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Protein

Globin-5

Gene
N/A
Organism
Petromyzon marinus (Sea lamprey)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi74Iron (heme distal ligand)PROSITE-ProRule annotation1 Publication1
Metal bindingi106Iron (heme proximal ligand)PROSITE-ProRule annotation1 Publication1

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Globin-5
Alternative name(s):
Hemoglobin V
OrganismiPetromyzon marinus (Sea lamprey)
Taxonomic identifieri7757 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataCyclostomataHyperoartiaPetromyzontiformesPetromyzontidaePetromyzon

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000525292 – 150Globin-5Add BLAST149

Interactioni

Subunit structurei

Monomer at high oxygen tension and high pH and dimeric at low oxygen tension and lower pH.

Protein-protein interaction databases

STRINGi7757.ENSPMAP00000005904.

Structurei

Secondary structure

1150
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi14 – 29Combined sources16
Helixi31 – 45Combined sources15
Helixi47 – 52Combined sources6
Helixi54 – 56Combined sources3
Helixi62 – 67Combined sources6
Helixi69 – 87Combined sources19
Turni88 – 90Combined sources3
Helixi92 – 108Combined sources17
Helixi114 – 116Combined sources3
Helixi117 – 129Combined sources13
Helixi133 – 147Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F5OX-ray2.90A/B/C/D/E/F2-150[»]
1F5PX-ray2.90A/B/C/D/E/F2-150[»]
2LHBX-ray2.00A2-150[»]
3LHBX-ray2.70A/B/C/D/E/F/G/H/I/J/K/L2-150[»]
ProteinModelPortaliP02208.
SMRiP02208.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02208.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
GeneTreeiENSGT00730000110844.
HOVERGENiHBG098500.
OrthoDBiEOG091G0PLX.
TreeFamiTF332967.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR013314. Globin_lamprey/hagfish.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR01906. FISHGLOBIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02208-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPIVDTGSVA PLSAAEKTKI RSAWAPVYST YETSGVDILV KFFTSTPAAQ
60 70 80 90 100
EFFPKFKGLT TADQLKKSAD VRWHAERIIN AVNDAVASMD DTEKMSMKLR
110 120 130 140 150
DLSGKHAKSF QVDPQYFKVL AAVIADTVAA GDAGFEKLMS MICILLRSAY
Length:150
Mass (Da):16,401
Last modified:January 23, 2007 - v2
Checksum:i39BE05B24670A88A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti96S → SS (PubMed:4692855).Curated1
Sequence conflicti99 – 100Missing AA sequence (PubMed:5484471).Curated2
Sequence conflicti99 – 100Missing (PubMed:4692855).Curated2
Sequence conflicti101D → N AA sequence (PubMed:5484471).Curated1
Sequence conflicti139M → R AA sequence (PubMed:5484471).Curated1
Sequence conflicti139M → R (PubMed:4692855).Curated1
Sequence conflicti140Missing AA sequence (PubMed:5484471).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti30T → N.1

Sequence databases

PIRiA90676. GGLMS.

Genome annotation databases

EnsembliENSPMAT00000005918; ENSPMAP00000005891; ENSPMAG00000005343.
ENSPMAT00000005931; ENSPMAP00000005904; ENSPMAG00000005354.

Cross-referencesi

Sequence databases

PIRiA90676. GGLMS.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F5OX-ray2.90A/B/C/D/E/F2-150[»]
1F5PX-ray2.90A/B/C/D/E/F2-150[»]
2LHBX-ray2.00A2-150[»]
3LHBX-ray2.70A/B/C/D/E/F/G/H/I/J/K/L2-150[»]
ProteinModelPortaliP02208.
SMRiP02208.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7757.ENSPMAP00000005904.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSPMAT00000005918; ENSPMAP00000005891; ENSPMAG00000005343.
ENSPMAT00000005931; ENSPMAP00000005904; ENSPMAG00000005354.

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
GeneTreeiENSGT00730000110844.
HOVERGENiHBG098500.
OrthoDBiEOG091G0PLX.
TreeFamiTF332967.

Miscellaneous databases

EvolutionaryTraceiP02208.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR013314. Globin_lamprey/hagfish.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR01906. FISHGLOBIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGLB5_PETMA
AccessioniPrimary (citable) accession number: P02208
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Globin V is the major component of the 6 globins found in the Sea lamprey.

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.