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P02208 (GLB5_PETMA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 93. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Globin-5
Alternative name(s):
Hemoglobin V
OrganismPetromyzon marinus (Sea lamprey)
Taxonomic identifier7757 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataCyclostomataHyperoartiaPetromyzontiformesPetromyzontidaePetromyzon

Protein attributes

Sequence length150 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Monomer at high oxygen tension and high pH and dimeric at low oxygen tension and lower pH.

Miscellaneous

Globin V is the major component of the 6 globins found in the Sea lamprey.

Sequence similarities

Belongs to the globin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 150149Globin-5
PRO_0000052529

Sites

Metal binding741Iron (heme distal ligand) Ref.4
Metal binding1061Iron (heme proximal ligand) Ref.4

Natural variations

Natural variant301T → N.

Experimental info

Sequence conflict961S → SS Ref.3
Sequence conflict99 – 1002Missing AA sequence Ref.2
Sequence conflict99 – 1002Missing Ref.3
Sequence conflict1011D → N AA sequence Ref.2
Sequence conflict1391M → R AA sequence Ref.2
Sequence conflict1391M → R Ref.3
Sequence conflict1401Missing AA sequence Ref.2

Secondary structure

..................... 150
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P02208 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 39BE05B24670A88A

FASTA15016,401
        10         20         30         40         50         60 
MPIVDTGSVA PLSAAEKTKI RSAWAPVYST YETSGVDILV KFFTSTPAAQ EFFPKFKGLT 

        70         80         90        100        110        120 
TADQLKKSAD VRWHAERIIN AVNDAVASMD DTEKMSMKLR DLSGKHAKSF QVDPQYFKVL 

       130        140        150 
AAVIADTVAA GDAGFEKLMS MICILLRSAY 

« Hide

References

[1]"Haemoglobins, LX. Primary structure of the major haemoglobin of the sea lamprey Petromyzon marinus (var. Garonne, Loire)."
Hombrados I., Rodewald K., Neuzil E., Braunitzer G.
Biochimie 65:247-257(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-150.
[2]"The amino acid sequence of hemoglobin V from the lamprey, Petromyzon marinus."
Li S.L., Riggs A.
J. Biol. Chem. 245:6149-6169(1970) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-150.
[3]"Crystal structure analysis of sea lamprey hemoglobin at 2-A resolution."
Hendrickson W.A., Love W.E., Karle J.
J. Mol. Biol. 74:331-361(1973) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
[4]"Refinement of a molecular model for lamprey hemoglobin from Petromyzon marinus."
Honzatko R.B., Hendrickson W.A., Love W.E.
J. Mol. Biol. 184:147-164(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
[5]"The 2.7-A crystal structure of deoxygenated hemoglobin from the sea lamprey (Petromyzon marinus): structural basis for a lowered oxygen affinity and Bohr effect."
Heaslet H.A., Royer W.E. Jr.
Structure 7:517-526(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

PIRGGLMS. A90676.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1F5OX-ray2.90A/B/C/D/E/F2-150[»]
1F5PX-ray2.90A/B/C/D/E/F2-150[»]
2LHBX-ray2.00A2-150[»]
3LHBX-ray2.70A/B/C/D/E/F/G/H/I/J/K/L2-150[»]
ProteinModelPortalP02208.
SMRP02208. Positions 2-150.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSPMAT00000005918; ENSPMAP00000005891; ENSPMAG00000005343.
ENSPMAT00000005931; ENSPMAP00000005904; ENSPMAG00000005354.

Phylogenomic databases

GeneTreeENSGT00730000110844.
HOVERGENHBG098500.
OrthoDBEOG7BZVVB.
TreeFamTF332967.

Family and domain databases

Gene3D1.10.490.10. 1 hit.
InterProIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR013314. Globin_lamprey/hagfish.
[Graphical view]
PfamPF00042. Globin. 1 hit.
[Graphical view]
PRINTSPR01906. FISHGLOBIN.
SUPFAMSSF46458. SSF46458. 1 hit.
PROSITEPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP02208.

Entry information

Entry nameGLB5_PETMA
AccessionPrimary (citable) accession number: P02208
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references