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Protein

Spermatid nuclear transition protein 1

Gene

Tnp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatid nuclear transition protein 1
Short name:
STP-1
Short name:
TP-1
Alternative name(s):
Testis-specific basic protein
Gene namesi
Name:Tnp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi3884. Tnp1.

Subcellular locationi

  • Nucleus By similarity
  • Chromosome By similarity

  • Note: Loaded onto the nucleosomes of condensing spermatids.By similarity

GO - Cellular componenti

  • male germ cell nucleus Source: RGD
  • nuclear nucleosome Source: UniProtKB
  • nucleosome Source: UniProtKB

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001914202 – 55Spermatid nuclear transition protein 1Add BLAST54

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei36PhosphoserineBy similarity1
Modified residuei37PhosphoserineBy similarity1
Modified residuei40PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP02317.
PRIDEiP02317.

PTM databases

iPTMnetiP02317.
PhosphoSitePlusiP02317.

Expressioni

Tissue specificityi

Testis.

Gene expression databases

BgeeiENSRNOG00000017611.
GenevisibleiP02317. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023769.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410JJTU. Eukaryota.
ENOG4111B50. LUCA.
GeneTreeiENSGT00390000000539.
HOGENOMiHOG000136637.
InParanoidiP02317.
OMAiKRCDDAN.
PhylomeDBiP02317.
TreeFamiTF338391.

Family and domain databases

InterProiView protein in InterPro
IPR001319. Nuclear_transition_prot1.
IPR020062. Nuclear_transition_prot1_CS.
PANTHERiPTHR17486. PTHR17486. 1 hit.
PfamiView protein in Pfam
PF02079. TP1. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010292. TP1. 1 hit.
PROSITEiView protein in PROSITE
PS00541. TP1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02317-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSRKLKTH GMRRGKNRAP HKGVKRGGSK RKYRKSSLKS RKRGDDASRN

YRSHL
Length:55
Mass (Da):6,395
Last modified:January 23, 2007 - v2
Checksum:iC371582FD98A7B92
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46 – 48DAS → SAD AA sequence (PubMed:1112834).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07284 Genomic DNA. Translation: CAA30264.1.
M17096 mRNA. Translation: AAA42260.1.
BC078850 mRNA. Translation: AAH78850.1.
PIRiA29095. BGRT.
RefSeqiNP_058752.1. NM_017056.2.
UniGeneiRn.9959.

Genome annotation databases

EnsembliENSRNOT00000023769; ENSRNOP00000023769; ENSRNOG00000017611.
GeneIDi24839.
KEGGirno:24839.
UCSCiRGD:3884. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSTP1_RAT
AccessioniPrimary (citable) accession number: P02317
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: July 5, 2017
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families