Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

60S acidic ribosomal protein P2

Gene

Rplp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the elongation step of protein synthesis.

GO - Molecular functioni

  • iron ion binding Source: RGD
  • ribonucleoprotein complex binding Source: RGD
  • structural constituent of ribosome Source: RGD

GO - Biological processi

  • cellular response to cAMP Source: RGD
  • cellular response to Thyroid stimulating hormone Source: RGD
  • cytoplasmic translation Source: GO_Central
  • positive regulation of translation Source: RGD
  • translational elongation Source: InterPro

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-RNO-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-RNO-1799339 SRP-dependent cotranslational protein targeting to membrane
R-RNO-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-RNO-72689 Formation of a pool of free 40S subunits
R-RNO-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-RNO-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-RNO-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S acidic ribosomal protein P2
Gene namesi
Name:Rplp2
Synonyms:Rp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi621775 Rplp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001576441 – 11560S acidic ribosomal protein P2Add BLAST115

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei19PhosphoserineBy similarity1
Modified residuei21N6-acetyllysine; alternateBy similarity1
Modified residuei21N6-succinyllysine; alternateBy similarity1
Modified residuei79PhosphoserineBy similarity1
Modified residuei86PhosphoserineBy similarity1
Modified residuei102PhosphoserineCombined sources1
Modified residuei105PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP02401
PRIDEiP02401

PTM databases

iPTMnetiP02401
PhosphoSitePlusiP02401

Expressioni

Gene expression databases

BgeeiENSRNOG00000002116
GenevisibleiP02401 RN

Interactioni

Subunit structurei

Heterodimer with RPLP1 at the lateral ribosomal stalk of the large ribosomal subunit.By similarity

Protein-protein interaction databases

BioGridi250823, 2 interactors
IntActiP02401, 3 interactors
STRINGi10116.ENSRNOP00000053863

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3449 Eukaryota
COG2058 LUCA
GeneTreeiENSGT00550000074828
HOGENOMiHOG000229897
HOVERGENiHBG014761
InParanoidiP02401
KOiK02943
OMAiAFFNFTM
OrthoDBiEOG091G14BD
PhylomeDBiP02401
TreeFamiTF320650

Family and domain databases

Gene3Di1.10.10.1410, 1 hit
HAMAPiMF_01478 Ribosomal_L12_arch, 1 hit
InterProiView protein in InterPro
IPR038716 P1/P2_N_sf
IPR027534 Ribosomal_L12

Sequencei

Sequence statusi: Complete.

P02401-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYVASYLLA ALGGNSNPSA KDIKKILDSV GIEADDERLN KVISELNGKN
60 70 80 90 100
IEDVIAQGVG KLASVPAGGA VAVSAAPGSA APAAGSAPAA AEEKKDEKKE
110
ESEESDDDMG FGLFD
Length:115
Mass (Da):11,692
Last modified:November 1, 1991 - v2
Checksum:i503B346F9F49591B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15098 mRNA Translation: CAA33201.1
X55153 Genomic DNA Translation: CAA38953.1
BC099697 mRNA Translation: AAH99697.1
PIRiS22320 R6RTP2
RefSeqiNP_001025192.1, NM_001030021.1
XP_003749061.1, XM_003749013.2
XP_008772967.1, XM_008774745.1
UniGeneiRn.144648
Rn.226833
Rn.976

Genome annotation databases

EnsembliENSRNOT00000038691; ENSRNOP00000038214; ENSRNOG00000002116
ENSRNOT00000057030; ENSRNOP00000053863; ENSRNOG00000037607
GeneIDi100911575
140662
KEGGirno:100911575
rno:140662
UCSCiRGD:621775 rat

Similar proteinsi

Entry informationi

Entry nameiRLA2_RAT
AccessioniPrimary (citable) accession number: P02401
Secondary accession number(s): Q499W9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1991
Last modified: April 25, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health