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Protein

Non-histone chromosomal protein HMG-17

Gene

HMGN2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation.

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-histone chromosomal protein HMG-17
Alternative name(s):
High mobility group nucleosome-binding domain-containing protein 2
Gene namesi
Name:HMGN2
Synonyms:HMG17
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 23

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 9089Non-histone chromosomal protein HMG-17PRO_0000206702Add
BLAST

Proteomic databases

PaxDbiP02314.
PRIDEiP02314.

Expressioni

Gene expression databases

BgeeiENSGALG00000000372.
ExpressionAtlasiP02314. baseline.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000000503.

Family & Domainsi

Sequence similaritiesi

Belongs to the HMGN family.Curated

Phylogenomic databases

eggNOGiENOG410J1B8. Eukaryota.
ENOG410Z0UC. LUCA.
GeneTreeiENSGT00730000110660.
HOGENOMiHOG000116395.
HOVERGENiHBG073479.
InParanoidiP02314.
KOiK11300.
OMAiDVKASHE.
PhylomeDBiP02314.

Family and domain databases

InterProiIPR000079. HMGN_fam.
[Graphical view]
PfamiPF01101. HMG14_17. 1 hit.
[Graphical view]
PRINTSiPR00925. NONHISHMG17.
SMARTiSM00527. HMG17. 1 hit.
[Graphical view]
PROSITEiPS00355. HMG14_17. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02314-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKRKAEGDT KGDKAKVKDE PQRRSARLSA KPAPPKPEPK PKKAAPKKSE
60 70 80 90
KVPKGKKGKA DAGKEGNNPA ENGDAKTDQA QKAEGAGDAK
Length:90
Mass (Da):9,453
Last modified:January 23, 2007 - v3
Checksum:iC1BF6EBC2AE4C399
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti81 – 811Q → E AA sequence (PubMed:7371857).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00416 mRNA. Translation: CAA68473.1.
M26676 mRNA. Translation: AAA48817.1.
J03229 Genomic DNA. Translation: AAA48816.1.
PIRiA29951. NSCHH7.
RefSeqiNP_001072953.1. NM_001079485.1.
UniGeneiGga.4166.

Genome annotation databases

EnsembliENSGALT00000000504; ENSGALP00000000503; ENSGALG00000000372.
GeneIDi768675.
KEGGigga:768675.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00416 mRNA. Translation: CAA68473.1.
M26676 mRNA. Translation: AAA48817.1.
J03229 Genomic DNA. Translation: AAA48816.1.
PIRiA29951. NSCHH7.
RefSeqiNP_001072953.1. NM_001079485.1.
UniGeneiGga.4166.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000000503.

Proteomic databases

PaxDbiP02314.
PRIDEiP02314.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000000504; ENSGALP00000000503; ENSGALG00000000372.
GeneIDi768675.
KEGGigga:768675.

Organism-specific databases

CTDi3151.

Phylogenomic databases

eggNOGiENOG410J1B8. Eukaryota.
ENOG410Z0UC. LUCA.
GeneTreeiENSGT00730000110660.
HOGENOMiHOG000116395.
HOVERGENiHBG073479.
InParanoidiP02314.
KOiK11300.
OMAiDVKASHE.
PhylomeDBiP02314.

Miscellaneous databases

PROiP02314.

Gene expression databases

BgeeiENSGALG00000000372.
ExpressionAtlasiP02314. baseline.

Family and domain databases

InterProiIPR000079. HMGN_fam.
[Graphical view]
PfamiPF01101. HMG14_17. 1 hit.
[Graphical view]
PRINTSiPR00925. NONHISHMG17.
SMARTiSM00527. HMG17. 1 hit.
[Graphical view]
PROSITEiPS00355. HMG14_17. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHMGN2_CHICK
AccessioniPrimary (citable) accession number: P02314
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 94 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.