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Protein

Collagen alpha-1(II) chain

Gene

COL2A1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi673CalciumBy similarity1
Metal bindingi675CalciumBy similarity1
Metal bindingi676Calcium; via carbonyl oxygenBy similarity1
Metal bindingi678Calcium; via carbonyl oxygenBy similarity1
Metal bindingi681CalciumBy similarity1

GO - Molecular functioni

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(II) chainBy similarity
Alternative name(s):
Alpha-1 type II collagenBy similarity
Gene namesi
Name:COL2A1By similarity
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componentsi: Unassembled WGS sequence, Unplaced

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000005727‹1 – 859Collagen alpha-1(II) chainAdd BLAST›859
PropeptideiPRO_0000005728614 – 859C-terminal propeptideAdd BLAST246

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi655 ↔ 687PROSITE-ProRule annotation
Disulfide bondi655InterchainPROSITE-ProRule annotation
Disulfide bondi661Interchain (with C-678)PROSITE-ProRule annotation
Disulfide bondi678Interchain (with C-661)PROSITE-ProRule annotation
Disulfide bondi687InterchainPROSITE-ProRule annotation
Disulfide bondi695 ↔ 857PROSITE-ProRule annotation
Glycosylationi760N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi765 ↔ 810PROSITE-ProRule annotation

Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei613 – 614Cleavage; by procollagen C-endopeptidase2

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

PaxDbiP02460.
PRIDEiP02460.

Miscellaneous databases

PMAP-CutDBiP02460.

Expressioni

Gene expression databases

BgeeiENSGALG00000013587.

Interactioni

Subunit structurei

Homotrimers of alpha 1(II) chains.

Protein-protein interaction databases

IntActiP02460. 1 interactor.
STRINGi9031.ENSGALP00000035064.

Structurei

3D structure databases

SMRiP02460.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini625 – 859Fibrillar collagen NC1PROSITE-ProRule annotationAdd BLAST235

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni491 – 586Triple-helical regionAdd BLAST96
Regioni587 – 613Nonhelical region (C-terminal)Add BLAST27

Domaini

The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function (By similarity).By similarity

Sequence similaritiesi

Belongs to the fibrillar collagen family.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Repeat

Phylogenomic databases

eggNOGiENOG410YF8Q. LUCA.
GeneTreeiENSGT00840000129673.
HOGENOMiHOG000085654.
HOVERGENiHBG103137.
InParanoidiP02460.
OrthoDBiEOG091G03LV.
PhylomeDBiP02460.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
InterProiView protein in InterPro
IPR008160. Collagen.
IPR000885. Fib_collagen_C.
IPR014716. Fibrinogen_a/b/g_C_1.
PfamiView protein in Pfam
PF01410. COLFI. 1 hit.
PF01391. Collagen. 2 hits.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002078. Fib_collagen_C. 1 hit.
SMARTiView protein in SMART
SM00038. COLFI. 1 hit.
PROSITEiView protein in PROSITE
PS51461. NC1_FIB. 1 hit.

Sequences (2)i

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P02460-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
LQGLPGKDGE TGAAGPLDPG PVGERGEQGA PGPSGFQGLP GPPGPPGESG
60 70 80 90 100
KPGDQGVPGE AGAPGLVGPR GERGFPGERG SPGAQGLQGP RGLPGTPGTD
110 120 130 140 150
GPKGATGPAG PNGAQGPPGL QGMPGERGAA GIAGPKGDRG DVGEKGPEGA
160 170 180 190 200
PGKDGARGLT GPIGPPGPAG PNGEKGESGP PGPSGAAGAR GAPGERGEPG
210 220 230 240 250
APGPAGFAGP PGADGQPGAK GEQGEPGQKG DAGAPGPQGP SGAPGPQGPT
260 270 280 290 300
GVTGPKGARG AQGPPGATGF PGAAGRVGPP GPNGNPGPPG PPGSAGKDGP
310 320 330 340 350
KGVRGDAGPP GRAGDPGLQG PAGPPGEKGE PGEDGPAGPD GPPGPQGLAG
360 370 380 390 400
QRGIVGLPGQ RGERGFPGLP GPSGEPGKQG APGSAGDRGP PGPVGPPGLT
410 420 430 440 450
GPAGEPGREG NPGADGPPGR DGAAGVKGDR GETGPVGAPG APGAPGAPGP
460 470 480 490 500
VGPTGKQGDR GETGAQGPMG PSGPAGARGM PGPQGPRGDK GETGEAGERG
510 520 530 540 550
LKGHRGFTGL QGLPGPPGPS GDQGAAGPAG PSGPRGPPGP VGPSGKDGSN
560 570 580 590 600
GMPGPIGPPG PRGRSGEPGP AGPPGNPGPP GPPGPPGTGI DMSAFAGLGQ
610 620 630 640 650
TEKGPDPIRY MRADEAAGGL RQHDVEVDAT LKSLNNQIES IRSPEGSKKN
660 670 680 690 700
PARTCRDIKL CHPEWKSGDY WIDPNQGCTL DAIKVFCNME TGETCVYPTP
710 720 730 740 750
SSIPRKNWWT SKTKDKKHVW FAETINGGFH FSYGDENLSP NTASIQMTFL
760 770 780 790 800
RLLSTEGSQN VTYHCKNSIA YMDEETGNLK KAILIQGSND VEIRAEGNSR
810 820 830 840 850
FTYSVLEDGC TKHTGKWGKT VIEYRSQKTS RLPIVDIAPM DIGGADQEFG

VDIGPVCFL
Note: No experimental confirmation available. Incomplete sequence.Curated
Length:859
Mass (Da):83,228
Last modified:May 10, 2017 - v2
Checksum:i7C8A32F0CEF64705
GO
Isoform 2 (identifier: P02460-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     731-811: Missing.

Note: No experimental confirmation available. Incomplete sequence.Curated
Show »
Length:778
Mass (Da):74,257
Checksum:i6B0C9DC991172372
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_058908731 – 811Missing in isoform 2. CuratedAdd BLAST81

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02663 mRNA. Translation: CAA26499.1.
L00063, L00061, L00062 Genomic DNA. Translation: AAB59967.1.
PIRiA02860. CGCH6C.
S07133.
UniGeneiGga.2839.
Gga.51529.

Genome annotation databases

EnsembliENSGALT00000068432; ENSGALP00000052906; ENSGALG00000030712.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02663 mRNA. Translation: CAA26499.1.
L00063, L00061, L00062 Genomic DNA. Translation: AAB59967.1.
PIRiA02860. CGCH6C.
S07133.
UniGeneiGga.2839.
Gga.51529.

3D structure databases

SMRiP02460.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP02460. 1 interactor.
STRINGi9031.ENSGALP00000035064.

Proteomic databases

PaxDbiP02460.
PRIDEiP02460.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000068432; ENSGALP00000052906; ENSGALG00000030712.

Phylogenomic databases

eggNOGiENOG410YF8Q. LUCA.
GeneTreeiENSGT00840000129673.
HOGENOMiHOG000085654.
HOVERGENiHBG103137.
InParanoidiP02460.
OrthoDBiEOG091G03LV.
PhylomeDBiP02460.

Miscellaneous databases

PMAP-CutDBiP02460.

Gene expression databases

BgeeiENSGALG00000013587.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
InterProiView protein in InterPro
IPR008160. Collagen.
IPR000885. Fib_collagen_C.
IPR014716. Fibrinogen_a/b/g_C_1.
PfamiView protein in Pfam
PF01410. COLFI. 1 hit.
PF01391. Collagen. 2 hits.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD002078. Fib_collagen_C. 1 hit.
SMARTiView protein in SMART
SM00038. COLFI. 1 hit.
PROSITEiView protein in PROSITE
PS51461. NC1_FIB. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCO2A1_CHICK
AccessioniPrimary (citable) accession number: P02460
Secondary accession number(s): A0A1D5PJB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: May 10, 2017
Last modified: May 10, 2017
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.