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Protein

Myoglobin

Gene

MB

Organism
Elephas maximus (Indian elephant)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi94 – 941Iron (heme proximal ligand)

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myoglobin
Gene namesi
Name:MB
OrganismiElephas maximus (Indian elephant)
Taxonomic identifieri9783 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaAfrotheriaProboscideaElephantidaeElephas

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 154153MyoglobinPRO_0000053290Add
BLAST

Structurei

Secondary structure

1
154
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi5 – 1915Combined sources
Helixi22 – 3615Combined sources
Helixi38 – 436Combined sources
Turni45 – 495Combined sources
Helixi53 – 575Combined sources
Helixi60 – 7819Combined sources
Turni79 – 813Combined sources
Helixi84 – 9613Combined sources
Helixi102 – 11918Combined sources
Turni121 – 1233Combined sources
Helixi126 – 14924Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EMYX-ray1.78A2-154[»]
ProteinModelPortaliP02186.
SMRiP02186. Positions 2-154.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02186.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG107340.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002335. Myoglobin.
[Graphical view]
PANTHERiPTHR11442:SF5. PTHR11442:SF5. 1 hit.
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00613. MYOGLOBIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02186-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLSDGEWEL VLKTWGKVEA DIPGHGETVF VRLFTGHPET LEKFDKFKHL
60 70 80 90 100
KTEGEMKASE DLKKQGVTVL TALGGILKKK GHHEAEIQPL AQSHATKHKI
110 120 130 140 150
PIKYLEFISD AIIHVLQSKH PAEFGADAQG AMKKALELFR NDIAAKYKEL

GFQG
Length:154
Mass (Da):17,127
Last modified:January 23, 2007 - v3
Checksum:iF1031658D39BEAD5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281T → F AA sequence (PubMed:6102395).Curated
Sequence conflicti30 – 301F → L AA sequence (PubMed:6102395).Curated

Sequence databases

PIRiA94228. MYELI.

Cross-referencesi

Sequence databases

PIRiA94228. MYELI.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1EMYX-ray1.78A2-154[»]
ProteinModelPortaliP02186.
SMRiP02186. Positions 2-154.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG107340.

Miscellaneous databases

EvolutionaryTraceiP02186.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002335. Myoglobin.
[Graphical view]
PANTHERiPTHR11442:SF5. PTHR11442:SF5. 1 hit.
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00613. MYOGLOBIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The amino acid sequence of elephant (Elephas maximus) myoglobin and the phylogeny of Proboscidea."
    Dene H., Goodman M., Romero-Herrera A.E.
    Proc. R. Soc. Lond., B, Biol. Sci. 207:111-127(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-154.
    Tissue: Skeletal muscle.
  2. "Crystal structure of Asian elephant (Elephas maximus) cyano-metmyoglobin at 1.78-A resolution. Phe29(B10) accounts for its unusual ligand binding properties."
    Bisig D.A., di Iorio E.E., Diederichs K., Winterhalter K.H., Piontek K.
    J. Biol. Chem. 270:20754-20762(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.78 ANGSTROMS), SEQUENCE REVISION TO 28 AND 30.

Entry informationi

Entry nameiMYG_ELEMA
AccessioniPrimary (citable) accession number: P02186
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: July 22, 2015
This is version 84 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.