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Protein

Globin

Gene
N/A
Organism
Aplysia limacina (Sea hare)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

This molluscan globin lacks one of the heme-binding histidine residues found in most other globins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi96Iron (heme proximal ligand)1

GO - Molecular functioni

Keywordsi

Molecular functionMuscle protein
Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Globin
Alternative name(s):
Myoglobin
OrganismiAplysia limacina (Sea hare)
Taxonomic identifieri6502 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaHeterobranchiaEuthyneuraEuopisthobranchiaAplysiomorphaAplysioideaAplysiidaeAplysia

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000524732 – 147GlobinAdd BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1

Keywords - PTMi

Acetylation

PTM databases

iPTMnetiP02210

Interactioni

Subunit structurei

Monomer.

Structurei

Secondary structure

1147
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 20Combined sources16
Helixi22 – 36Combined sources15
Helixi38 – 43Combined sources6
Turni45 – 49Combined sources5
Helixi52 – 56Combined sources5
Helixi61 – 78Combined sources18
Helixi82 – 98Combined sources17
Helixi103 – 118Combined sources16
Helixi127 – 144Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DM1X-ray1.99A2-147[»]
1MBAX-ray1.60A2-146[»]
2FALX-ray1.80A2-146[»]
2FAMX-ray2.00A2-147[»]
3MBAX-ray2.00A2-146[»]
4MBAX-ray2.00A2-146[»]
5MBAX-ray1.90A2-146[»]
ProteinModelPortaliP02210
SMRiP02210
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02210

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Family and domain databases

Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR002336 Erythrocruorin
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00611 ERYTHCRUORIN
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02210-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSAAEADL AGKSWAPVFA NKDANGDAFL VALFEKFPDS ANFFADFKGK
60 70 80 90 100
SVADIKASPK LRDVSSRIFT RLNEFVNNAA DAGKMSAMLS QFAKEHVGFG
110 120 130 140
VGSAQFENVR SMFPGFVASV AAPPAGADAA WTKLFGLIID ALKAAGK
Length:147
Mass (Da):15,456
Last modified:January 23, 2007 - v4
Checksum:i631C4959E1B7CC86
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23D → N AA sequence (PubMed:4759566).Curated1
Sequence conflicti27 – 28DA → LD AA sequence (PubMed:4759566).Curated2
Sequence conflicti78N → D AA sequence (PubMed:4759566).Curated1
Sequence conflicti81D → N AA sequence (PubMed:4759566).Curated1
Sequence conflicti130Missing AA sequence (PubMed:4759566).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79304 mRNA Translation: CAA55885.1
PIRiS64703 GGGAA

Similar proteinsi

Entry informationi

Entry nameiGLB_APLLI
AccessioniPrimary (citable) accession number: P02210
Secondary accession number(s): Q93114
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 103 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

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