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Protein

Globin-5

Gene
N/A
Organism
Petromyzon marinus (Sea lamprey)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi74 – 741Iron (heme distal ligand)PROSITE-ProRule annotation1 Publication
Metal bindingi106 – 1061Iron (heme proximal ligand)PROSITE-ProRule annotation1 Publication

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. oxygen binding Source: InterPro
  4. oxygen transporter activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Globin-5
Alternative name(s):
Hemoglobin V
OrganismiPetromyzon marinus (Sea lamprey)
Taxonomic identifieri7757 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataCyclostomataHyperoartiaPetromyzontiformesPetromyzontidaePetromyzon

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 150149Globin-5PRO_0000052529Add
BLAST

Interactioni

Subunit structurei

Monomer at high oxygen tension and high pH and dimeric at low oxygen tension and lower pH.

Structurei

Secondary structure

1
150
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi14 – 2916Combined sources
Helixi31 – 4515Combined sources
Helixi47 – 526Combined sources
Helixi54 – 563Combined sources
Helixi62 – 676Combined sources
Helixi69 – 8719Combined sources
Turni88 – 903Combined sources
Helixi92 – 10817Combined sources
Helixi114 – 1163Combined sources
Helixi117 – 12913Combined sources
Helixi133 – 14715Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1F5OX-ray2.90A/B/C/D/E/F2-150[»]
1F5PX-ray2.90A/B/C/D/E/F2-150[»]
2LHBX-ray2.00A2-150[»]
3LHBX-ray2.70A/B/C/D/E/F/G/H/I/J/K/L2-150[»]
SMRiP02208. Positions 2-150.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02208.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00730000110844.
HOVERGENiHBG098500.
OrthoDBiEOG7BZVVB.
TreeFamiTF332967.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR013314. Globin_lamprey/hagfish.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR01906. FISHGLOBIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02208-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIVDTGSVA PLSAAEKTKI RSAWAPVYST YETSGVDILV KFFTSTPAAQ
60 70 80 90 100
EFFPKFKGLT TADQLKKSAD VRWHAERIIN AVNDAVASMD DTEKMSMKLR
110 120 130 140 150
DLSGKHAKSF QVDPQYFKVL AAVIADTVAA GDAGFEKLMS MICILLRSAY
Length:150
Mass (Da):16,401
Last modified:January 23, 2007 - v2
Checksum:i39BE05B24670A88A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti96 – 961S → SS (PubMed:4692855).Curated
Sequence conflicti99 – 1002Missing AA sequence (PubMed:5484471).Curated
Sequence conflicti99 – 1002Missing (PubMed:4692855).Curated
Sequence conflicti101 – 1011D → N AA sequence (PubMed:5484471).Curated
Sequence conflicti139 – 1391M → R AA sequence (PubMed:5484471).Curated
Sequence conflicti139 – 1391M → R (PubMed:4692855).Curated
Sequence conflicti140 – 1401Missing AA sequence (PubMed:5484471).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti30 – 301T → N.

Sequence databases

PIRiA90676. GGLMS.

Genome annotation databases

EnsembliENSPMAT00000005918; ENSPMAP00000005891; ENSPMAG00000005343.
ENSPMAT00000005931; ENSPMAP00000005904; ENSPMAG00000005354.

Cross-referencesi

Sequence databases

PIRiA90676. GGLMS.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1F5OX-ray2.90A/B/C/D/E/F2-150[»]
1F5PX-ray2.90A/B/C/D/E/F2-150[»]
2LHBX-ray2.00A2-150[»]
3LHBX-ray2.70A/B/C/D/E/F/G/H/I/J/K/L2-150[»]
SMRiP02208. Positions 2-150.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPMAT00000005918; ENSPMAP00000005891; ENSPMAG00000005343.
ENSPMAT00000005931; ENSPMAP00000005904; ENSPMAG00000005354.

Phylogenomic databases

GeneTreeiENSGT00730000110844.
HOVERGENiHBG098500.
OrthoDBiEOG7BZVVB.
TreeFamiTF332967.

Miscellaneous databases

EvolutionaryTraceiP02208.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR013314. Globin_lamprey/hagfish.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR01906. FISHGLOBIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Haemoglobins, LX. Primary structure of the major haemoglobin of the sea lamprey Petromyzon marinus (var. Garonne, Loire)."
    Hombrados I., Rodewald K., Neuzil E., Braunitzer G.
    Biochimie 65:247-257(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-150.
  2. "The amino acid sequence of hemoglobin V from the lamprey, Petromyzon marinus."
    Li S.L., Riggs A.
    J. Biol. Chem. 245:6149-6169(1969) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-150.
  3. "Crystal structure analysis of sea lamprey hemoglobin at 2-A resolution."
    Hendrickson W.A., Love W.E., Karle J.
    J. Mol. Biol. 74:331-361(1972) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
  4. "Refinement of a molecular model for lamprey hemoglobin from Petromyzon marinus."
    Honzatko R.B., Hendrickson W.A., Love W.E.
    J. Mol. Biol. 184:147-164(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
  5. "The 2.7-A crystal structure of deoxygenated hemoglobin from the sea lamprey (Petromyzon marinus): structural basis for a lowered oxygen affinity and Bohr effect."
    Heaslet H.A., Royer W.E. Jr.
    Structure 7:517-526(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).

Entry informationi

Entry nameiGLB5_PETMA
AccessioniPrimary (citable) accession number: P02208
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: April 1, 2015
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Globin V is the major component of the 6 globins found in the Sea lamprey.

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.