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P02221 (GLB1_CHITH) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Globin CTT-I/CTT-IA
Alternative name(s):
Erythrocruorin
Gene names
Name:CTT-1
OrganismChironomus thummi thummi (Midge)
Taxonomic identifier7155 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraChironomoideaChironomidaeChironominaeChironomus

Protein attributes

Sequence length158 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Monomer.

Miscellaneous

There are at least 12 different components in Midge globin.

Sequence similarities

Belongs to the globin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515 Ref.2 Ref.3
Chain16 – 158143Globin CTT-I/CTT-IA
PRO_0000011188

Sites

Metal binding741Iron (heme distal ligand) By similarity
Metal binding1091Iron (heme proximal ligand) By similarity

Natural variations

Natural variant1131A → T in CTT-IA.

Sequences

Sequence LengthMass (Da)Tools
P02221 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: 9639E8A38908B8AB

FASTA15817,012
        10         20         30         40         50         60 
MKFLILALCV AAAMAGPSGD QIAAAKASWN TVKNNQVDIL YAVFKANPDI QTAFSQFAGK 

        70         80         90        100        110        120 
DLDSIKGTPD FSKHAGRVVG LFSEVMDLLG NDANTPTILA KAKDFGKSHK SRASPAQLDN 

       130        140        150 
FRKSLVVYLK GATKWDSAVE SSWAPVLDFV FSTLKNEL 

« Hide

References

[1]"Sequence and evolution of the gene for the monomeric globin I and its linkage to genes coding for dimeric globins in the insect Chironomus thummi."
Kao W.-Y., Hankeln T., Schmidt E.R., Bergtrom G.
J. Mol. Evol. 40:354-361(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (CTT-I).
[2]"Hemoglobin, XXXI. Analysis or the primary structure of the monomeric hemoglobin CTT I (erythrocruorin) of Chironomus thummi thummi, Diptera."
Kleinschmidt T., von der Mark-Neuwirth H., Braunitzer G.
Hoppe-Seyler's Z. Physiol. Chem. 361:401-411(1980) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 16-158 (CTT-I).
[3]"The analysis of a protein-polymorphism. Evolution of monomeric and homodimeric haemoglobins (erythrocruorins) of Chironomus thummi thummi (Insecta, Diptera)."
Goodman M., Braunitzer G., Kleinschmidt T., Aschauer H.
Hoppe-Seyler's Z. Physiol. Chem. 364:205-217(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 16-158 (CTT-IA).
[4]"Differential regulation of insect globin and actin mRNAs during larval development in Chironomus thummi."
Saffarini D.A., Trewitt P.M., Luhm R.A., Bergtrom G.
Gene 101:215-222(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 83-158 (CTT-IA).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U14627 Genomic DNA. Translation: AAA80189.1.
U14628 Genomic DNA. Translation: AAA80190.1.
U14629 Genomic DNA. Translation: AAA80191.1.
M57410 mRNA. Translation: AAA62727.1.
PIRGGICE1. A91690.
GGIC1A. A91719.

3D structure databases

ProteinModelPortalP02221.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome1650. Chi t 2.
205. Chi t 2.0101.
206. Chi t 2.0102.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.490.10. 1 hit.
InterProIPR002336. Erythrocruorin.
IPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
[Graphical view]
PfamPF00042. Globin. 1 hit.
[Graphical view]
PRINTSPR00611. ERYTHCRUORIN.
SUPFAMSSF46458. SSF46458. 1 hit.
PROSITEPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLB1_CHITH
AccessionPrimary (citable) accession number: P02221
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: November 1, 1997
Last modified: October 16, 2013
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families