P02186 (MYG_ELEMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Myoglobin

Gene names

Name:

MB

Organism

Elephas maximus (Indian elephant)

Taxonomic identifier

9783 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Afrotheria › Proboscidea › Elephantidae › Elephas

Protein attributes

Sequence length	154 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
Sequence similarities	Belongs to the globin family.

Ontologies

Keywords
Biological process	Oxygen transport Transport
Ligand	Heme Iron Metal-binding
Molecular function	Muscle protein
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Molecular_function	heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro oxygen binding Inferred from electronic annotation. Source: InterPro oxygen transporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

1

1

Removed Ref.1

Chain

2 – 154

153

Myoglobin

PRO_0000053290

Sites

Metal binding

94

1

Iron (heme proximal ligand)

Experimental info

Sequence conflict

28

1

T → F AA sequence Ref.1

Sequence conflict

30

1

F → L AA sequence Ref.1

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

154

Helix Strand Turn

Details...

Helix

5 – 19

15

Helix

22 – 36

15

Helix

38 – 43

6

Turn

45 – 49

5

Helix

53 – 57

5

Helix

60 – 78

19

Turn

79 – 81

3

Helix

84 – 96

13

Helix

102 – 119

18

Turn

121 – 123

3

Helix

126 – 149

24

Sequences

	Sequence		Length	Mass (Da)
	P02186 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: F1031658D39BEAD5	FASTA	154	17,127
	10 20 30 40 50 60 MGLSDGEWEL VLKTWGKVEA DIPGHGETVF VRLFTGHPET LEKFDKFKHL KTEGEMKASE 70 80 90 100 110 120 DLKKQGVTVL TALGGILKKK GHHEAEIQPL AQSHATKHKI PIKYLEFISD AIIHVLQSKH 130 140 150 PAEFGADAQG AMKKALELFR NDIAAKYKEL GFQG

References

[1]	"The amino acid sequence of elephant (Elephas maximus) myoglobin and the phylogeny of Proboscidea." Dene H., Goodman M., Romero-Herrera A.E. Proc. R. Soc. Lond., B, Biol. Sci. 207:111-127(1980) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-154. Tissue: Skeletal muscle.
[2]	"Crystal structure of Asian elephant (Elephas maximus) cyano-metmyoglobin at 1.78-A resolution. Phe29(B10) accounts for its unusual ligand binding properties." Bisig D.A., di Iorio E.E., Diederichs K., Winterhalter K.H., Piontek K. J. Biol. Chem. 270:20754-20762(1995) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.78 ANGSTROMS), SEQUENCE REVISION TO 28 AND 30.

Cross-references

Sequence databases

PIR

MYELI. A94228.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1EMY	X-ray	1.78	A	2-154	[»]

ProteinModelPortal

P02186.

SMR

P02186. Positions 2-154.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Phylogenomic databases

HOVERGEN

HBG107340.

Family and domain databases

Gene3D

1.10.490.10. 1 hit.

InterPro

IPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002335. Myoglobin.
[Graphical view]

PANTHER

PTHR11442:SF5. PTHR11442:SF5. 1 hit.

Pfam

PF00042. Globin. 1 hit.
[Graphical view]

PRINTS

PR00613. MYOGLOBIN.

SUPFAM

SSF46458. Globin_like. 1 hit.

PROSITE

PS01033. GLOBIN. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P02186.

Entry information

Entry name

MYG_ELEMA

Accession

Primary (citable) accession number: P02186

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 78 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program