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Protein

Non-histone chromosomal protein HMG-14

Gene

HMGN1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-BTA-6781823. Formation of TC-NER Pre-Incision Complex.
R-BTA-6782135. Dual incision in TC-NER.
R-BTA-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.

Names & Taxonomyi

Protein namesi
Recommended name:
Non-histone chromosomal protein HMG-14
Alternative name(s):
High mobility group nucleosome-binding domain-containing protein 1
Gene namesi
Name:HMGN1
Synonyms:HMG14
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 101100Non-histone chromosomal protein HMG-14PRO_0000206690Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei8 – 81PhosphoserineBy similarity
Modified residuei14 – 141N6-acetyllysineBy similarity
Modified residuei21 – 211PhosphoserineBy similarity
Modified residuei25 – 251PhosphoserineBy similarity
Modified residuei27 – 271N6-acetyllysineBy similarity
Modified residuei82 – 821PhosphothreonineBy similarity
Modified residuei83 – 831N6-acetyllysineBy similarity
Modified residuei87 – 871PhosphoserineBy similarity
Modified residuei90 – 901PhosphoserineBy similarity
Modified residuei100 – 1001PhosphoserineBy similarity

Post-translational modificationi

Phosphorylation on Ser-21 and Ser-25 weakens binding to nucleosomes and increases the rate of H3 phosphorylation.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP02316.
PRIDEiP02316.

PTM databases

iPTMnetiP02316.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008696.

Structurei

3D structure databases

DisProtiDP00038.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMGN family.Curated

Phylogenomic databases

eggNOGiENOG410J491. Eukaryota.
ENOG410ZFVH. LUCA.
GeneTreeiENSGT00730000110877.
HOGENOMiHOG000116394.
HOVERGENiHBG073479.
InParanoidiP02316.
KOiK11299.
OMAiAQFREGS.
OrthoDBiEOG76MKC1.
TreeFamiTF105374.

Family and domain databases

InterProiIPR000079. HMGN_fam.
[Graphical view]
PfamiPF01101. HMG14_17. 1 hit.
[Graphical view]
PRINTSiPR00925. NONHISHMG17.
SMARTiSM00527. HMG17. 1 hit.
[Graphical view]
PROSITEiPS00355. HMG14_17. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02316-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKRKVSSAE GAAKEEPKRR SARLSAKPAP AKVETKPKKA AGKDKSSDKK
60 70 80 90 100
VQTKGKRGAK GKQAEVANQE TKEDLPAENG ETKNEESPAS DEAEEKEAKS

D
Length:101
Mass (Da):10,831
Last modified:January 23, 2007 - v2
Checksum:iCAE905527B3B618D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102449 mRNA. Translation: AAI02450.1.
PIRiA02654. NSBOH4.
RefSeqiNP_001029944.1. NM_001034772.1.
UniGeneiBt.87121.

Genome annotation databases

EnsembliENSBTAT00000008696; ENSBTAP00000008696; ENSBTAG00000018768.
GeneIDi614915.
KEGGibta:614915.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC102449 mRNA. Translation: AAI02450.1.
PIRiA02654. NSBOH4.
RefSeqiNP_001029944.1. NM_001034772.1.
UniGeneiBt.87121.

3D structure databases

DisProtiDP00038.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000008696.

PTM databases

iPTMnetiP02316.

Proteomic databases

PaxDbiP02316.
PRIDEiP02316.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000008696; ENSBTAP00000008696; ENSBTAG00000018768.
GeneIDi614915.
KEGGibta:614915.

Organism-specific databases

CTDi3150.

Phylogenomic databases

eggNOGiENOG410J491. Eukaryota.
ENOG410ZFVH. LUCA.
GeneTreeiENSGT00730000110877.
HOGENOMiHOG000116394.
HOVERGENiHBG073479.
InParanoidiP02316.
KOiK11299.
OMAiAQFREGS.
OrthoDBiEOG76MKC1.
TreeFamiTF105374.

Enzyme and pathway databases

ReactomeiR-BTA-6781823. Formation of TC-NER Pre-Incision Complex.
R-BTA-6782135. Dual incision in TC-NER.
R-BTA-6782210. Gap-filling DNA repair synthesis and ligation in TC-NER.

Miscellaneous databases

NextBioi20899354.

Family and domain databases

InterProiIPR000079. HMGN_fam.
[Graphical view]
PfamiPF01101. HMG14_17. 1 hit.
[Graphical view]
PRINTSiPR00925. NONHISHMG17.
SMARTiSM00527. HMG17. 1 hit.
[Graphical view]
PROSITEiPS00355. HMG14_17. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Ileum.
  2. "The primary structure of the nucleosome-associated chromosomal protein HMG 14."
    Walker J.M., Goodwin G.H., Johns E.W.
    FEBS Lett. 100:394-398(1979) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-101.

Entry informationi

Entry nameiHMGN1_BOVIN
AccessioniPrimary (citable) accession number: P02316
Secondary accession number(s): Q3T0D1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: January 20, 2016
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.