Reviewed, UniProtKB/Swiss-Prot P02488 (CRYAA_MACMU)

Names and origin

Protein names

Recommended name:
    Alpha-crystallin A chain
Cleaved into the following chain:
    1- Recommended name:
            Alpha-crystallin A chain, short form

Gene names

Name:

CRYAA

Organism

Macaca mulatta (Rhesus macaque)

Taxonomic identifier

9544 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	172 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	May contribute to the transparency and refractive index of the lens.
Sequence similarities	Belongs to the small heat shock protein (HSP20) family.

Ontologies

Keywords
Cellular component	Eye lens protein
PTM	Acetylation Glycoprotein Methylation Oxidation Phosphoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	response to heat Inferred from electronic annotation. Source: InterPro
Molecular function	structural constituent of eye lens Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 172	172	Alpha-crystallin A chain		PRO_0000125867
	Chain	1 – 171	171	Alpha-crystallin A chain, short form		PRO_0000226643
	Propeptide	172	1	Removed in short form By similarity		PRO_0000226644
Sites
	Site	18	1	Susceptible to oxidation By similarity
	Site	34	1	Susceptible to oxidation By similarity
	Site	138	1	Susceptible to oxidation By similarity
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine Probable
	Modified residue	13	1	Phosphothreonine By similarity
	Modified residue	21	1	Omega-N-methylated arginine By similarity
	Modified residue	45	1	Phosphoserine By similarity
	Modified residue	70	1	N6-acetyllysine By similarity
	Modified residue	78	1	N6-acetyllysine By similarity
	Modified residue	88	1	N6-acetyllysine; alternate By similarity
	Modified residue	88	1	N6-methylated lysine; alternate By similarity
	Modified residue	122	1	Phosphoserine By similarity
	Modified residue	140	1	Phosphothreonine By similarity
	Modified residue	145	1	N6-acetyllysine By similarity
	Glycosylation	168	1	O-linked (GlcNAc) Ref.3
Experimental info
	Sequence conflict	153 – 154	2	TH → HT AA sequence Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P02488-1 [UniParc]. Last modified October 1, 1996. Version 2. Checksum: 1F7AF9066BEEB2D7	FASTA	172	19,792
	10 20 30 40 50 60 MDVTIQHPWF KRTLGPFYPS RLFDQFFGEG LFEYDLLPFL SSTISPYYRQ SLFRTVLDSG 70 80 90 100 110 120 ISEVRSDRDK FVIFLDVKHF SPEDLTVKVQ DDFVEIHGKH NERQDDHGYI SREFHRRYRL 130 140 150 160 170 PSNVDQSALS CSLSADGMLT FSGPKIQTGL DATHERAIPV AREEKPSSAP SS

References

[1]	"Primary structures of the alpha-crystallin A chains of seven mammalian species." de Jong W.W., van der Ouderaa F.J., Versteeg M., Groenewoud G., van Amelsvoort J.M., Bloemendal H. Eur. J. Biochem. 53:237-242(1975) Cited for: PROTEIN SEQUENCE.
[2]	"A reassessment of mammalian alpha A-crystallin sequences using DNA sequencing: implications for anthropoid affinities of tarsier." Jaworski C.J. J. Mol. Evol. 41:901-908(1995) [PubMed: 8587135] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 122-162.
[3]	"Dynamic O-GlcNAcylation of the small heat shock protein alpha B-crystallin." Roquemore E.P., Chevrier M.R., Cotter R.J., Hart G.W. Biochemistry 35:3578-3586(1996) [PubMed: 8639509] [Abstract] Cited for: GLYCOSYLATION AT SER-168.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U24061 Genomic DNA. Translation: AAA97563.1.
PIR	CYMQAA. A02890.
3D structure databases
ModBase	Search...
PTM databases
GlycoSuiteDB	P02488.
Genome annotation databases
Ensembl	ENSMMUT00000028514; ENSMMUP00000026679; ENSMMUG00000020271; Macaca mulatta. [Genome view]
Phylogenomic databases
HOVERGEN	P02488.
Family and domain databases
InterPro	IPR001436. Alpha-crystallin/HSP. IPR012274. Alpha-crystallin_A. IPR003090. Alpha-crystallin_N. IPR002068. Hsp20. IPR008978. HSP20-like_chaperone. [Graphical view]
PANTHER	PTHR11527:SF36. A-crystallin_A. 1 hit.
Pfam	PF00525. Crystallin. 1 hit. PF00011. HSP20. 1 hit. [Graphical view]
PRINTS	PR00299. ACRYSTALLIN.
PROSITE	PS01031. HSP20. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CRYAA_MACMU

Accession

Primary (citable) accession number: P02488

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	October 1, 1996
Last modified:	November 24, 2009
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)