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P02357

- RS5_GEOSE

UniProt

P02357 - RS5_GEOSE

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Protein

30S ribosomal protein S5

Gene

rpsE

Organism
Geobacillus stearothermophilus (Bacillus stearothermophilus)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

With S4 and S12 plays an important role in translational accuracy.By similarity
Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.By similarity

GO - Molecular functioni

  1. rRNA binding Source: UniProtKB-HAMAP
  2. structural constituent of ribosome Source: UniProtKB-HAMAP

GO - Biological processi

  1. response to antibiotic Source: UniProtKB-KW
  2. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Biological processi

Antibiotic resistance

Keywords - Ligandi

RNA-binding, rRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
30S ribosomal protein S5
Short name:
BS5
Alternative name(s):
BS6
Gene namesi
Name:rpsE
OrganismiGeobacillus stearothermophilus (Bacillus stearothermophilus)
Taxonomic identifieri1422 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

Subcellular locationi

GO - Cellular componenti

  1. small ribosomal subunit Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16616630S ribosomal protein S5PRO_0000131469Add
BLAST

Interactioni

Subunit structurei

Part of the 30S ribosomal subunit. Contacts proteins S4 and S8 (By similarity).By similarity

Protein-protein interaction databases

MINTiMINT-112114.

Structurei

Secondary structure

1
166
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 83Combined sources
Beta strandi12 – 198Combined sources
Beta strandi21 – 244Combined sources
Beta strandi33 – 408Combined sources
Beta strandi42 – 5514Combined sources
Helixi56 – 6712Combined sources
Beta strandi85 – 895Combined sources
Beta strandi92 – 987Combined sources
Beta strandi105 – 1073Combined sources
Helixi109 – 11810Combined sources
Beta strandi122 – 1276Combined sources
Helixi133 – 14614Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1DV4X-ray4.50E4-148[»]
1PKPX-ray2.80A1-150[»]
ProteinModelPortaliP02357.
SMRiP02357. Positions 4-148.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02357.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 7464S5 DRBMAdd
BLAST

Domaini

The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.

Sequence similaritiesi

Belongs to the ribosomal protein S5P family.Curated
Contains 1 S5 DRBM domain.Curated

Family and domain databases

Gene3Di3.30.160.20. 1 hit.
3.30.230.10. 1 hit.
HAMAPiMF_01307_B. Ribosomal_S5_B.
InterProiIPR014720. dsRNA-bd_dom.
IPR000851. Ribosomal_S5.
IPR005712. Ribosomal_S5_bac-type.
IPR005324. Ribosomal_S5_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR013810. Ribosomal_S5_N.
IPR018192. Ribosomal_S5_N_CS.
[Graphical view]
PANTHERiPTHR13718. PTHR13718. 1 hit.
PfamiPF00333. Ribosomal_S5. 1 hit.
PF03719. Ribosomal_S5_C. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
TIGRFAMsiTIGR01021. rpsE_bact. 1 hit.
PROSITEiPS00585. RIBOSOMAL_S5. 1 hit.
PS50881. S5_DSRBD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P02357-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRRINPNKLE LEERVVAVNR VAKVVKGGRR LRFSALVVVG DKNGHVGFGT
60 70 80 90 100
GKAQEVPEAI RKAIEDAKKN LIEVPIVGTT IPHEVIGHFG AGEIILKPAS
110 120 130 140 150
EGTGVIAGGP ARAVLELAGI SDILSKSIGS NTPINMVRAT FDGLKQLKRA
160
EDVAKLRGKT VEELLG
Length:166
Mass (Da):17,628
Last modified:July 21, 1986 - v1
Checksum:i774E82A2ED1D8EC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57621 Genomic DNA. Translation: AAA22699.1.
PIRiA02708. R3BS5F.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57621 Genomic DNA. Translation: AAA22699.1 .
PIRi A02708. R3BS5F.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1DV4 X-ray 4.50 E 4-148 [» ]
1PKP X-ray 2.80 A 1-150 [» ]
ProteinModelPortali P02357.
SMRi P02357. Positions 4-148.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-112114.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P02357.

Family and domain databases

Gene3Di 3.30.160.20. 1 hit.
3.30.230.10. 1 hit.
HAMAPi MF_01307_B. Ribosomal_S5_B.
InterProi IPR014720. dsRNA-bd_dom.
IPR000851. Ribosomal_S5.
IPR005712. Ribosomal_S5_bac-type.
IPR005324. Ribosomal_S5_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR013810. Ribosomal_S5_N.
IPR018192. Ribosomal_S5_N_CS.
[Graphical view ]
PANTHERi PTHR13718. PTHR13718. 1 hit.
Pfami PF00333. Ribosomal_S5. 1 hit.
PF03719. Ribosomal_S5_C. 1 hit.
[Graphical view ]
SUPFAMi SSF54211. SSF54211. 1 hit.
TIGRFAMsi TIGR01021. rpsE_bact. 1 hit.
PROSITEi PS00585. RIBOSOMAL_S5. 1 hit.
PS50881. S5_DSRBD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Proteins of the Bacillus stearothermophilus ribosome. The amino acid sequences of proteins S5 and L30."
    Kimura M.
    J. Biol. Chem. 259:1051-1055(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.
    Strain: ATCC 29609 / DSM 2027 / NCA 1503 / NCIMB 8924.
  2. "Cloning, sequencing, and overexpression of genes for ribosomal proteins from Bacillus stearothermophilus."
    Ramakrishnan V., Gerchman S.E.
    J. Biol. Chem. 266:880-885(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Procaryotic ribosomal proteins: N-terminal sequence homologies and structural correspondence of 30 S ribosomal proteins from Escherichia coli and Bacillus stearothermophilus."
    Yaguchi M., Matheson A.T., Visentin L.P.
    FEBS Lett. 46:296-300(1974) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-15.
    Strain: DSM 13240 / CIP 106956 / 10.
  4. "Isolation and characterization of Bacillus stearothermophilus 30S and 50S ribosomal protein mutations."
    Schnier J., Gewitz H.S., Behrens S.E., Lee A., Ginther C., Leighton T.
    J. Bacteriol. 172:7306-7309(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: ISOLATION OF STREPTOMYCIN INDEPENDENT STRAINS.
    Strain: 799.
  5. "The structure of ribosomal protein S5 reveals sites of interaction with 16S rRNA."
    Ramakrishnan V., White S.W.
    Nature 358:768-771(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).
  6. "Ribosomal proteins S5 and L6: high-resolution crystal structures and roles in protein synthesis and antibiotic resistance."
    Davies C., Bussiere D.E., Golden B.L., Porter S.J., Ramakrishnan V., White S.W.
    J. Mol. Biol. 279:873-888(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS).

Entry informationi

Entry nameiRS5_GEOSE
AccessioniPrimary (citable) accession number: P02357
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 26, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3