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Protein

Collagen alpha-1(II) chain

Gene

COL2A1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi183CalciumBy similarity1
Metal bindingi185CalciumBy similarity1
Metal bindingi186Calcium; via carbonyl oxygenBy similarity1
Metal bindingi188Calcium; via carbonyl oxygenBy similarity1
Metal bindingi191CalciumBy similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(II) chain
Alternative name(s):
Alpha-1 type II collagen
Gene namesi
Name:COL2A1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000005727‹1 – 123Collagen alpha-1(II) chainAdd BLAST›123
PropeptideiPRO_0000005728124 – 369C-terminal propeptideAdd BLAST246

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi165 ↔ 197PROSITE-ProRule annotation
Disulfide bondi171Interchain (with C-188)PROSITE-ProRule annotation
Disulfide bondi188Interchain (with C-171)PROSITE-ProRule annotation
Disulfide bondi205 ↔ 367PROSITE-ProRule annotation
Glycosylationi270N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi275 ↔ 320PROSITE-ProRule annotation

Post-translational modificationi

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei123 – 124Cleavage; by procollagen C-endopeptidase2

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

PaxDbiP02460.
PRIDEiP02460.

Miscellaneous databases

PMAP-CutDBP02460.

Expressioni

Gene expression databases

BgeeiENSGALG00000013587.

Interactioni

Subunit structurei

Homotrimers of alpha 1(II) chains.

Protein-protein interaction databases

IntActiP02460. 1 interactor.
STRINGi9031.ENSGALP00000035064.

Structurei

3D structure databases

ProteinModelPortaliP02460.
SMRiP02460.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini135 – 369Fibrillar collagen NC1PROSITE-ProRule annotationAdd BLAST235

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni‹1 – 96Triple-helical regionAdd BLAST›96
Regioni97 – 123Nonhelical region (C-terminal)Add BLAST27

Domaini

The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function (By similarity).By similarity

Sequence similaritiesi

Belongs to the fibrillar collagen family.PROSITE-ProRule annotation
Contains 1 fibrillar collagen NC1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Collagen, Repeat

Phylogenomic databases

eggNOGiENOG410YF8Q. LUCA.
HOGENOMiHOG000085654.
HOVERGENiHBG103137.
InParanoidiP02460.
OrthoDBiEOG091G03LV.
PhylomeDBiP02460.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
InterProiIPR008160. Collagen.
IPR000885. Fib_collagen_C.
IPR014716. Fibrinogen_a/b/g_C_1.
[Graphical view]
PfamiPF01410. COLFI. 1 hit.
PF01391. Collagen. 2 hits.
[Graphical view]
ProDomiPD002078. Fib_collagen_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00038. COLFI. 1 hit.
[Graphical view]
PROSITEiPS51461. NC1_FIB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02460-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GETGEAGERG LKGHRGFTGL QGLPGPPGPS GDQGAAGPAG PSGPRGPPGP
60 70 80 90 100
VGPSGKDGSN GMPGPIGPPG PRGRSGEPGP AGPPGNPGPP GPPGPPGTGI
110 120 130 140 150
DMSAFAGLGQ TEKGPDPIRY MRADEAAGGL RQHDVEVDAT LKSLNNQIES
160 170 180 190 200
IRSPEGSKKN PARTCRDIKL CHPEWKSGDY WIDPNQGCTL DAIKVFCNME
210 220 230 240 250
TGETCVYPTP SSIPRKNWWT SKTKDKKHVW FAETINGGFH FSYGDENLSP
260 270 280 290 300
NTASIQMTFL RLLSTEGSQN VTYHCKNSIA YMDEETGNLK KAILIQGSND
310 320 330 340 350
VEIRAEGNSR FTYSVLEDGC TKHTGKWGKT VIEYRSQKTS RLPIVDIAPM
360
DIGGADQEFG VDIGPVCFL
Length:369
Mass (Da):38,990
Last modified:November 1, 1988 - v1
Checksum:iEF5306925B0BA3B0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02663 mRNA. Translation: CAA26499.1.
L00063, L00061, L00062 Genomic DNA. Translation: AAB59967.1.
PIRiA02860. CGCH6C.
S07133.
UniGeneiGga.2839.
Gga.51529.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02663 mRNA. Translation: CAA26499.1.
L00063, L00061, L00062 Genomic DNA. Translation: AAB59967.1.
PIRiA02860. CGCH6C.
S07133.
UniGeneiGga.2839.
Gga.51529.

3D structure databases

ProteinModelPortaliP02460.
SMRiP02460.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP02460. 1 interactor.
STRINGi9031.ENSGALP00000035064.

Proteomic databases

PaxDbiP02460.
PRIDEiP02460.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG410YF8Q. LUCA.
HOGENOMiHOG000085654.
HOVERGENiHBG103137.
InParanoidiP02460.
OrthoDBiEOG091G03LV.
PhylomeDBiP02460.

Miscellaneous databases

PMAP-CutDBP02460.

Gene expression databases

BgeeiENSGALG00000013587.

Family and domain databases

Gene3Di3.90.215.10. 1 hit.
InterProiIPR008160. Collagen.
IPR000885. Fib_collagen_C.
IPR014716. Fibrinogen_a/b/g_C_1.
[Graphical view]
PfamiPF01410. COLFI. 1 hit.
PF01391. Collagen. 2 hits.
[Graphical view]
ProDomiPD002078. Fib_collagen_C. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00038. COLFI. 1 hit.
[Graphical view]
PROSITEiPS51461. NC1_FIB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCO2A1_CHICK
AccessioniPrimary (citable) accession number: P02460
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1988
Last modified: November 30, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.