Reviewed, UniProtKB/Swiss-Prot P02255 (H1_DROME)

Names and origin

Protein names

Recommended name:
    Histone H1

Gene names

Name:	His1
AND
Name:	His1:CG31617
ORF Names:	CG31617
AND
Name:	His1:CG33804
ORF Names:	CG33804
AND
Name:	His1:CG33810
ORF Names:	CG33810
AND
Name:	His1:CG33813
ORF Names:	CG33813
AND
Name:	His1:CG33816
ORF Names:	CG33816
AND
Name:	His1:CG33819
ORF Names:	CG33819
AND
Name:	His1:CG33822
ORF Names:	CG33822
AND
Name:	His1:CG33825
ORF Names:	CG33825
AND
Name:	His1:CG33828
ORF Names:	CG33828
AND
Name:	His1:CG33831
ORF Names:	CG33831
AND
Name:	His1:CG33837
ORF Names:	CG33837
AND
Name:	His1:CG33840
ORF Names:	CG33840
AND
Name:	His1:CG33843
ORF Names:	CG33843
AND
Name:	His1:CG33846
ORF Names:	CG33846
AND
Name:	His1:CG33849
ORF Names:	CG33849
AND
Name:	His1:CG33852
ORF Names:	CG33852
AND
Name:	His1:CG33864
ORF Names:	CG33864

Organism

Drosophila melanogaster (Fruit fly) [Complete proteome]

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	256 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Histones H1 are necessary for the condensation of nucleosome chains into higher order structures.
Subcellular location	Nucleus.
Post-translational modification	Phosphorylated in oocytes during prophase I of meiosis. Ref.8 Ref.9
Sequence similarities	Belongs to the histone H1/H5 family.

Ontologies

Keywords
Cellular component	Chromosomal protein Nucleus
Ligand	DNA-binding
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing
Gene Ontology (GO)
Biological process	negative regulation of histone modification Inferred from direct assay. Source: FlyBase nucleosome assembly Inferred from electronic annotation. Source: InterPro
Cellular component	nucleosome Inferred from electronic annotation. Source: InterPro nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 256	256	Histone H1		PRO_0000195961
Amino acid modifications
	Modified residue	11	1	Phosphoserine Ref.9

Sequences

	Sequence		Length	Mass (Da)
	P02255-1 [UniParc]. Last modified August 13, 1987. Version 1. Checksum: 5314DA250A7D0B23	FASTA	256	26,359
	10 20 30 40 50 60 MSDSAVATSA SPVAAPPATV EKKVVQKKAS GSAGTKAKKA SATPSHPPTQ QMVDASIKNL 70 80 90 100 110 120 KERGGSSLLA IKKYITATYK CDAQKLAPFI KKYLKSAVVN GKLIQTKGKG ASGSFKLSAS 130 140 150 160 170 180 AKKEKDPKAK SKVLSAEKKV QSKKVASKKI GVSSKKTAVG AADKKPKAKK AVATKKTAEN 190 200 210 220 230 240 KKTEKAKAKD AKKTGIIKSK PAATKAKVTA AKPKAVVAKA SKAKPAVSAK PKKTVKKASV 250 SATAKKPKAK TTAAKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Nucleotide sequence of a Drosophila melanogaster H1 histone gene." Murphy T.J., Blumenfeld M. Nucleic Acids Res. 14:5563-5563(1986) [PubMed: 3090518] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (HIS1).
[2]	"tRNA derived insertion element in histone gene repeating unit of Drosophila melanogaster." Matsuo Y., Yamazaki T. Nucleic Acids Res. 17:225-238(1989) [PubMed: 2536150] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (HIS1). Strain: AK-194.
[3]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (HIS1:CG31617; HIS1:CG31617; HIS1:CG33804; HIS1:CG33810; HIS1:CG33813; HIS1:CG33816; HIS1:CG33819; HIS1:CG33822; HIS1:CG33825; HIS1:CG33828; HIS1:CG33831; HIS1:CG33837; HIS1:CG33840; HIS1:CG33843; HIS1:CG33846; HIS1:CG33849; HIS1:CG33852 AND HIS1:CG33864). Strain: Berkeley.
[4]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: GENOME REANNOTATION.
[5]	Goldberg M.L. Thesis (1979), University of Stanford, United States Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 14-47 AND 63-215 (HIS1).
[6]	"Sequence-specific antirepression of histone H1-mediated inhibition of basal RNA polymerase II transcription." Croston G.E., Kerrigan L.A., Lira L.M., Marshak D.R., Kadonaga J.T. Science 251:643-649(1991) [PubMed: 1899487] [Abstract] Cited for: PROTEIN SEQUENCE OF 22-117; 125-172 AND 185-231 (HIS1).
[7]	"In vivo topoisomerase II cleavage of the Drosophila histone and satellite III repeats: DNA sequence and structural characteristics." Kas E., Laemmli U.K. EMBO J. 11:705-716(1992) [PubMed: 1311255] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11 (HIS1).
[8]	"A histone code in meiosis: the histone kinase, NHK-1, is required for proper chromosomal architecture in Drosophila oocytes." Ivanovska I., Khandan T., Ito T., Orr-Weaver T.L. Genes Dev. 19:2571-2582(2005) [PubMed: 16230526] [Abstract] Cited for: PHOSPHORYLATION.
[9]	"An integrated chemical, mass spectrometric and computational strategy for (quantitative) phosphoproteomics: application to Drosophila melanogaster Kc167 cells." Bodenmiller B., Mueller L.N., Pedrioli P.G.A., Pflieger D., Juenger M.A., Eng J.K., Aebersold R., Tao W.A. Mol. Biosyst. 3:275-286(2007) [PubMed: 17372656] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X04073 Genomic DNA. Translation: CAA27716.1. X14215 Genomic DNA. Translation: CAA32433.1. AE014134 Genomic DNA. Translation: AAN11123.1. AE014134 Genomic DNA. Translation: AAZ66482.1. AE014134 Genomic DNA. Translation: AAZ66491.1. AE014134 Genomic DNA. Translation: AAZ66495.1. AE014134 Genomic DNA. Translation: AAZ66500.1. AE014134 Genomic DNA. Translation: AAZ66505.1. AE014134 Genomic DNA. Translation: AAZ66510.1. AE014134 Genomic DNA. Translation: AAZ66515.1. AE014134 Genomic DNA. Translation: AAZ66520.1. AE014134 Genomic DNA. Translation: AAZ66525.1. AE014134 Genomic DNA. Translation: AAZ66535.1. AE014134 Genomic DNA. Translation: AAZ66540.1. AE014134 Genomic DNA. Translation: AAZ66545.1. AE014134 Genomic DNA. Translation: AAZ66555.1. AE014134 Genomic DNA. Translation: AAZ66550.1. AE014134 Genomic DNA. Translation: AAZ66560.1. AE014134 Genomic DNA. Translation: AAZ66580.1. X60225 Genomic DNA. Translation: CAA42786.1.
PIR	HSFF1. A02585. S07371.
RefSeq	NP_001027286.1. NP_001027295.1. NP_001027299.1. NP_001027304.1. NP_001027309.1. NP_001027314.1. NP_001027319.1. NP_001027324.1. NP_001027329.1. NP_001027339.1. NP_001027344.1. NP_001027349.1. NP_001027354.1. NP_001027359.1. NP_001027364.1. NP_001027384.1. NP_724341.1.
UniGene	Dm.33572 Dm.33619 Dm.33728 Dm.33730 Dm.34558 Dm.34563 Dm.34565 Dm.34568 Dm.34570
3D structure databases
HSSP	HSSP built from PDB template 1HST based on UniProtKB P02259.
ModBase	Search...
Protein-protein interaction databases
IntAct	P02255. 2 interactions.
Proteomic databases
PRIDE	P02255.
Genome annotation databases
Ensembl	FBgn0051617. Drosophila melanogaster. [Contig view]
GeneID	318854. 3771803. 3771816. 3771818. 3771838. 3771879. 3771910. 3771912. 3771981. 3772004. 3772075. 3772077. 3772225. 3772409. 3772665. 3772702. 3772715.
KEGG	dme:Dmel_CG31617. dme:Dmel_CG33804. dme:Dmel_CG33810. dme:Dmel_CG33813. dme:Dmel_CG33816. dme:Dmel_CG33819. dme:Dmel_CG33822. dme:Dmel_CG33825. dme:Dmel_CG33828. dme:Dmel_CG33831. dme:Dmel_CG33837. dme:Dmel_CG33840. dme:Dmel_CG33843. dme:Dmel_CG33846. dme:Dmel_CG33849. dme:Dmel_CG33852. dme:Dmel_CG33864.
NMPDR	fig|7227.3.peg.3271.
Organism-specific databases
FlyBase	FBgn0001195. His1. FBgn0051617. His1:CG31617. FBgn0053804. His1:CG33804. FBgn0053810. His1:CG33810. FBgn0053813. His1:CG33813. FBgn0053816. His1:CG33816. FBgn0053819. His1:CG33819. FBgn0053822. His1:CG33822. FBgn0053825. His1:CG33825. FBgn0053828. His1:CG33828. FBgn0053831. His1:CG33831. FBgn0053837. His1:CG33837. FBgn0053840. His1:CG33840. FBgn0053843. His1:CG33843. FBgn0053846. His1:CG33846. FBgn0053849. His1:CG33849. FBgn0053852. His1:CG33852. FBgn0053864. His1:CG33864.
Phylogenomic databases
HOGENOM	P02255.
Enzyme and pathway databases
BioCyc	DMEL-XXX-02:DMEL-XXX-02-009781-MON.
Gene expression databases
GermOnline	CG31617. Drosophila melanogaster. CG33804. Drosophila melanogaster. CG33810. Drosophila melanogaster. CG33813. Drosophila melanogaster. CG33816. Drosophila melanogaster. CG33819. Drosophila melanogaster. CG33822. Drosophila melanogaster. CG33825. Drosophila melanogaster. CG33828. Drosophila melanogaster. CG33831. Drosophila melanogaster. CG33837. Drosophila melanogaster. CG33840. Drosophila melanogaster. CG33843. Drosophila melanogaster. CG33846. Drosophila melanogaster. CG33849. Drosophila melanogaster. CG33852. Drosophila melanogaster. CG33864. Drosophila melanogaster.
Family and domain databases
InterPro	IPR005818. Histone_H1/H5. IPR005819. Histone_H5. IPR011991. Wing_hlx_DNA_bd. [Graphical view]
Gene3D	G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
Pfam	PF00538. Linker_histone. 1 hit. [Graphical view]
PRINTS	PR00624. HISTONEH5.
ProDom	PD000373. Linkerhist_N. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00526. H15. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	846327.

Entry information

Entry name

H1_DROME

Accession

Primary (citable) accession number: P02255
Secondary accession number(s): Q4ABD3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	August 13, 1987
Last modified:	June 16, 2009
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Drosophila annotation project