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P02208

- GLB5_PETMA

UniProt

P02208 - GLB5_PETMA

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Protein
Globin-5
Gene
N/A
Organism
Petromyzon marinus (Sea lamprey)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi74 – 741Iron (heme distal ligand)1 Publication
Metal bindingi106 – 1061Iron (heme proximal ligand)1 Publication

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. oxygen binding Source: InterPro
  4. oxygen transporter activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Biological processi

    Oxygen transport, Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Globin-5
    Alternative name(s):
    Hemoglobin V
    OrganismiPetromyzon marinus (Sea lamprey)
    Taxonomic identifieri7757 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataCyclostomataHyperoartiaPetromyzontiformesPetromyzontidaePetromyzon

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed By similarity
    Chaini2 – 150149Globin-5
    PRO_0000052529Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer at high oxygen tension and high pH and dimeric at low oxygen tension and lower pH.

    Structurei

    Secondary structure

    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi14 – 2916
    Helixi31 – 4515
    Helixi47 – 526
    Helixi54 – 563
    Helixi62 – 676
    Helixi69 – 8719
    Turni88 – 903
    Helixi92 – 10817
    Helixi114 – 1163
    Helixi117 – 12913
    Helixi133 – 14715

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1F5OX-ray2.90A/B/C/D/E/F2-150[»]
    1F5PX-ray2.90A/B/C/D/E/F2-150[»]
    2LHBX-ray2.00A2-150[»]
    3LHBX-ray2.70A/B/C/D/E/F/G/H/I/J/K/L2-150[»]
    ProteinModelPortaliP02208.
    SMRiP02208. Positions 2-150.

    Miscellaneous databases

    EvolutionaryTraceiP02208.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the globin family.

    Phylogenomic databases

    GeneTreeiENSGT00730000110844.
    HOVERGENiHBG098500.
    OrthoDBiEOG7BZVVB.
    TreeFamiTF332967.

    Family and domain databases

    Gene3Di1.10.490.10. 1 hit.
    InterProiIPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    IPR013314. Globin_lamprey/hagfish.
    [Graphical view]
    PfamiPF00042. Globin. 1 hit.
    [Graphical view]
    PRINTSiPR01906. FISHGLOBIN.
    SUPFAMiSSF46458. SSF46458. 1 hit.
    PROSITEiPS01033. GLOBIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P02208-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPIVDTGSVA PLSAAEKTKI RSAWAPVYST YETSGVDILV KFFTSTPAAQ    50
    EFFPKFKGLT TADQLKKSAD VRWHAERIIN AVNDAVASMD DTEKMSMKLR 100
    DLSGKHAKSF QVDPQYFKVL AAVIADTVAA GDAGFEKLMS MICILLRSAY 150
    Length:150
    Mass (Da):16,401
    Last modified:January 23, 2007 - v2
    Checksum:i39BE05B24670A88A
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti30 – 301T → N.

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti96 – 961S → SS1 Publication
    Sequence conflicti99 – 1002Missing AA sequence 1 Publication
    Sequence conflicti99 – 1002Missing1 Publication
    Sequence conflicti101 – 1011D → N AA sequence 1 Publication
    Sequence conflicti139 – 1391M → R AA sequence 1 Publication
    Sequence conflicti139 – 1391M → R1 Publication
    Sequence conflicti140 – 1401Missing AA sequence 1 Publication

    Sequence databases

    PIRiA90676. GGLMS.

    Genome annotation databases

    EnsembliENSPMAT00000005918; ENSPMAP00000005891; ENSPMAG00000005343.
    ENSPMAT00000005931; ENSPMAP00000005904; ENSPMAG00000005354.

    Cross-referencesi

    Sequence databases

    PIRi A90676. GGLMS.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1F5O X-ray 2.90 A/B/C/D/E/F 2-150 [» ]
    1F5P X-ray 2.90 A/B/C/D/E/F 2-150 [» ]
    2LHB X-ray 2.00 A 2-150 [» ]
    3LHB X-ray 2.70 A/B/C/D/E/F/G/H/I/J/K/L 2-150 [» ]
    ProteinModelPortali P02208.
    SMRi P02208. Positions 2-150.
    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSPMAT00000005918 ; ENSPMAP00000005891 ; ENSPMAG00000005343 .
    ENSPMAT00000005931 ; ENSPMAP00000005904 ; ENSPMAG00000005354 .

    Phylogenomic databases

    GeneTreei ENSGT00730000110844.
    HOVERGENi HBG098500.
    OrthoDBi EOG7BZVVB.
    TreeFami TF332967.

    Miscellaneous databases

    EvolutionaryTracei P02208.

    Family and domain databases

    Gene3Di 1.10.490.10. 1 hit.
    InterProi IPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    IPR013314. Globin_lamprey/hagfish.
    [Graphical view ]
    Pfami PF00042. Globin. 1 hit.
    [Graphical view ]
    PRINTSi PR01906. FISHGLOBIN.
    SUPFAMi SSF46458. SSF46458. 1 hit.
    PROSITEi PS01033. GLOBIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Haemoglobins, LX. Primary structure of the major haemoglobin of the sea lamprey Petromyzon marinus (var. Garonne, Loire)."
      Hombrados I., Rodewald K., Neuzil E., Braunitzer G.
      Biochimie 65:247-257(1983) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-150.
    2. "The amino acid sequence of hemoglobin V from the lamprey, Petromyzon marinus."
      Li S.L., Riggs A.
      J. Biol. Chem. 245:6149-6169(1970) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-150.
    3. "Crystal structure analysis of sea lamprey hemoglobin at 2-A resolution."
      Hendrickson W.A., Love W.E., Karle J.
      J. Mol. Biol. 74:331-361(1973) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
    4. "Refinement of a molecular model for lamprey hemoglobin from Petromyzon marinus."
      Honzatko R.B., Hendrickson W.A., Love W.E.
      J. Mol. Biol. 184:147-164(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
    5. "The 2.7-A crystal structure of deoxygenated hemoglobin from the sea lamprey (Petromyzon marinus): structural basis for a lowered oxygen affinity and Bohr effect."
      Heaslet H.A., Royer W.E. Jr.
      Structure 7:517-526(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).

    Entry informationi

    Entry nameiGLB5_PETMA
    AccessioniPrimary (citable) accession number: P02208
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: January 23, 2007
    Last modified: June 11, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Globin V is the major component of the 6 globins found in the Sea lamprey.

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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