Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Histone H2B

Gene

His2B

more
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

GO - Molecular functioni

  • DNA binding Source: UniProtKB

GO - Biological processi

  • chromatin assembly or disassembly Source: FlyBase
  • nucleosome assembly Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-DME-212300. PRC2 methylates histones and DNA.
R-DME-2559580. Oxidative Stress Induced Senescence.
R-DME-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-DME-427359. SIRT1 negatively regulates rRNA Expression.
R-DME-427413. NoRC negatively regulates rRNA expression.
R-DME-5578749. Transcriptional regulation by small RNAs.
R-DME-5689880. Ub-specific processing proteases.
R-DME-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-DME-73777. RNA Polymerase I Chain Elongation.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2B
Gene namesi
Name:His2B
AND
ORF Names:CG17949
AND
ORF Names:CG33868
AND
ORF Names:CG33870
AND
ORF Names:CG33872
AND
ORF Names:CG33874
AND
ORF Names:CG33876
AND
ORF Names:CG33878
AND
ORF Names:CG33880
AND
ORF Names:CG33882
AND
ORF Names:CG33884
AND
ORF Names:CG33886
AND
ORF Names:CG33888
AND
ORF Names:CG33890
AND
ORF Names:CG33892
AND
ORF Names:CG33894
AND
ORF Names:CG33896
AND
ORF Names:CG33898
AND
ORF Names:CG33900
AND
ORF Names:CG33902
AND
ORF Names:CG33904
AND
ORF Names:CG33906
AND
ORF Names:CG33908
AND
ORF Names:CG33910
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0001198. His2B.
FBgn0061209. His2B:CG17949.
FBgn0053868. His2B:CG33868.
FBgn0053870. His2B:CG33870.
FBgn0053872. His2B:CG33872.
FBgn0053874. His2B:CG33874.
FBgn0053876. His2B:CG33876.
FBgn0053878. His2B:CG33878.
FBgn0053880. His2B:CG33880.
FBgn0053882. His2B:CG33882.
FBgn0053884. His2B:CG33884.
FBgn0053886. His2B:CG33886.
FBgn0053888. His2B:CG33888.
FBgn0053890. His2B:CG33890.
FBgn0053892. His2B:CG33892.
FBgn0053894. His2B:CG33894.
FBgn0053896. His2B:CG33896.
FBgn0053898. His2B:CG33898.
FBgn0053900. His2B:CG33900.
FBgn0053902. His2B:CG33902.
FBgn0053904. His2B:CG33904.
FBgn0053906. His2B:CG33906.
FBgn0053908. His2B:CG33908.
FBgn0053910. His2B:CG33910.

Subcellular locationi

GO - Cellular componenti

  • lipid particle Source: FlyBase
  • nuclear nucleosome Source: FlyBase
  • nucleosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved
ChainiPRO_00000718612 – 123Histone H2BAdd BLAST122

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-methylproline; partial1 Publication1
Glycosylationi110O-linked (GlcNAc)By similarity1
Cross-linki118Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Curated

Post-translational modificationi

Monoubiquitination of Lys-118 by Bre1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.1 Publication
Methylation at Pro-2 increases upon heat shock.1 Publication
GlcNAcylation at Ser-110 promotes monoubiquitination of Lys-118. It fluctuates in response to extracellular glucose, and associates with transcribed genes (Probable).Curated

Keywords - PTMi

Glycoprotein, Isopeptide bond, Methylation, Ubl conjugation

Proteomic databases

PaxDbiP02283.
PRIDEiP02283.

PTM databases

iPTMnetiP02283.

Expressioni

Gene expression databases

BgeeiFBgn0061209.
GenevisibleiP02283. DM.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Binary interactionsi

WithEntry#Exp.IntActNotes
ATXN7O152652EBI-188137,EBI-708350From a different organism.

Protein-protein interaction databases

BioGridi533862. 1 interactor.
77520. 6 interactors.
DIPiDIP-22804N.
IntActiP02283. 7 interactors.
MINTiMINT-1560639.
STRINGi7227.FBpp0091155.

Structurei

Secondary structure

1123
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi36 – 46Combined sources11
Helixi54 – 81Combined sources28
Helixi89 – 99Combined sources11
Helixi102 – 121Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NQBX-ray2.30D/H2-123[»]
2PYOX-ray2.43D/H2-123[»]
4QLCX-ray3.50D/H2-123[»]
4X23X-ray3.50D/H/N/R33-122[»]
5CVEX-ray1.50D/E3-10[»]
ProteinModelPortaliP02283.
SMRiP02283.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02283.

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2B family.Curated

Phylogenomic databases

eggNOGiKOG1744. Eukaryota.
ENOG4111NV5. LUCA.
GeneTreeiENSGT00860000133714.
ENSGT00860000134657.
InParanoidiP02283.
KOiK11252.
OMAiHPRMSIM.
OrthoDBiEOG091G0XGD.
PhylomeDBiP02283.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000558. Histone_H2B.
[Graphical view]
PANTHERiPTHR23428. PTHR23428. 1 hit.
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00621. HISTONEH2B.
SMARTiSM00427. H2B. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00357. HISTONE_H2B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02283-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPKTSGKAA KKAGKAQKNI TKTDKKKKRK RKESYAIYIY KVLKQVHPDT
60 70 80 90 100
GISSKAMSIM NSFVNDIFER IAAEASRLAH YNKRSTITSR EIQTAVRLLL
110 120
PGELAKHAVS EGTKAVTKYT SSK
Length:123
Mass (Da):13,696
Last modified:January 23, 2007 - v2
Checksum:i0774D25F34003062
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti77R → C AA sequence (PubMed:117830).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14215 Genomic DNA. Translation: CAA32432.1.
AE014134 Genomic DNA. Translation: AAN11124.1.
AE014134 Genomic DNA. Translation: AAZ66483.1.
AE014134 Genomic DNA. Translation: AAZ66487.1.
AE014134 Genomic DNA. Translation: AAZ66492.1.
AE014134 Genomic DNA. Translation: AAZ66496.1.
AE014134 Genomic DNA. Translation: AAZ66501.1.
AE014134 Genomic DNA. Translation: AAZ66506.1.
AE014134 Genomic DNA. Translation: AAZ66511.1.
AE014134 Genomic DNA. Translation: AAZ66521.1.
AE014134 Genomic DNA. Translation: AAZ66531.1.
AE014134 Genomic DNA. Translation: AAZ66576.1.
AE014134 Genomic DNA. Translation: AAZ66571.1.
AE014134 Genomic DNA. Translation: AAZ66566.1.
AE014134 Genomic DNA. Translation: AAZ66561.1.
AE014134 Genomic DNA. Translation: AAZ66556.1.
AE014134 Genomic DNA. Translation: AAZ66551.1.
AE014134 Genomic DNA. Translation: AAZ66546.1.
AE014134 Genomic DNA. Translation: AAZ66541.1.
AE014134 Genomic DNA. Translation: AAZ66536.1.
AE014134 Genomic DNA. Translation: AAZ66479.1.
AE014134 Genomic DNA. Translation: AAZ66581.1.
AE014134 Genomic DNA. Translation: AAZ66526.1.
AE014134 Genomic DNA. Translation: AAZ66516.1.
PIRiS10095. HSFF22.
RefSeqiNP_001027283.1. NM_001032112.2.
NP_001027287.1. NM_001032116.2.
NP_001027291.1. NM_001032120.2.
NP_001027296.1. NM_001032125.2.
NP_001027300.1. NM_001032129.2.
NP_001027305.1. NM_001032134.2.
NP_001027310.1. NM_001032139.2.
NP_001027315.1. NM_001032144.2.
NP_001027320.1. NM_001032149.2.
NP_001027325.1. NM_001032154.2.
NP_001027330.1. NM_001032159.2.
NP_001027335.1. NM_001032164.2.
NP_001027340.1. NM_001032169.2.
NP_001027345.1. NM_001032174.2.
NP_001027350.1. NM_001032179.2.
NP_001027355.1. NM_001032184.2.
NP_001027360.1. NM_001032189.2.
NP_001027365.1. NM_001032194.2.
NP_001027370.1. NM_001032199.2.
NP_001027375.1. NM_001032204.2.
NP_001027380.1. NM_001032209.2.
NP_001027385.1. NM_001032214.2.
NP_724342.1. NM_165381.4.

Genome annotation databases

EnsemblMetazoaiFBtr0085927; FBpp0085281; FBgn0061209.
FBtr0091872; FBpp0091113; FBgn0053868.
FBtr0091874; FBpp0091115; FBgn0053870.
FBtr0091876; FBpp0091117; FBgn0053872.
FBtr0091878; FBpp0091119; FBgn0053874.
FBtr0091880; FBpp0091121; FBgn0053876.
FBtr0091882; FBpp0091123; FBgn0053878.
FBtr0091884; FBpp0091125; FBgn0053880.
FBtr0091886; FBpp0091127; FBgn0053882.
FBtr0091888; FBpp0091129; FBgn0053884.
FBtr0091890; FBpp0091131; FBgn0053886.
FBtr0091892; FBpp0091133; FBgn0053888.
FBtr0091894; FBpp0091135; FBgn0053890.
FBtr0091896; FBpp0091137; FBgn0053892.
FBtr0091898; FBpp0091139; FBgn0053894.
FBtr0091900; FBpp0091141; FBgn0053896.
FBtr0091902; FBpp0091143; FBgn0053898.
FBtr0091904; FBpp0091145; FBgn0053900.
FBtr0091906; FBpp0091147; FBgn0053902.
FBtr0091908; FBpp0091149; FBgn0053904.
FBtr0091910; FBpp0091151; FBgn0053906.
FBtr0091912; FBpp0091153; FBgn0053908.
FBtr0091914; FBpp0091155; FBgn0053910.
GeneIDi326273.
3771809.
3771891.
3771957.
3772013.
3772058.
3772081.
3772083.
3772094.
3772099.
3772104.
3772166.
3772203.
3772248.
3772264.
3772265.
3772271.
3772276.
3772299.
3772336.
3772496.
3772502.
3772575.
KEGGidme:Dmel_CG17949.
dme:Dmel_CG33868.
dme:Dmel_CG33870.
dme:Dmel_CG33872.
dme:Dmel_CG33874.
dme:Dmel_CG33876.
dme:Dmel_CG33878.
dme:Dmel_CG33880.
dme:Dmel_CG33882.
dme:Dmel_CG33884.
dme:Dmel_CG33886.
dme:Dmel_CG33888.
dme:Dmel_CG33890.
dme:Dmel_CG33892.
dme:Dmel_CG33894.
dme:Dmel_CG33896.
dme:Dmel_CG33898.
dme:Dmel_CG33900.
dme:Dmel_CG33902.
dme:Dmel_CG33904.
dme:Dmel_CG33906.
dme:Dmel_CG33908.
dme:Dmel_CG33910.
UCSCiCG17949-RA. d. melanogaster.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14215 Genomic DNA. Translation: CAA32432.1.
AE014134 Genomic DNA. Translation: AAN11124.1.
AE014134 Genomic DNA. Translation: AAZ66483.1.
AE014134 Genomic DNA. Translation: AAZ66487.1.
AE014134 Genomic DNA. Translation: AAZ66492.1.
AE014134 Genomic DNA. Translation: AAZ66496.1.
AE014134 Genomic DNA. Translation: AAZ66501.1.
AE014134 Genomic DNA. Translation: AAZ66506.1.
AE014134 Genomic DNA. Translation: AAZ66511.1.
AE014134 Genomic DNA. Translation: AAZ66521.1.
AE014134 Genomic DNA. Translation: AAZ66531.1.
AE014134 Genomic DNA. Translation: AAZ66576.1.
AE014134 Genomic DNA. Translation: AAZ66571.1.
AE014134 Genomic DNA. Translation: AAZ66566.1.
AE014134 Genomic DNA. Translation: AAZ66561.1.
AE014134 Genomic DNA. Translation: AAZ66556.1.
AE014134 Genomic DNA. Translation: AAZ66551.1.
AE014134 Genomic DNA. Translation: AAZ66546.1.
AE014134 Genomic DNA. Translation: AAZ66541.1.
AE014134 Genomic DNA. Translation: AAZ66536.1.
AE014134 Genomic DNA. Translation: AAZ66479.1.
AE014134 Genomic DNA. Translation: AAZ66581.1.
AE014134 Genomic DNA. Translation: AAZ66526.1.
AE014134 Genomic DNA. Translation: AAZ66516.1.
PIRiS10095. HSFF22.
RefSeqiNP_001027283.1. NM_001032112.2.
NP_001027287.1. NM_001032116.2.
NP_001027291.1. NM_001032120.2.
NP_001027296.1. NM_001032125.2.
NP_001027300.1. NM_001032129.2.
NP_001027305.1. NM_001032134.2.
NP_001027310.1. NM_001032139.2.
NP_001027315.1. NM_001032144.2.
NP_001027320.1. NM_001032149.2.
NP_001027325.1. NM_001032154.2.
NP_001027330.1. NM_001032159.2.
NP_001027335.1. NM_001032164.2.
NP_001027340.1. NM_001032169.2.
NP_001027345.1. NM_001032174.2.
NP_001027350.1. NM_001032179.2.
NP_001027355.1. NM_001032184.2.
NP_001027360.1. NM_001032189.2.
NP_001027365.1. NM_001032194.2.
NP_001027370.1. NM_001032199.2.
NP_001027375.1. NM_001032204.2.
NP_001027380.1. NM_001032209.2.
NP_001027385.1. NM_001032214.2.
NP_724342.1. NM_165381.4.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2NQBX-ray2.30D/H2-123[»]
2PYOX-ray2.43D/H2-123[»]
4QLCX-ray3.50D/H2-123[»]
4X23X-ray3.50D/H/N/R33-122[»]
5CVEX-ray1.50D/E3-10[»]
ProteinModelPortaliP02283.
SMRiP02283.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi533862. 1 interactor.
77520. 6 interactors.
DIPiDIP-22804N.
IntActiP02283. 7 interactors.
MINTiMINT-1560639.
STRINGi7227.FBpp0091155.

PTM databases

iPTMnetiP02283.

Proteomic databases

PaxDbiP02283.
PRIDEiP02283.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0085927; FBpp0085281; FBgn0061209.
FBtr0091872; FBpp0091113; FBgn0053868.
FBtr0091874; FBpp0091115; FBgn0053870.
FBtr0091876; FBpp0091117; FBgn0053872.
FBtr0091878; FBpp0091119; FBgn0053874.
FBtr0091880; FBpp0091121; FBgn0053876.
FBtr0091882; FBpp0091123; FBgn0053878.
FBtr0091884; FBpp0091125; FBgn0053880.
FBtr0091886; FBpp0091127; FBgn0053882.
FBtr0091888; FBpp0091129; FBgn0053884.
FBtr0091890; FBpp0091131; FBgn0053886.
FBtr0091892; FBpp0091133; FBgn0053888.
FBtr0091894; FBpp0091135; FBgn0053890.
FBtr0091896; FBpp0091137; FBgn0053892.
FBtr0091898; FBpp0091139; FBgn0053894.
FBtr0091900; FBpp0091141; FBgn0053896.
FBtr0091902; FBpp0091143; FBgn0053898.
FBtr0091904; FBpp0091145; FBgn0053900.
FBtr0091906; FBpp0091147; FBgn0053902.
FBtr0091908; FBpp0091149; FBgn0053904.
FBtr0091910; FBpp0091151; FBgn0053906.
FBtr0091912; FBpp0091153; FBgn0053908.
FBtr0091914; FBpp0091155; FBgn0053910.
GeneIDi326273.
3771809.
3771891.
3771957.
3772013.
3772058.
3772081.
3772083.
3772094.
3772099.
3772104.
3772166.
3772203.
3772248.
3772264.
3772265.
3772271.
3772276.
3772299.
3772336.
3772496.
3772502.
3772575.
KEGGidme:Dmel_CG17949.
dme:Dmel_CG33868.
dme:Dmel_CG33870.
dme:Dmel_CG33872.
dme:Dmel_CG33874.
dme:Dmel_CG33876.
dme:Dmel_CG33878.
dme:Dmel_CG33880.
dme:Dmel_CG33882.
dme:Dmel_CG33884.
dme:Dmel_CG33886.
dme:Dmel_CG33888.
dme:Dmel_CG33890.
dme:Dmel_CG33892.
dme:Dmel_CG33894.
dme:Dmel_CG33896.
dme:Dmel_CG33898.
dme:Dmel_CG33900.
dme:Dmel_CG33902.
dme:Dmel_CG33904.
dme:Dmel_CG33906.
dme:Dmel_CG33908.
dme:Dmel_CG33910.
UCSCiCG17949-RA. d. melanogaster.

Organism-specific databases

CTDi326273.
3771809.
3771891.
3771957.
3772013.
3772058.
3772081.
3772083.
3772094.
3772099.
3772104.
3772166.
3772203.
3772248.
3772264.
3772265.
3772271.
3772276.
3772299.
3772336.
3772496.
3772502.
3772575.
FlyBaseiFBgn0001198. His2B.
FBgn0061209. His2B:CG17949.
FBgn0053868. His2B:CG33868.
FBgn0053870. His2B:CG33870.
FBgn0053872. His2B:CG33872.
FBgn0053874. His2B:CG33874.
FBgn0053876. His2B:CG33876.
FBgn0053878. His2B:CG33878.
FBgn0053880. His2B:CG33880.
FBgn0053882. His2B:CG33882.
FBgn0053884. His2B:CG33884.
FBgn0053886. His2B:CG33886.
FBgn0053888. His2B:CG33888.
FBgn0053890. His2B:CG33890.
FBgn0053892. His2B:CG33892.
FBgn0053894. His2B:CG33894.
FBgn0053896. His2B:CG33896.
FBgn0053898. His2B:CG33898.
FBgn0053900. His2B:CG33900.
FBgn0053902. His2B:CG33902.
FBgn0053904. His2B:CG33904.
FBgn0053906. His2B:CG33906.
FBgn0053908. His2B:CG33908.
FBgn0053910. His2B:CG33910.

Phylogenomic databases

eggNOGiKOG1744. Eukaryota.
ENOG4111NV5. LUCA.
GeneTreeiENSGT00860000133714.
ENSGT00860000134657.
InParanoidiP02283.
KOiK11252.
OMAiHPRMSIM.
OrthoDBiEOG091G0XGD.
PhylomeDBiP02283.

Enzyme and pathway databases

ReactomeiR-DME-212300. PRC2 methylates histones and DNA.
R-DME-2559580. Oxidative Stress Induced Senescence.
R-DME-2559582. Senescence-Associated Secretory Phenotype (SASP).
R-DME-427359. SIRT1 negatively regulates rRNA Expression.
R-DME-427413. NoRC negatively regulates rRNA expression.
R-DME-5578749. Transcriptional regulation by small RNAs.
R-DME-5689880. Ub-specific processing proteases.
R-DME-5693565. Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.
R-DME-73777. RNA Polymerase I Chain Elongation.

Miscellaneous databases

EvolutionaryTraceiP02283.
PROiP02283.

Gene expression databases

BgeeiFBgn0061209.
GenevisibleiP02283. DM.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000558. Histone_H2B.
[Graphical view]
PANTHERiPTHR23428. PTHR23428. 1 hit.
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00621. HISTONEH2B.
SMARTiSM00427. H2B. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00357. HISTONE_H2B. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiH2B_DROME
AccessioniPrimary (citable) accession number: P02283
Secondary accession number(s): Q4ABE1, Q9W5U7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 170 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Caution

Was reported to be phosphorylated at Ser-34 (PubMed:15143281). However, the paper was retracted because some data, results and conclusions in the paper are not reliable.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.