ID   H2B_DROME               Reviewed;         123 AA.
AC   P02283; Q4ABE1; Q9W5U7;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   27-MAR-2024, entry version 217.
DE   RecName: Full=Histone H2B;
GN   Name=His2B;
GN   and
GN   Name=His2B:CG17949; ORFNames=CG17949;
GN   and
GN   Name=His2B:CG33868; ORFNames=CG33868;
GN   and
GN   Name=His2B:CG33870; ORFNames=CG33870;
GN   and
GN   Name=His2B:CG33872; ORFNames=CG33872;
GN   and
GN   Name=His2B:CG33874; ORFNames=CG33874;
GN   and
GN   Name=His2B:CG33876; ORFNames=CG33876;
GN   and
GN   Name=His2B:CG33878; ORFNames=CG33878;
GN   and
GN   Name=His2B:CG33880; ORFNames=CG33880;
GN   and
GN   Name=His2B:CG33882; ORFNames=CG33882;
GN   and
GN   Name=His2B:CG33884; ORFNames=CG33884;
GN   and
GN   Name=His2B:CG33886; ORFNames=CG33886;
GN   and
GN   Name=His2B:CG33888; ORFNames=CG33888;
GN   and
GN   Name=His2B:CG33890; ORFNames=CG33890;
GN   and
GN   Name=His2B:CG33892; ORFNames=CG33892;
GN   and
GN   Name=His2B:CG33894; ORFNames=CG33894;
GN   and
GN   Name=His2B:CG33896; ORFNames=CG33896;
GN   and
GN   Name=His2B:CG33898; ORFNames=CG33898;
GN   and
GN   Name=His2B:CG33900; ORFNames=CG33900;
GN   and
GN   Name=His2B:CG33902; ORFNames=CG33902;
GN   and
GN   Name=His2B:CG33904; ORFNames=CG33904;
GN   and
GN   Name=His2B:CG33906; ORFNames=CG33906;
GN   and
GN   Name=His2B:CG33908; ORFNames=CG33908;
GN   and
GN   Name=His2B:CG33910; ORFNames=CG33910;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   PROTEIN SEQUENCE (HIS2B).
RX   PubMed=117830; DOI=10.1021/bi00592a025;
RA   Elgin S.C.R., Schilling J., Hood L.E.;
RT   "Sequence of histone 2B of Drosophila melanogaster.";
RL   Biochemistry 18:5679-5685(1979).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] (HIS2B).
RC   STRAIN=AK-194;
RX   PubMed=2536150; DOI=10.1093/nar/17.1.225;
RA   Matsuo Y., Yamazaki T.;
RT   "tRNA derived insertion element in histone gene repeating unit of
RT   Drosophila melanogaster.";
RL   Nucleic Acids Res. 17:225-238(1989).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (HIS2B:CG17949).
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-118 (HIS2B).
RA   Goldberg M.L.;
RL   Thesis (1979), University of Stanford, United States.
RN   [6]
RP   METHYLATION AT PRO-2.
RX   PubMed=3127388; DOI=10.1016/s0021-9258(18)68837-4;
RA   Desrosiers R., Tanguay R.M.;
RT   "Methylation of Drosophila histones at proline, lysine, and arginine
RT   residues during heat shock.";
RL   J. Biol. Chem. 263:4686-4692(1988).
RN   [7]
RP   RETRACTED PAPER.
RX   PubMed=15143281; DOI=10.1126/science.1095001;
RA   Maile T., Kwoczynski S., Katzenberger R.J., Wassarman D.A., Sauer F.;
RT   "TAF1 activates transcription by phosphorylation of serine 33 in histone
RT   H2B.";
RL   Science 304:1010-1014(2004).
RN   [8]
RP   RETRACTION NOTICE OF PUBMED:15143281.
RX   PubMed=24876484; DOI=10.1126/science.344.6187.981-a;
RA   McNutt M.;
RL   Science 344:981-981(2014).
RN   [9]
RP   PROBABLE UBIQUITINATION.
RX   PubMed=15691768; DOI=10.1016/j.devcel.2004.11.020;
RA   Bray S., Musisi H., Bienz M.;
RT   "Bre1 is required for Notch signaling and histone modification.";
RL   Dev. Cell 8:279-286(2005).
RN   [10]
RP   GLYCOSYLATION.
RX   PubMed=22121020; DOI=10.1038/nature10656;
RA   Fujiki R., Hashiba W., Sekine H., Yokoyama A., Chikanishi T., Ito S.,
RA   Imai Y., Kim J., He H.H., Igarashi K., Kanno J., Ohtake F., Kitagawa H.,
RA   Roeder R.G., Brown M., Kato S.;
RT   "GlcNAcylation of histone H2B facilitates its monoubiquitination.";
RL   Nature 480:557-560(2011).
RN   [11]
RP   SUCCINYLATION AT LYS-44; LYS-114 AND LYS-118.
RX   PubMed=22389435; DOI=10.1074/mcp.m111.015875;
RA   Xie Z., Dai J., Dai L., Tan M., Cheng Z., Wu Y., Boeke J.D., Zhao Y.;
RT   "Lysine succinylation and lysine malonylation in histones.";
RL   Mol. Cell. Proteomics 11:100-107(2012).
CC   -!- FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact
CC       DNA into chromatin, limiting DNA accessibility to the cellular
CC       machineries which require DNA as a template. Histones thereby play a
CC       central role in transcription regulation, DNA repair, DNA replication
CC       and chromosomal stability. DNA accessibility is regulated via a complex
CC       set of post-translational modifications of histones, also called
CC       histone code, and nucleosome remodeling.
CC   -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC       each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC       two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC       DNA.
CC   -!- INTERACTION:
CC       P02283; O15265: ATXN7; Xeno; NbExp=2; IntAct=EBI-188137, EBI-708350;
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC   -!- PTM: Monoubiquitination of Lys-118 by Bre1 gives a specific tag for
CC       epigenetic transcriptional activation and is also prerequisite for
CC       histone H3 'Lys-4' and 'Lys-79' methylation.
CC       {ECO:0000305|PubMed:3127388}.
CC   -!- PTM: Methylation at Pro-2 increases upon heat shock.
CC       {ECO:0000269|PubMed:3127388}.
CC   -!- PTM: GlcNAcylation at Ser-110 promotes monoubiquitination of Lys-118.
CC       It fluctuates in response to extracellular glucose, and associates with
CC       transcribed genes (Probable). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the histone H2B family. {ECO:0000305}.
CC   -!- CAUTION: Was reported to be phosphorylated at Ser-34. However, the
CC       paper was retracted because some data, results and conclusions in the
CC       paper are not reliable. {ECO:0000305|PubMed:15143281,
CC       ECO:0000305|PubMed:24876484}.
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DR   EMBL; X14215; CAA32432.1; -; Genomic_DNA.
DR   EMBL; AE014134; AAN11124.1; -; Genomic_DNA.
DR   EMBL; AE014134; AAZ66483.1; -; Genomic_DNA.
DR   EMBL; AE014134; AAZ66487.1; -; Genomic_DNA.
DR   EMBL; AE014134; AAZ66492.1; -; Genomic_DNA.
DR   EMBL; AE014134; AAZ66496.1; -; Genomic_DNA.
DR   EMBL; AE014134; AAZ66501.1; -; Genomic_DNA.
DR   EMBL; AE014134; AAZ66506.1; -; Genomic_DNA.
DR   EMBL; AE014134; AAZ66511.1; -; Genomic_DNA.
DR   EMBL; AE014134; AAZ66521.1; -; Genomic_DNA.
DR   EMBL; AE014134; AAZ66531.1; -; Genomic_DNA.
DR   EMBL; AE014134; AAZ66576.1; -; Genomic_DNA.
DR   EMBL; AE014134; AAZ66571.1; -; Genomic_DNA.
DR   EMBL; AE014134; AAZ66566.1; -; Genomic_DNA.
DR   EMBL; AE014134; AAZ66561.1; -; Genomic_DNA.
DR   EMBL; AE014134; AAZ66556.1; -; Genomic_DNA.
DR   EMBL; AE014134; AAZ66551.1; -; Genomic_DNA.
DR   EMBL; AE014134; AAZ66546.1; -; Genomic_DNA.
DR   EMBL; AE014134; AAZ66541.1; -; Genomic_DNA.
DR   EMBL; AE014134; AAZ66536.1; -; Genomic_DNA.
DR   EMBL; AE014134; AAZ66479.1; -; Genomic_DNA.
DR   EMBL; AE014134; AAZ66581.1; -; Genomic_DNA.
DR   EMBL; AE014134; AAZ66526.1; -; Genomic_DNA.
DR   EMBL; AE014134; AAZ66516.1; -; Genomic_DNA.
DR   PIR; S10095; HSFF22.
DR   RefSeq; NP_001027283.1; NM_001032112.2.
DR   RefSeq; NP_001027287.1; NM_001032116.2.
DR   RefSeq; NP_001027291.1; NM_001032120.2.
DR   RefSeq; NP_001027296.1; NM_001032125.2.
DR   RefSeq; NP_001027300.1; NM_001032129.2.
DR   RefSeq; NP_001027305.1; NM_001032134.2.
DR   RefSeq; NP_001027310.1; NM_001032139.2.
DR   RefSeq; NP_001027315.1; NM_001032144.2.
DR   RefSeq; NP_001027320.1; NM_001032149.2.
DR   RefSeq; NP_001027325.1; NM_001032154.2.
DR   RefSeq; NP_001027330.1; NM_001032159.2.
DR   RefSeq; NP_001027335.1; NM_001032164.2.
DR   RefSeq; NP_001027340.1; NM_001032169.2.
DR   RefSeq; NP_001027345.1; NM_001032174.2.
DR   RefSeq; NP_001027350.1; NM_001032179.2.
DR   RefSeq; NP_001027355.1; NM_001032184.2.
DR   RefSeq; NP_001027360.1; NM_001032189.2.
DR   RefSeq; NP_001027365.1; NM_001032194.2.
DR   RefSeq; NP_001027370.1; NM_001032199.2.
DR   RefSeq; NP_001027375.1; NM_001032204.2.
DR   RefSeq; NP_001027380.1; NM_001032209.2.
DR   RefSeq; NP_001027385.1; NM_001032214.2.
DR   RefSeq; NP_724342.1; NM_165381.4.
DR   PDB; 2NQB; X-ray; 2.30 A; D/H=2-123.
DR   PDB; 2PYO; X-ray; 2.43 A; D/H=2-123.
DR   PDB; 4QLC; X-ray; 3.50 A; D/H=2-123.
DR   PDB; 4X23; X-ray; 3.50 A; D/H/N/R=33-122.
DR   PDB; 5CVE; X-ray; 1.50 A; D/E=3-10.
DR   PDB; 5WCU; X-ray; 5.53 A; D/H/N/R=29-122.
DR   PDB; 6DZT; EM; 2.99 A; D/H=2-123.
DR   PDB; 6PWE; EM; 3.95 A; D/H=1-123.
DR   PDB; 6PWF; EM; 4.07 A; D/H=1-123.
DR   PDB; 7PJ1; NMR; -; B=2-123.
DR   PDB; 7XYF; EM; 4.30 A; D/H=29-123.
DR   PDB; 7XYG; EM; 5.40 A; D/H=1-123.
DR   PDB; 8UX1; EM; 2.50 A; D/H=2-123.
DR   PDBsum; 2NQB; -.
DR   PDBsum; 2PYO; -.
DR   PDBsum; 4QLC; -.
DR   PDBsum; 4X23; -.
DR   PDBsum; 5CVE; -.
DR   PDBsum; 5WCU; -.
DR   PDBsum; 6DZT; -.
DR   PDBsum; 6PWE; -.
DR   PDBsum; 6PWF; -.
DR   PDBsum; 7PJ1; -.
DR   PDBsum; 7XYF; -.
DR   PDBsum; 7XYG; -.
DR   PDBsum; 8UX1; -.
DR   AlphaFoldDB; P02283; -.
DR   EMDB; EMD-20506; -.
DR   EMDB; EMD-20507; -.
DR   EMDB; EMD-42685; -.
DR   EMDB; EMD-8938; -.
DR   SASBDB; P02283; -.
DR   SMR; P02283; -.
DR   BioGRID; 533862; 1.
DR   BioGRID; 77520; 27.
DR   DIP; DIP-22804N; -.
DR   IntAct; P02283; 8.
DR   MINT; P02283; -.
DR   STRING; 7227.FBpp0085281; -.
DR   GlyCosmos; P02283; 1 site, No reported glycans.
DR   GlyGen; P02283; 1 site.
DR   iPTMnet; P02283; -.
DR   PaxDb; 7227-FBpp0085281; -.
DR   ABCD; P02283; 1 sequenced antibody.
DR   EnsemblMetazoa; FBtr0085927; FBpp0085281; FBgn0061209.
DR   EnsemblMetazoa; FBtr0091872; FBpp0091113; FBgn0053868.
DR   EnsemblMetazoa; FBtr0091874; FBpp0091115; FBgn0053870.
DR   EnsemblMetazoa; FBtr0091876; FBpp0091117; FBgn0053872.
DR   EnsemblMetazoa; FBtr0091878; FBpp0091119; FBgn0053874.
DR   EnsemblMetazoa; FBtr0091880; FBpp0091121; FBgn0053876.
DR   EnsemblMetazoa; FBtr0091882; FBpp0091123; FBgn0053878.
DR   EnsemblMetazoa; FBtr0091884; FBpp0091125; FBgn0053880.
DR   EnsemblMetazoa; FBtr0091886; FBpp0091127; FBgn0053882.
DR   EnsemblMetazoa; FBtr0091888; FBpp0091129; FBgn0053884.
DR   EnsemblMetazoa; FBtr0091890; FBpp0091131; FBgn0053886.
DR   EnsemblMetazoa; FBtr0091892; FBpp0091133; FBgn0053888.
DR   EnsemblMetazoa; FBtr0091894; FBpp0091135; FBgn0053890.
DR   EnsemblMetazoa; FBtr0091896; FBpp0091137; FBgn0053892.
DR   EnsemblMetazoa; FBtr0091898; FBpp0091139; FBgn0053894.
DR   EnsemblMetazoa; FBtr0091900; FBpp0091141; FBgn0053896.
DR   EnsemblMetazoa; FBtr0091902; FBpp0091143; FBgn0053898.
DR   EnsemblMetazoa; FBtr0091904; FBpp0091145; FBgn0053900.
DR   EnsemblMetazoa; FBtr0091906; FBpp0091147; FBgn0053902.
DR   EnsemblMetazoa; FBtr0091908; FBpp0091149; FBgn0053904.
DR   EnsemblMetazoa; FBtr0091910; FBpp0091151; FBgn0053906.
DR   EnsemblMetazoa; FBtr0091912; FBpp0091153; FBgn0053908.
DR   EnsemblMetazoa; FBtr0091914; FBpp0091155; FBgn0053910.
DR   GeneID; 326273; -.
DR   GeneID; 3771809; -.
DR   GeneID; 3771891; -.
DR   GeneID; 3771957; -.
DR   GeneID; 3772013; -.
DR   GeneID; 3772058; -.
DR   GeneID; 3772081; -.
DR   GeneID; 3772083; -.
DR   GeneID; 3772094; -.
DR   GeneID; 3772099; -.
DR   GeneID; 3772104; -.
DR   GeneID; 3772166; -.
DR   GeneID; 3772203; -.
DR   GeneID; 3772248; -.
DR   GeneID; 3772264; -.
DR   GeneID; 3772265; -.
DR   GeneID; 3772271; -.
DR   GeneID; 3772276; -.
DR   GeneID; 3772299; -.
DR   GeneID; 3772336; -.
DR   GeneID; 3772496; -.
DR   GeneID; 3772502; -.
DR   GeneID; 3772575; -.
DR   KEGG; dme:Dmel_CG17949; -.
DR   KEGG; dme:Dmel_CG33868; -.
DR   KEGG; dme:Dmel_CG33870; -.
DR   KEGG; dme:Dmel_CG33872; -.
DR   KEGG; dme:Dmel_CG33874; -.
DR   KEGG; dme:Dmel_CG33876; -.
DR   KEGG; dme:Dmel_CG33878; -.
DR   KEGG; dme:Dmel_CG33880; -.
DR   KEGG; dme:Dmel_CG33882; -.
DR   KEGG; dme:Dmel_CG33884; -.
DR   KEGG; dme:Dmel_CG33886; -.
DR   KEGG; dme:Dmel_CG33888; -.
DR   KEGG; dme:Dmel_CG33890; -.
DR   KEGG; dme:Dmel_CG33892; -.
DR   KEGG; dme:Dmel_CG33894; -.
DR   KEGG; dme:Dmel_CG33896; -.
DR   KEGG; dme:Dmel_CG33898; -.
DR   KEGG; dme:Dmel_CG33900; -.
DR   KEGG; dme:Dmel_CG33902; -.
DR   KEGG; dme:Dmel_CG33904; -.
DR   KEGG; dme:Dmel_CG33906; -.
DR   KEGG; dme:Dmel_CG33908; -.
DR   KEGG; dme:Dmel_CG33910; -.
DR   UCSC; CG17949-RA; d. melanogaster.
DR   AGR; FB:FBgn0001198; -.
DR   AGR; FB:FBgn0053868; -.
DR   AGR; FB:FBgn0053870; -.
DR   AGR; FB:FBgn0053872; -.
DR   AGR; FB:FBgn0053874; -.
DR   AGR; FB:FBgn0053876; -.
DR   AGR; FB:FBgn0053878; -.
DR   AGR; FB:FBgn0053880; -.
DR   AGR; FB:FBgn0053882; -.
DR   AGR; FB:FBgn0053884; -.
DR   AGR; FB:FBgn0053886; -.
DR   AGR; FB:FBgn0053888; -.
DR   AGR; FB:FBgn0053890; -.
DR   AGR; FB:FBgn0053892; -.
DR   AGR; FB:FBgn0053894; -.
DR   AGR; FB:FBgn0053896; -.
DR   AGR; FB:FBgn0053898; -.
DR   AGR; FB:FBgn0053900; -.
DR   AGR; FB:FBgn0053902; -.
DR   AGR; FB:FBgn0053904; -.
DR   AGR; FB:FBgn0053906; -.
DR   AGR; FB:FBgn0053908; -.
DR   AGR; FB:FBgn0053910; -.
DR   AGR; FB:FBgn0061209; -.
DR   CTD; 326273; -.
DR   CTD; 3771809; -.
DR   CTD; 3771891; -.
DR   CTD; 3771957; -.
DR   CTD; 3772013; -.
DR   CTD; 3772058; -.
DR   CTD; 3772081; -.
DR   CTD; 3772083; -.
DR   CTD; 3772094; -.
DR   CTD; 3772099; -.
DR   CTD; 3772104; -.
DR   CTD; 3772166; -.
DR   CTD; 3772203; -.
DR   CTD; 3772248; -.
DR   CTD; 3772264; -.
DR   CTD; 3772265; -.
DR   CTD; 3772271; -.
DR   CTD; 3772276; -.
DR   CTD; 3772299; -.
DR   CTD; 3772336; -.
DR   CTD; 3772496; -.
DR   CTD; 3772502; -.
DR   CTD; 3772575; -.
DR   FlyBase; FBgn0001198; His2B.
DR   FlyBase; FBgn0061209; His2B:CG17949.
DR   FlyBase; FBgn0053868; His2B:CG33868.
DR   FlyBase; FBgn0053870; His2B:CG33870.
DR   FlyBase; FBgn0053872; His2B:CG33872.
DR   FlyBase; FBgn0053874; His2B:CG33874.
DR   FlyBase; FBgn0053876; His2B:CG33876.
DR   FlyBase; FBgn0053878; His2B:CG33878.
DR   FlyBase; FBgn0053880; His2B:CG33880.
DR   FlyBase; FBgn0053882; His2B:CG33882.
DR   FlyBase; FBgn0053884; His2B:CG33884.
DR   FlyBase; FBgn0053886; His2B:CG33886.
DR   FlyBase; FBgn0053888; His2B:CG33888.
DR   FlyBase; FBgn0053890; His2B:CG33890.
DR   FlyBase; FBgn0053892; His2B:CG33892.
DR   FlyBase; FBgn0053894; His2B:CG33894.
DR   FlyBase; FBgn0053896; His2B:CG33896.
DR   FlyBase; FBgn0053898; His2B:CG33898.
DR   FlyBase; FBgn0053900; His2B:CG33900.
DR   FlyBase; FBgn0053902; His2B:CG33902.
DR   FlyBase; FBgn0053904; His2B:CG33904.
DR   FlyBase; FBgn0053906; His2B:CG33906.
DR   FlyBase; FBgn0053908; His2B:CG33908.
DR   FlyBase; FBgn0053910; His2B:CG33910.
DR   VEuPathDB; VectorBase:FBgn0053868; -.
DR   VEuPathDB; VectorBase:FBgn0053870; -.
DR   VEuPathDB; VectorBase:FBgn0053872; -.
DR   VEuPathDB; VectorBase:FBgn0053874; -.
DR   VEuPathDB; VectorBase:FBgn0053876; -.
DR   VEuPathDB; VectorBase:FBgn0053878; -.
DR   VEuPathDB; VectorBase:FBgn0053880; -.
DR   VEuPathDB; VectorBase:FBgn0053882; -.
DR   VEuPathDB; VectorBase:FBgn0053884; -.
DR   VEuPathDB; VectorBase:FBgn0053886; -.
DR   VEuPathDB; VectorBase:FBgn0053888; -.
DR   VEuPathDB; VectorBase:FBgn0053890; -.
DR   VEuPathDB; VectorBase:FBgn0053892; -.
DR   VEuPathDB; VectorBase:FBgn0053894; -.
DR   VEuPathDB; VectorBase:FBgn0053896; -.
DR   VEuPathDB; VectorBase:FBgn0053898; -.
DR   VEuPathDB; VectorBase:FBgn0053900; -.
DR   VEuPathDB; VectorBase:FBgn0053902; -.
DR   VEuPathDB; VectorBase:FBgn0053904; -.
DR   VEuPathDB; VectorBase:FBgn0053906; -.
DR   VEuPathDB; VectorBase:FBgn0053908; -.
DR   VEuPathDB; VectorBase:FBgn0053910; -.
DR   VEuPathDB; VectorBase:FBgn0061209; -.
DR   eggNOG; KOG1744; Eukaryota.
DR   GeneTree; ENSGT01100000263569; -.
DR   HOGENOM; CLU_075666_2_0_1; -.
DR   InParanoid; P02283; -.
DR   OMA; TEMGAGE; -.
DR   OrthoDB; 3566571at2759; -.
DR   PhylomeDB; P02283; -.
DR   Reactome; R-DME-3214847; HATs acetylate histones.
DR   Reactome; R-DME-5689880; Ub-specific processing proteases.
DR   Reactome; R-DME-8866654; E3 ubiquitin ligases ubiquitinate target proteins.
DR   Reactome; R-DME-8936459; RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function.
DR   SignaLink; P02283; -.
DR   EvolutionaryTrace; P02283; -.
DR   PRO; PR:P02283; -.
DR   Proteomes; UP000000803; Chromosome 2L.
DR   Bgee; FBgn0053868; Expressed in midgut and 11 other cell types or tissues.
DR   GO; GO:0000786; C:nucleosome; TAS:FlyBase.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; ISS:FlyBase.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0044877; F:protein-containing complex binding; IDA:UniProtKB.
DR   GO; GO:0030527; F:structural constituent of chromatin; IEA:InterPro.
DR   GO; GO:0006325; P:chromatin organization; ISS:FlyBase.
DR   DisProt; DP01250; -.
DR   Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR007125; Histone_H2A/H2B/H3.
DR   InterPro; IPR000558; Histone_H2B.
DR   PANTHER; PTHR23428; HISTONE H2B; 1.
DR   PANTHER; PTHR23428:SF70; HISTONE H2B; 1.
DR   Pfam; PF00125; Histone; 1.
DR   PRINTS; PR00621; HISTONEH2B.
DR   SMART; SM00427; H2B; 1.
DR   SUPFAM; SSF47113; Histone-fold; 1.
DR   PROSITE; PS00357; HISTONE_H2B; 1.
DR   Genevisible; P02283; DM.
PE   1: Evidence at protein level;
KW   3D-structure; Chromosome; Direct protein sequencing; DNA-binding;
KW   Glycoprotein; Isopeptide bond; Methylation; Nucleosome core; Nucleus;
KW   Reference proteome; Ubl conjugation.
FT   INIT_MET        1
FT                   /note="Removed"
FT   CHAIN           2..123
FT                   /note="Histone H2B"
FT                   /id="PRO_0000071861"
FT   REGION          1..30
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-methylproline; partial"
FT                   /evidence="ECO:0000269|PubMed:3127388"
FT   MOD_RES         44
FT                   /note="N6-succinyllysine"
FT                   /evidence="ECO:0000269|PubMed:22389435"
FT   MOD_RES         114
FT                   /note="N6-succinyllysine"
FT                   /evidence="ECO:0000269|PubMed:22389435"
FT   MOD_RES         118
FT                   /note="N6-succinyllysine"
FT                   /evidence="ECO:0000269|PubMed:22389435"
FT   CARBOHYD        110
FT                   /note="O-linked (GlcNAc) serine"
FT                   /evidence="ECO:0000250"
FT   CROSSLNK        118
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in ubiquitin)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        77
FT                   /note="R -> C (in Ref. 1; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   HELIX           17..19
FT                   /evidence="ECO:0007829|PDB:7PJ1"
FT   STRAND          22..24
FT                   /evidence="ECO:0007829|PDB:7PJ1"
FT   HELIX           36..46
FT                   /evidence="ECO:0007829|PDB:2NQB"
FT   HELIX           54..81
FT                   /evidence="ECO:0007829|PDB:2NQB"
FT   STRAND          85..87
FT                   /evidence="ECO:0007829|PDB:6DZT"
FT   HELIX           89..99
FT                   /evidence="ECO:0007829|PDB:2NQB"
FT   HELIX           102..121
FT                   /evidence="ECO:0007829|PDB:2NQB"
SQ   SEQUENCE   123 AA;  13696 MW;  0774D25F34003062 CRC64;
     MPPKTSGKAA KKAGKAQKNI TKTDKKKKRK RKESYAIYIY KVLKQVHPDT GISSKAMSIM
     NSFVNDIFER IAAEASRLAH YNKRSTITSR EIQTAVRLLL PGELAKHAVS EGTKAVTKYT
     SSK
//