Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Myoglobin

Gene

MB

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi65 – 651Iron (heme distal ligand)
Metal bindingi94 – 941Iron (heme proximal ligand)

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myoglobin
Gene namesi
Name:MB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Protein family/group databases

Allergomei1305. Bos d Myoglobin.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemoved1 Publication
Chaini2 – 154153MyoglobinPRO_0000053280Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei4 – 41PhosphoserineBy similarity
Modified residuei68 – 681PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP02192.
PRIDEiP02192.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007014.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Z2Hmodel-A1-154[»]
1Z2Smodel-A1-154[»]
ProteinModelPortaliP02192.
SMRiP02192. Positions 2-154.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
GeneTreeiENSGT00730000110844.
HOGENOMiHOG000070111.
HOVERGENiHBG107340.
InParanoidiP02192.
OMAiKKKGQHE.
OrthoDBiEOG7KSX9V.
TreeFamiTF332967.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002335. Myoglobin.
[Graphical view]
PANTHERiPTHR11442:SF5. PTHR11442:SF5. 1 hit.
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00613. MYOGLOBIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02192-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLSDGEWQL VLNAWGKVEA DVAGHGQEVL IRLFTGHPET LEKFDKFKHL
60 70 80 90 100
KTEAEMKASE DLKKHGNTVL TALGGILKKK GHHEAEVKHL AESHANKHKI
110 120 130 140 150
PVKYLEFISD AIIHVLHAKH PSDFGADAQA AMSKALELFR NDMAAQYKVL

GFHG
Length:154
Mass (Da):17,078
Last modified:January 23, 2007 - v3
Checksum:iE74911B6C6851761
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti6 – 61G → W in AAI02987 (Ref. 2) Curated
Sequence conflicti10 – 101L → A AA sequence (PubMed:5477290).Curated
Sequence conflicti100 – 1023IPV → VIP AA sequence (PubMed:5477290).Curated
Sequence conflicti123 – 1253DFG → NFA AA sequence (PubMed:5477290).Curated
Sequence conflicti143 – 1464MAAQ → AAEK AA sequence (PubMed:5477290).Curated

Mass spectrometryi

Molecular mass is 16949 Da from positions 2 - 154. Determined by MALDI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00409 mRNA. Translation: BAA00311.1.
BC102986 mRNA. Translation: AAI02987.1.
PIRiJX0068. MYBO.
RefSeqiNP_776306.1. NM_173881.2.
UniGeneiBt.107415.

Genome annotation databases

EnsembliENSBTAT00000007014; ENSBTAP00000007014; ENSBTAG00000005333.
GeneIDi280695.
KEGGibta:280695.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00409 mRNA. Translation: BAA00311.1.
BC102986 mRNA. Translation: AAI02987.1.
PIRiJX0068. MYBO.
RefSeqiNP_776306.1. NM_173881.2.
UniGeneiBt.107415.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1Z2Hmodel-A1-154[»]
1Z2Smodel-A1-154[»]
ProteinModelPortaliP02192.
SMRiP02192. Positions 2-154.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007014.

Protein family/group databases

Allergomei1305. Bos d Myoglobin.

Proteomic databases

PaxDbiP02192.
PRIDEiP02192.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000007014; ENSBTAP00000007014; ENSBTAG00000005333.
GeneIDi280695.
KEGGibta:280695.

Organism-specific databases

CTDi4151.

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
GeneTreeiENSGT00730000110844.
HOGENOMiHOG000070111.
HOVERGENiHBG107340.
InParanoidiP02192.
OMAiKKKGQHE.
OrthoDBiEOG7KSX9V.
TreeFamiTF332967.

Miscellaneous databases

NextBioi20804880.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002335. Myoglobin.
[Graphical view]
PANTHERiPTHR11442:SF5. PTHR11442:SF5. 1 hit.
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00613. MYOGLOBIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of bovine myoglobin cDNA as a functionally active holoprotein in Saccharomyces cerevisiae."
    Shimada H., Fukasawa T., Ishimura Y.
    J. Biochem. 105:417-422(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Heart ventricle.
  3. "The covalent structure of beef heart myoglobin."
    Han K., Dautrevaux M., Chaila X., Biserte G.
    Eur. J. Biochem. 16:465-471(1970) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-154.
    Tissue: Heart.
  4. "Characterization of bison (Bison bison) myoglobin."
    Joseph P., Suman S.P., Li S., Beach C.M., Steinke L., Fontaine M.
    Meat Sci. 84:71-78(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: MASS SPECTROMETRY.

Entry informationi

Entry nameiMYG_BOVIN
AccessioniPrimary (citable) accession number: P02192
Secondary accession number(s): Q3ZC11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: December 9, 2015
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.