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Protein

Hemerythrin

Gene
N/A
Organism
Phascolopsis gouldii (Peanut worm) (Golfingia gouldii)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Hemerythrin is a respiratory protein in blood cells of certain marine worms. The oxygen-binding site in each chain contains two iron atoms.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi26Iron 1Combined sources1 Publication1
Metal bindingi55Iron 1Combined sources1 Publication1
Metal bindingi59Iron 1Combined sources1 Publication1
Metal bindingi59Iron 2Combined sources1 Publication1
Metal bindingi74Iron 2Combined sources1 Publication1
Metal bindingi78Iron 2Combined sources1 Publication1
Metal bindingi102Iron 2Combined sources1 Publication1
Metal bindingi107Iron 1Combined sources1 Publication1
Metal bindingi107Iron 2Combined sources1 Publication1

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemerythrin
OrganismiPhascolopsis gouldii (Peanut worm) (Golfingia gouldii)
Taxonomic identifieri6442 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaAnnelidaPolychaetaSipunculaSipunculideaGolfingiidaSipunculidaePhascolopsis

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi99L → X: Increased auto-oxidation rate (when X different from Tyr). 1 Publication1
Mutagenesisi99L → Y: Decreased auto-oxidation rate. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001918372 – 114HemerythrinAdd BLAST113

Interactioni

Subunit structurei

Homooctamer.1 Publication

Structurei

Secondary structure

1114
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi13 – 15Combined sources3
Helixi20 – 38Combined sources19
Helixi42 – 65Combined sources24
Helixi71 – 86Combined sources16
Helixi92 – 105Combined sources14
Helixi107 – 110Combined sources4
Turni111 – 113Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HRBX-ray5.50A/B2-114[»]
1I4YX-ray1.80A/B/C/D/E/F/G/H1-114[»]
1I4ZX-ray2.10A/B/C/D/E/F/G/H1-114[»]
ProteinModelPortaliP02244.
SMRiP02244.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02244.

Family & Domainsi

Sequence similaritiesi

Belongs to the hemerythrin family.Curated

Family and domain databases

Gene3Di1.20.120.50. 1 hit.
InterProiIPR002063. Haemerythrin.
IPR016131. Haemerythrin_Fe_BS.
IPR012827. Haemerythrin_metal-bd.
[Graphical view]
PIRSFiPIRSF002033. Hemerythrin. 1 hit.
PRINTSiPR00186. HEMERYTHRIN.
SUPFAMiSSF47188. SSF47188. 1 hit.
TIGRFAMsiTIGR02481. hemeryth_dom. 1 hit.
TIGR00058. Hemerythrin. 1 hit.
PROSITEiPS00550. HEMERYTHRINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02244-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFPIPDPYV WDPSFRTFYS IIDDEHKTLF NGIFHLAIDD NADNLGELRR
60 70 80 90 100
CTGKHFLNEQ VLMQASQYQF YDEHKKEHET FIHALDNWKG DVKWAKSWLV
110
NHIKTIDFKY KGKI
Length:114
Mass (Da):13,605
Last modified:January 23, 2007 - v3
Checksum:iBF730C540D0769FC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti64Q → E in minor component. 1
Natural varianti79E → D in minor component. 1
Natural varianti80T → G.1
Natural varianti83H → N in minor component. 1
Natural varianti97S → A in minor and major variants. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220529 mRNA. Translation: AAF25482.1.
PIRiA90553. HRGG.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220529 mRNA. Translation: AAF25482.1.
PIRiA90553. HRGG.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HRBX-ray5.50A/B2-114[»]
1I4YX-ray1.80A/B/C/D/E/F/G/H1-114[»]
1I4ZX-ray2.10A/B/C/D/E/F/G/H1-114[»]
ProteinModelPortaliP02244.
SMRiP02244.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP02244.

Family and domain databases

Gene3Di1.20.120.50. 1 hit.
InterProiIPR002063. Haemerythrin.
IPR016131. Haemerythrin_Fe_BS.
IPR012827. Haemerythrin_metal-bd.
[Graphical view]
PIRSFiPIRSF002033. Hemerythrin. 1 hit.
PRINTSiPR00186. HEMERYTHRIN.
SUPFAMiSSF47188. SSF47188. 1 hit.
TIGRFAMsiTIGR02481. hemeryth_dom. 1 hit.
TIGR00058. Hemerythrin. 1 hit.
PROSITEiPS00550. HEMERYTHRINS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHEMT_PHAGO
AccessioniPrimary (citable) accession number: P02244
Secondary accession number(s): Q9U3V2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 98 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

The sequence from one of the four major component variants is shown.

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.