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Protein

Histone H3

Gene

His3

more
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-DME-1266695. Interleukin-7 signaling.
R-DME-212300. PRC2 methylates histones and DNA.
R-DME-2559580. Oxidative Stress Induced Senescence.
R-DME-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-DME-3247509. Chromatin modifying enzymes.
R-DME-427359. SIRT1 negatively regulates rRNA Expression.
R-DME-427413. NoRC negatively regulates rRNA expression.
R-DME-5578749. Transcriptional regulation by small RNAs.
R-DME-73777. RNA Polymerase I Chain Elongation.
R-DME-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H3
Gene namesi
Name:His3
AND
ORF Names:CG31613
AND
ORF Names:CG33803
AND
ORF Names:CG33806
AND
ORF Names:CG33809
AND
ORF Names:CG33812
AND
ORF Names:CG33815
AND
ORF Names:CG33818
AND
ORF Names:CG33821
AND
ORF Names:CG33824
AND
ORF Names:CG33827
AND
ORF Names:CG33830
AND
ORF Names:CG33833
AND
ORF Names:CG33836
AND
ORF Names:CG33839
AND
ORF Names:CG33842
AND
ORF Names:CG33845
AND
ORF Names:CG33848
AND
ORF Names:CG33851
AND
ORF Names:CG33854
AND
ORF Names:CG33857
AND
ORF Names:CG33860
AND
ORF Names:CG33863
AND
ORF Names:CG33866
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0001199. His3.
FBgn0051613. His3:CG31613.
FBgn0053803. His3:CG33803.
FBgn0053806. His3:CG33806.
FBgn0053809. His3:CG33809.
FBgn0053812. His3:CG33812.
FBgn0053815. His3:CG33815.
FBgn0053818. His3:CG33818.
FBgn0053821. His3:CG33821.
FBgn0053824. His3:CG33824.
FBgn0053827. His3:CG33827.
FBgn0053830. His3:CG33830.
FBgn0053833. His3:CG33833.
FBgn0053836. His3:CG33836.
FBgn0053839. His3:CG33839.
FBgn0053842. His3:CG33842.
FBgn0053845. His3:CG33845.
FBgn0053848. His3:CG33848.
FBgn0053851. His3:CG33851.
FBgn0053854. His3:CG33854.
FBgn0053857. His3:CG33857.
FBgn0053860. His3:CG33860.
FBgn0053863. His3:CG33863.
FBgn0053866. His3:CG33866.

Subcellular locationi

GO - Cellular componenti

  • nuclear nucleosome Source: FlyBase
  • nucleosome Source: GO_Central
  • nucleus Source: GO_Central
  • polytene chromosome Source: FlyBase
  • RCAF complex Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00002213002 – 136Histone H3Add BLAST135

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5N6,N6,N6-trimethyllysine; alternate2 Publications1
Modified residuei5N6,N6-dimethyllysine; alternate2 Publications1
Modified residuei5N6-methyllysine; alternate2 Publications1
Modified residuei10N6,N6-dimethyllysine; alternate1 Publication1
Modified residuei10N6-acetyllysine; alternate3 Publications1
Modified residuei10N6-methyllysine; alternate1 Publication1
Modified residuei11Phosphoserine5 Publications1
Modified residuei15N6,N6-dimethyllysine; alternate1 Publication1
Modified residuei15N6-acetyllysine; alternate4 Publications1
Modified residuei15N6-methyllysine; alternate1 Publication1
Modified residuei19N6-acetyllysine1 Publication1
Modified residuei24N6-acetyllysine1 Publication1
Modified residuei28N6,N6,N6-trimethyllysine; alternate1 Publication1
Modified residuei28N6,N6-dimethyllysine; alternate1 Publication1
Modified residuei28N6-methyllysine; alternate1 Publication1
Modified residuei37N6,N6-dimethyllysine; alternate1 Publication1
Modified residuei37N6-methyllysine; alternate1 Publication1
Modified residuei38N6,N6-dimethyllysine; alternate1 Publication1
Modified residuei38N6-methyllysine; alternate1 Publication1
Modified residuei80N6,N6-dimethyllysine; alternate3 Publications1
Modified residuei80N6-methyllysine; alternate3 Publications1

Post-translational modificationi

Phosphorylation at Ser-11 by ial/aurora-B during mitosis and meiosis is crucial for chromosome condensation and cell-cycle progression. Phosphorylation at Ser-11 by JIL-1 during interphase is linked to gene activation and restricts the formation of heterochromatin at inappropriate sites. Phosphorylation at Ser-11 is enriched on male X chromosome compared to the autosome.5 Publications
Acetylation is generally linked to gene activation. Acetylated on Lys-15 during prophase I of meiosis. Phosphorylation of H2A 'Thr-119' is a prerequisite for H3 Lys-15 acetylation. Acetylation on Lys-15 is enriched on male X chromosome compared to the autosome.5 Publications
Methylation at Lys-5 or Lys-80 is generally associated with active chromatin. Methylation at Lys-80 by gpp occurs at low levels in specific developmental stages and tissues undergoing active cell division, and at highest levels in epidermal cells undergoing differentiation.3 Publications

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiP02299.
PRIDEiP02299.

PTM databases

iPTMnetiP02299.

Expressioni

Gene expression databases

BgeeiFBgn0051613.
GenevisibleiP02299. DM.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Binary interactionsi

WithEntry#Exp.IntActNotes
KAT2BQ928312EBI-522090,EBI-477430From a different organism.
rhiQ7JXA84EBI-522090,EBI-149916
ScmQ9VHA04EBI-522090,EBI-89256
Su(var)205P052053EBI-522090,EBI-155532

Protein-protein interaction databases

BioGridi77140. 10 interactors.
DIPiDIP-38722N.
IntActiP02299. 17 interactors.
MINTiMINT-271349.
STRINGi7227.FBpp0091112.

Structurei

Secondary structure

1136
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi46 – 57Combined sources12
Helixi65 – 77Combined sources13
Beta strandi80 – 82Combined sources3
Helixi87 – 114Combined sources28
Beta strandi118 – 120Combined sources3
Helixi122 – 131Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KNAX-ray2.10P2-17[»]
1KNEX-ray2.40P2-17[»]
2NQBX-ray2.30A/E2-136[»]
2PYOX-ray2.43A/E2-136[»]
2YBAX-ray2.55C/D2-20[»]
4QLCX-ray3.50A/E2-136[»]
4UUZX-ray2.90A1-136[»]
4X23X-ray3.50A/E/K/O41-133[»]
ProteinModelPortaliP02299.
SMRiP02299.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02299.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni6 – 11Su(var)205 chromodomain-binding6

Sequence similaritiesi

Belongs to the histone H3 family.Curated

Phylogenomic databases

eggNOGiKOG1745. Eukaryota.
COG2036. LUCA.
GeneTreeiENSGT00760000118967.
InParanoidiP02299.
KOiK11253.
OMAiASEAYLX.
OrthoDBiEOG091G0XGD.
PhylomeDBiP02299.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000164. Histone_H3/CENP-A.
[Graphical view]
PANTHERiPTHR11426. PTHR11426. 1 hit.
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00622. HISTONEH3.
SMARTiSM00428. H3. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00322. HISTONE_H3_1. 1 hit.
PS00959. HISTONE_H3_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02299-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARTKQTARK STGGKAPRKQ LATKAARKSA PATGGVKKPH RYRPGTVALR
60 70 80 90 100
EIRRYQKSTE LLIRKLPFQR LVREIAQDFK TDLRFQSSAV MALQEASEAY
110 120 130
LVGLFEDTNL CAIHAKRVTI MPKDIQLARR IRGERA
Length:136
Mass (Da):15,388
Last modified:January 23, 2007 - v4
Checksum:i6FD8508EA50A0EEC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti118V → I (PubMed:2536150).Curated1
Sequence conflicti118V → I (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14215 Genomic DNA. Translation: CAA32434.1.
AB019400 Genomic DNA. Translation: BAA93621.1.
AE014134 Genomic DNA. Translation: AAN11127.1.
AE014134 Genomic DNA. Translation: AAZ66481.1.
AE014134 Genomic DNA. Translation: AAZ66485.1.
AE014134 Genomic DNA. Translation: AAZ66490.1.
AE014134 Genomic DNA. Translation: AAZ66494.1.
AE014134 Genomic DNA. Translation: AAZ66499.1.
AE014134 Genomic DNA. Translation: AAZ66504.1.
AE014134 Genomic DNA. Translation: AAZ66509.1.
AE014134 Genomic DNA. Translation: AAZ66514.1.
AE014134 Genomic DNA. Translation: AAZ66519.1.
AE014134 Genomic DNA. Translation: AAZ66524.1.
AE014134 Genomic DNA. Translation: AAZ66529.1.
AE014134 Genomic DNA. Translation: AAZ66534.1.
AE014134 Genomic DNA. Translation: AAZ66539.1.
AE014134 Genomic DNA. Translation: AAZ66544.1.
AE014134 Genomic DNA. Translation: AAZ66549.1.
AE014134 Genomic DNA. Translation: AAZ66554.1.
AE014134 Genomic DNA. Translation: AAZ66559.1.
AE014134 Genomic DNA. Translation: AAZ66564.1.
AE014134 Genomic DNA. Translation: AAZ66569.1.
AE014134 Genomic DNA. Translation: AAZ66574.1.
AE014134 Genomic DNA. Translation: AAZ66579.1.
AE014134 Genomic DNA. Translation: AAZ66583.1.
PIRiA02630.
S10097.
RefSeqiNP_001027285.1. NM_001032114.2.
NP_001027289.1. NM_001032118.2.
NP_001027294.1. NM_001032123.2.
NP_001027298.1. NM_001032127.2.
NP_001027303.1. NM_001032132.2.
NP_001027308.1. NM_001032137.2.
NP_001027313.1. NM_001032142.2.
NP_001027318.1. NM_001032147.2.
NP_001027323.1. NM_001032152.2.
NP_001027328.1. NM_001032157.2.
NP_001027333.1. NM_001032162.2.
NP_001027338.1. NM_001032167.2.
NP_001027343.1. NM_001032172.2.
NP_001027348.1. NM_001032177.2.
NP_001027353.1. NM_001032182.2.
NP_001027358.1. NM_001032187.2.
NP_001027363.1. NM_001032192.2.
NP_001027368.1. NM_001032197.2.
NP_001027373.1. NM_001032202.2.
NP_001027378.1. NM_001032207.2.
NP_001027383.1. NM_001032212.2.
NP_001027387.1. NM_001032216.2.
NP_724345.1. NM_165384.3.

Genome annotation databases

EnsemblMetazoaiFBtr0085894; FBpp0085250; FBgn0051613.
FBtr0091807; FBpp0091051; FBgn0053803.
FBtr0091810; FBpp0091053; FBgn0053806.
FBtr0091813; FBpp0091056; FBgn0053809.
FBtr0091816; FBpp0091058; FBgn0053812.
FBtr0091819; FBpp0091061; FBgn0053815.
FBtr0091822; FBpp0091064; FBgn0053818.
FBtr0091825; FBpp0091067; FBgn0053821.
FBtr0091828; FBpp0091070; FBgn0053824.
FBtr0091831; FBpp0091073; FBgn0053827.
FBtr0091834; FBpp0091076; FBgn0053830.
FBtr0091837; FBpp0091079; FBgn0053833.
FBtr0091840; FBpp0091082; FBgn0053836.
FBtr0091843; FBpp0091085; FBgn0053839.
FBtr0091846; FBpp0091088; FBgn0053842.
FBtr0091849; FBpp0091091; FBgn0053845.
FBtr0091852; FBpp0091094; FBgn0053848.
FBtr0091855; FBpp0091097; FBgn0053851.
FBtr0091858; FBpp0091100; FBgn0053854.
FBtr0091861; FBpp0091103; FBgn0053857.
FBtr0091864; FBpp0091106; FBgn0053860.
FBtr0091867; FBpp0091109; FBgn0053863.
FBtr0091870; FBpp0091112; FBgn0053866.
GeneIDi318847.
3771723.
3771729.
3771771.
3771792.
3771959.
3772032.
3772149.
3772163.
3772173.
3772189.
3772191.
3772198.
3772231.
3772370.
3772374.
3772421.
3772489.
3772517.
3772518.
3772552.
3772607.
3772619.
KEGGidme:Dmel_CG31613.
dme:Dmel_CG33803.
dme:Dmel_CG33806.
dme:Dmel_CG33809.
dme:Dmel_CG33812.
dme:Dmel_CG33815.
dme:Dmel_CG33818.
dme:Dmel_CG33821.
dme:Dmel_CG33824.
dme:Dmel_CG33827.
dme:Dmel_CG33830.
dme:Dmel_CG33833.
dme:Dmel_CG33836.
dme:Dmel_CG33839.
dme:Dmel_CG33842.
dme:Dmel_CG33845.
dme:Dmel_CG33848.
dme:Dmel_CG33851.
dme:Dmel_CG33854.
dme:Dmel_CG33857.
dme:Dmel_CG33860.
dme:Dmel_CG33863.
dme:Dmel_CG33866.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14215 Genomic DNA. Translation: CAA32434.1.
AB019400 Genomic DNA. Translation: BAA93621.1.
AE014134 Genomic DNA. Translation: AAN11127.1.
AE014134 Genomic DNA. Translation: AAZ66481.1.
AE014134 Genomic DNA. Translation: AAZ66485.1.
AE014134 Genomic DNA. Translation: AAZ66490.1.
AE014134 Genomic DNA. Translation: AAZ66494.1.
AE014134 Genomic DNA. Translation: AAZ66499.1.
AE014134 Genomic DNA. Translation: AAZ66504.1.
AE014134 Genomic DNA. Translation: AAZ66509.1.
AE014134 Genomic DNA. Translation: AAZ66514.1.
AE014134 Genomic DNA. Translation: AAZ66519.1.
AE014134 Genomic DNA. Translation: AAZ66524.1.
AE014134 Genomic DNA. Translation: AAZ66529.1.
AE014134 Genomic DNA. Translation: AAZ66534.1.
AE014134 Genomic DNA. Translation: AAZ66539.1.
AE014134 Genomic DNA. Translation: AAZ66544.1.
AE014134 Genomic DNA. Translation: AAZ66549.1.
AE014134 Genomic DNA. Translation: AAZ66554.1.
AE014134 Genomic DNA. Translation: AAZ66559.1.
AE014134 Genomic DNA. Translation: AAZ66564.1.
AE014134 Genomic DNA. Translation: AAZ66569.1.
AE014134 Genomic DNA. Translation: AAZ66574.1.
AE014134 Genomic DNA. Translation: AAZ66579.1.
AE014134 Genomic DNA. Translation: AAZ66583.1.
PIRiA02630.
S10097.
RefSeqiNP_001027285.1. NM_001032114.2.
NP_001027289.1. NM_001032118.2.
NP_001027294.1. NM_001032123.2.
NP_001027298.1. NM_001032127.2.
NP_001027303.1. NM_001032132.2.
NP_001027308.1. NM_001032137.2.
NP_001027313.1. NM_001032142.2.
NP_001027318.1. NM_001032147.2.
NP_001027323.1. NM_001032152.2.
NP_001027328.1. NM_001032157.2.
NP_001027333.1. NM_001032162.2.
NP_001027338.1. NM_001032167.2.
NP_001027343.1. NM_001032172.2.
NP_001027348.1. NM_001032177.2.
NP_001027353.1. NM_001032182.2.
NP_001027358.1. NM_001032187.2.
NP_001027363.1. NM_001032192.2.
NP_001027368.1. NM_001032197.2.
NP_001027373.1. NM_001032202.2.
NP_001027378.1. NM_001032207.2.
NP_001027383.1. NM_001032212.2.
NP_001027387.1. NM_001032216.2.
NP_724345.1. NM_165384.3.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KNAX-ray2.10P2-17[»]
1KNEX-ray2.40P2-17[»]
2NQBX-ray2.30A/E2-136[»]
2PYOX-ray2.43A/E2-136[»]
2YBAX-ray2.55C/D2-20[»]
4QLCX-ray3.50A/E2-136[»]
4UUZX-ray2.90A1-136[»]
4X23X-ray3.50A/E/K/O41-133[»]
ProteinModelPortaliP02299.
SMRiP02299.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi77140. 10 interactors.
DIPiDIP-38722N.
IntActiP02299. 17 interactors.
MINTiMINT-271349.
STRINGi7227.FBpp0091112.

PTM databases

iPTMnetiP02299.

Proteomic databases

PaxDbiP02299.
PRIDEiP02299.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0085894; FBpp0085250; FBgn0051613.
FBtr0091807; FBpp0091051; FBgn0053803.
FBtr0091810; FBpp0091053; FBgn0053806.
FBtr0091813; FBpp0091056; FBgn0053809.
FBtr0091816; FBpp0091058; FBgn0053812.
FBtr0091819; FBpp0091061; FBgn0053815.
FBtr0091822; FBpp0091064; FBgn0053818.
FBtr0091825; FBpp0091067; FBgn0053821.
FBtr0091828; FBpp0091070; FBgn0053824.
FBtr0091831; FBpp0091073; FBgn0053827.
FBtr0091834; FBpp0091076; FBgn0053830.
FBtr0091837; FBpp0091079; FBgn0053833.
FBtr0091840; FBpp0091082; FBgn0053836.
FBtr0091843; FBpp0091085; FBgn0053839.
FBtr0091846; FBpp0091088; FBgn0053842.
FBtr0091849; FBpp0091091; FBgn0053845.
FBtr0091852; FBpp0091094; FBgn0053848.
FBtr0091855; FBpp0091097; FBgn0053851.
FBtr0091858; FBpp0091100; FBgn0053854.
FBtr0091861; FBpp0091103; FBgn0053857.
FBtr0091864; FBpp0091106; FBgn0053860.
FBtr0091867; FBpp0091109; FBgn0053863.
FBtr0091870; FBpp0091112; FBgn0053866.
GeneIDi318847.
3771723.
3771729.
3771771.
3771792.
3771959.
3772032.
3772149.
3772163.
3772173.
3772189.
3772191.
3772198.
3772231.
3772370.
3772374.
3772421.
3772489.
3772517.
3772518.
3772552.
3772607.
3772619.
KEGGidme:Dmel_CG31613.
dme:Dmel_CG33803.
dme:Dmel_CG33806.
dme:Dmel_CG33809.
dme:Dmel_CG33812.
dme:Dmel_CG33815.
dme:Dmel_CG33818.
dme:Dmel_CG33821.
dme:Dmel_CG33824.
dme:Dmel_CG33827.
dme:Dmel_CG33830.
dme:Dmel_CG33833.
dme:Dmel_CG33836.
dme:Dmel_CG33839.
dme:Dmel_CG33842.
dme:Dmel_CG33845.
dme:Dmel_CG33848.
dme:Dmel_CG33851.
dme:Dmel_CG33854.
dme:Dmel_CG33857.
dme:Dmel_CG33860.
dme:Dmel_CG33863.
dme:Dmel_CG33866.

Organism-specific databases

CTDi318847.
3771723.
3771729.
3771771.
3771792.
3771959.
3772032.
3772149.
3772163.
3772173.
3772189.
3772191.
3772198.
3772231.
3772370.
3772374.
3772421.
3772489.
3772517.
3772518.
3772552.
3772607.
3772619.
FlyBaseiFBgn0001199. His3.
FBgn0051613. His3:CG31613.
FBgn0053803. His3:CG33803.
FBgn0053806. His3:CG33806.
FBgn0053809. His3:CG33809.
FBgn0053812. His3:CG33812.
FBgn0053815. His3:CG33815.
FBgn0053818. His3:CG33818.
FBgn0053821. His3:CG33821.
FBgn0053824. His3:CG33824.
FBgn0053827. His3:CG33827.
FBgn0053830. His3:CG33830.
FBgn0053833. His3:CG33833.
FBgn0053836. His3:CG33836.
FBgn0053839. His3:CG33839.
FBgn0053842. His3:CG33842.
FBgn0053845. His3:CG33845.
FBgn0053848. His3:CG33848.
FBgn0053851. His3:CG33851.
FBgn0053854. His3:CG33854.
FBgn0053857. His3:CG33857.
FBgn0053860. His3:CG33860.
FBgn0053863. His3:CG33863.
FBgn0053866. His3:CG33866.

Phylogenomic databases

eggNOGiKOG1745. Eukaryota.
COG2036. LUCA.
GeneTreeiENSGT00760000118967.
InParanoidiP02299.
KOiK11253.
OMAiASEAYLX.
OrthoDBiEOG091G0XGD.
PhylomeDBiP02299.

Enzyme and pathway databases

ReactomeiR-DME-1266695. Interleukin-7 signaling.
R-DME-212300. PRC2 methylates histones and DNA.
R-DME-2559580. Oxidative Stress Induced Senescence.
R-DME-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-DME-3247509. Chromatin modifying enzymes.
R-DME-427359. SIRT1 negatively regulates rRNA Expression.
R-DME-427413. NoRC negatively regulates rRNA expression.
R-DME-5578749. Transcriptional regulation by small RNAs.
R-DME-73777. RNA Polymerase I Chain Elongation.
R-DME-983231. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

EvolutionaryTraceiP02299.
PROiP02299.

Gene expression databases

BgeeiFBgn0051613.
GenevisibleiP02299. DM.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000164. Histone_H3/CENP-A.
[Graphical view]
PANTHERiPTHR11426. PTHR11426. 1 hit.
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00622. HISTONEH3.
SMARTiSM00428. H3. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00322. HISTONE_H3_1. 1 hit.
PS00959. HISTONE_H3_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiH3_DROME
AccessioniPrimary (citable) accession number: P02299
Secondary accession number(s): Q4ABE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 168 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.