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Protein

Globin-5

Gene
N/A
Organism
Petromyzon marinus (Sea lamprey)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Globin V is the major component of the 6 globins found in the Sea lamprey.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi74Iron (heme distal ligand)PROSITE-ProRule annotation1 Publication1
Metal bindingi106Iron (heme proximal ligand)PROSITE-ProRule annotation1 Publication1

GO - Molecular functioni

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Globin-5
Alternative name(s):
Hemoglobin V
OrganismiPetromyzon marinus (Sea lamprey)
Taxonomic identifieri7757 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataCyclostomataHyperoartiaPetromyzontiformesPetromyzontidaePetromyzon

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000525292 – 150Globin-5Add BLAST149

Interactioni

Subunit structurei

Monomer at high oxygen tension and high pH and dimeric at low oxygen tension and lower pH.

Structurei

Secondary structure

1150
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi14 – 29Combined sources16
Helixi31 – 45Combined sources15
Helixi47 – 52Combined sources6
Helixi54 – 56Combined sources3
Helixi62 – 67Combined sources6
Helixi69 – 87Combined sources19
Turni88 – 90Combined sources3
Helixi92 – 108Combined sources17
Helixi114 – 116Combined sources3
Helixi117 – 129Combined sources13
Helixi133 – 147Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F5OX-ray2.90A/B/C/D/E/F2-150[»]
1F5PX-ray2.90A/B/C/D/E/F2-150[»]
2LHBX-ray2.00A2-150[»]
3LHBX-ray2.70A/B/C/D/E/F/G/H/I/J/K/L2-150[»]
ProteinModelPortaliP02208
SMRiP02208
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02208

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378 Eukaryota
COG1018 LUCA
GeneTreeiENSGT00730000110844
HOVERGENiHBG098500
OrthoDBiEOG091G0PLX
TreeFamiTF332967

Family and domain databases

Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR013314 Globin_lamprey/hagfish
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR01906 FISHGLOBIN
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02208-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIVDTGSVA PLSAAEKTKI RSAWAPVYST YETSGVDILV KFFTSTPAAQ
60 70 80 90 100
EFFPKFKGLT TADQLKKSAD VRWHAERIIN AVNDAVASMD DTEKMSMKLR
110 120 130 140 150
DLSGKHAKSF QVDPQYFKVL AAVIADTVAA GDAGFEKLMS MICILLRSAY
Length:150
Mass (Da):16,401
Last modified:January 23, 2007 - v2
Checksum:i39BE05B24670A88A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96S → SS (PubMed:4692855).Curated1
Sequence conflicti99 – 100Missing AA sequence (PubMed:5484471).Curated2
Sequence conflicti99 – 100Missing (PubMed:4692855).Curated2
Sequence conflicti101D → N AA sequence (PubMed:5484471).Curated1
Sequence conflicti139M → R AA sequence (PubMed:5484471).Curated1
Sequence conflicti139M → R (PubMed:4692855).Curated1
Sequence conflicti140Missing AA sequence (PubMed:5484471).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti30T → N. 1

Sequence databases

PIRiA90676 GGLMS

Genome annotation databases

EnsembliENSPMAT00000005918; ENSPMAP00000005891; ENSPMAG00000005343
ENSPMAT00000005931; ENSPMAP00000005904; ENSPMAG00000005354

Similar proteinsi

Entry informationi

Entry nameiGLB5_PETMA
AccessioniPrimary (citable) accession number: P02208
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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