P02227 (GLB8_CHITH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Globin CTT-VIII

Gene names

Name:

CTT-8

Organism

Chironomus thummi thummi (Midge)

Taxonomic identifier

7155 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicimorpha › Chironomoidea › Chironomidae › Chironominae › Chironomini › Chironomus › Chironomus › Chironomus thummi

Protein attributes

Sequence length	151 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Homodimer.
Miscellaneous	There are at least 12 different components in Midge globin.
Sequence similarities	Belongs to the globin family.

Ontologies

Keywords
Biological process	Oxygen transport Transport
Ligand	Heme Iron Metal-binding
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: InterPro hemoglobin complex Inferred from electronic annotation. Source: InterPro
Molecular_function	heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro oxygen binding Inferred from electronic annotation. Source: InterPro oxygen transporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 151	151	Globin CTT-VIII		PRO_0000052469
Sites
	Metal binding	62	1	Iron (heme distal ligand) By similarity
	Metal binding	97	1	Iron (heme proximal ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	P02227 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 3BAFD45225E51B59	FASTA	151	16,898
	10 20 30 40 50 60 AVTPMSADQL ALFKSSWNTV KHNEVDILYA VFKANPDIQA KFPQFAGKDL DSIKDSADFA 70 80 90 100 110 120 VHSGRIVGFF SEVIGLIGNP ENRPALKTLI DGLASSHKAR GIEKAQFEEF RASLVDYLSH 130 140 150 HLDWNDTMKS TWDLALNNMF FYILHALEVA Q

References

[1]	"Hemoglobins, XXXIX. Amino acid sequence of a dimeric hemoglobin (erythrocruorin) from Chironomus thummi thummi: component CTT VIII." Aschauer H., Braunitzer G. Hoppe-Seyler's Z. Physiol. Chem. 362:409-420(1981) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases
PIR	GGICEH. A02549.
3D structure databases
ProteinModelPortal	P02227.
ModBase	Search...
Protein family/group databases
Allergome	207. Chi t 3. 3196. Chi t 3.0901.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.10.490.10. 1 hit.
InterPro	IPR002336. Erythrocruorin. IPR000971. Globin. IPR009050. Globin-like. IPR012292. Globin_dom. [Graphical view]
Pfam	PF00042. Globin. 1 hit. [Graphical view]
PRINTS	PR00611. ERYTHCRUORIN.
SUPFAM	SSF46458. Globin_like. 1 hit.
PROSITE	PS01033. GLOBIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLB8_CHITH

Accession

Primary (citable) accession number: P02227

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	April 3, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)