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P02391 (RL6_GEOSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
50S ribosomal protein L6
Alternative name(s):
BL10
Gene names
Name:rplF
OrganismGeobacillus stearothermophilus (Bacillus stearothermophilus)
Taxonomic identifier1422 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

Protein attributes

Sequence length178 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center By similarity. This protein binds to the 23S rRNA, and is important in its secondary structure. HAMAP-Rule MF_01365

Subunit structure

Part of the 50S ribosomal subunit.

Sequence similarities

Belongs to the ribosomal protein L6P family.

Ontologies

Keywords
   LigandRNA-binding
rRNA-binding
   Molecular functionRibonucleoprotein
Ribosomal protein
   Technical term3D-structure
Direct protein sequencing
Gene Ontology (GO)
   Biological_processtranslation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentribosome

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionrRNA binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

structural constituent of ribosome

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.2
Chain2 – 17817750S ribosomal protein L6 HAMAP-Rule MF_01365
PRO_0000131037

Secondary structure

............................... 178
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P02391 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: C9D83BA8F35DB4FA

FASTA17819,299
        10         20         30         40         50         60 
MSRVGKKPIE IPAGVTVTVN GNTVTVKGPK GELTRTFHPD MTITVEGNVI TVTRPSDEKH 

        70         80         90        100        110        120 
HRALHGTTRS LLANMVEGVS KGYEKALELV GVGYRASKQG KKLVLSVGYS HPVEIEPEEG 

       130        140        150        160        170 
LEIEVPSQTK IIVKGADKQR VGELAANIRA VRPPEPYKGK GIRYEGELVR LKEGKTGK 

« Hide

References

[1]"Cloning, sequencing, and overexpression of genes for ribosomal proteins from Bacillus stearothermophilus."
Ramakrishnan V., Gerchman S.E.
J. Biol. Chem. 266:880-885(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The amino acid sequence of protein BL10 from the 50S subunit of the Bacillus stearothermophilus ribosome."
Kimura M., Rawlings N., Appelt K.
FEBS Lett. 136:58-64(1981)
Cited for: PROTEIN SEQUENCE OF 2-178.
[3]"Protein-rRNA binding features and their structural and functional implications in ribosomes as determined by cross-linking studies."
Urlaub H., Kruft V., Bischof O., Mueller E.-C., Wittmann-Liebold B.
EMBO J. 14:4578-4588(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 150-164, CROSS-LINKING TO RRNA.
Strain: 799.
[4]"Ribosomal protein L6: structural evidence of gene duplication from a primitive RNA binding protein."
Golden B.L., Ramakrishnan V., White S.W.
EMBO J. 12:4901-4908(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS).
[5]"Ribosomal proteins S5 and L6: high-resolution crystal structures and roles in protein synthesis and antibiotic resistance."
Davies C., Bussiere D.E., Golden B.L., Porter S.J., Ramakrishnan V., White S.W.
J. Mol. Biol. 279:873-888(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
[6]"Placement of protein and RNA structures into a 5 A-resolution map of the 50S ribosomal subunit."
Ban N., Nissen P., Hansen J., Capel M., Moore P.B., Steitz T.A.
Nature 400:841-847(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: 3D-STRUCTURE MODELING ONTO THE H.MARISMORTUI 50S RIBOSOME.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M57622 Genomic DNA. Translation: AAA22700.1. Sequence problems.
PIRR5BS0F. A02766.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1RL6X-ray2.00A2-178[»]
2B9PX-ray6.46H2-178[»]
ProteinModelPortalP02391.
SMRP02391. Positions 8-171.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.90.930.12. 2 hits.
HAMAPMF_01365_B. Ribosomal_L6_B.
InterProIPR000702. Ribosomal_L6.
IPR020040. Ribosomal_L6_a/b-dom.
IPR019906. Ribosomal_L6_bac-type.
IPR002358. Ribosomal_L6_CS.
[Graphical view]
PANTHERPTHR11655. PTHR11655. 1 hit.
PfamPF00347. Ribosomal_L6. 2 hits.
[Graphical view]
PIRSFPIRSF002162. Ribosomal_L6. 1 hit.
PRINTSPR00059. RIBOSOMALL6.
SUPFAMSSF56053. SSF56053. 2 hits.
TIGRFAMsTIGR03654. L6_bact. 1 hit.
PROSITEPS00525. RIBOSOMAL_L6_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP02391.

Entry information

Entry nameRL6_GEOSE
AccessionPrimary (citable) accession number: P02391
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

PDB cross-references

Index of Protein Data Bank (PDB) cross-references