Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Spermatid nuclear transition protein 1

Gene

Tnp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatid nuclear transition protein 1
Short name:
STP-1
Short name:
TP-1
Alternative name(s):
Testis-specific basic protein
Gene namesi
Name:Tnp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi3884 Tnp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001914202 – 55Spermatid nuclear transition protein 1Add BLAST54

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei36PhosphoserineBy similarity1
Modified residuei37PhosphoserineBy similarity1
Modified residuei40PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP02317
PRIDEiP02317

PTM databases

iPTMnetiP02317
PhosphoSitePlusiP02317

Expressioni

Tissue specificityi

Testis.

Gene expression databases

BgeeiENSRNOG00000017611
GenevisibleiP02317 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023769

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410JJTU Eukaryota
ENOG4111B50 LUCA
GeneTreeiENSGT00390000000539
HOGENOMiHOG000136637
InParanoidiP02317
OMAiKRCDDAN
PhylomeDBiP02317
TreeFamiTF338391

Family and domain databases

InterProiView protein in InterPro
IPR001319 Nuclear_transition_prot1
IPR020062 Nuclear_transition_prot1_CS
PANTHERiPTHR17486 PTHR17486, 1 hit
PfamiView protein in Pfam
PF02079 TP1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010292 TP1, 1 hit
PROSITEiView protein in PROSITE
PS00541 TP1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02317-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSRKLKTH GMRRGKNRAP HKGVKRGGSK RKYRKSSLKS RKRGDDASRN

YRSHL
Length:55
Mass (Da):6,395
Last modified:January 23, 2007 - v2
Checksum:iC371582FD98A7B92
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46 – 48DAS → SAD AA sequence (PubMed:1112834).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07284 Genomic DNA Translation: CAA30264.1
M17096 mRNA Translation: AAA42260.1
BC078850 mRNA Translation: AAH78850.1
PIRiA29095 BGRT
RefSeqiNP_058752.1, NM_017056.2
UniGeneiRn.9959

Genome annotation databases

EnsembliENSRNOT00000023769; ENSRNOP00000023769; ENSRNOG00000017611
GeneIDi24839
KEGGirno:24839
UCSCiRGD:3884 rat

Similar proteinsi

Entry informationi

Entry nameiSTP1_RAT
AccessioniPrimary (citable) accession number: P02317
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health