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P02283

- H2B_DROME

UniProt

P02283 - H2B_DROME

Protein

Histone H2B

Gene

His2B

more
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. protein binding Source: IntAct

    GO - Biological processi

    1. nucleosome assembly Source: UniProtKB

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone H2B
    Gene namesi
    Name:His2B
    AND
    Name:His2B:CG17949
    ORF Names:CG17949
    AND
    Name:His2B:CG33868
    ORF Names:CG33868
    AND
    Name:His2B:CG33870
    ORF Names:CG33870
    AND
    Name:His2B:CG33872
    ORF Names:CG33872
    AND
    Name:His2B:CG33874
    ORF Names:CG33874
    AND
    Name:His2B:CG33876
    ORF Names:CG33876
    AND
    Name:His2B:CG33878
    ORF Names:CG33878
    AND
    Name:His2B:CG33880
    ORF Names:CG33880
    AND
    Name:His2B:CG33882
    ORF Names:CG33882
    AND
    Name:His2B:CG33884
    ORF Names:CG33884
    AND
    Name:His2B:CG33886
    ORF Names:CG33886
    AND
    Name:His2B:CG33888
    ORF Names:CG33888
    AND
    Name:His2B:CG33890
    ORF Names:CG33890
    AND
    Name:His2B:CG33892
    ORF Names:CG33892
    AND
    Name:His2B:CG33894
    ORF Names:CG33894
    AND
    Name:His2B:CG33896
    ORF Names:CG33896
    AND
    Name:His2B:CG33898
    ORF Names:CG33898
    AND
    Name:His2B:CG33900
    ORF Names:CG33900
    AND
    Name:His2B:CG33902
    ORF Names:CG33902
    AND
    Name:His2B:CG33904
    ORF Names:CG33904
    AND
    Name:His2B:CG33906
    ORF Names:CG33906
    AND
    Name:His2B:CG33908
    ORF Names:CG33908
    AND
    Name:His2B:CG33910
    ORF Names:CG33910
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2L

    Organism-specific databases

    FlyBaseiFBgn0001198. His2B.
    FBgn0061209. His2B:CG17949.
    FBgn0053868. His2B:CG33868.
    FBgn0053870. His2B:CG33870.
    FBgn0053872. His2B:CG33872.
    FBgn0053874. His2B:CG33874.
    FBgn0053876. His2B:CG33876.
    FBgn0053878. His2B:CG33878.
    FBgn0053880. His2B:CG33880.
    FBgn0053882. His2B:CG33882.
    FBgn0053884. His2B:CG33884.
    FBgn0053886. His2B:CG33886.
    FBgn0053888. His2B:CG33888.
    FBgn0053890. His2B:CG33890.
    FBgn0053892. His2B:CG33892.
    FBgn0053894. His2B:CG33894.
    FBgn0053896. His2B:CG33896.
    FBgn0053898. His2B:CG33898.
    FBgn0053900. His2B:CG33900.
    FBgn0053902. His2B:CG33902.
    FBgn0053904. His2B:CG33904.
    FBgn0053906. His2B:CG33906.
    FBgn0053908. His2B:CG33908.
    FBgn0053910. His2B:CG33910.

    Subcellular locationi

    GO - Cellular componenti

    1. lipid particle Source: FlyBase
    2. nucleosome Source: UniProtKB
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chromosome, Nucleosome core, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed
    Chaini2 – 123122Histone H2BPRO_0000071861Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-methylproline; partial1 Publication
    Glycosylationi110 – 1101O-linked (GlcNAc)By similarity
    Cross-linki118 – 118Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Curated

    Post-translational modificationi

    Monoubiquitination of Lys-118 by Bre1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.1 Publication
    Methylation at Pro-2 increases upon heat shock.1 Publication
    GlcNAcylation at Ser-110 promotes monoubiquitination of Lys-118. It fluctuates in response to extracellular glucose, and associates with transcribed genes Probable.Curated

    Keywords - PTMi

    Glycoprotein, Isopeptide bond, Methylation, Ubl conjugation

    Proteomic databases

    PaxDbiP02283.
    PRIDEiP02283.

    Interactioni

    Subunit structurei

    The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ATXN7O152652EBI-188137,EBI-708350From a different organism.

    Protein-protein interaction databases

    BioGridi533862. 1 interaction.
    77520. 6 interactions.
    DIPiDIP-22804N.
    IntActiP02283. 7 interactions.
    MINTiMINT-1560639.

    Structurei

    Secondary structure

    1
    123
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi36 – 4611
    Helixi54 – 8128
    Beta strandi85 – 873
    Helixi89 – 9911
    Helixi102 – 12120

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2NQBX-ray2.30D/H2-123[»]
    2PYOX-ray2.43D/H2-123[»]
    4INMX-ray3.50D/H/N/R33-122[»]
    ProteinModelPortaliP02283.
    SMRiP02283. Positions 4-123.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP02283.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histone H2B family.Curated

    Phylogenomic databases

    eggNOGiNOG289161.
    GeneTreeiENSGT00730000110319.
    InParanoidiP02283.
    KOiK11252.
    OMAiTQKKEGR.
    OrthoDBiEOG72VH8J.
    PhylomeDBiP02283.

    Family and domain databases

    Gene3Di1.10.20.10. 1 hit.
    InterProiIPR009072. Histone-fold.
    IPR007125. Histone_core_D.
    IPR000558. Histone_H2B.
    [Graphical view]
    PANTHERiPTHR23428. PTHR23428. 1 hit.
    PfamiPF00125. Histone. 1 hit.
    [Graphical view]
    PRINTSiPR00621. HISTONEH2B.
    SMARTiSM00427. H2B. 1 hit.
    [Graphical view]
    SUPFAMiSSF47113. SSF47113. 1 hit.
    PROSITEiPS00357. HISTONE_H2B. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P02283-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPPKTSGKAA KKAGKAQKNI TKTDKKKKRK RKESYAIYIY KVLKQVHPDT    50
    GISSKAMSIM NSFVNDIFER IAAEASRLAH YNKRSTITSR EIQTAVRLLL 100
    PGELAKHAVS EGTKAVTKYT SSK 123
    Length:123
    Mass (Da):13,696
    Last modified:January 23, 2007 - v2
    Checksum:i0774D25F34003062
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti77 – 771R → C AA sequence (PubMed:117830)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14215 Genomic DNA. Translation: CAA32432.1.
    AE014134 Genomic DNA. Translation: AAN11124.1.
    AE014134 Genomic DNA. Translation: AAZ66483.1.
    AE014134 Genomic DNA. Translation: AAZ66487.1.
    AE014134 Genomic DNA. Translation: AAZ66492.1.
    AE014134 Genomic DNA. Translation: AAZ66496.1.
    AE014134 Genomic DNA. Translation: AAZ66501.1.
    AE014134 Genomic DNA. Translation: AAZ66506.1.
    AE014134 Genomic DNA. Translation: AAZ66511.1.
    AE014134 Genomic DNA. Translation: AAZ66521.1.
    AE014134 Genomic DNA. Translation: AAZ66531.1.
    AE014134 Genomic DNA. Translation: AAZ66576.1.
    AE014134 Genomic DNA. Translation: AAZ66571.1.
    AE014134 Genomic DNA. Translation: AAZ66566.1.
    AE014134 Genomic DNA. Translation: AAZ66561.1.
    AE014134 Genomic DNA. Translation: AAZ66556.1.
    AE014134 Genomic DNA. Translation: AAZ66551.1.
    AE014134 Genomic DNA. Translation: AAZ66546.1.
    AE014134 Genomic DNA. Translation: AAZ66541.1.
    AE014134 Genomic DNA. Translation: AAZ66536.1.
    AE014134 Genomic DNA. Translation: AAZ66479.1.
    AE014134 Genomic DNA. Translation: AAZ66581.1.
    AE014134 Genomic DNA. Translation: AAZ66526.1.
    AE014134 Genomic DNA. Translation: AAZ66516.1.
    PIRiS10095. HSFF22.
    RefSeqiNP_001027283.1. NM_001032112.1.
    NP_001027287.1. NM_001032116.1.
    NP_001027291.1. NM_001032120.1.
    NP_001027296.1. NM_001032125.1.
    NP_001027300.1. NM_001032129.1.
    NP_001027305.1. NM_001032134.1.
    NP_001027310.1. NM_001032139.1.
    NP_001027315.1. NM_001032144.1.
    NP_001027320.1. NM_001032149.1.
    NP_001027325.1. NM_001032154.1.
    NP_001027330.1. NM_001032159.1.
    NP_001027335.1. NM_001032164.1.
    NP_001027340.1. NM_001032169.1.
    NP_001027345.1. NM_001032174.1.
    NP_001027350.1. NM_001032179.1.
    NP_001027355.1. NM_001032184.1.
    NP_001027360.1. NM_001032189.1.
    NP_001027365.1. NM_001032194.1.
    NP_001027370.1. NM_001032199.1.
    NP_001027375.1. NM_001032204.1.
    NP_001027380.1. NM_001032209.1.
    NP_001027385.1. NM_001032214.1.
    NP_724342.1. NM_165381.3.
    UniGeneiDm.29523.
    Dm.30218.
    Dm.30222.
    Dm.30875.
    Dm.30877.
    Dm.30878.

    Genome annotation databases

    EnsemblMetazoaiFBtr0085927; FBpp0085281; FBgn0061209.
    FBtr0091872; FBpp0091113; FBgn0053868.
    FBtr0091874; FBpp0091115; FBgn0053870.
    FBtr0091876; FBpp0091117; FBgn0053872.
    FBtr0091878; FBpp0091119; FBgn0053874.
    FBtr0091880; FBpp0091121; FBgn0053876.
    FBtr0091882; FBpp0091123; FBgn0053878.
    FBtr0091884; FBpp0091125; FBgn0053880.
    FBtr0091886; FBpp0091127; FBgn0053882.
    FBtr0091888; FBpp0091129; FBgn0053884.
    FBtr0091890; FBpp0091131; FBgn0053886.
    FBtr0091892; FBpp0091133; FBgn0053888.
    FBtr0091894; FBpp0091135; FBgn0053890.
    FBtr0091896; FBpp0091137; FBgn0053892.
    FBtr0091898; FBpp0091139; FBgn0053894.
    FBtr0091900; FBpp0091141; FBgn0053896.
    FBtr0091902; FBpp0091143; FBgn0053898.
    FBtr0091904; FBpp0091145; FBgn0053900.
    FBtr0091906; FBpp0091147; FBgn0053902.
    FBtr0091908; FBpp0091149; FBgn0053904.
    FBtr0091910; FBpp0091151; FBgn0053906.
    FBtr0091912; FBpp0091153; FBgn0053908.
    FBtr0091914; FBpp0091155; FBgn0053910.
    GeneIDi326273.
    3771809.
    3771891.
    3771957.
    3772013.
    3772058.
    3772081.
    3772083.
    3772094.
    3772099.
    3772104.
    3772166.
    3772203.
    3772248.
    3772264.
    3772265.
    3772271.
    3772276.
    3772299.
    3772336.
    3772496.
    3772502.
    3772575.
    KEGGidme:Dmel_CG17949.
    dme:Dmel_CG33868.
    dme:Dmel_CG33870.
    dme:Dmel_CG33872.
    dme:Dmel_CG33874.
    dme:Dmel_CG33876.
    dme:Dmel_CG33878.
    dme:Dmel_CG33880.
    dme:Dmel_CG33882.
    dme:Dmel_CG33884.
    dme:Dmel_CG33886.
    dme:Dmel_CG33888.
    dme:Dmel_CG33890.
    dme:Dmel_CG33892.
    dme:Dmel_CG33894.
    dme:Dmel_CG33896.
    dme:Dmel_CG33898.
    dme:Dmel_CG33900.
    dme:Dmel_CG33902.
    dme:Dmel_CG33904.
    dme:Dmel_CG33906.
    dme:Dmel_CG33908.
    dme:Dmel_CG33910.
    UCSCiCG17949-RA. d. melanogaster.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14215 Genomic DNA. Translation: CAA32432.1 .
    AE014134 Genomic DNA. Translation: AAN11124.1 .
    AE014134 Genomic DNA. Translation: AAZ66483.1 .
    AE014134 Genomic DNA. Translation: AAZ66487.1 .
    AE014134 Genomic DNA. Translation: AAZ66492.1 .
    AE014134 Genomic DNA. Translation: AAZ66496.1 .
    AE014134 Genomic DNA. Translation: AAZ66501.1 .
    AE014134 Genomic DNA. Translation: AAZ66506.1 .
    AE014134 Genomic DNA. Translation: AAZ66511.1 .
    AE014134 Genomic DNA. Translation: AAZ66521.1 .
    AE014134 Genomic DNA. Translation: AAZ66531.1 .
    AE014134 Genomic DNA. Translation: AAZ66576.1 .
    AE014134 Genomic DNA. Translation: AAZ66571.1 .
    AE014134 Genomic DNA. Translation: AAZ66566.1 .
    AE014134 Genomic DNA. Translation: AAZ66561.1 .
    AE014134 Genomic DNA. Translation: AAZ66556.1 .
    AE014134 Genomic DNA. Translation: AAZ66551.1 .
    AE014134 Genomic DNA. Translation: AAZ66546.1 .
    AE014134 Genomic DNA. Translation: AAZ66541.1 .
    AE014134 Genomic DNA. Translation: AAZ66536.1 .
    AE014134 Genomic DNA. Translation: AAZ66479.1 .
    AE014134 Genomic DNA. Translation: AAZ66581.1 .
    AE014134 Genomic DNA. Translation: AAZ66526.1 .
    AE014134 Genomic DNA. Translation: AAZ66516.1 .
    PIRi S10095. HSFF22.
    RefSeqi NP_001027283.1. NM_001032112.1.
    NP_001027287.1. NM_001032116.1.
    NP_001027291.1. NM_001032120.1.
    NP_001027296.1. NM_001032125.1.
    NP_001027300.1. NM_001032129.1.
    NP_001027305.1. NM_001032134.1.
    NP_001027310.1. NM_001032139.1.
    NP_001027315.1. NM_001032144.1.
    NP_001027320.1. NM_001032149.1.
    NP_001027325.1. NM_001032154.1.
    NP_001027330.1. NM_001032159.1.
    NP_001027335.1. NM_001032164.1.
    NP_001027340.1. NM_001032169.1.
    NP_001027345.1. NM_001032174.1.
    NP_001027350.1. NM_001032179.1.
    NP_001027355.1. NM_001032184.1.
    NP_001027360.1. NM_001032189.1.
    NP_001027365.1. NM_001032194.1.
    NP_001027370.1. NM_001032199.1.
    NP_001027375.1. NM_001032204.1.
    NP_001027380.1. NM_001032209.1.
    NP_001027385.1. NM_001032214.1.
    NP_724342.1. NM_165381.3.
    UniGenei Dm.29523.
    Dm.30218.
    Dm.30222.
    Dm.30875.
    Dm.30877.
    Dm.30878.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2NQB X-ray 2.30 D/H 2-123 [» ]
    2PYO X-ray 2.43 D/H 2-123 [» ]
    4INM X-ray 3.50 D/H/N/R 33-122 [» ]
    ProteinModelPortali P02283.
    SMRi P02283. Positions 4-123.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 533862. 1 interaction.
    77520. 6 interactions.
    DIPi DIP-22804N.
    IntActi P02283. 7 interactions.
    MINTi MINT-1560639.

    Proteomic databases

    PaxDbi P02283.
    PRIDEi P02283.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0085927 ; FBpp0085281 ; FBgn0061209 .
    FBtr0091872 ; FBpp0091113 ; FBgn0053868 .
    FBtr0091874 ; FBpp0091115 ; FBgn0053870 .
    FBtr0091876 ; FBpp0091117 ; FBgn0053872 .
    FBtr0091878 ; FBpp0091119 ; FBgn0053874 .
    FBtr0091880 ; FBpp0091121 ; FBgn0053876 .
    FBtr0091882 ; FBpp0091123 ; FBgn0053878 .
    FBtr0091884 ; FBpp0091125 ; FBgn0053880 .
    FBtr0091886 ; FBpp0091127 ; FBgn0053882 .
    FBtr0091888 ; FBpp0091129 ; FBgn0053884 .
    FBtr0091890 ; FBpp0091131 ; FBgn0053886 .
    FBtr0091892 ; FBpp0091133 ; FBgn0053888 .
    FBtr0091894 ; FBpp0091135 ; FBgn0053890 .
    FBtr0091896 ; FBpp0091137 ; FBgn0053892 .
    FBtr0091898 ; FBpp0091139 ; FBgn0053894 .
    FBtr0091900 ; FBpp0091141 ; FBgn0053896 .
    FBtr0091902 ; FBpp0091143 ; FBgn0053898 .
    FBtr0091904 ; FBpp0091145 ; FBgn0053900 .
    FBtr0091906 ; FBpp0091147 ; FBgn0053902 .
    FBtr0091908 ; FBpp0091149 ; FBgn0053904 .
    FBtr0091910 ; FBpp0091151 ; FBgn0053906 .
    FBtr0091912 ; FBpp0091153 ; FBgn0053908 .
    FBtr0091914 ; FBpp0091155 ; FBgn0053910 .
    GeneIDi 326273.
    3771809.
    3771891.
    3771957.
    3772013.
    3772058.
    3772081.
    3772083.
    3772094.
    3772099.
    3772104.
    3772166.
    3772203.
    3772248.
    3772264.
    3772265.
    3772271.
    3772276.
    3772299.
    3772336.
    3772496.
    3772502.
    3772575.
    KEGGi dme:Dmel_CG17949.
    dme:Dmel_CG33868.
    dme:Dmel_CG33870.
    dme:Dmel_CG33872.
    dme:Dmel_CG33874.
    dme:Dmel_CG33876.
    dme:Dmel_CG33878.
    dme:Dmel_CG33880.
    dme:Dmel_CG33882.
    dme:Dmel_CG33884.
    dme:Dmel_CG33886.
    dme:Dmel_CG33888.
    dme:Dmel_CG33890.
    dme:Dmel_CG33892.
    dme:Dmel_CG33894.
    dme:Dmel_CG33896.
    dme:Dmel_CG33898.
    dme:Dmel_CG33900.
    dme:Dmel_CG33902.
    dme:Dmel_CG33904.
    dme:Dmel_CG33906.
    dme:Dmel_CG33908.
    dme:Dmel_CG33910.
    UCSCi CG17949-RA. d. melanogaster.

    Organism-specific databases

    CTDi 326273.
    3771809.
    3771891.
    3771957.
    3772013.
    3772058.
    3772081.
    3772083.
    3772094.
    3772099.
    3772104.
    3772166.
    3772203.
    3772248.
    3772264.
    3772265.
    3772271.
    3772276.
    3772299.
    3772336.
    3772496.
    3772502.
    3772575.
    FlyBasei FBgn0001198. His2B.
    FBgn0061209. His2B:CG17949.
    FBgn0053868. His2B:CG33868.
    FBgn0053870. His2B:CG33870.
    FBgn0053872. His2B:CG33872.
    FBgn0053874. His2B:CG33874.
    FBgn0053876. His2B:CG33876.
    FBgn0053878. His2B:CG33878.
    FBgn0053880. His2B:CG33880.
    FBgn0053882. His2B:CG33882.
    FBgn0053884. His2B:CG33884.
    FBgn0053886. His2B:CG33886.
    FBgn0053888. His2B:CG33888.
    FBgn0053890. His2B:CG33890.
    FBgn0053892. His2B:CG33892.
    FBgn0053894. His2B:CG33894.
    FBgn0053896. His2B:CG33896.
    FBgn0053898. His2B:CG33898.
    FBgn0053900. His2B:CG33900.
    FBgn0053902. His2B:CG33902.
    FBgn0053904. His2B:CG33904.
    FBgn0053906. His2B:CG33906.
    FBgn0053908. His2B:CG33908.
    FBgn0053910. His2B:CG33910.

    Phylogenomic databases

    eggNOGi NOG289161.
    GeneTreei ENSGT00730000110319.
    InParanoidi P02283.
    KOi K11252.
    OMAi TQKKEGR.
    OrthoDBi EOG72VH8J.
    PhylomeDBi P02283.

    Miscellaneous databases

    EvolutionaryTracei P02283.
    NextBioi 847933.
    PROi P02283.

    Family and domain databases

    Gene3Di 1.10.20.10. 1 hit.
    InterProi IPR009072. Histone-fold.
    IPR007125. Histone_core_D.
    IPR000558. Histone_H2B.
    [Graphical view ]
    PANTHERi PTHR23428. PTHR23428. 1 hit.
    Pfami PF00125. Histone. 1 hit.
    [Graphical view ]
    PRINTSi PR00621. HISTONEH2B.
    SMARTi SM00427. H2B. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47113. SSF47113. 1 hit.
    PROSITEi PS00357. HISTONE_H2B. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of histone 2B of Drosophila melanogaster."
      Elgin S.C.R., Schilling J., Hood L.E.
      Biochemistry 18:5679-5685(1979) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE (HIS2B).
    2. "tRNA derived insertion element in histone gene repeating unit of Drosophila melanogaster."
      Matsuo Y., Yamazaki T.
      Nucleic Acids Res. 17:225-238(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (HIS2B).
      Strain: AK-194.
    3. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (HIS2B:CG17949).
      Strain: Berkeley.
    4. Cited for: GENOME REANNOTATION.
      Strain: Berkeley.
    5. Goldberg M.L.
      Thesis (1979), University of Stanford, United States
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-118 (HIS2B).
    6. "Methylation of Drosophila histones at proline, lysine, and arginine residues during heat shock."
      Desrosiers R., Tanguay R.M.
      J. Biol. Chem. 263:4686-4692(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: METHYLATION AT PRO-2.
    7. "TAF1 activates transcription by phosphorylation of serine 33 in histone H2B."
      Maile T., Kwoczynski S., Katzenberger R.J., Wassarman D.A., Sauer F.
      Science 304:1010-1014(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: CAUTION.
    8. "Bre1 is required for Notch signaling and histone modification."
      Bray S., Musisi H., Bienz M.
      Dev. Cell 8:279-286(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROBABLE UBIQUITINATION.
    9. Cited for: GLYCOSYLATION.

    Entry informationi

    Entry nameiH2B_DROME
    AccessioniPrimary (citable) accession number: P02283
    Secondary accession number(s): Q4ABE1, Q9W5U7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 147 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Caution

    Was reported to be phosphorylated at Ser-34 (PubMed:15143281). However, the paper was retracted because some data, results and conclusions in the paper are not reliable.1 Publication

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3