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P02391

- RL6_GEOSE

UniProt

P02391 - RL6_GEOSE

Protein

50S ribosomal protein L6

Gene

rplF

Organism
Geobacillus stearothermophilus (Bacillus stearothermophilus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center By similarity. This protein binds to the 23S rRNA, and is important in its secondary structure.By similarity

    GO - Molecular functioni

    1. rRNA binding Source: UniProtKB-HAMAP
    2. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Ligandi

    RNA-binding, rRNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    50S ribosomal protein L6UniRule annotation
    Alternative name(s):
    BL10
    Gene namesi
    Name:rplFUniRule annotation
    OrganismiGeobacillus stearothermophilus (Bacillus stearothermophilus)
    Taxonomic identifieri1422 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

    Subcellular locationi

    GO - Cellular componenti

    1. ribosome Source: UniProtKB-KW

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 17817750S ribosomal protein L6PRO_0000131037Add
    BLAST

    Interactioni

    Subunit structurei

    Part of the 50S ribosomal subunit.

    Structurei

    Secondary structure

    1
    178
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi16 – 205
    Beta strandi23 – 286
    Beta strandi31 – 366
    Beta strandi42 – 465
    Beta strandi49 – 535
    Helixi59 – 8022
    Beta strandi83 – 919
    Beta strandi95 – 995
    Beta strandi102 – 11110
    Beta strandi113 – 1153
    Beta strandi121 – 1277
    Beta strandi130 – 1367
    Helixi138 – 14912
    Turni156 – 1583
    Beta strandi161 – 1644

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1RL6X-ray2.00A2-178[»]
    2B9PX-ray6.46H2-178[»]
    ProteinModelPortaliP02391.
    SMRiP02391. Positions 8-171.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP02391.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L6P family.UniRule annotation

    Family and domain databases

    Gene3Di3.90.930.12. 2 hits.
    HAMAPiMF_01365_B. Ribosomal_L6_B.
    InterProiIPR000702. Ribosomal_L6.
    IPR020040. Ribosomal_L6_a/b-dom.
    IPR019906. Ribosomal_L6_bac-type.
    IPR002358. Ribosomal_L6_CS.
    [Graphical view]
    PANTHERiPTHR11655. PTHR11655. 1 hit.
    PfamiPF00347. Ribosomal_L6. 2 hits.
    [Graphical view]
    PIRSFiPIRSF002162. Ribosomal_L6. 1 hit.
    PRINTSiPR00059. RIBOSOMALL6.
    SUPFAMiSSF56053. SSF56053. 2 hits.
    TIGRFAMsiTIGR03654. L6_bact. 1 hit.
    PROSITEiPS00525. RIBOSOMAL_L6_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P02391-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRVGKKPIE IPAGVTVTVN GNTVTVKGPK GELTRTFHPD MTITVEGNVI    50
    TVTRPSDEKH HRALHGTTRS LLANMVEGVS KGYEKALELV GVGYRASKQG 100
    KKLVLSVGYS HPVEIEPEEG LEIEVPSQTK IIVKGADKQR VGELAANIRA 150
    VRPPEPYKGK GIRYEGELVR LKEGKTGK 178
    Length:178
    Mass (Da):19,299
    Last modified:January 23, 2007 - v2
    Checksum:iC9D83BA8F35DB4FA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M57622 Genomic DNA. Translation: AAA22700.1. Sequence problems.
    PIRiA02766. R5BS0F.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M57622 Genomic DNA. Translation: AAA22700.1 . Sequence problems.
    PIRi A02766. R5BS0F.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1RL6 X-ray 2.00 A 2-178 [» ]
    2B9P X-ray 6.46 H 2-178 [» ]
    ProteinModelPortali P02391.
    SMRi P02391. Positions 8-171.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P02391.

    Family and domain databases

    Gene3Di 3.90.930.12. 2 hits.
    HAMAPi MF_01365_B. Ribosomal_L6_B.
    InterProi IPR000702. Ribosomal_L6.
    IPR020040. Ribosomal_L6_a/b-dom.
    IPR019906. Ribosomal_L6_bac-type.
    IPR002358. Ribosomal_L6_CS.
    [Graphical view ]
    PANTHERi PTHR11655. PTHR11655. 1 hit.
    Pfami PF00347. Ribosomal_L6. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF002162. Ribosomal_L6. 1 hit.
    PRINTSi PR00059. RIBOSOMALL6.
    SUPFAMi SSF56053. SSF56053. 2 hits.
    TIGRFAMsi TIGR03654. L6_bact. 1 hit.
    PROSITEi PS00525. RIBOSOMAL_L6_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, sequencing, and overexpression of genes for ribosomal proteins from Bacillus stearothermophilus."
      Ramakrishnan V., Gerchman S.E.
      J. Biol. Chem. 266:880-885(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The amino acid sequence of protein BL10 from the 50S subunit of the Bacillus stearothermophilus ribosome."
      Kimura M., Rawlings N., Appelt K.
      FEBS Lett. 136:58-64(1981)
      Cited for: PROTEIN SEQUENCE OF 2-178.
    3. "Protein-rRNA binding features and their structural and functional implications in ribosomes as determined by cross-linking studies."
      Urlaub H., Kruft V., Bischof O., Mueller E.-C., Wittmann-Liebold B.
      EMBO J. 14:4578-4588(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 150-164, CROSS-LINKING TO RRNA.
      Strain: 799.
    4. "Ribosomal protein L6: structural evidence of gene duplication from a primitive RNA binding protein."
      Golden B.L., Ramakrishnan V., White S.W.
      EMBO J. 12:4901-4908(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS).
    5. "Ribosomal proteins S5 and L6: high-resolution crystal structures and roles in protein synthesis and antibiotic resistance."
      Davies C., Bussiere D.E., Golden B.L., Porter S.J., Ramakrishnan V., White S.W.
      J. Mol. Biol. 279:873-888(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
    6. "Placement of protein and RNA structures into a 5 A-resolution map of the 50S ribosomal subunit."
      Ban N., Nissen P., Hansen J., Capel M., Moore P.B., Steitz T.A.
      Nature 400:841-847(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING ONTO THE H.MARISMORTUI 50S RIBOSOME.

    Entry informationi

    Entry nameiRL6_GEOSE
    AccessioniPrimary (citable) accession number: P02391
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3