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P02186

- MYG_ELEMA

UniProt

P02186 - MYG_ELEMA

Protein

Myoglobin

Gene

MB

Organism
Elephas maximus (Indian elephant)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi94 – 941Iron (heme proximal ligand)

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. oxygen binding Source: InterPro
    4. oxygen transporter activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Muscle protein

    Keywords - Biological processi

    Oxygen transport, Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myoglobin
    Gene namesi
    Name:MB
    OrganismiElephas maximus (Indian elephant)
    Taxonomic identifieri9783 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaAfrotheriaProboscideaElephantidaeElephas

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 154153MyoglobinPRO_0000053290Add
    BLAST

    Structurei

    Secondary structure

    1
    154
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi5 – 1915
    Helixi22 – 3615
    Helixi38 – 436
    Turni45 – 495
    Helixi53 – 575
    Helixi60 – 7819
    Turni79 – 813
    Helixi84 – 9613
    Helixi102 – 11918
    Turni121 – 1233
    Helixi126 – 14924

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1EMYX-ray1.78A2-154[»]
    ProteinModelPortaliP02186.
    SMRiP02186. Positions 2-154.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP02186.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the globin family.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG107340.

    Family and domain databases

    Gene3Di1.10.490.10. 1 hit.
    InterProiIPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    IPR002335. Myoglobin.
    [Graphical view]
    PANTHERiPTHR11442:SF5. PTHR11442:SF5. 1 hit.
    PfamiPF00042. Globin. 1 hit.
    [Graphical view]
    PRINTSiPR00613. MYOGLOBIN.
    SUPFAMiSSF46458. SSF46458. 1 hit.
    PROSITEiPS01033. GLOBIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P02186-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGLSDGEWEL VLKTWGKVEA DIPGHGETVF VRLFTGHPET LEKFDKFKHL    50
    KTEGEMKASE DLKKQGVTVL TALGGILKKK GHHEAEIQPL AQSHATKHKI 100
    PIKYLEFISD AIIHVLQSKH PAEFGADAQG AMKKALELFR NDIAAKYKEL 150
    GFQG 154
    Length:154
    Mass (Da):17,127
    Last modified:January 23, 2007 - v3
    Checksum:iF1031658D39BEAD5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti28 – 281T → F AA sequence (PubMed:6102395)Curated
    Sequence conflicti30 – 301F → L AA sequence (PubMed:6102395)Curated

    Sequence databases

    PIRiA94228. MYELI.

    Cross-referencesi

    Sequence databases

    PIRi A94228. MYELI.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1EMY X-ray 1.78 A 2-154 [» ]
    ProteinModelPortali P02186.
    SMRi P02186. Positions 2-154.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG107340.

    Miscellaneous databases

    EvolutionaryTracei P02186.

    Family and domain databases

    Gene3Di 1.10.490.10. 1 hit.
    InterProi IPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    IPR002335. Myoglobin.
    [Graphical view ]
    PANTHERi PTHR11442:SF5. PTHR11442:SF5. 1 hit.
    Pfami PF00042. Globin. 1 hit.
    [Graphical view ]
    PRINTSi PR00613. MYOGLOBIN.
    SUPFAMi SSF46458. SSF46458. 1 hit.
    PROSITEi PS01033. GLOBIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The amino acid sequence of elephant (Elephas maximus) myoglobin and the phylogeny of Proboscidea."
      Dene H., Goodman M., Romero-Herrera A.E.
      Proc. R. Soc. Lond., B, Biol. Sci. 207:111-127(1980) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-154.
      Tissue: Skeletal muscle.
    2. "Crystal structure of Asian elephant (Elephas maximus) cyano-metmyoglobin at 1.78-A resolution. Phe29(B10) accounts for its unusual ligand binding properties."
      Bisig D.A., di Iorio E.E., Diederichs K., Winterhalter K.H., Piontek K.
      J. Biol. Chem. 270:20754-20762(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.78 ANGSTROMS), SEQUENCE REVISION TO 28 AND 30.

    Entry informationi

    Entry nameiMYG_ELEMA
    AccessioniPrimary (citable) accession number: P02186
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 80 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3