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Protein

Extracellular globin-2

Gene
N/A
Organism
Lumbricus terrestris (Common earthworm)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi96 – 961Iron (heme proximal ligand)

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Extracellular globin-2
Alternative name(s):
Erythrocruorin
Globin AIII
Globin B
Globin II
OrganismiLumbricus terrestris (Common earthworm)
Taxonomic identifieri6398 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaAnnelidaClitellataOligochaetaHaplotaxidaLumbricinaLumbricidaeLumbricinaeLumbricus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 145145Extracellular globin-2PRO_0000052512Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi4 ↔ 133By similarity
Disulfide bondi124 – 124Interchain (with chain IV)By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

The extracellular hemoglobin of the earthworm consists of 12 subunits that have a hexagonal bilayer structure with a molecular weight near 3.8 million. Each one-twelfth subunit is composed primarily of disulfide linked trimers (chains A, B, and C) and monomers (chain D).1 Publication

Protein-protein interaction databases

DIPiDIP-29123N.

Structurei

Secondary structure

1
145
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 2015Combined sources
Helixi23 – 4018Combined sources
Helixi42 – 5110Combined sources
Turni52 – 543Combined sources
Helixi59 – 7719Combined sources
Turni78 – 803Combined sources
Helixi82 – 9615Combined sources
Helixi103 – 12119Combined sources
Helixi127 – 14216Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X9FX-ray2.60B/F/J1-145[»]
2GTLX-ray3.50B/F/J1-145[»]
4V93electron microscopy8.10A4/AB/AG/AL/AQ/AV/Aa/Af/Ak/Ap/Au/Az/B2/B3/B7/BA/BE/BF/BJ/BK/BO/BP/BT/BU/BY/BZ/Bd/Be/Bi/Bj/Bn/Bo/Bs/Bt/Bx/By1-145[»]
ProteinModelPortaliP02218.
SMRiP02218. Positions 1-145.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02218.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR002336. Erythrocruorin.
IPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR014610. Haemoglobin_extracell.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PIRSFiPIRSF036517. Ext_hemo. 1 hit.
PRINTSiPR00611. ERYTHCRUORIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P02218-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
KKQCGVLEGL KVKSEWGRAY GSGHDREAFS QAIWRATFAQ VPESRSLFKR
60 70 80 90 100
VHGDDTSHPA FIAHAERVLG GLDIAISTLD QPATLKEELD HLQVQHEGRK
110 120 130 140
IPDNYFDAFK TAILHVVAAQ LGRCYDREAW DACIDHIEDG IKGHH
Length:145
Mass (Da):16,254
Last modified:January 1, 1990 - v2
Checksum:i5F62E08A11AA52A6
GO

Sequence databases

PIRiA02540. GGEWA3.
B28151.

Cross-referencesi

Sequence databases

PIRiA02540. GGEWA3.
B28151.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1X9FX-ray2.60B/F/J1-145[»]
2GTLX-ray3.50B/F/J1-145[»]
4V93electron microscopy8.10A4/AB/AG/AL/AQ/AV/Aa/Af/Ak/Ap/Au/Az/B2/B3/B7/BA/BE/BF/BJ/BK/BO/BP/BT/BU/BY/BZ/Bd/Be/Bi/Bj/Bn/Bo/Bs/Bt/Bx/By1-145[»]
ProteinModelPortaliP02218.
SMRiP02218. Positions 1-145.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-29123N.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP02218.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR002336. Erythrocruorin.
IPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR014610. Haemoglobin_extracell.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PIRSFiPIRSF036517. Ext_hemo. 1 hit.
PRINTSiPR00611. ERYTHCRUORIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLB2_LUMTE
AccessioniPrimary (citable) accession number: P02218
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 1, 1990
Last modified: October 14, 2015
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.