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P02391

- RL6_GEOSE

UniProt

P02391 - RL6_GEOSE

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Protein

50S ribosomal protein L6

Gene

rplF

Organism
Geobacillus stearothermophilus (Bacillus stearothermophilus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center By similarity. This protein binds to the 23S rRNA, and is important in its secondary structure.By similarity

GO - Molecular functioni

  1. rRNA binding Source: UniProtKB-HAMAP
  2. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L6UniRule annotation
Alternative name(s):
BL10
Gene namesi
Name:rplFUniRule annotation
OrganismiGeobacillus stearothermophilus (Bacillus stearothermophilus)
Taxonomic identifieri1422 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

Subcellular locationi

GO - Cellular componenti

  1. ribosome Source: UniProtKB-KW
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 17817750S ribosomal protein L6PRO_0000131037Add
BLAST

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit.

Structurei

Secondary structure

1
178
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi16 – 205
Beta strandi23 – 286
Beta strandi31 – 366
Beta strandi42 – 465
Beta strandi49 – 535
Helixi59 – 8022
Beta strandi83 – 919
Beta strandi95 – 995
Beta strandi102 – 11110
Beta strandi113 – 1153
Beta strandi121 – 1277
Beta strandi130 – 1367
Helixi138 – 14912
Turni156 – 1583
Beta strandi161 – 1644

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1RL6X-ray2.00A2-178[»]
2B9PX-ray6.46H2-178[»]
ProteinModelPortaliP02391.
SMRiP02391. Positions 8-171.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02391.

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein L6P family.UniRule annotation

Family and domain databases

Gene3Di3.90.930.12. 2 hits.
HAMAPiMF_01365_B. Ribosomal_L6_B.
InterProiIPR000702. Ribosomal_L6.
IPR020040. Ribosomal_L6_a/b-dom.
IPR019906. Ribosomal_L6_bac-type.
IPR002358. Ribosomal_L6_CS.
[Graphical view]
PANTHERiPTHR11655. PTHR11655. 1 hit.
PfamiPF00347. Ribosomal_L6. 2 hits.
[Graphical view]
PIRSFiPIRSF002162. Ribosomal_L6. 1 hit.
PRINTSiPR00059. RIBOSOMALL6.
SUPFAMiSSF56053. SSF56053. 2 hits.
TIGRFAMsiTIGR03654. L6_bact. 1 hit.
PROSITEiPS00525. RIBOSOMAL_L6_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02391-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRVGKKPIE IPAGVTVTVN GNTVTVKGPK GELTRTFHPD MTITVEGNVI
60 70 80 90 100
TVTRPSDEKH HRALHGTTRS LLANMVEGVS KGYEKALELV GVGYRASKQG
110 120 130 140 150
KKLVLSVGYS HPVEIEPEEG LEIEVPSQTK IIVKGADKQR VGELAANIRA
160 170
VRPPEPYKGK GIRYEGELVR LKEGKTGK
Length:178
Mass (Da):19,299
Last modified:January 23, 2007 - v2
Checksum:iC9D83BA8F35DB4FA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M57622 Genomic DNA. Translation: AAA22700.1. Sequence problems.
PIRiA02766. R5BS0F.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M57622 Genomic DNA. Translation: AAA22700.1 . Sequence problems.
PIRi A02766. R5BS0F.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1RL6 X-ray 2.00 A 2-178 [» ]
2B9P X-ray 6.46 H 2-178 [» ]
ProteinModelPortali P02391.
SMRi P02391. Positions 8-171.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P02391.

Family and domain databases

Gene3Di 3.90.930.12. 2 hits.
HAMAPi MF_01365_B. Ribosomal_L6_B.
InterProi IPR000702. Ribosomal_L6.
IPR020040. Ribosomal_L6_a/b-dom.
IPR019906. Ribosomal_L6_bac-type.
IPR002358. Ribosomal_L6_CS.
[Graphical view ]
PANTHERi PTHR11655. PTHR11655. 1 hit.
Pfami PF00347. Ribosomal_L6. 2 hits.
[Graphical view ]
PIRSFi PIRSF002162. Ribosomal_L6. 1 hit.
PRINTSi PR00059. RIBOSOMALL6.
SUPFAMi SSF56053. SSF56053. 2 hits.
TIGRFAMsi TIGR03654. L6_bact. 1 hit.
PROSITEi PS00525. RIBOSOMAL_L6_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning, sequencing, and overexpression of genes for ribosomal proteins from Bacillus stearothermophilus."
    Ramakrishnan V., Gerchman S.E.
    J. Biol. Chem. 266:880-885(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The amino acid sequence of protein BL10 from the 50S subunit of the Bacillus stearothermophilus ribosome."
    Kimura M., Rawlings N., Appelt K.
    FEBS Lett. 136:58-64(1981)
    Cited for: PROTEIN SEQUENCE OF 2-178.
  3. "Protein-rRNA binding features and their structural and functional implications in ribosomes as determined by cross-linking studies."
    Urlaub H., Kruft V., Bischof O., Mueller E.-C., Wittmann-Liebold B.
    EMBO J. 14:4578-4588(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 150-164, CROSS-LINKING TO RRNA.
    Strain: 799.
  4. "Ribosomal protein L6: structural evidence of gene duplication from a primitive RNA binding protein."
    Golden B.L., Ramakrishnan V., White S.W.
    EMBO J. 12:4901-4908(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS).
  5. "Ribosomal proteins S5 and L6: high-resolution crystal structures and roles in protein synthesis and antibiotic resistance."
    Davies C., Bussiere D.E., Golden B.L., Porter S.J., Ramakrishnan V., White S.W.
    J. Mol. Biol. 279:873-888(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
  6. "Placement of protein and RNA structures into a 5 A-resolution map of the 50S ribosomal subunit."
    Ban N., Nissen P., Hansen J., Capel M., Moore P.B., Steitz T.A.
    Nature 400:841-847(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING ONTO THE H.MARISMORTUI 50S RIBOSOME.

Entry informationi

Entry nameiRL6_GEOSE
AccessioniPrimary (citable) accession number: P02391
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: October 1, 2014
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3