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P02221

- GLB1_CHITH

UniProt

P02221 - GLB1_CHITH

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Protein

Globin CTT-I/CTT-IA

Gene

CTT-1

Organism
Chironomus thummi thummi (Midge)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi74 – 741Iron (heme distal ligand)PROSITE-ProRule annotation
Metal bindingi109 – 1091Iron (heme proximal ligand)PROSITE-ProRule annotation

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. oxygen binding Source: InterPro
  4. oxygen transporter activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Globin CTT-I/CTT-IA
Alternative name(s):
Erythrocruorin
Gene namesi
Name:CTT-1
OrganismiChironomus thummi thummi (Midge)
Taxonomic identifieri7155 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraChironomoideaChironomidaeChironominaeChironomus

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: InterPro
  2. hemoglobin complex Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Protein family/group databases

Allergomei1650. Chi t 2.
205. Chi t 2.0101.
206. Chi t 2.0102.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 15152 PublicationsAdd
BLAST
Chaini16 – 158143Globin CTT-I/CTT-IAPRO_0000011188Add
BLAST

Interactioni

Subunit structurei

Monomer.

Structurei

3D structure databases

ProteinModelPortaliP02221.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR002336. Erythrocruorin.
IPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00611. ERYTHCRUORIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02221-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKFLILALCV AAAMAGPSGD QIAAAKASWN TVKNNQVDIL YAVFKANPDI
60 70 80 90 100
QTAFSQFAGK DLDSIKGTPD FSKHAGRVVG LFSEVMDLLG NDANTPTILA
110 120 130 140 150
KAKDFGKSHK SRASPAQLDN FRKSLVVYLK GATKWDSAVE SSWAPVLDFV

FSTLKNEL
Length:158
Mass (Da):17,012
Last modified:November 1, 1997 - v2
Checksum:i9639E8A38908B8AB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti113 – 1131A → T in CTT-IA.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U14627 Genomic DNA. Translation: AAA80189.1.
U14628 Genomic DNA. Translation: AAA80190.1.
U14629 Genomic DNA. Translation: AAA80191.1.
M57410 mRNA. Translation: AAA62727.1.
PIRiA91690. GGICE1.
A91719. GGIC1A.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U14627 Genomic DNA. Translation: AAA80189.1 .
U14628 Genomic DNA. Translation: AAA80190.1 .
U14629 Genomic DNA. Translation: AAA80191.1 .
M57410 mRNA. Translation: AAA62727.1 .
PIRi A91690. GGICE1.
A91719. GGIC1A.

3D structure databases

ProteinModelPortali P02221.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 1650. Chi t 2.
205. Chi t 2.0101.
206. Chi t 2.0102.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.490.10. 1 hit.
InterProi IPR002336. Erythrocruorin.
IPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
[Graphical view ]
Pfami PF00042. Globin. 1 hit.
[Graphical view ]
PRINTSi PR00611. ERYTHCRUORIN.
SUPFAMi SSF46458. SSF46458. 1 hit.
PROSITEi PS01033. GLOBIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence and evolution of the gene for the monomeric globin I and its linkage to genes coding for dimeric globins in the insect Chironomus thummi."
    Kao W.-Y., Hankeln T., Schmidt E.R., Bergtrom G.
    J. Mol. Evol. 40:354-361(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (CTT-I).
  2. "Hemoglobin, XXXI. Analysis or the primary structure of the monomeric hemoglobin CTT I (erythrocruorin) of Chironomus thummi thummi, Diptera."
    Kleinschmidt T., von der Mark-Neuwirth H., Braunitzer G.
    Hoppe-Seyler's Z. Physiol. Chem. 361:401-411(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 16-158 (CTT-I).
  3. "The analysis of a protein-polymorphism. Evolution of monomeric and homodimeric haemoglobins (erythrocruorins) of Chironomus thummi thummi (Insecta, Diptera)."
    Goodman M., Braunitzer G., Kleinschmidt T., Aschauer H.
    Hoppe-Seyler's Z. Physiol. Chem. 364:205-217(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 16-158 (CTT-IA).
  4. "Differential regulation of insect globin and actin mRNAs during larval development in Chironomus thummi."
    Saffarini D.A., Trewitt P.M., Luhm R.A., Bergtrom G.
    Gene 101:215-222(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 83-158 (CTT-IA).

Entry informationi

Entry nameiGLB1_CHITH
AccessioniPrimary (citable) accession number: P02221
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1997
Last modified: October 1, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Miscellaneous

There are at least 12 different components in Midge globin.

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3