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Protein

40S ribosomal protein S17-A

Gene

RPS17A

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.1 Publication

Miscellaneous

Present with 30900 molecules/cell in log phase SD medium.1 Publication
There are 2 genes for eS17 in yeast.Curated

GO - Molecular functioni

  • structural constituent of ribosome Source: SGD

GO - Biological processi

  • cytoplasmic translation Source: SGD
  • ribosomal small subunit assembly Source: SGD

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciYEAST:G3O-32626-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-SCE-72702. Ribosomal scanning and start codon recognition.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S17-A1 Publication
Alternative name(s):
RP51A
Small ribosomal subunit protein eS17-A1 Publication
Gene namesi
Name:RPS17A1 Publication
Synonyms:RP51A
Ordered Locus Names:YML024W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XIII

Organism-specific databases

EuPathDBiFungiDB:YML024W.
SGDiS000004486. RPS17A.

Subcellular locationi

GO - Cellular componenti

  • cytosolic small ribosomal subunit Source: SGD

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001415461 – 13640S ribosomal protein S17-AAdd BLAST136

Proteomic databases

MaxQBiP02407.
PRIDEiP02407.

PTM databases

iPTMnetiP02407.

Interactioni

Subunit structurei

Component of the small ribosomal subunit (SSU). Mature yeast ribosomes consist of a small (40S) and a large (60S) subunit. The 40S small subunit contains 1 molecule of ribosomal RNA (18S rRNA) and 33 different proteins (encoded by 57 genes). The large 60S subunit contains 3 rRNA molecules (25S, 5.8S and 5S rRNA) and 46 different proteins (encoded by 81 genes) (PubMed:9559554, PubMed:22096102).1 Publication1 Publication

Protein-protein interaction databases

BioGridi35145. 108 interactors.
IntActiP02407. 62 interactors.
MINTiMINT-8285645.

Structurei

Secondary structure

1136
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 19Combined sources13
Helixi21 – 23Combined sources3
Helixi28 – 38Combined sources11
Beta strandi39 – 42Combined sources4
Helixi44 – 61Combined sources18
Beta strandi62 – 64Combined sources3
Helixi73 – 80Combined sources8
Beta strandi97 – 99Combined sources3
Helixi104 – 113Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J6Xelectron microscopy6.10171-136[»]
3J6Yelectron microscopy6.10171-136[»]
3J77electron microscopy6.20171-136[»]
3J78electron microscopy6.30171-136[»]
3V88X-ray3.00R1-136[»]
4U3MX-ray3.00C7/c71-136[»]
4U3NX-ray3.20C7/c71-136[»]
4U3UX-ray2.90C7/c71-136[»]
4U4NX-ray3.10C7/c71-136[»]
4U4OX-ray3.60C7/c71-136[»]
4U4QX-ray3.00C7/c71-136[»]
4U4RX-ray2.80C7/c71-136[»]
4U4UX-ray3.00C7/c71-136[»]
4U4YX-ray3.20C7/c71-136[»]
4U4ZX-ray3.10C7/c71-136[»]
4U50X-ray3.20C7/c71-136[»]
4U51X-ray3.20C7/c71-136[»]
4U52X-ray3.00C7/c71-136[»]
4U53X-ray3.30C7/c71-136[»]
4U55X-ray3.20C7/c71-136[»]
4U56X-ray3.45C7/c71-136[»]
4U6FX-ray3.10C7/c71-136[»]
4V6Ielectron microscopy8.80AQ1-136[»]
4V7RX-ray4.00AK/CK1-136[»]
4V88X-ray3.00AR/CR1-136[»]
4V8Yelectron microscopy4.30AR1-136[»]
4V8Zelectron microscopy6.60AR1-136[»]
4V92electron microscopy3.70R2-125[»]
5DATX-ray3.15C7/c71-136[»]
5DC3X-ray3.25C7/c71-136[»]
5DGEX-ray3.45C7/c71-136[»]
5DGFX-ray3.30C7/c71-136[»]
5DGVX-ray3.10C7/c71-136[»]
5FCIX-ray3.40C7/c71-136[»]
5FCJX-ray3.10C7/c71-136[»]
5I4LX-ray3.10C7/c71-136[»]
5JUOelectron microscopy4.00OB1-136[»]
5JUPelectron microscopy3.50OB1-136[»]
5JUSelectron microscopy4.20OB1-136[»]
5JUTelectron microscopy4.00OB1-136[»]
5JUUelectron microscopy4.00OB1-136[»]
5LYBX-ray3.25C7/c72-126[»]
ProteinModelPortaliP02407.
SMRiP02407.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000006548.
HOGENOMiHOG000227166.
InParanoidiP02407.
KOiK02962.
OMAiCEEISII.
OrthoDBiEOG092C5HRI.

Family and domain databases

Gene3Di1.10.60.20. 1 hit.
HAMAPiMF_00511. Ribosomal_S17e. 1 hit.
InterProiView protein in InterPro
IPR001210. Ribosomal_S17e.
IPR018273. Ribosomal_S17e_CS.
PANTHERiPTHR10732. PTHR10732. 1 hit.
PfamiView protein in Pfam
PF00833. Ribosomal_S17e. 1 hit.
SUPFAMiSSF116820. SSF116820. 1 hit.
PROSITEiView protein in PROSITE
PS00712. RIBOSOMAL_S17E. 1 hit.

Sequencei

Sequence statusi: Complete.

P02407-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRVRTKTVK RASKALIERY YPKLTLDFQT NKRLCDEIAT IQSKRLRNKI
60 70 80 90 100
AGYTTHLMKR IQKGPVRGIS FKLQEEERER KDQYVPEVSA LDLSRSNGVL
110 120 130
NVDNQTSDLV KSLGLKLPLS VINVSAQRDR RYRKRV
Length:136
Mass (Da):15,788
Last modified:July 21, 1986 - v1
Checksum:i956E5382870EA289
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01349 Genomic DNA. Translation: AAA88733.1.
Z46659 Genomic DNA. Translation: CAA86631.1.
BK006946 Genomic DNA. Translation: DAA09874.1.
PIRiA02784. R5BY51.
RefSeqiNP_013688.1. NM_001182382.1.

Genome annotation databases

EnsemblFungiiYML024W; YML024W; YML024W.
GeneIDi854984.
KEGGisce:YML024W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J01349 Genomic DNA. Translation: AAA88733.1.
Z46659 Genomic DNA. Translation: CAA86631.1.
BK006946 Genomic DNA. Translation: DAA09874.1.
PIRiA02784. R5BY51.
RefSeqiNP_013688.1. NM_001182382.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J6Xelectron microscopy6.10171-136[»]
3J6Yelectron microscopy6.10171-136[»]
3J77electron microscopy6.20171-136[»]
3J78electron microscopy6.30171-136[»]
3V88X-ray3.00R1-136[»]
4U3MX-ray3.00C7/c71-136[»]
4U3NX-ray3.20C7/c71-136[»]
4U3UX-ray2.90C7/c71-136[»]
4U4NX-ray3.10C7/c71-136[»]
4U4OX-ray3.60C7/c71-136[»]
4U4QX-ray3.00C7/c71-136[»]
4U4RX-ray2.80C7/c71-136[»]
4U4UX-ray3.00C7/c71-136[»]
4U4YX-ray3.20C7/c71-136[»]
4U4ZX-ray3.10C7/c71-136[»]
4U50X-ray3.20C7/c71-136[»]
4U51X-ray3.20C7/c71-136[»]
4U52X-ray3.00C7/c71-136[»]
4U53X-ray3.30C7/c71-136[»]
4U55X-ray3.20C7/c71-136[»]
4U56X-ray3.45C7/c71-136[»]
4U6FX-ray3.10C7/c71-136[»]
4V6Ielectron microscopy8.80AQ1-136[»]
4V7RX-ray4.00AK/CK1-136[»]
4V88X-ray3.00AR/CR1-136[»]
4V8Yelectron microscopy4.30AR1-136[»]
4V8Zelectron microscopy6.60AR1-136[»]
4V92electron microscopy3.70R2-125[»]
5DATX-ray3.15C7/c71-136[»]
5DC3X-ray3.25C7/c71-136[»]
5DGEX-ray3.45C7/c71-136[»]
5DGFX-ray3.30C7/c71-136[»]
5DGVX-ray3.10C7/c71-136[»]
5FCIX-ray3.40C7/c71-136[»]
5FCJX-ray3.10C7/c71-136[»]
5I4LX-ray3.10C7/c71-136[»]
5JUOelectron microscopy4.00OB1-136[»]
5JUPelectron microscopy3.50OB1-136[»]
5JUSelectron microscopy4.20OB1-136[»]
5JUTelectron microscopy4.00OB1-136[»]
5JUUelectron microscopy4.00OB1-136[»]
5LYBX-ray3.25C7/c72-126[»]
ProteinModelPortaliP02407.
SMRiP02407.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi35145. 108 interactors.
IntActiP02407. 62 interactors.
MINTiMINT-8285645.

PTM databases

iPTMnetiP02407.

Proteomic databases

MaxQBiP02407.
PRIDEiP02407.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYML024W; YML024W; YML024W.
GeneIDi854984.
KEGGisce:YML024W.

Organism-specific databases

EuPathDBiFungiDB:YML024W.
SGDiS000004486. RPS17A.

Phylogenomic databases

GeneTreeiENSGT00390000006548.
HOGENOMiHOG000227166.
InParanoidiP02407.
KOiK02962.
OMAiCEEISII.
OrthoDBiEOG092C5HRI.

Enzyme and pathway databases

BioCyciYEAST:G3O-32626-MONOMER.
ReactomeiR-SCE-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-SCE-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-SCE-72689. Formation of a pool of free 40S subunits.
R-SCE-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-SCE-72702. Ribosomal scanning and start codon recognition.
R-SCE-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-SCE-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-SCE-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

PROiPR:P02407.

Family and domain databases

Gene3Di1.10.60.20. 1 hit.
HAMAPiMF_00511. Ribosomal_S17e. 1 hit.
InterProiView protein in InterPro
IPR001210. Ribosomal_S17e.
IPR018273. Ribosomal_S17e_CS.
PANTHERiPTHR10732. PTHR10732. 1 hit.
PfamiView protein in Pfam
PF00833. Ribosomal_S17e. 1 hit.
SUPFAMiSSF116820. SSF116820. 1 hit.
PROSITEiView protein in PROSITE
PS00712. RIBOSOMAL_S17E. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRS17A_YEAST
AccessioniPrimary (citable) accession number: P02407
Secondary accession number(s): D6VZF0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 12, 2017
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  5. Yeast chromosome XIII
    Yeast (Saccharomyces cerevisiae) chromosome XIII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.