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Protein

Non-histone chromosomal protein HMG-17

Gene

HMGN2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-histone chromosomal protein HMG-17
Alternative name(s):
High mobility group nucleosome-binding domain-containing protein 2
Gene namesi
Name:HMGN2
Synonyms:HMG17
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

  • Note: Cytoplasmic enrichment upon phosphorylation.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002066952 – 90Non-histone chromosomal protein HMG-17Add BLAST89

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25PhosphoserineBy similarity1
Modified residuei29PhosphoserineBy similarity1
Modified residuei82N6-acetyllysine; alternateBy similarity1
Cross-linki82Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity

Post-translational modificationi

Phosphorylation favors cytoplasmic localization.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP02313.
PeptideAtlasiP02313.
PRIDEiP02313.

PTM databases

iPTMnetiP02313.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000048748.

Structurei

3D structure databases

DisProtiDP00195.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HMGN family.Curated

Phylogenomic databases

eggNOGiENOG410J1B8. Eukaryota.
ENOG410Z0UC. LUCA.
HOGENOMiHOG000116395.
HOVERGENiHBG073479.
InParanoidiP02313.
KOiK11300.

Family and domain databases

InterProiIPR000079. HMGN_fam.
[Graphical view]
PfamiPF01101. HMG14_17. 1 hit.
[Graphical view]
PRINTSiPR00925. NONHISHMG17.
SMARTiSM00527. HMG17. 1 hit.
[Graphical view]
PROSITEiPS00355. HMG14_17. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02313-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKRKAEGDA EGDKAKVKDE PQRRSARLSA KPAPPKPEPK PKKAPAKKGE
60 70 80 90
KVPKGKKGKA DAGKDGNNPA ENGDAKTDQA QKAEGAGDAK
Length:90
Mass (Da):9,380
Last modified:May 20, 2008 - v2
Checksum:i4B64344980A422C5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti11E → K AA sequence (PubMed:793593).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti4R → A.1
Natural varianti4R → V.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC142241 mRNA. Translation: AAI42242.1.
PIRiA90200. NSBOH7.
RefSeqiNP_001092415.1. NM_001098945.1.
UniGeneiBt.1758.

Genome annotation databases

GeneIDi512161.
KEGGibta:512161.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC142241 mRNA. Translation: AAI42242.1.
PIRiA90200. NSBOH7.
RefSeqiNP_001092415.1. NM_001098945.1.
UniGeneiBt.1758.

3D structure databases

DisProtiDP00195.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000048748.

PTM databases

iPTMnetiP02313.

Proteomic databases

PaxDbiP02313.
PeptideAtlasiP02313.
PRIDEiP02313.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi512161.
KEGGibta:512161.

Organism-specific databases

CTDi3151.

Phylogenomic databases

eggNOGiENOG410J1B8. Eukaryota.
ENOG410Z0UC. LUCA.
HOGENOMiHOG000116395.
HOVERGENiHBG073479.
InParanoidiP02313.
KOiK11300.

Family and domain databases

InterProiIPR000079. HMGN_fam.
[Graphical view]
PfamiPF01101. HMG14_17. 1 hit.
[Graphical view]
PRINTSiPR00925. NONHISHMG17.
SMARTiSM00527. HMG17. 1 hit.
[Graphical view]
PROSITEiPS00355. HMG14_17. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHMGN2_BOVIN
AccessioniPrimary (citable) accession number: P02313
Secondary accession number(s): A5PJU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: May 20, 2008
Last modified: November 30, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.