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Protein

Histone H5

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Histone H5 performs the same function as H1, being necessary for the condensation of nucleosome chains into higher order structures, and replaces histone H1 in certain cells.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

DNA condensation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-GGA-211227. Activation of DNA fragmentation factor.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H5
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • nucleosome Source: InterPro
  • nucleus Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001960052 – 190Histone H5Add BLAST189

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23Phosphoserine1 Publication1
Modified residuei30Phosphoserine1 Publication1
Modified residuei146Phosphoserine1 Publication1
Modified residuei167Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP02259.

PTM databases

iPTMnetiP02259.

Miscellaneous databases

PMAP-CutDBP02259.

Expressioni

Tissue specificityi

Erythroid cells.

Gene expression databases

BgeeiENSGALG00000012313.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020094.

Structurei

Secondary structure

1190
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi29 – 38Combined sources10
Helixi48 – 58Combined sources11
Helixi65 – 78Combined sources14
Beta strandi81 – 85Combined sources5
Beta strandi93 – 96Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HSTX-ray2.60A/B20-109[»]
4QLCX-ray3.50U23-99[»]
DisProtiDP00044.
ProteinModelPortaliP02259.
SMRiP02259.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02259.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 98H15PROSITE-ProRule annotationAdd BLAST74

Sequence similaritiesi

Belongs to the histone H1/H5 family.PROSITE-ProRule annotation
Contains 1 H15 (linker histone H1/H5 globular) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4012. Eukaryota.
ENOG4112541. LUCA.
HOGENOMiHOG000251627.
HOVERGENiHBG005939.
InParanoidiP02259.
KOiK11275.
OrthoDBiEOG091G0LIU.
PhylomeDBiP02259.
TreeFamiTF313664.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005818. Histone_H1/H5_H15.
IPR005819. Histone_H5.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00538. Linker_histone. 1 hit.
[Graphical view]
PRINTSiPR00624. HISTONEH5.
SMARTiSM00526. H15. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS51504. H15. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02259-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTESLVLSPA PAKPKRVKAS RRSASHPTYS EMIAAAIRAE KSRGGSSRQS
60 70 80 90 100
IQKYIKSHYK VGHNADLQIK LSIRRLLAAG VLKQTKGVGA SGSFRLAKSD
110 120 130 140 150
KAKRSPGKKK KAVRRSTSPK KAARPRKARS PAKKPKATAR KARKKSRASP
160 170 180 190
KKAKKPKTVK AKSRKASKAK KVKRSKPRAK SGARKSPKKK
Length:190
Mass (Da):20,734
Last modified:January 23, 2007 - v2
Checksum:iE2BA83C7A39F87DF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti16R → Q.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00870 Genomic DNA. Translation: AAA48798.1.
X00169 mRNA. Translation: CAA24994.1.
PIRiA93487. HSCH5.
RefSeqiNP_001038138.1. NM_001044673.1.
UniGeneiGga.48182.

Genome annotation databases

GeneIDi693250.
KEGGigga:693250.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00870 Genomic DNA. Translation: AAA48798.1.
X00169 mRNA. Translation: CAA24994.1.
PIRiA93487. HSCH5.
RefSeqiNP_001038138.1. NM_001044673.1.
UniGeneiGga.48182.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HSTX-ray2.60A/B20-109[»]
4QLCX-ray3.50U23-99[»]
DisProtiDP00044.
ProteinModelPortaliP02259.
SMRiP02259.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020094.

PTM databases

iPTMnetiP02259.

Proteomic databases

PaxDbiP02259.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi693250.
KEGGigga:693250.

Organism-specific databases

CTDi3005.

Phylogenomic databases

eggNOGiKOG4012. Eukaryota.
ENOG4112541. LUCA.
HOGENOMiHOG000251627.
HOVERGENiHBG005939.
InParanoidiP02259.
KOiK11275.
OrthoDBiEOG091G0LIU.
PhylomeDBiP02259.
TreeFamiTF313664.

Enzyme and pathway databases

ReactomeiR-GGA-211227. Activation of DNA fragmentation factor.

Miscellaneous databases

EvolutionaryTraceiP02259.
PMAP-CutDBP02259.
PROiP02259.

Gene expression databases

BgeeiENSGALG00000012313.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR005818. Histone_H1/H5_H15.
IPR005819. Histone_H5.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00538. Linker_histone. 1 hit.
[Graphical view]
PRINTSiPR00624. HISTONEH5.
SMARTiSM00526. H15. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS51504. H15. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiH5_CHICK
AccessioniPrimary (citable) accession number: P02259
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.