotic process Source: AgBase
  • negative regulation of intracellular transport Source: AgBase
  • protein homooligomerization Source: AgBase
  • visual perception Source: AgBase

Keywordsi

Molecular functionEye lens protein
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-crystallin A chain
Gene namesi
Name:CRYAA
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001258931 – 173Alpha-crystallin A chainAdd BLAST173

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1
Glycosylationi162O-linked (GlcNAc) serineBy similarity1

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

PaxDbiP02504.

Expressioni

Gene expression databases

BgeeiENSGALG00000016199.
ExpressionAtlasiP02504. baseline.

Interactioni

Subunit structurei

Heteropolymer composed of three CRYAA and one CRYAB subunits. Inter-subunit bridging via zinc ions enhances stability, which is crucial as there is no protein turn over in the lens (By similarity).By similarity

GO - Molecular functioni

  • identical protein binding Source: AgBase
  • unfolded protein binding Source: AgBase

Protein-protein interaction databases

STRINGi9031.ENSGALP00000035906.

Structurei

3D structure databases

ProteinModelPortaliP02504.
SMRiP02504.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 162sHSPPROSITE-ProRule annotationAdd BLAST111

Sequence similaritiesi

Belongs to the small heat shock protein (HSP20) family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3591. Eukaryota.
ENOG410YERS. LUCA.
GeneTreeiENSGT00760000119238.
HOGENOMiHOG000233954.
HOVERGENiHBG054766.
InParanoidiP02504.
KOiK09541.
OMAiGERQDDH.
OrthoDBiEOG091G0USC.
PhylomeDBiP02504.
TreeFamiTF105049.

Family and domain databases

Gene3Di2.60.40.790. 1 hit.
InterProiView protein in InterPro
IPR002068. A-crystallin/Hsp20_dom.
IPR001436. Alpha-crystallin/HSP.
IPR012274. Alpha-crystallin_A.
IPR003090. Alpha-crystallin_N.
IPR031107. HSP20.
IPR008978. HSP20-like_chaperone.
PANTHERiPTHR11527. PTHR11527. 1 hit.
PTHR11527:SF205. PTHR11527:SF205. 1 hit.
PfamiView protein in Pfam
PF00525. Crystallin. 1 hit.
PF00011. HSP20. 1 hit.
PIRSFiPIRSF036514. Sm_HSP_B1. 1 hit.
PRINTSiPR00299. ACRYSTALLIN.
SUPFAMiSSF49764. SSF49764. 1 hit.
PROSITEiView protein in PROSITE
PS01031. SHSP. 1 hit.

Sequencei

Sequence statusi: Complete.

P02504-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDITIQHPWF KRALGPLIPS RLFDQFFGEG LLEYDLLPLF SSTISPYYRQ
60 70 80 90 100
SLFRSVLESG ISEVRSDRDK FTIMLDVKHF SPEDLSVKII DDFVEIHGKH
110 120 130 140 150
SERQDDHGYI SREFHRRYRL PANVDQSAIT CSLSSDGMLT FSGPKVPSNM
160 170
DPSHSERPIP VSREEKPTSA PSS
Length:173
Mass (Da):19,787
Last modified:July 1, 1989 - v2
Checksum:i327AAFCA3D79B399
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17627 Genomic DNA. Translation: AAA48722.1.
PIRiA27309. CYCHAA.
RefSeqiNP_001025968.1. NM_001030797.2.
UniGeneiGga.32115.

Genome annotation databases

EnsembliENSGALT00000064401; ENSGALP00000054560; ENSGALG00000016199.
GeneIDi418546.
KEGGigga:418546.

Similar proteinsi

Entry informationi

Entry nameiCRYAA_CHICK
AccessioniPrimary (citable) accession number: P02504
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 1, 1989
Last modified: August 30, 2017
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families