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P02229 (GLB3_CHITH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Globin CTT-III
Alternative name(s):
Erythrocruorin III
Gene names
Name:A
AND
Name:A'
AND
Name:B
AND
Name:B'
OrganismChironomus thummi thummi (Midge)
Taxonomic identifier7155 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Chironomoidea › Chironomidae › Chironominae › Chironomus ›

Protein attributes

Sequence length151 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Monomer.

Miscellaneous

There are at least 12 different components in Midge globin.

The sequence of genes B and B' are shown.

Sequence similarities

Belongs to the globin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515 Ref.3
Chain16 – 151136Globin CTT-III
PRO_0000011190

Sites

Metal binding731Iron (heme axial ligand)
Metal binding1021Iron (heme axial ligand)

Natural variations

Natural variant721I → T in A and A'.
Natural variant92 – 932EA → DG in A.

Secondary structure

1 ....................... 151
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P02229 [UniParc].

Last modified October 1, 1989. Version 2.
Checksum: 19EF29594AEF9FFB

FASTA15116,348
        10         20         30         40         50         60 
MKFLILALCF AAASALSADQ ISTVQASFDK VKGDPVGILY AVFKADPSIM AKFTQFAGKD 

        70         80         90        100        110        120 
LESIKGTAPF EIHANRIVGF FSKIIGELPN IEADVNTFVA SHKPRGVTHD QLNNFRAGFV 

       130        140        150 
SYMKAHTDFA GAEAAWGATL DTFFGMIFSK M

« Hide

References

[1]"Genomic organization and primary structure of five homologous pairs of intron-less genes encoding secretory globins from the insect Chironomus thummi thummi."
Antoine M., Erbil C., Muench E., Schnell S., Niessing J.
Gene 56:41-51(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Hankeln T., Amid C., Weich B., Schmidt E.R.
Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Hemoglobins, XXV. Hemoglobin (erythrocruorin) CTT III from Chironomus thummi thummi (Diptera). Primary structure and relationship to other heme proteins."
Buse G., Steffens G.J., Braunitzer G., Steer W.
Hoppe-Seyler's Z. Physiol. Chem. 360:89-97(1979) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 16-151.
[4]"The environment of the haem group in erythrocruorin (Chironomus thummi)."
Huber R., Epp O., Formanek H.
J. Mol. Biol. 42:591-594(1969) [PubMed] [Europe PMC] [Abstract]
Cited for: HEME-BINDING.
[5]"Hemoglobins, XVIII. Isoelectric focussing of hemoglobins (erythrocruorins) from insects (Chironomus thummi, thummi, Diptera)."
Glossmann H., Horst J., Plagens U., Braunitzer G.
Hoppe-Seyler's Z. Physiol. Chem. 351:342-348(1970) [PubMed] [Europe PMC] [Abstract]
Cited for: HEME-BINDING.
[6]"The structure of oxy-erythrocruorin at 1.4-A resolution."
Weber E., Steigemann W., Jones T.A., Huber R.
J. Mol. Biol. 120:327-336(1978) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS).
[7]"The atomic structure of erythrocruorin in the light of the chemical sequence and its comparison with myoglobin."
Huber R., Epp O., Steigemann W., Formanek H.
Eur. J. Biochem. 19:42-50(1971) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M17600 Genomic DNA. Translation: AAA28249.1.
M17601 Genomic DNA. Translation: AAA28250.1.
M17691 Genomic DNA. Translation: AAA28254.1.
M17692 Genomic DNA. Translation: AAA28255.1.
Y10622 Genomic DNA. Translation: CAA71640.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1ECAX-ray1.40A16-151[»]
1ECDX-ray1.40A16-151[»]
1ECNX-ray1.40A16-151[»]
1ECOX-ray1.40A16-151[»]
ProteinModelPortalP02229.
SMRP02229. Positions 16-151.
ModBaseSearch...

Protein family/group databases

Allergome201. Chi t 1.
202. Chi t 1.0101.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.490.10. 1 hit.
InterProIPR002336. Erythrocruorin.
IPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
[Graphical view]
PfamPF00042. Globin. 1 hit.
[Graphical view]
PRINTSPR00611. ERYTHCRUORIN.
SUPFAMSSF46458. Globin_like. 1 hit.
PROSITEPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP02229.

Entry information

Entry nameGLB3_CHITH
AccessionPrimary (citable) accession number: P02229
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: October 1, 1989
Last modified: April 3, 2013
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents