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Protein

Spermatid nuclear transition protein 1

Gene

Tnp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Spermatid nuclear transition protein 1
Short name:
STP-1
Short name:
TP-1
Alternative name(s):
Testis-specific basic protein
Gene namesi
Name:Tnp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 9

Organism-specific databases

RGDi3884. Tnp1.

Subcellular locationi

GO - Cellular componenti

  • male germ cell nucleus Source: RGD
  • nucleosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001914202 – 55Spermatid nuclear transition protein 1Add BLAST54

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei36PhosphoserineBy similarity1
Modified residuei37PhosphoserineBy similarity1
Modified residuei40PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP02317.
PRIDEiP02317.

PTM databases

iPTMnetiP02317.
PhosphoSitePlusiP02317.

Expressioni

Tissue specificityi

Testis.

Gene expression databases

BgeeiENSRNOG00000017611.
GenevisibleiP02317. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023769.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410JJTU. Eukaryota.
ENOG4111B50. LUCA.
GeneTreeiENSGT00390000000539.
HOGENOMiHOG000136637.
InParanoidiP02317.
OMAiKRCDDAN.
PhylomeDBiP02317.
TreeFamiTF338391.

Family and domain databases

InterProiIPR001319. Nuclear_transition_prot1.
IPR020062. Nuclear_transition_prot1_CS.
[Graphical view]
PANTHERiPTHR17486. PTHR17486. 1 hit.
PfamiPF02079. TP1. 1 hit.
[Graphical view]
ProDomiPD010292. TP1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00541. TP1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02317-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSRKLKTH GMRRGKNRAP HKGVKRGGSK RKYRKSSLKS RKRGDDASRN

YRSHL
Length:55
Mass (Da):6,395
Last modified:January 23, 2007 - v2
Checksum:iC371582FD98A7B92
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46 – 48DAS → SAD AA sequence (PubMed:1112834).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07284 Genomic DNA. Translation: CAA30264.1.
M17096 mRNA. Translation: AAA42260.1.
BC078850 mRNA. Translation: AAH78850.1.
PIRiA29095. BGRT.
RefSeqiNP_058752.1. NM_017056.2.
UniGeneiRn.9959.

Genome annotation databases

EnsembliENSRNOT00000023769; ENSRNOP00000023769; ENSRNOG00000017611.
GeneIDi24839.
KEGGirno:24839.
UCSCiRGD:3884. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07284 Genomic DNA. Translation: CAA30264.1.
M17096 mRNA. Translation: AAA42260.1.
BC078850 mRNA. Translation: AAH78850.1.
PIRiA29095. BGRT.
RefSeqiNP_058752.1. NM_017056.2.
UniGeneiRn.9959.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000023769.

PTM databases

iPTMnetiP02317.
PhosphoSitePlusiP02317.

Proteomic databases

PaxDbiP02317.
PRIDEiP02317.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000023769; ENSRNOP00000023769; ENSRNOG00000017611.
GeneIDi24839.
KEGGirno:24839.
UCSCiRGD:3884. rat.

Organism-specific databases

CTDi7141.
RGDi3884. Tnp1.

Phylogenomic databases

eggNOGiENOG410JJTU. Eukaryota.
ENOG4111B50. LUCA.
GeneTreeiENSGT00390000000539.
HOGENOMiHOG000136637.
InParanoidiP02317.
OMAiKRCDDAN.
PhylomeDBiP02317.
TreeFamiTF338391.

Miscellaneous databases

PROiP02317.

Gene expression databases

BgeeiENSRNOG00000017611.
GenevisibleiP02317. RN.

Family and domain databases

InterProiIPR001319. Nuclear_transition_prot1.
IPR020062. Nuclear_transition_prot1_CS.
[Graphical view]
PANTHERiPTHR17486. PTHR17486. 1 hit.
PfamiPF02079. TP1. 1 hit.
[Graphical view]
ProDomiPD010292. TP1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00541. TP1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTP1_RAT
AccessioniPrimary (citable) accession number: P02317
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.