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P02460

- CO2A1_CHICK

UniProt

P02460 - CO2A1_CHICK

Protein

Collagen alpha-1(II) chain

Gene

COL2A1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Nov 1988)
      Previous versions | rss
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    Functioni

    Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei123 – 1242Cleavage; by procollagen C-endopeptidase
    Metal bindingi183 – 1831CalciumBy similarity
    Metal bindingi185 – 1851CalciumBy similarity
    Metal bindingi186 – 1861Calcium; via carbonyl oxygenBy similarity
    Metal bindingi188 – 1881Calcium; via carbonyl oxygenBy similarity
    Metal bindingi191 – 1911CalciumBy similarity

    GO - Molecular functioni

    1. extracellular matrix structural constituent Source: InterPro
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cartilage condensation Source: Ensembl
    2. cartilage development involved in endochondral bone morphogenesis Source: Ensembl
    3. cellular response to BMP stimulus Source: Ensembl
    4. central nervous system development Source: Ensembl
    5. chondrocyte differentiation Source: Ensembl
    6. collagen fibril organization Source: Ensembl
    7. embryonic skeletal joint morphogenesis Source: Ensembl
    8. endochondral ossification Source: Ensembl
    9. heart morphogenesis Source: Ensembl
    10. inner ear morphogenesis Source: Ensembl
    11. limb bud formation Source: Ensembl
    12. negative regulation of extrinsic apoptotic signaling pathway in absence of ligand Source: Ensembl
    13. notochord development Source: Ensembl
    14. otic vesicle development Source: Ensembl
    15. palate development Source: Ensembl
    16. proteoglycan metabolic process Source: Ensembl
    17. regulation of gene expression Source: Ensembl
    18. sensory perception of sound Source: Ensembl
    19. tissue homeostasis Source: Ensembl
    20. visual perception Source: Ensembl

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_196873. Extracellular matrix organization.
    REACT_197163. Assembly of collagen fibrils and other multimeric structures.
    REACT_197191. Collagen degradation.
    REACT_198057. Non-integrin membrane-ECM interactions.
    REACT_198079. ECM proteoglycans.
    REACT_198187. Collagen biosynthesis and modifying enzymes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Collagen alpha-1(II) chain
    Alternative name(s):
    Alpha-1 type II collagen
    Gene namesi
    Name:COL2A1
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    Secretedextracellular spaceextracellular matrix PROSITE-ProRule annotation

    GO - Cellular componenti

    1. basement membrane Source: Ensembl
    2. collagen type II trimer Source: Ensembl
    3. cytoplasm Source: Ensembl
    4. extracellular space Source: Ensembl

    Keywords - Cellular componenti

    Extracellular matrix, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 123›123Collagen alpha-1(II) chainPRO_0000005727Add
    BLAST
    Propeptidei124 – 369246C-terminal propeptidePRO_0000005728Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi165 ↔ 197PROSITE-ProRule annotation
    Disulfide bondi171 – 171Interchain (with C-188)PROSITE-ProRule annotation
    Disulfide bondi188 – 188Interchain (with C-171)PROSITE-ProRule annotation
    Disulfide bondi205 ↔ 367PROSITE-ProRule annotation
    Glycosylationi270 – 2701N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi275 ↔ 320PROSITE-ProRule annotation

    Post-translational modificationi

    Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Hydroxylation

    Proteomic databases

    PaxDbiP02460.

    Miscellaneous databases

    PMAP-CutDBP02460.

    Interactioni

    Subunit structurei

    Homotrimers of alpha 1(II) chains.

    Protein-protein interaction databases

    IntActiP02460. 1 interaction.
    STRINGi9031.ENSGALP00000035064.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini135 – 369235Fibrillar collagen NC1PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni‹1 – 96›96Triple-helical regionAdd
    BLAST
    Regioni97 – 12327Nonhelical region (C-terminal)Add
    BLAST

    Domaini

    The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function By similarity.By similarity

    Sequence similaritiesi

    Belongs to the fibrillar collagen family.PROSITE-ProRule annotation
    Contains 1 fibrillar collagen NC1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Collagen, Repeat

    Phylogenomic databases

    eggNOGiNOG12793.
    HOGENOMiHOG000085654.
    HOVERGENiHBG103137.
    InParanoidiP02460.
    PhylomeDBiP02460.

    Family and domain databases

    InterProiIPR008160. Collagen.
    IPR000885. Fib_collagen_C.
    [Graphical view]
    PfamiPF01410. COLFI. 1 hit.
    PF01391. Collagen. 2 hits.
    [Graphical view]
    ProDomiPD002078. Fib_collagen_C. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00038. COLFI. 1 hit.
    [Graphical view]
    PROSITEiPS51461. NC1_FIB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P02460-1 [UniParc]FASTAAdd to Basket

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    GETGEAGERG LKGHRGFTGL QGLPGPPGPS GDQGAAGPAG PSGPRGPPGP    50
    VGPSGKDGSN GMPGPIGPPG PRGRSGEPGP AGPPGNPGPP GPPGPPGTGI 100
    DMSAFAGLGQ TEKGPDPIRY MRADEAAGGL RQHDVEVDAT LKSLNNQIES 150
    IRSPEGSKKN PARTCRDIKL CHPEWKSGDY WIDPNQGCTL DAIKVFCNME 200
    TGETCVYPTP SSIPRKNWWT SKTKDKKHVW FAETINGGFH FSYGDENLSP 250
    NTASIQMTFL RLLSTEGSQN VTYHCKNSIA YMDEETGNLK KAILIQGSND 300
    VEIRAEGNSR FTYSVLEDGC TKHTGKWGKT VIEYRSQKTS RLPIVDIAPM 350
    DIGGADQEFG VDIGPVCFL 369
    Length:369
    Mass (Da):38,990
    Last modified:November 1, 1988 - v1
    Checksum:iEF5306925B0BA3B0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X02663 mRNA. Translation: CAA26499.1.
    L00063, L00061, L00062 Genomic DNA. Translation: AAB59967.1.
    PIRiA02860. CGCH6C.
    S07133.
    UniGeneiGga.2839.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X02663 mRNA. Translation: CAA26499.1 .
    L00063 , L00061 , L00062 Genomic DNA. Translation: AAB59967.1 .
    PIRi A02860. CGCH6C.
    S07133.
    UniGenei Gga.2839.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P02460. 1 interaction.
    STRINGi 9031.ENSGALP00000035064.

    Proteomic databases

    PaxDbi P02460.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG12793.
    HOGENOMi HOG000085654.
    HOVERGENi HBG103137.
    InParanoidi P02460.
    PhylomeDBi P02460.

    Enzyme and pathway databases

    Reactomei REACT_196873. Extracellular matrix organization.
    REACT_197163. Assembly of collagen fibrils and other multimeric structures.
    REACT_197191. Collagen degradation.
    REACT_198057. Non-integrin membrane-ECM interactions.
    REACT_198079. ECM proteoglycans.
    REACT_198187. Collagen biosynthesis and modifying enzymes.

    Miscellaneous databases

    PMAP-CutDB P02460.
    PROi P02460.

    Family and domain databases

    InterProi IPR008160. Collagen.
    IPR000885. Fib_collagen_C.
    [Graphical view ]
    Pfami PF01410. COLFI. 1 hit.
    PF01391. Collagen. 2 hits.
    [Graphical view ]
    ProDomi PD002078. Fib_collagen_C. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00038. COLFI. 1 hit.
    [Graphical view ]
    PROSITEi PS51461. NC1_FIB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure of the telopeptide and a portion of the helical domain of chicken type II procollagen as determined by DNA sequence analysis."
      Deak F., Argraves W.S., Kiss I., Sparks K.J., Goetinck P.F.
      Biochem. J. 229:189-196(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-193.
    2. "Structure and sequence of the chicken type II procollagen gene. Characterization of the region encoding the carboxyl-terminal telopeptide and propeptide."
      Sandell L.J., Prentice H.L., Kravis D., Upholt W.B.
      J. Biol. Chem. 259:7826-7834(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 82-369.
    3. "Structure of the carboxyl propeptide of chicken type II procollagen determined by DNA and protein sequence analysis."
      Ninomiya Y., Showalter A.M., van der Rest M., Seidah N.G., Chretien M., Olsen B.R.
      Biochemistry 23:617-624(1984)
      Cited for: NUCLEOTIDE SEQUENCE OF 114-369.

    Entry informationi

    Entry nameiCO2A1_CHICK
    AccessioniPrimary (citable) accession number: P02460
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: November 1, 1988
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3