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Protein

Leghemoglobin-2

Gene
N/A
Organism
Lupinus luteus (European yellow lupin)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Provides oxygen to the bacteroids. This role is essential for symbiotic nitrogen fixation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi64 – 641Iron (heme distal ligand)PROSITE-ProRule annotation
Metal bindingi98 – 981Iron (heme proximal ligand)PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Nitrogen fixation, Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Leghemoglobin-2
Alternative name(s):
Leghemoglobin II
OrganismiLupinus luteus (European yellow lupin)
Taxonomic identifieri3873 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeGenisteaeLupinus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 154153Leghemoglobin-2PRO_0000192985Add
BLAST

Expressioni

Tissue specificityi

Root nodules.

Interactioni

Subunit structurei

Monomer.

Structurei

Secondary structure

1
154
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 2015Combined sources
Helixi23 – 3715Combined sources
Helixi39 – 446Combined sources
Turni46 – 505Combined sources
Helixi59 – 8224Combined sources
Helixi89 – 10113Combined sources
Helixi105 – 1073Combined sources
Helixi108 – 12316Combined sources
Helixi124 – 1263Combined sources
Helixi129 – 15325Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1GDIX-ray1.80A2-154[»]
1GDJX-ray1.70A2-154[»]
1GDKX-ray1.80A2-154[»]
1GDLX-ray1.80A2-154[»]
1LH1X-ray2.00A2-154[»]
1LH2X-ray2.00A2-154[»]
1LH3X-ray2.00A2-154[»]
1LH5X-ray2.00A2-154[»]
1LH6X-ray2.00A2-154[»]
1LH7X-ray2.00A2-154[»]
2GDMX-ray1.70A2-154[»]
2LH1X-ray2.00A2-154[»]
2LH2X-ray2.00A2-154[»]
2LH3X-ray2.00A2-154[»]
2LH5X-ray2.00A2-154[»]
2LH6X-ray2.00A2-154[»]
2LH7X-ray2.00A2-154[»]
ProteinModelPortaliP02240.
SMRiP02240. Positions 2-154.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02240.

Family & Domainsi

Sequence similaritiesi

Belongs to the plant globin family.Curated

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR001032. Leghaemoglobin.
IPR019824. Leghaemoglobin_Fe_BS.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00188. PLANTGLOBIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
PS00208. PLANT_GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02240-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGALTESQAA LVKSSWEEFN ANIPKHTHRF FILVLEIAPA AKDLFSFLKG
60 70 80 90 100
TSEVPQNNPE LQAHAGKVFK LVYEAAIQLQ VTGVVVTDAT LKNLGSVHVS
110 120 130 140 150
KGVADAHFPV VKEAILKTIK EVVGAKWSEE LNSAWTIAYD ELAIVIKKEM

NDAA
Length:154
Mass (Da):16,783
Last modified:January 23, 2007 - v2
Checksum:i57091640CBAEAF81
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti62 – 621Q → AS in AAA33410 (PubMed:2442601).Curated
Sequence conflicti80 – 801Q → E AA sequence (Ref. 1) Curated
Sequence conflicti87 – 871T → S AA sequence (Ref. 1) Curated
Sequence conflicti151 – 1511N → D AA sequence (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17893 mRNA. Translation: AAA33410.1.
PIRiS41328. GPYL2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M17893 mRNA. Translation: AAA33410.1.
PIRiS41328. GPYL2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1GDIX-ray1.80A2-154[»]
1GDJX-ray1.70A2-154[»]
1GDKX-ray1.80A2-154[»]
1GDLX-ray1.80A2-154[»]
1LH1X-ray2.00A2-154[»]
1LH2X-ray2.00A2-154[»]
1LH3X-ray2.00A2-154[»]
1LH5X-ray2.00A2-154[»]
1LH6X-ray2.00A2-154[»]
1LH7X-ray2.00A2-154[»]
2GDMX-ray1.70A2-154[»]
2LH1X-ray2.00A2-154[»]
2LH2X-ray2.00A2-154[»]
2LH3X-ray2.00A2-154[»]
2LH5X-ray2.00A2-154[»]
2LH6X-ray2.00A2-154[»]
2LH7X-ray2.00A2-154[»]
ProteinModelPortaliP02240.
SMRiP02240. Positions 2-154.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP02240.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR001032. Leghaemoglobin.
IPR019824. Leghaemoglobin_Fe_BS.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00188. PLANTGLOBIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
PS00208. PLANT_GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Primary structure of leghemoglobin II from the nodules of the yellow lupin (Lupinus luteus L.)."
    Egorov T.A., Kazakov V.K., Shakhparonov M.I., Feigina M.Y., Kostetsky P.V.
    Bioorg. Khim. 4:476-480(1978)
    Cited for: PROTEIN SEQUENCE OF 2-154.
    Tissue: Root nodule.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 62-154.
  3. "X-ray structural investigation of leghemoglobin. VI. Structure of acetate-ferrileghemoglobin at a resolution of 2.0 A."
    Arutiunian E.G., Kuranova I.P., Vainshtein B.K., Steigemann W.
    Sov. Phys. Crystallogr. 25:43-52(1980)
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
  4. Cited for: X-RAY CRYSTALLOGRAPHY (5.0 ANGSTROMS).
    Tissue: Root nodule.

Entry informationi

Entry nameiLGB2_LUPLU
AccessioniPrimary (citable) accession number: P02240
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: December 9, 2015
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.