Reviewed, UniProtKB/Swiss-Prot P02253 (H11_BOVIN)

Names and origin

Protein names	Recommended name:     Histone H1.1 Alternative name(s):     CTL-1
Organism	Bos taurus (Bovine)
Taxonomic identifier	9913 [NCBI]
Taxonomic lineage	Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	104 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Histones H1 are necessary for the condensation of nucleosome chains into higher order structures.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the histone H1/H5 family.

Ontologies

Keywords
Cellular component	Chromosomal protein Nucleus
Ligand	DNA-binding
PTM	Acetylation Phosphoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	nucleosome assembly Inferred from electronic annotation. Source: InterPro
Cellular component	nucleosome Inferred from electronic annotation. Source: InterPro nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›104	›104	Histone H1.1		PRO_0000195903
Regions
	Region	35 – ›104	›70	Globular
Amino acid modifications
	Modified residue	1	1	N-acetylserine Ref.1
	Modified residue	35	1	Phosphoserine Potential
	Modified residue	84	1	N6-acetyllysine By similarity
	Modified residue	103	1	Phosphoserine; by PKC Ref.3
Experimental info
	Non-terminal residue	104	1

Sequences

	Sequence		Length	Mass (Da)
	P02253-1 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 801BF289751E41B2	FASTA	104	10,365
	10 20 30 40 50 60 SETAPAAPAA APPAEKTPVK KKAAKKPAGA RRKASGPPVS ELITKAVAAS KERSGVSLAA 70 80 90 100 LKKALAAAGY DVEKNNSRIK LGLKSLVSKG TLVQTKGTGA SGSF

References

[1]	"The amino acid sequence of residues 1-104 of CTL-1, a bovine H1 histone." Liao L.W., Cole R.D. J. Biol. Chem. 256:3024-3029(1981) [PubMed: 7204387] [Abstract] Cited for: PROTEIN SEQUENCE.
[2]	"Amino acid sequence and sequence variability of the amino-terminal regions of lysine-rich histones." Rall S.C., Cole R.D. J. Biol. Chem. 246:7175-7190(1971) [PubMed: 5167020] [Abstract] Cited for: AMINO-ACID COMPOSITION OF TRYPTIC PEPTIDES.
[3]	"Identification of the phosphoserine residue in histone H1 phosphorylated by protein kinase C." Jakes S., Hastings T.G., Reimann E.M., Schlender K.K. FEBS Lett. 234:31-34(1988) [PubMed: 3134256] [Abstract] Cited for: PHOSPHORYLATION AT SER-103.

Cross-references

Sequence databases
IPI	IPI00699808.
PIR	HSBO11. A92316.
UniGene	Bt.85301
3D structure databases
HSSP	HSSP built from PDB template 1GHC based on UniProtKB P08287.
ModBase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000015499; ENSBTAP00000015499; ENSBTAG00000011677; Bos taurus. [Genome view]
Phylogenomic databases
HOVERGEN	P02253.
Family and domain databases
InterPro	IPR005818. Histone_H1/H5. IPR005819. Histone_H5. IPR011991. Wing_hlx_DNA_bd. [Graphical view]
Gene3D	G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit.
Pfam	PF00538. Linker_histone. 1 hit. [Graphical view]
PRINTS	PR00624. HISTONEH5.
SMART	SM00526. H15. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

H11_BOVIN

Accession

Primary (citable) accession number: P02253

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	October 13, 2009
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)