Reviewed, UniProtKB/Swiss-Prot P02316 (HMGN1_BOVIN)

Names and origin

Protein names

Recommended name:
    Non-histone chromosomal protein HMG-14
Alternative name(s):
    High-mobility group nucleosome-binding domain-containing protein 1

Gene names

Name:	HMGN1
Synonyms:	HMG14

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	101 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 By similarity.
Subcellular location	Nucleus.
Post-translational modification	Phosphorylation on Ser-21 and Ser-25 weakens binding to nucleosomes and increases the rate of H3 phosphorylation By similarity.
Sequence similarities	Belongs to the HMGN family.

Ontologies

Keywords
Cellular component	Nucleus
Ligand	DNA-binding
PTM	Acetylation Phosphoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular component	chromatin Inferred from electronic annotation. Source: InterPro nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.2
	Chain	2 – 101	100	Non-histone chromosomal protein HMG-14		PRO_0000206690
Amino acid modifications
	Modified residue	7	1	Phosphoserine By similarity
	Modified residue	8	1	Phosphoserine By similarity
	Modified residue	14	1	N6-acetyllysine By similarity
	Modified residue	21	1	Phosphoserine By similarity
	Modified residue	25	1	Phosphoserine By similarity
	Modified residue	71	1	Phosphothreonine By similarity
	Modified residue	82	1	Phosphothreonine By similarity
	Modified residue	83	1	N6-acetyllysine By similarity
	Modified residue	87	1	Phosphoserine By similarity
	Modified residue	90	1	Phosphoserine By similarity
	Modified residue	100	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P02316-1 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: CAE905527B3B618D	FASTA	101	10,831
	10 20 30 40 50 60 MPKRKVSSAE GAAKEEPKRR SARLSAKPAP AKVETKPKKA AGKDKSSDKK VQTKGKRGAK 70 80 90 100 GKQAEVANQE TKEDLPAENG ETKNEESPAS DEAEEKEAKS D

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	NIH - Mammalian Gene Collection (MGC) project Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Crossbred X Angus. Tissue: Ileum.
[2]	"The primary structure of the nucleosome-associated chromosomal protein HMG 14." Walker J.M., Goodwin G.H., Johns E.W. FEBS Lett. 100:394-398(1979) [PubMed: 456580] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-101.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC102449 mRNA. Translation: AAI02450.1.
IPI	IPI00715836.
PIR	NSBOH4. A02654.
RefSeq	NP_001029944.1.
UniGene	Bt.87121
3D structure databases
DisProt	DP00038.
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000008696; ENSBTAP00000008696; ENSBTAG00000018768; Bos taurus. [Genome view]
GeneID	614915.
KEGG	bta:614915.
Organism-specific databases
CTD	614915.
Phylogenomic databases
eggNOG	maNOG21326.
HOVERGEN	P02316.
InParanoid	P02316.
OMA	TKTEENP.
OrthoDB	EOG97H88K.
Family and domain databases
InterPro	IPR000079. HMG14/HMG17. [Graphical view]
PANTHER	PTHR23087. HMG_14_17. 1 hit.
Pfam	PF01101. HMG14_17. 1 hit. [Graphical view]
PRINTS	PR00925. NONHISHMG17.
SMART	SM00527. HMG17. 1 hit. [Graphical view]
PROSITE	PS00355. HMG14_17. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HMGN1_BOVIN

Accession

Primary (citable) accession number: P02316
Secondary accession number(s): Q3T0D1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	January 23, 2007
Last modified:	January 19, 2010
This is version 66 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)