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P02283

- H2B_DROME

UniProt

P02283 - H2B_DROME

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Protein

Histone H2B

Gene

His2B

more
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

GO - Molecular functioni

  1. DNA binding Source: UniProtKB

GO - Biological processi

  1. nucleosome assembly Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2B
Gene namesi
Name:His2B
AND
Name:His2B:CG17949
ORF Names:CG17949
AND
Name:His2B:CG33868
ORF Names:CG33868
AND
Name:His2B:CG33870
ORF Names:CG33870
AND
Name:His2B:CG33872
ORF Names:CG33872
AND
Name:His2B:CG33874
ORF Names:CG33874
AND
Name:His2B:CG33876
ORF Names:CG33876
AND
Name:His2B:CG33878
ORF Names:CG33878
AND
Name:His2B:CG33880
ORF Names:CG33880
AND
Name:His2B:CG33882
ORF Names:CG33882
AND
Name:His2B:CG33884
ORF Names:CG33884
AND
Name:His2B:CG33886
ORF Names:CG33886
AND
Name:His2B:CG33888
ORF Names:CG33888
AND
Name:His2B:CG33890
ORF Names:CG33890
AND
Name:His2B:CG33892
ORF Names:CG33892
AND
Name:His2B:CG33894
ORF Names:CG33894
AND
Name:His2B:CG33896
ORF Names:CG33896
AND
Name:His2B:CG33898
ORF Names:CG33898
AND
Name:His2B:CG33900
ORF Names:CG33900
AND
Name:His2B:CG33902
ORF Names:CG33902
AND
Name:His2B:CG33904
ORF Names:CG33904
AND
Name:His2B:CG33906
ORF Names:CG33906
AND
Name:His2B:CG33908
ORF Names:CG33908
AND
Name:His2B:CG33910
ORF Names:CG33910
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0001198. His2B.
FBgn0061209. His2B:CG17949.
FBgn0053868. His2B:CG33868.
FBgn0053870. His2B:CG33870.
FBgn0053872. His2B:CG33872.
FBgn0053874. His2B:CG33874.
FBgn0053876. His2B:CG33876.
FBgn0053878. His2B:CG33878.
FBgn0053880. His2B:CG33880.
FBgn0053882. His2B:CG33882.
FBgn0053884. His2B:CG33884.
FBgn0053886. His2B:CG33886.
FBgn0053888. His2B:CG33888.
FBgn0053890. His2B:CG33890.
FBgn0053892. His2B:CG33892.
FBgn0053894. His2B:CG33894.
FBgn0053896. His2B:CG33896.
FBgn0053898. His2B:CG33898.
FBgn0053900. His2B:CG33900.
FBgn0053902. His2B:CG33902.
FBgn0053904. His2B:CG33904.
FBgn0053906. His2B:CG33906.
FBgn0053908. His2B:CG33908.
FBgn0053910. His2B:CG33910.

Subcellular locationi

GO - Cellular componenti

  1. lipid particle Source: FlyBase
  2. nucleosome Source: UniProtKB
  3. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 123122Histone H2BPRO_0000071861Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-methylproline; partial1 Publication
Glycosylationi110 – 1101O-linked (GlcNAc)By similarity
Cross-linki118 – 118Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Curated

Post-translational modificationi

Monoubiquitination of Lys-118 by Bre1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.1 Publication
Methylation at Pro-2 increases upon heat shock.1 Publication
GlcNAcylation at Ser-110 promotes monoubiquitination of Lys-118. It fluctuates in response to extracellular glucose, and associates with transcribed genes (Probable).Curated

Keywords - PTMi

Glycoprotein, Isopeptide bond, Methylation, Ubl conjugation

Proteomic databases

PaxDbiP02283.
PRIDEiP02283.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Binary interactionsi

WithEntry#Exp.IntActNotes
ATXN7O152652EBI-188137,EBI-708350From a different organism.

Protein-protein interaction databases

BioGridi533862. 1 interaction.
77520. 6 interactions.
DIPiDIP-22804N.
IntActiP02283. 7 interactions.
MINTiMINT-1560639.

Structurei

Secondary structure

1
123
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi36 – 4611
Helixi54 – 8128
Beta strandi85 – 873
Helixi89 – 9911
Helixi102 – 12120

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2NQBX-ray2.30D/H2-123[»]
2PYOX-ray2.43D/H2-123[»]
4INMX-ray3.50D/H/N/R33-122[»]
ProteinModelPortaliP02283.
SMRiP02283. Positions 4-123.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02283.

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2B family.Curated

Phylogenomic databases

eggNOGiNOG289161.
GeneTreeiENSGT00730000110319.
InParanoidiP02283.
KOiK11252.
OMAiTQKKEGR.
OrthoDBiEOG72VH8J.
PhylomeDBiP02283.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_core_D.
IPR000558. Histone_H2B.
[Graphical view]
PANTHERiPTHR23428. PTHR23428. 1 hit.
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00621. HISTONEH2B.
SMARTiSM00427. H2B. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00357. HISTONE_H2B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02283-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPPKTSGKAA KKAGKAQKNI TKTDKKKKRK RKESYAIYIY KVLKQVHPDT
60 70 80 90 100
GISSKAMSIM NSFVNDIFER IAAEASRLAH YNKRSTITSR EIQTAVRLLL
110 120
PGELAKHAVS EGTKAVTKYT SSK
Length:123
Mass (Da):13,696
Last modified:January 23, 2007 - v2
Checksum:i0774D25F34003062
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti77 – 771R → C AA sequence (PubMed:117830)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14215 Genomic DNA. Translation: CAA32432.1.
AE014134 Genomic DNA. Translation: AAN11124.1.
AE014134 Genomic DNA. Translation: AAZ66483.1.
AE014134 Genomic DNA. Translation: AAZ66487.1.
AE014134 Genomic DNA. Translation: AAZ66492.1.
AE014134 Genomic DNA. Translation: AAZ66496.1.
AE014134 Genomic DNA. Translation: AAZ66501.1.
AE014134 Genomic DNA. Translation: AAZ66506.1.
AE014134 Genomic DNA. Translation: AAZ66511.1.
AE014134 Genomic DNA. Translation: AAZ66521.1.
AE014134 Genomic DNA. Translation: AAZ66531.1.
AE014134 Genomic DNA. Translation: AAZ66576.1.
AE014134 Genomic DNA. Translation: AAZ66571.1.
AE014134 Genomic DNA. Translation: AAZ66566.1.
AE014134 Genomic DNA. Translation: AAZ66561.1.
AE014134 Genomic DNA. Translation: AAZ66556.1.
AE014134 Genomic DNA. Translation: AAZ66551.1.
AE014134 Genomic DNA. Translation: AAZ66546.1.
AE014134 Genomic DNA. Translation: AAZ66541.1.
AE014134 Genomic DNA. Translation: AAZ66536.1.
AE014134 Genomic DNA. Translation: AAZ66479.1.
AE014134 Genomic DNA. Translation: AAZ66581.1.
AE014134 Genomic DNA. Translation: AAZ66526.1.
AE014134 Genomic DNA. Translation: AAZ66516.1.
PIRiS10095. HSFF22.
RefSeqiNP_001027283.1. NM_001032112.2.
NP_001027287.1. NM_001032116.2.
NP_001027291.1. NM_001032120.2.
NP_001027296.1. NM_001032125.2.
NP_001027300.1. NM_001032129.2.
NP_001027305.1. NM_001032134.2.
NP_001027310.1. NM_001032139.2.
NP_001027315.1. NM_001032144.2.
NP_001027320.1. NM_001032149.2.
NP_001027325.1. NM_001032154.2.
NP_001027330.1. NM_001032159.2.
NP_001027335.1. NM_001032164.2.
NP_001027340.1. NM_001032169.2.
NP_001027345.1. NM_001032174.2.
NP_001027350.1. NM_001032179.2.
NP_001027355.1. NM_001032184.2.
NP_001027360.1. NM_001032189.2.
NP_001027365.1. NM_001032194.2.
NP_001027370.1. NM_001032199.2.
NP_001027375.1. NM_001032204.2.
NP_001027380.1. NM_001032209.2.
NP_001027385.1. NM_001032214.2.
NP_724342.1. NM_165381.4.

Genome annotation databases

EnsemblMetazoaiFBtr0085927; FBpp0085281; FBgn0061209.
FBtr0091872; FBpp0091113; FBgn0053868.
FBtr0091874; FBpp0091115; FBgn0053870.
FBtr0091876; FBpp0091117; FBgn0053872.
FBtr0091878; FBpp0091119; FBgn0053874.
FBtr0091880; FBpp0091121; FBgn0053876.
FBtr0091882; FBpp0091123; FBgn0053878.
FBtr0091884; FBpp0091125; FBgn0053880.
FBtr0091886; FBpp0091127; FBgn0053882.
FBtr0091888; FBpp0091129; FBgn0053884.
FBtr0091890; FBpp0091131; FBgn0053886.
FBtr0091892; FBpp0091133; FBgn0053888.
FBtr0091894; FBpp0091135; FBgn0053890.
FBtr0091896; FBpp0091137; FBgn0053892.
FBtr0091898; FBpp0091139; FBgn0053894.
FBtr0091900; FBpp0091141; FBgn0053896.
FBtr0091902; FBpp0091143; FBgn0053898.
FBtr0091904; FBpp0091145; FBgn0053900.
FBtr0091906; FBpp0091147; FBgn0053902.
FBtr0091908; FBpp0091149; FBgn0053904.
FBtr0091910; FBpp0091151; FBgn0053906.
FBtr0091912; FBpp0091153; FBgn0053908.
FBtr0091914; FBpp0091155; FBgn0053910.
GeneIDi326273.
3771809.
3771891.
3771957.
3772013.
3772058.
3772081.
3772083.
3772094.
3772099.
3772104.
3772166.
3772203.
3772248.
3772264.
3772265.
3772271.
3772276.
3772299.
3772336.
3772496.
3772502.
3772575.
KEGGidme:Dmel_CG17949.
dme:Dmel_CG33868.
dme:Dmel_CG33870.
dme:Dmel_CG33872.
dme:Dmel_CG33874.
dme:Dmel_CG33876.
dme:Dmel_CG33878.
dme:Dmel_CG33880.
dme:Dmel_CG33882.
dme:Dmel_CG33884.
dme:Dmel_CG33886.
dme:Dmel_CG33888.
dme:Dmel_CG33890.
dme:Dmel_CG33892.
dme:Dmel_CG33894.
dme:Dmel_CG33896.
dme:Dmel_CG33898.
dme:Dmel_CG33900.
dme:Dmel_CG33902.
dme:Dmel_CG33904.
dme:Dmel_CG33906.
dme:Dmel_CG33908.
dme:Dmel_CG33910.
UCSCiCG17949-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X14215 Genomic DNA. Translation: CAA32432.1 .
AE014134 Genomic DNA. Translation: AAN11124.1 .
AE014134 Genomic DNA. Translation: AAZ66483.1 .
AE014134 Genomic DNA. Translation: AAZ66487.1 .
AE014134 Genomic DNA. Translation: AAZ66492.1 .
AE014134 Genomic DNA. Translation: AAZ66496.1 .
AE014134 Genomic DNA. Translation: AAZ66501.1 .
AE014134 Genomic DNA. Translation: AAZ66506.1 .
AE014134 Genomic DNA. Translation: AAZ66511.1 .
AE014134 Genomic DNA. Translation: AAZ66521.1 .
AE014134 Genomic DNA. Translation: AAZ66531.1 .
AE014134 Genomic DNA. Translation: AAZ66576.1 .
AE014134 Genomic DNA. Translation: AAZ66571.1 .
AE014134 Genomic DNA. Translation: AAZ66566.1 .
AE014134 Genomic DNA. Translation: AAZ66561.1 .
AE014134 Genomic DNA. Translation: AAZ66556.1 .
AE014134 Genomic DNA. Translation: AAZ66551.1 .
AE014134 Genomic DNA. Translation: AAZ66546.1 .
AE014134 Genomic DNA. Translation: AAZ66541.1 .
AE014134 Genomic DNA. Translation: AAZ66536.1 .
AE014134 Genomic DNA. Translation: AAZ66479.1 .
AE014134 Genomic DNA. Translation: AAZ66581.1 .
AE014134 Genomic DNA. Translation: AAZ66526.1 .
AE014134 Genomic DNA. Translation: AAZ66516.1 .
PIRi S10095. HSFF22.
RefSeqi NP_001027283.1. NM_001032112.2.
NP_001027287.1. NM_001032116.2.
NP_001027291.1. NM_001032120.2.
NP_001027296.1. NM_001032125.2.
NP_001027300.1. NM_001032129.2.
NP_001027305.1. NM_001032134.2.
NP_001027310.1. NM_001032139.2.
NP_001027315.1. NM_001032144.2.
NP_001027320.1. NM_001032149.2.
NP_001027325.1. NM_001032154.2.
NP_001027330.1. NM_001032159.2.
NP_001027335.1. NM_001032164.2.
NP_001027340.1. NM_001032169.2.
NP_001027345.1. NM_001032174.2.
NP_001027350.1. NM_001032179.2.
NP_001027355.1. NM_001032184.2.
NP_001027360.1. NM_001032189.2.
NP_001027365.1. NM_001032194.2.
NP_001027370.1. NM_001032199.2.
NP_001027375.1. NM_001032204.2.
NP_001027380.1. NM_001032209.2.
NP_001027385.1. NM_001032214.2.
NP_724342.1. NM_165381.4.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2NQB X-ray 2.30 D/H 2-123 [» ]
2PYO X-ray 2.43 D/H 2-123 [» ]
4INM X-ray 3.50 D/H/N/R 33-122 [» ]
ProteinModelPortali P02283.
SMRi P02283. Positions 4-123.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 533862. 1 interaction.
77520. 6 interactions.
DIPi DIP-22804N.
IntActi P02283. 7 interactions.
MINTi MINT-1560639.

Proteomic databases

PaxDbi P02283.
PRIDEi P02283.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0085927 ; FBpp0085281 ; FBgn0061209 .
FBtr0091872 ; FBpp0091113 ; FBgn0053868 .
FBtr0091874 ; FBpp0091115 ; FBgn0053870 .
FBtr0091876 ; FBpp0091117 ; FBgn0053872 .
FBtr0091878 ; FBpp0091119 ; FBgn0053874 .
FBtr0091880 ; FBpp0091121 ; FBgn0053876 .
FBtr0091882 ; FBpp0091123 ; FBgn0053878 .
FBtr0091884 ; FBpp0091125 ; FBgn0053880 .
FBtr0091886 ; FBpp0091127 ; FBgn0053882 .
FBtr0091888 ; FBpp0091129 ; FBgn0053884 .
FBtr0091890 ; FBpp0091131 ; FBgn0053886 .
FBtr0091892 ; FBpp0091133 ; FBgn0053888 .
FBtr0091894 ; FBpp0091135 ; FBgn0053890 .
FBtr0091896 ; FBpp0091137 ; FBgn0053892 .
FBtr0091898 ; FBpp0091139 ; FBgn0053894 .
FBtr0091900 ; FBpp0091141 ; FBgn0053896 .
FBtr0091902 ; FBpp0091143 ; FBgn0053898 .
FBtr0091904 ; FBpp0091145 ; FBgn0053900 .
FBtr0091906 ; FBpp0091147 ; FBgn0053902 .
FBtr0091908 ; FBpp0091149 ; FBgn0053904 .
FBtr0091910 ; FBpp0091151 ; FBgn0053906 .
FBtr0091912 ; FBpp0091153 ; FBgn0053908 .
FBtr0091914 ; FBpp0091155 ; FBgn0053910 .
GeneIDi 326273.
3771809.
3771891.
3771957.
3772013.
3772058.
3772081.
3772083.
3772094.
3772099.
3772104.
3772166.
3772203.
3772248.
3772264.
3772265.
3772271.
3772276.
3772299.
3772336.
3772496.
3772502.
3772575.
KEGGi dme:Dmel_CG17949.
dme:Dmel_CG33868.
dme:Dmel_CG33870.
dme:Dmel_CG33872.
dme:Dmel_CG33874.
dme:Dmel_CG33876.
dme:Dmel_CG33878.
dme:Dmel_CG33880.
dme:Dmel_CG33882.
dme:Dmel_CG33884.
dme:Dmel_CG33886.
dme:Dmel_CG33888.
dme:Dmel_CG33890.
dme:Dmel_CG33892.
dme:Dmel_CG33894.
dme:Dmel_CG33896.
dme:Dmel_CG33898.
dme:Dmel_CG33900.
dme:Dmel_CG33902.
dme:Dmel_CG33904.
dme:Dmel_CG33906.
dme:Dmel_CG33908.
dme:Dmel_CG33910.
UCSCi CG17949-RA. d. melanogaster.

Organism-specific databases

CTDi 326273.
3771809.
3771891.
3771957.
3772013.
3772058.
3772081.
3772083.
3772094.
3772099.
3772104.
3772166.
3772203.
3772248.
3772264.
3772265.
3772271.
3772276.
3772299.
3772336.
3772496.
3772502.
3772575.
FlyBasei FBgn0001198. His2B.
FBgn0061209. His2B:CG17949.
FBgn0053868. His2B:CG33868.
FBgn0053870. His2B:CG33870.
FBgn0053872. His2B:CG33872.
FBgn0053874. His2B:CG33874.
FBgn0053876. His2B:CG33876.
FBgn0053878. His2B:CG33878.
FBgn0053880. His2B:CG33880.
FBgn0053882. His2B:CG33882.
FBgn0053884. His2B:CG33884.
FBgn0053886. His2B:CG33886.
FBgn0053888. His2B:CG33888.
FBgn0053890. His2B:CG33890.
FBgn0053892. His2B:CG33892.
FBgn0053894. His2B:CG33894.
FBgn0053896. His2B:CG33896.
FBgn0053898. His2B:CG33898.
FBgn0053900. His2B:CG33900.
FBgn0053902. His2B:CG33902.
FBgn0053904. His2B:CG33904.
FBgn0053906. His2B:CG33906.
FBgn0053908. His2B:CG33908.
FBgn0053910. His2B:CG33910.

Phylogenomic databases

eggNOGi NOG289161.
GeneTreei ENSGT00730000110319.
InParanoidi P02283.
KOi K11252.
OMAi TQKKEGR.
OrthoDBi EOG72VH8J.
PhylomeDBi P02283.

Miscellaneous databases

EvolutionaryTracei P02283.
NextBioi 847933.
PROi P02283.

Family and domain databases

Gene3Di 1.10.20.10. 1 hit.
InterProi IPR009072. Histone-fold.
IPR007125. Histone_core_D.
IPR000558. Histone_H2B.
[Graphical view ]
PANTHERi PTHR23428. PTHR23428. 1 hit.
Pfami PF00125. Histone. 1 hit.
[Graphical view ]
PRINTSi PR00621. HISTONEH2B.
SMARTi SM00427. H2B. 1 hit.
[Graphical view ]
SUPFAMi SSF47113. SSF47113. 1 hit.
PROSITEi PS00357. HISTONE_H2B. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of histone 2B of Drosophila melanogaster."
    Elgin S.C.R., Schilling J., Hood L.E.
    Biochemistry 18:5679-5685(1979) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE (HIS2B).
  2. "tRNA derived insertion element in histone gene repeating unit of Drosophila melanogaster."
    Matsuo Y., Yamazaki T.
    Nucleic Acids Res. 17:225-238(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (HIS2B).
    Strain: AK-194.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (HIS2B:CG17949).
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  5. Goldberg M.L.
    Thesis (1979), University of Stanford, United States
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-118 (HIS2B).
  6. "Methylation of Drosophila histones at proline, lysine, and arginine residues during heat shock."
    Desrosiers R., Tanguay R.M.
    J. Biol. Chem. 263:4686-4692(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: METHYLATION AT PRO-2.
  7. "TAF1 activates transcription by phosphorylation of serine 33 in histone H2B."
    Maile T., Kwoczynski S., Katzenberger R.J., Wassarman D.A., Sauer F.
    Science 304:1010-1014(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: CAUTION.
  8. "Bre1 is required for Notch signaling and histone modification."
    Bray S., Musisi H., Bienz M.
    Dev. Cell 8:279-286(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROBABLE UBIQUITINATION.
  9. Cited for: GLYCOSYLATION.

Entry informationi

Entry nameiH2B_DROME
AccessioniPrimary (citable) accession number: P02283
Secondary accession number(s): Q4ABE1, Q9W5U7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 148 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Caution

Was reported to be phosphorylated at Ser-34 (PubMed:15143281). However, the paper was retracted because some data, results and conclusions in the paper are not reliable.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3