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UniProtKB - P02469 (LAMB1_MOUSE)

UniProt

P02469 - LAMB1_MOUSE

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Protein

Laminin subunit beta-1

Gene

Lamb1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Involved in the organization of the laminar architecture of the cerebral cortex (By similarity). It is probably required for the integrity of the basement membrane/glia limitans that serves as an anchor point for the endfeet of radial glial cells and as a physical barrier to migrating neurons (By similarity). Radial glial cells play a central role in cerebral cortical development, where they act both as the proliferative unit of the cerebral cortex and a scaffold for neurons migrating toward the pial surface (By similarity).By similarity

GO - Molecular functioni

  • enzyme binding Source: MGI
  • extracellular matrix structural constituent Source: HGNC
  • glycosphingolipid binding Source: MGI
  • integrin binding Source: MGI

GO - Biological processi

  • axon guidance Source: Reactome
  • cell migration Source: MGI
  • embryo implantation Source: MGI
  • extracellular matrix disassembly Source: Reactome
  • extracellular matrix organization Source: Reactome
  • learning or memory Source: UniProtKB
  • negative regulation of cell adhesion Source: UniProtKB
  • neuronal-glial interaction involved in cerebral cortex radial glia guided migration Source: MGI
  • neuron projection development Source: HGNC
  • odontogenesis Source: HGNC
  • positive regulation of cell migration Source: HGNC
  • substrate adhesion-dependent cell spreading Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-1474228. Degradation of the extracellular matrix.
R-MMU-3000157. Laminin interactions.
R-MMU-3000171. Non-integrin membrane-ECM interactions.
R-MMU-373760. L1CAM interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Laminin subunit beta-1
Alternative name(s):
Laminin B1 chain
Laminin-1 subunit beta
Laminin-10 subunit beta
Laminin-12 subunit beta
Laminin-2 subunit beta
Laminin-6 subunit beta
Laminin-8 subunit beta
Gene namesi
Name:Lamb1
Synonyms:Lamb-1, Lamb1-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:96743. Lamb1.

Subcellular locationi

GO - Cellular componenti

  • basal lamina Source: MGI
  • basement membrane Source: UniProtKB
  • extracellular exosome Source: MGI
  • extracellular matrix Source: MGI
  • extracellular region Source: Reactome
  • extracellular space Source: MGI
  • laminin-10 complex Source: HGNC
  • laminin-1 complex Source: HGNC
  • laminin-2 complex Source: HGNC
  • laminin-8 complex Source: HGNC
  • laminin complex Source: MGI
  • nucleus Source: MGI
  • perinuclear region of cytoplasm Source: UniProtKB
  • proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Add
BLAST
Chaini22 – 17861765Laminin subunit beta-1PRO_0000017066Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi120 – 1201N-linked (GlcNAc...)Sequence analysis
Modified residuei250 – 2501PhosphoserineCombined sources
Disulfide bondi271 ↔ 280PROSITE-ProRule annotation
Disulfide bondi273 ↔ 298PROSITE-ProRule annotation
Disulfide bondi300 ↔ 309PROSITE-ProRule annotation
Disulfide bondi312 ↔ 332PROSITE-ProRule annotation
Disulfide bondi335 ↔ 344PROSITE-ProRule annotation
Disulfide bondi337 ↔ 362PROSITE-ProRule annotation
Glycosylationi356 – 3561N-linked (GlcNAc...)Sequence analysis
Disulfide bondi365 ↔ 374PROSITE-ProRule annotation
Disulfide bondi377 ↔ 395PROSITE-ProRule annotation
Disulfide bondi398 ↔ 411PROSITE-ProRule annotation
Disulfide bondi400 ↔ 426PROSITE-ProRule annotation
Disulfide bondi428 ↔ 437PROSITE-ProRule annotation
Disulfide bondi440 ↔ 455PROSITE-ProRule annotation
Disulfide bondi458 ↔ 472PROSITE-ProRule annotation
Disulfide bondi460 ↔ 479PROSITE-ProRule annotation
Disulfide bondi481 ↔ 490PROSITE-ProRule annotation
Disulfide bondi493 ↔ 507PROSITE-ProRule annotation
Disulfide bondi510 ↔ 522PROSITE-ProRule annotation
Disulfide bondi512 ↔ 529PROSITE-ProRule annotation
Glycosylationi519 – 5191N-linked (GlcNAc...)Sequence analysis
Disulfide bondi531 ↔ 540PROSITE-ProRule annotation
Glycosylationi677 – 6771N-linked (GlcNAc...)Sequence analysis
Disulfide bondi773 ↔ 785PROSITE-ProRule annotation
Disulfide bondi775 ↔ 792PROSITE-ProRule annotation
Disulfide bondi794 ↔ 803PROSITE-ProRule annotation
Disulfide bondi806 ↔ 818PROSITE-ProRule annotation
Disulfide bondi821 ↔ 833PROSITE-ProRule annotation
Disulfide bondi823 ↔ 840PROSITE-ProRule annotation
Disulfide bondi842 ↔ 851PROSITE-ProRule annotation
Disulfide bondi854 ↔ 864PROSITE-ProRule annotation
Disulfide bondi867 ↔ 876PROSITE-ProRule annotation
Disulfide bondi869 ↔ 883PROSITE-ProRule annotation
Disulfide bondi886 ↔ 895PROSITE-ProRule annotation
Disulfide bondi898 ↔ 914PROSITE-ProRule annotation
Disulfide bondi917 ↔ 933PROSITE-ProRule annotation
Disulfide bondi919 ↔ 944PROSITE-ProRule annotation
Disulfide bondi946 ↔ 955PROSITE-ProRule annotation
Disulfide bondi958 ↔ 973PROSITE-ProRule annotation
Disulfide bondi976 ↔ 990PROSITE-ProRule annotation
Disulfide bondi978 ↔ 997PROSITE-ProRule annotation
Disulfide bondi1000 ↔ 1009PROSITE-ProRule annotation
Disulfide bondi1012 ↔ 1025PROSITE-ProRule annotation
Disulfide bondi1028 ↔ 1040PROSITE-ProRule annotation
Disulfide bondi1030 ↔ 1054PROSITE-ProRule annotation
Glycosylationi1041 – 10411N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1056 ↔ 1065PROSITE-ProRule annotation
Disulfide bondi1068 ↔ 1081PROSITE-ProRule annotation
Disulfide bondi1084 ↔ 1096PROSITE-ProRule annotation
Disulfide bondi1086 ↔ 1103PROSITE-ProRule annotation
Disulfide bondi1105 ↔ 1114PROSITE-ProRule annotation
Disulfide bondi1117 ↔ 1129PROSITE-ProRule annotation
Disulfide bondi1132 ↔ 1144PROSITE-ProRule annotation
Disulfide bondi1134 ↔ 1151PROSITE-ProRule annotation
Disulfide bondi1153 ↔ 1162PROSITE-ProRule annotation
Disulfide bondi1165 ↔ 1176PROSITE-ProRule annotation
Disulfide bondi1179 – 1179InterchainCurated
Disulfide bondi1182 – 1182InterchainCurated
Glycosylationi1195 – 11951N-linked (GlcNAc...)Sequence analysis
Glycosylationi1279 – 12791N-linked (GlcNAc...)1 Publication
Glycosylationi1336 – 13361N-linked (GlcNAc...)1 Publication
Glycosylationi1343 – 13431N-linked (GlcNAc...)1 Publication
Glycosylationi1487 – 14871N-linked (GlcNAc...)Sequence analysis
Modified residuei1496 – 14961PhosphoserineBy similarity
Glycosylationi1542 – 15421N-linked (GlcNAc...)Sequence analysis
Glycosylationi1643 – 16431N-linked (GlcNAc...)Sequence analysis
Modified residuei1666 – 16661PhosphoserineBy similarity
Disulfide bondi1785 – 1785InterchainCurated

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP02469.
PaxDbiP02469.
PeptideAtlasiP02469.
PRIDEiP02469.

PTM databases

iPTMnetiP02469.
PhosphoSiteiP02469.

Expressioni

Tissue specificityi

Widely expressed in the embryo. High levels are detected in the cerebellar basement membrane, at postnatal day 7.1 Publication

Gene expression databases

BgeeiENSMUSG00000002900.
CleanExiMM_LAMB1-1.
ExpressionAtlasiP02469. baseline and differential.
GenevisibleiP02469. MM.

Interactioni

Subunit structurei

Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Beta-1 is a subunit of laminin-1 (laminin-111 or EHS laminin), laminin-2 (laminin-211 or merosin), laminin-6 (laminin-311 or K-laminin), laminin-8 (laminin-411), laminin-10 (laminin-511) and laminin-12 (laminin-213).

Binary interactionsi

WithEntry#Exp.IntActNotes
AGRNP316962EBI-6662997,EBI-457650From a different organism.
Lamc1P024684EBI-6662997,EBI-7059830

GO - Molecular functioni

  • enzyme binding Source: MGI
  • integrin binding Source: MGI

Protein-protein interaction databases

BioGridi201101. 4 interactions.
IntActiP02469. 7 interactions.
MINTiMINT-1206337.
STRINGi10090.ENSMUSP00000002979.

Structurei

Secondary structure

1
1786
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi30 – 323Combined sources
Beta strandi40 – 434Combined sources
Helixi47 – 493Combined sources
Beta strandi58 – 603Combined sources
Beta strandi62 – 676Combined sources
Beta strandi69 – 724Combined sources
Beta strandi74 – 796Combined sources
Turni87 – 893Combined sources
Helixi96 – 983Combined sources
Beta strandi122 – 14221Combined sources
Beta strandi146 – 15510Combined sources
Beta strandi161 – 1699Combined sources
Turni170 – 1723Combined sources
Beta strandi173 – 1775Combined sources
Turni200 – 2023Combined sources
Beta strandi204 – 2107Combined sources
Beta strandi212 – 2143Combined sources
Helixi222 – 2287Combined sources
Beta strandi229 – 23911Combined sources
Helixi252 – 2554Combined sources
Beta strandi261 – 27010Combined sources
Beta strandi304 – 3096Combined sources
Beta strandi342 – 3465Combined sources
Helixi348 – 3536Combined sources
Beta strandi360 – 3645Combined sources
Beta strandi369 – 3713Combined sources
Beta strandi381 – 3833Combined sources
Beta strandi385 – 3873Combined sources
Beta strandi395 – 3973Combined sources
Turni402 – 4043Combined sources
Helixi407 – 4093Combined sources
Helixi417 – 4193Combined sources
Turni434 – 4374Combined sources
Beta strandi454 – 4574Combined sources
Turni462 – 4643Combined sources
Turni474 – 4763Combined sources
Turni488 – 4903Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AQSX-ray3.11A22-542[»]
ProteinModelPortaliP02469.
SMRiP02469. Positions 29-492.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 270240Laminin N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini271 – 33464Laminin EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini335 – 39763Laminin EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini398 – 45760Laminin EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini458 – 50952Laminin EGF-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini510 – 54031Laminin EGF-like 5; truncatedPROSITE-ProRule annotationAdd
BLAST
Domaini549 – 767219Laminin IV type BPROSITE-ProRule annotationAdd
BLAST
Domaini773 – 82048Laminin EGF-like 6PROSITE-ProRule annotationAdd
BLAST
Domaini821 – 86646Laminin EGF-like 7PROSITE-ProRule annotationAdd
BLAST
Domaini867 – 91650Laminin EGF-like 8PROSITE-ProRule annotationAdd
BLAST
Domaini917 – 97559Laminin EGF-like 9PROSITE-ProRule annotationAdd
BLAST
Domaini976 – 102752Laminin EGF-like 10PROSITE-ProRule annotationAdd
BLAST
Domaini1028 – 108356Laminin EGF-like 11PROSITE-ProRule annotationAdd
BLAST
Domaini1084 – 113148Laminin EGF-like 12PROSITE-ProRule annotationAdd
BLAST
Domaini1132 – 117847Laminin EGF-like 13PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1179 – 1397219Domain IIAdd
BLAST
Regioni1398 – 143033Domain alphaAdd
BLAST
Regioni1431 – 1786356Domain IAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1216 – 1315100Sequence analysisAdd
BLAST
Coiled coili1368 – 138821Sequence analysisAdd
BLAST
Coiled coili1448 – 1778331Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 13 laminin EGF-like domains.PROSITE-ProRule annotation
Contains 1 laminin IV type B domain.PROSITE-ProRule annotation
Contains 1 laminin N-terminal domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Laminin EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0994. Eukaryota.
ENOG410XPEG. LUCA.
GeneTreeiENSGT00780000121851.
HOVERGENiHBG052301.
InParanoidiP02469.

Family and domain databases

InterProiIPR000742. EGF-like_dom.
IPR002049. Laminin_EGF.
IPR013015. Laminin_IV_B.
IPR008211. Laminin_N.
[Graphical view]
PfamiPF00053. Laminin_EGF. 13 hits.
PF00055. Laminin_N. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 10 hits.
SM00180. EGF_Lam. 13 hits.
SM00136. LamNT. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 9 hits.
PS01186. EGF_2. 2 hits.
PS01248. EGF_LAM_1. 11 hits.
PS50027. EGF_LAM_2. 13 hits.
PS51116. LAMININ_IVB. 1 hit.
PS51117. LAMININ_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02469-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLLQVFAFG VLALWGTRVC AQEPEFSYGC AEGSCYPATG DLLIGRAQKL 
        60         70         80         90        100
SVTSTCGLHK PEPYCIVSHL QEDKKCFICD SRDPYHETLN PDSHLIENVV 
       110        120        130        140        150
TTFAPNRLKI WWQSENGVEN VTIQLDLEAE FHFTHLIMTF KTFRPAAMLI 
       160        170        180        190        200
ERSSDFGKAW GVYRYFAYDC ESSFPGISTG PMKKVDDIIC DSRYSDIEPS 
       210        220        230        240        250
TEGEVIFRAL DPAFKIEDPY SPRIQNLLKI TNLRIKFVKL HTLGDNLLDS 
       260        270        280        290        300
RMEIREKYYY AVYDMVVRGN CFCYGHASEC APVDGVNEEV EGMVHGHCMC 
       310        320        330        340        350
RHNTKGLNCE LCMDFYHDLP WRPAEGRNSN ACKKCNCNEH SSSCHFDMAV 
       360        370        380        390        400
FLATGNVSGG VCDNCQHNTM GRNCEQCKPF YFQHPERDIR DPNLCEPCTC 
       410        420        430        440        450
DPAGSENGGI CDGYTDFSVG LIAGQCRCKL HVEGERCDVC KEGFYDLSAE 
       460        470        480        490        500
DPYGCKSCAC NPLGTIPGGN PCDSETGYCY CKRLVTGQRC DQCLPQHWGL 
       510        520        530        540        550
SNDLDGCRPC DCDLGGALNN SCSEDSGQCS CLPHMIGRQC NEVESGYYFT 
       560        570        580        590        600
TLDHYIYEAE EANLGPGVIV VERQYIQDRI PSWTGPGFVR VPEGAYLEFF 
       610        620        630        640        650
IDNIPYSMEY EILIRYEPQL PDHWEKAVIT VQRPGKIPAS SRCGNTVPDD 
       660        670        680        690        700
DNQVVSLSPG SRYVVLPRPV CFEKGMNYTV RLELPQYTAS GSDVESPYTF 
       710        720        730        740        750
IDSLVLMPYC KSLDIFTVGG SGDGEVTNSA WETFQRYRCL ENSRSVVKTP 
       760        770        780        790        800
MTDVCRNIIF SISALIHQTG LACECDPQGS LSSVCDPNGG QCQCRPNVVG 
       810        820        830        840        850
RTCNRCAPGT FGFGPNGCKP CDCHLQGSAS AFCDAITGQC HCFQGIYARQ 
       860        870        880        890        900
CDRCLPGYWG FPSCQPCQCN GHALDCDTVT GECLSCQDYT TGHNCERCLA 
       910        920        930        940        950
GYYGDPIIGS GDHCRPCPCP DGPDSGRQFA RSCYQDPVTL QLACVCDPGY 
       960        970        980        990       1000
IGSRCDDCAS GFFGNPSDFG GSCQPCQCHH NIDTTDPEAC DKETGRCLKC 
      1010       1020       1030       1040       1050
LYHTEGDHCQ LCQYGYYGDA LRQDCRKCVC NYLGTVKEHC NGSDCHCDKA 
      1060       1070       1080       1090       1100
TGQCSCLPNV IGQNCDRCAP NTWQLASGTG CGPCNCNAAH SFGPSCNEFT 
      1110       1120       1130       1140       1150
GQCQCMPGFG GRTCSECQEL FWGDPDVECR ACDCDPRGIE TPQCDQSTGQ 
      1160       1170       1180       1190       1200
CVCVEGVEGP RCDKCTRGYS GVFPDCTPCH QCFALWDAII GELTNRTHKF 
      1210       1220       1230       1240       1250
LEKAKALKIS GVIGPYRETV DSVEKKVNEI KDILAQSPAA EPLKNIGILF 
      1260       1270       1280       1290       1300
EEAEKLTKDV TEKMAQVEVK LTDTASQSNS TAGELGALQA EAESLDKTVK 
      1310       1320       1330       1340       1350
ELAEQLEFIK NSDIQGALDS ITKYFQMSLE AEKRVNASTT DPNSTVEQSA 
      1360       1370       1380       1390       1400
LTRDRVEDLM LERESPFKEQ QEEQARLLDE LAGKLQSLDL SAVAQMTCGT 
      1410       1420       1430       1440       1450
PPGADCSESE CGGPNCRTDE GEKKCGGPGC GGLVTVAHSA WQKAMDFDRD 
      1460       1470       1480       1490       1500
VLSALAEVEQ LSKMVSEAKV RADEAKQNAQ DVLLKTNATK EKVDKSNEDL 
      1510       1520       1530       1540       1550
RNLIKQIRNF LTEDSADLDS IEAVANEVLK MEMPSTPQQL QNLTEDIRER 
      1560       1570       1580       1590       1600
VETLSQVEVI LQQSAADIAR AELLLEEAKR ASKSATDVKV TADMVKEALE 
      1610       1620       1630       1640       1650
EAEKAQVAAE KAIKQADEDI QGTQNLLTSI ESETAASEET LTNASQRISK 
      1660       1670       1680       1690       1700
LERNVEELKR KAAQNSGEAE YIEKVVYSVK QNADDVKKTL DGELDEKYKK 
      1710       1720       1730       1740       1750
VESLIAQKTE ESADARRKAE LLQNEAKTLL AQANSKLQLL EDLERKYEDN 
      1760       1770       1780 
QKYLEDKAQE LVRLEGEVRS LLKDISEKVA VYSTCL
Length:1,786
Mass (Da):197,090
Last modified:July 27, 2011 - v3
Checksum:iE7F258170C3626DD
GO

Sequence cautioni

The sequence AAA39407 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti159 – 1591A → T in AAA39407 (PubMed:3493487).Curated
Sequence conflicti569 – 5691I → V in AAA39407 (PubMed:3493487).Curated
Sequence conflicti993 – 9931E → D in AAA39407 (PubMed:3493487).Curated
Sequence conflicti1393 – 13931V → A in AAA39407 (PubMed:3493487).Curated
Sequence conflicti1393 – 13931V → A in CAA28839 (PubMed:6209134).Curated
Sequence conflicti1531 – 15344MEMP → SGNA in AAA39407 (PubMed:3493487).Curated
Sequence conflicti1692 – 16921G → C in CAA28839 (PubMed:6209134).Curated
Sequence conflicti1749 – 17491D → N in CAA28839 (PubMed:6209134).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15525 mRNA. Translation: AAA39407.1. Different initiation.
CR974423 Genomic DNA. No translation available.
CT571245 Genomic DNA. No translation available.
X05212 mRNA. Translation: CAA28839.1.
PIRiA26413. MMMSB1.
RefSeqiXP_006515055.2. XM_006514992.2.
XP_006515056.1. XM_006514993.1.
UniGeneiMm.172674.

Genome annotation databases

EnsembliENSMUST00000169088; ENSMUSP00000132778; ENSMUSG00000002900.
GeneIDi16777.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M15525 mRNA. Translation: AAA39407.1. Different initiation.
CR974423 Genomic DNA. No translation available.
CT571245 Genomic DNA. No translation available.
X05212 mRNA. Translation: CAA28839.1.
PIRiA26413. MMMSB1.
RefSeqiXP_006515055.2. XM_006514992.2.
XP_006515056.1. XM_006514993.1.
UniGeneiMm.172674.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AQSX-ray3.11A22-542[»]
ProteinModelPortaliP02469.
SMRiP02469. Positions 29-492.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201101. 4 interactions.
IntActiP02469. 7 interactions.
MINTiMINT-1206337.
STRINGi10090.ENSMUSP00000002979.

PTM databases

iPTMnetiP02469.
PhosphoSiteiP02469.

Proteomic databases

MaxQBiP02469.
PaxDbiP02469.
PeptideAtlasiP02469.
PRIDEiP02469.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000169088; ENSMUSP00000132778; ENSMUSG00000002900.
GeneIDi16777.

Organism-specific databases

CTDi3912.
MGIiMGI:96743. Lamb1.

Phylogenomic databases

eggNOGiKOG0994. Eukaryota.
ENOG410XPEG. LUCA.
GeneTreeiENSGT00780000121851.
HOVERGENiHBG052301.
InParanoidiP02469.

Enzyme and pathway databases

ReactomeiR-MMU-1474228. Degradation of the extracellular matrix.
R-MMU-3000157. Laminin interactions.
R-MMU-3000171. Non-integrin membrane-ECM interactions.
R-MMU-373760. L1CAM interactions.

Miscellaneous databases

ChiTaRSiLamb1. mouse.
PROiP02469.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002900.
CleanExiMM_LAMB1-1.
ExpressionAtlasiP02469. baseline and differential.
GenevisibleiP02469. MM.

Family and domain databases

InterProiIPR000742. EGF-like_dom.
IPR002049. Laminin_EGF.
IPR013015. Laminin_IV_B.
IPR008211. Laminin_N.
[Graphical view]
PfamiPF00053. Laminin_EGF. 13 hits.
PF00055. Laminin_N. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 10 hits.
SM00180. EGF_Lam. 13 hits.
SM00136. LamNT. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 9 hits.
PS01186. EGF_2. 2 hits.
PS01248. EGF_LAM_1. 11 hits.
PS50027. EGF_LAM_2. 13 hits.
PS51116. LAMININ_IVB. 1 hit.
PS51117. LAMININ_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAMB1_MOUSE
AccessioniPrimary (citable) accession number: P02469
Secondary accession number(s): E9PXZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 158 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.