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P02221

- GLB1_CHITH

UniProt

P02221 - GLB1_CHITH

Protein

Globin CTT-I/CTT-IA

Gene

CTT-1

Organism
Chironomus thummi thummi (Midge)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi74 – 741Iron (heme distal ligand)PROSITE-ProRule annotation
    Metal bindingi109 – 1091Iron (heme proximal ligand)PROSITE-ProRule annotation

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. oxygen binding Source: InterPro
    4. oxygen transporter activity Source: UniProtKB-KW

    Keywords - Biological processi

    Oxygen transport, Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Globin CTT-I/CTT-IA
    Alternative name(s):
    Erythrocruorin
    Gene namesi
    Name:CTT-1
    OrganismiChironomus thummi thummi (Midge)
    Taxonomic identifieri7155 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraChironomoideaChironomidaeChironominaeChironomus

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: InterPro
    2. hemoglobin complex Source: InterPro

    Pathology & Biotechi

    Protein family/group databases

    Allergomei1650. Chi t 2.
    205. Chi t 2.0101.
    206. Chi t 2.0102.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 15152 PublicationsAdd
    BLAST
    Chaini16 – 158143Globin CTT-I/CTT-IAPRO_0000011188Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.

    Structurei

    3D structure databases

    ProteinModelPortaliP02221.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the globin family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Family and domain databases

    Gene3Di1.10.490.10. 1 hit.
    InterProiIPR002336. Erythrocruorin.
    IPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    [Graphical view]
    PfamiPF00042. Globin. 1 hit.
    [Graphical view]
    PRINTSiPR00611. ERYTHCRUORIN.
    SUPFAMiSSF46458. SSF46458. 1 hit.
    PROSITEiPS01033. GLOBIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P02221-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKFLILALCV AAAMAGPSGD QIAAAKASWN TVKNNQVDIL YAVFKANPDI    50
    QTAFSQFAGK DLDSIKGTPD FSKHAGRVVG LFSEVMDLLG NDANTPTILA 100
    KAKDFGKSHK SRASPAQLDN FRKSLVVYLK GATKWDSAVE SSWAPVLDFV 150
    FSTLKNEL 158
    Length:158
    Mass (Da):17,012
    Last modified:November 1, 1997 - v2
    Checksum:i9639E8A38908B8AB
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti113 – 1131A → T in CTT-IA.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U14627 Genomic DNA. Translation: AAA80189.1.
    U14628 Genomic DNA. Translation: AAA80190.1.
    U14629 Genomic DNA. Translation: AAA80191.1.
    M57410 mRNA. Translation: AAA62727.1.
    PIRiA91690. GGICE1.
    A91719. GGIC1A.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U14627 Genomic DNA. Translation: AAA80189.1 .
    U14628 Genomic DNA. Translation: AAA80190.1 .
    U14629 Genomic DNA. Translation: AAA80191.1 .
    M57410 mRNA. Translation: AAA62727.1 .
    PIRi A91690. GGICE1.
    A91719. GGIC1A.

    3D structure databases

    ProteinModelPortali P02221.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 1650. Chi t 2.
    205. Chi t 2.0101.
    206. Chi t 2.0102.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.490.10. 1 hit.
    InterProi IPR002336. Erythrocruorin.
    IPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    [Graphical view ]
    Pfami PF00042. Globin. 1 hit.
    [Graphical view ]
    PRINTSi PR00611. ERYTHCRUORIN.
    SUPFAMi SSF46458. SSF46458. 1 hit.
    PROSITEi PS01033. GLOBIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and evolution of the gene for the monomeric globin I and its linkage to genes coding for dimeric globins in the insect Chironomus thummi."
      Kao W.-Y., Hankeln T., Schmidt E.R., Bergtrom G.
      J. Mol. Evol. 40:354-361(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (CTT-I).
    2. "Hemoglobin, XXXI. Analysis or the primary structure of the monomeric hemoglobin CTT I (erythrocruorin) of Chironomus thummi thummi, Diptera."
      Kleinschmidt T., von der Mark-Neuwirth H., Braunitzer G.
      Hoppe-Seyler's Z. Physiol. Chem. 361:401-411(1980) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 16-158 (CTT-I).
    3. "The analysis of a protein-polymorphism. Evolution of monomeric and homodimeric haemoglobins (erythrocruorins) of Chironomus thummi thummi (Insecta, Diptera)."
      Goodman M., Braunitzer G., Kleinschmidt T., Aschauer H.
      Hoppe-Seyler's Z. Physiol. Chem. 364:205-217(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 16-158 (CTT-IA).
    4. "Differential regulation of insect globin and actin mRNAs during larval development in Chironomus thummi."
      Saffarini D.A., Trewitt P.M., Luhm R.A., Bergtrom G.
      Gene 101:215-222(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 83-158 (CTT-IA).

    Entry informationi

    Entry nameiGLB1_CHITH
    AccessioniPrimary (citable) accession number: P02221
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 77 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Miscellaneous

    There are at least 12 different components in Midge globin.

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3