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Protein

Myoglobin

Gene

MB

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi65Iron (heme distal ligand)1
Metal bindingi94Iron (heme proximal ligand)1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMuscle protein
Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-BTA-8981607 Intracellular oxygen transport

Names & Taxonomyi

Protein namesi
Recommended name:
Myoglobin
Gene namesi
Name:MB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Organism-specific databases

VGNCiVGNC:31270 MB

Pathology & Biotechi

Protein family/group databases

Allergomei1305 Bos d Myoglobin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000532802 – 154MyoglobinAdd BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphoserineBy similarity1
Modified residuei68PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP02192
PRIDEiP02192

PTM databases

CarbonylDBiP02192

Expressioni

Gene expression databases

BgeeiENSBTAG00000005333
ExpressionAtlasiP02192 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007014

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z2Hmodel-A1-154[»]
1Z2Smodel-A1-154[»]
ProteinModelPortaliP02192
SMRiP02192
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378 Eukaryota
COG1018 LUCA
GeneTreeiENSGT00730000110844
HOGENOMiHOG000070111
HOVERGENiHBG107340
InParanoidiP02192
KOiK21892
OMAiLFRNDIA
OrthoDBiEOG091G0OAO
TreeFamiTF332967

Family and domain databases

Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002335 Myoglobin
PANTHERiPTHR11442:SF5 PTHR11442:SF5, 1 hit
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00613 MYOGLOBIN
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02192-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLSDGEWQL VLNAWGKVEA DVAGHGQEVL IRLFTGHPET LEKFDKFKHL
60 70 80 90 100
KTEAEMKASE DLKKHGNTVL TALGGILKKK GHHEAEVKHL AESHANKHKI
110 120 130 140 150
PVKYLEFISD AIIHVLHAKH PSDFGADAQA AMSKALELFR NDMAAQYKVL

GFHG
Length:154
Mass (Da):17,078
Last modified:January 23, 2007 - v3
Checksum:iE74911B6C6851761
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6G → W in AAI02987 (Ref. 2) Curated1
Sequence conflicti10L → A AA sequence (PubMed:5477290).Curated1
Sequence conflicti100 – 102IPV → VIP AA sequence (PubMed:5477290).Curated3
Sequence conflicti123 – 125DFG → NFA AA sequence (PubMed:5477290).Curated3
Sequence conflicti143 – 146MAAQ → AAEK AA sequence (PubMed:5477290).Curated4

Mass spectrometryi

Molecular mass is 16949 Da from positions 2 - 154. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00409 mRNA Translation: BAA00311.1
BC102986 mRNA Translation: AAI02987.1
PIRiJX0068 MYBO
RefSeqiNP_776306.1, NM_173881.2
UniGeneiBt.107415

Genome annotation databases

EnsembliENSBTAT00000007014; ENSBTAP00000007014; ENSBTAG00000005333
GeneIDi280695
KEGGibta:280695

Similar proteinsi

Entry informationi

Entry nameiMYG_BOVIN
AccessioniPrimary (citable) accession number: P02192
Secondary accession number(s): Q3ZC11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 133 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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