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Protein

Myoglobin

Gene

MB

Organism
Physeter catodon (Sperm whale) (Physeter macrocephalus)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi65Iron (heme distal ligand)PROSITE-ProRule annotation1 Publication1
Metal bindingi94Iron (heme proximal ligand)PROSITE-ProRule annotation1 Publication1

GO - Molecular functioni

Keywordsi

Molecular functionMuscle protein
Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Myoglobin
Gene namesi
Name:MB
OrganismiPhyseter catodon (Sperm whale) (Physeter macrocephalus)
Taxonomic identifieri9755 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaCetaceaOdontocetiPhyseteridaePhyseter

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000533352 – 154MyoglobinAdd BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphoserineBy similarity1
Modified residuei68PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PeptideAtlasiP02185.

Structurei

Secondary structure

1154
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 18Combined sources14
Helixi19 – 21Combined sources3
Helixi22 – 36Combined sources15
Helixi38 – 41Combined sources4
Turni45 – 49Combined sources5
Helixi53 – 57Combined sources5
Helixi60 – 77Combined sources18
Turni78 – 81Combined sources4
Helixi84 – 96Combined sources13
Turni97 – 99Combined sources3
Helixi102 – 119Combined sources18
Helixi121 – 123Combined sources3
Helixi126 – 150Combined sources25

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
101MX-ray2.07A1-154[»]
102MX-ray1.84A1-154[»]
103MX-ray2.07A1-154[»]
104MX-ray1.71A2-154[»]
105MX-ray2.02A2-154[»]
106MX-ray1.99A1-154[»]
107MX-ray2.09A1-154[»]
108MX-ray2.67A1-154[»]
109MX-ray1.83A1-154[»]
110MX-ray1.77A1-154[»]
111MX-ray1.88A1-154[»]
112MX-ray2.34A1-154[»]
1A6GX-ray1.15A2-152[»]
1A6KX-ray1.10A2-152[»]
1A6MX-ray1.00A2-152[»]
1A6NX-ray1.15A2-152[»]
1ABSX-ray1.50A1-154[»]
1AJGX-ray1.69A2-154[»]
1AJHX-ray1.69A2-154[»]
1BVCX-ray1.50A2-154[»]
1BVDX-ray1.40A2-154[»]
1BZ6X-ray1.20A2-154[»]
1BZPX-ray1.15A2-154[»]
1BZRX-ray1.15A2-154[»]
1CH1X-ray1.90A1-154[»]
1CH2X-ray1.80A2-154[»]
1CH3X-ray2.00A2-154[»]
1CH5X-ray2.10A2-154[»]
1CH7X-ray1.90A2-154[»]
1CH9X-ray1.80A2-154[»]
1CIKX-ray1.70A2-154[»]
1CIOX-ray1.60A2-154[»]
1CO8X-ray1.80A1-154[»]
1CO9X-ray1.60A1-154[»]
1CP0X-ray2.00A1-154[»]
1CP5X-ray2.10A1-154[»]
1CPWX-ray2.20A1-154[»]
1CQ2neutron diffraction2.00A2-154[»]
1DO1X-ray1.50A1-154[»]
1DO3X-ray1.55A1-154[»]
1DO4X-ray1.70A1-154[»]
1DO7X-ray1.85A1-154[»]
1DTIX-ray1.70A1-154[»]
1DTMX-ray2.13A2-154[»]
1DUKX-ray2.13A2-154[»]
1DUOX-ray2.00A2-154[»]
1DXCX-ray1.40A1-154[»]
1DXDX-ray1.40A1-154[»]
1EBCX-ray1.80A2-154[»]
1F63X-ray1.80A1-154[»]
1F65X-ray1.70A1-154[»]
1F6HX-ray3.31A2-154[»]
1FCSX-ray1.60A1-154[»]
1H1XX-ray1.40A2-154[»]
1HJTX-ray1.70A2-154[»]
1IOPX-ray1.90A2-154[»]
1IRCX-ray2.17A1-154[»]
1J3FX-ray1.45A1-154[»]
1J52X-ray1.90A1-154[»]
1JDOX-ray1.90A1-154[»]
1JP6X-ray2.30A2-154[»]
1JP8X-ray2.30A2-154[»]
1JP9X-ray1.70A2-154[»]
1JPBX-ray1.70A2-154[»]
1JW8X-ray1.30A1-154[»]
1L2Kneutron diffraction1.50A2-154[»]
1LTWX-ray1.70A1-154[»]
1LUEX-ray1.70A1-154[»]
1MBCX-ray1.50A2-154[»]
1MBDX-ray1.40A2-154[»]
1MBIX-ray2.00A2-154[»]
1MBNX-ray2.00A2-154[»]
1MBOX-ray1.60A2-154[»]
1MCYX-ray1.70A1-154[»]
1MGNX-ray1.90A1-154[»]
1MLFX-ray2.00A1-154[»]
1MLGX-ray2.00A1-154[»]
1MLHX-ray2.00A1-154[»]
1MLJX-ray2.00A1-154[»]
1MLKX-ray1.80A1-154[»]
1MLLX-ray1.70A1-154[»]
1MLMX-ray1.80A1-154[»]
1MLNX-ray2.00A1-154[»]
1MLOX-ray1.80A1-154[»]
1MLQX-ray2.00A1-154[»]
1MLRX-ray2.00A1-154[»]
1MLSX-ray1.70A1-154[»]
1MLUX-ray1.90A1-154[»]
1MOAX-ray1.90A1-154[»]
1MOBX-ray2.20A1-154[»]
1MOCX-ray2.00A1-154[»]
1MODX-ray2.00A1-154[»]
1MTIX-ray1.90A1-154[»]
1MTJX-ray1.70A1-154[»]
1MTKX-ray1.80A1-154[»]
1MYFNMR-A2-154[»]
1MYMX-ray1.70A1-154[»]
1MYZX-ray1.60A1-154[»]
1MZ0X-ray1.60A1-154[»]
1N9FX-ray1.80A1-154[»]
1N9HX-ray1.80A1-154[»]
1N9IX-ray1.60A1-154[»]
1N9XX-ray1.60A1-154[»]
1NAZX-ray1.04A1-154[»]
1O16X-ray1.95A1-154[»]
1OBMX-ray1.85A1-154[»]
1OFJX-ray1.80A1-154[»]
1OFKX-ray1.80A1-154[»]
1SPEX-ray2.00A2-154[»]
1SWMX-ray1.80A2-154[»]
1TESX-ray1.70A1-154[»]
1U7RX-ray1.15A2-154[»]
1U7SX-ray1.40A2-154[»]
1UFJX-ray1.60A1-154[»]
1UFPX-ray2.10A1-154[»]
1V9QX-ray1.45A1-154[»]
1VXAX-ray2.00A2-154[»]
1VXBX-ray2.00A2-154[»]
1VXCX-ray1.70A2-154[»]
1VXDX-ray1.70A2-154[»]
1VXEX-ray1.70A2-154[»]
1VXFX-ray1.70A2-154[»]
1VXGX-ray1.70A2-154[»]
1VXHX-ray1.70A2-154[»]
1WVPX-ray1.53A2-154[»]
1YOGX-ray1.65A2-154[»]
1YOHX-ray1.65A2-154[»]
1YOIX-ray1.65A2-154[»]
2BLHX-ray1.77A2-154[»]
2BLIX-ray1.70A2-154[»]
2BLJX-ray1.80M2-154[»]
2BW9X-ray1.68M2-154[»]
2BWHX-ray1.90A2-154[»]
2CMMX-ray1.80A2-154[»]
2D6CX-ray2.26A/B2-154[»]
2E2YX-ray1.60A1-154[»]
2EB8X-ray1.65A1-154[»]
2EB9X-ray1.80A1-154[»]
2EF2X-ray1.80A1-154[»]
2EKTX-ray1.10A2-154[»]
2EKUX-ray1.40A2-154[»]
2EVKX-ray1.40A2-154[»]
2EVPX-ray1.70A2-154[»]
2G0RX-ray1.95A1-154[»]
2G0SX-ray1.90A1-154[»]
2G0VX-ray1.95A1-154[»]
2G0XX-ray1.95A1-154[»]
2G0ZX-ray1.95A1-154[»]
2G10X-ray1.90A1-154[»]
2G11X-ray1.90A1-154[»]
2G12X-ray1.90A1-154[»]
2G14X-ray1.90A1-154[»]
2JHOX-ray1.40A2-154[»]
2MB5neutron diffraction1.80A2-154[»]
2MBWX-ray1.50A1-154[»]
2MGAX-ray2.20A1-154[»]
2MGBX-ray2.00A1-154[»]
2MGCX-ray1.90A1-154[»]
2MGDX-ray1.80A1-154[»]
2MGEX-ray1.70A1-154[»]
2MGFX-ray1.80A1-154[»]
2MGGX-ray1.80A1-154[»]
2MGHX-ray2.00A1-154[»]
2MGIX-ray2.00A1-154[»]
2MGJX-ray2.00A1-154[»]
2MGKX-ray2.00A1-154[»]
2MGLX-ray2.00A1-154[»]
2MGMX-ray1.90A1-154[»]
2MYAX-ray1.80A2-154[»]
2MYBX-ray1.90A2-154[»]
2MYCX-ray1.80A2-154[»]
2MYDX-ray1.80A2-154[»]
2MYEX-ray1.68A2-154[»]
2OH8X-ray1.80A1-154[»]
2OH9X-ray1.80A1-154[»]
2OHAX-ray1.80A1-154[»]
2OHBX-ray1.80A1-154[»]
2SPLX-ray1.70A1-154[»]
2SPMX-ray1.70A1-154[»]
2SPNX-ray1.70A1-154[»]
2SPOX-ray1.70A1-154[»]
2W6WX-ray1.99A1-154[»]
2W6XX-ray1.73A1-154[»]
2W6YX-ray1.60A1-154[»]
2Z6SX-ray1.25A2-154[»]
2Z6TX-ray1.20A2-154[»]
2ZSNX-ray1.21A2-154[»]
2ZSOX-ray1.21A2-154[»]
2ZSPX-ray1.21A2-154[»]
2ZSQX-ray1.21A2-154[»]
2ZSRX-ray1.21A2-154[»]
2ZSSX-ray1.21A2-154[»]
2ZSTX-ray1.21A2-154[»]
2ZSXX-ray1.21A2-154[»]
2ZSYX-ray1.21A2-154[»]
2ZSZX-ray1.21A2-154[»]
2ZT0X-ray1.21A2-154[»]
2ZT1X-ray1.21A2-154[»]
2ZT2X-ray1.21A2-154[»]
2ZT3X-ray1.21A2-154[»]
2ZT4X-ray1.21A2-154[»]
3A2GX-ray1.75A1-154[»]
3ASEX-ray1.75A1-154[»]
3E4NX-ray1.21A2-154[»]
3E55X-ray1.21A2-154[»]
3E5IX-ray1.22A2-154[»]
3E5OX-ray1.21A2-154[»]
3ECLX-ray1.21A2-154[»]
3ECXX-ray1.21A2-154[»]
3ECZX-ray1.21A2-154[»]
3ED9X-ray1.21A2-154[»]
3EDAX-ray1.21A2-154[»]
3EDBX-ray1.21A2-154[»]
3H57X-ray1.70A1-154[»]
3H58X-ray1.80A1-154[»]
3K9ZX-ray1.72A2-154[»]
3M38X-ray1.42A2-154[»]
3M39X-ray1.65A2-154[»]
3M3AX-ray1.37A2-154[»]
3M3BX-ray1.60A2-154[»]
3MN0X-ray1.65A2-154[»]
3NMLX-ray1.68A1-154[»]
3O89X-ray1.10A2-154[»]
3OGBX-ray1.60A1-154[»]
3SDNX-ray1.50A1-154[»]
3U3EX-ray1.21A1-154[»]
4FWXX-ray1.90A2-154[»]
4FWYX-ray1.80A2-154[»]
4FWZX-ray1.90A2-154[»]
4H07X-ray1.14A1-154[»]
4H0BX-ray1.26A1-154[»]
4IT8X-ray1.50A1-154[»]
4LPIX-ray1.36A1-154[»]
4MBNX-ray2.00A2-154[»]
4MXKX-ray1.52A2-154[»]
4MXLX-ray1.50A2-154[»]
4NXAX-ray1.60A1-154[»]
4NXCX-ray1.55A1-154[»]
4OF9X-ray1.24A2-154[»]
4OODX-ray1.24A1-154[»]
4PNJX-ray1.36A1-154[»]
4PQ6X-ray1.45A1-154[»]
4PQBX-ray1.94A1-154[»]
4PQCX-ray1.50A1-154[»]
4QAUX-ray1.60A1-154[»]
4TYXX-ray1.64A2-154[»]
5B84X-ray1.61A2-154[»]
5B85X-ray1.85A2-154[»]
5C6YX-ray1.79A1-154[»]
5HAVX-ray1.27A2-154[»]
5HLQX-ray1.50A2-154[»]
5HLUX-ray1.50A2-154[»]
5HLXX-ray1.50A2-154[»]
5IKSX-ray1.87A2-152[»]
5ILEX-ray1.77A1-154[»]
5ILMX-ray1.70A1-154[»]
5ILPX-ray1.88A1-154[»]
5ILRX-ray1.87A1-154[»]
5JOMX-ray1.90A1-154[»]
5KD1X-ray1.70A2-154[»]
5KKKX-ray1.70A1-154[»]
5M3SX-ray1.80A1-154[»]
5MBNX-ray2.00A2-154[»]
5O41X-ray1.80A1-154[»]
DisProtiDP00303.
ProteinModelPortaliP02185.
SMRiP02185.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02185.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG107340.
OrthoDBiEOG091G0OAO.

Family and domain databases

InterProiView protein in InterPro
IPR000971. Globin.
IPR009050. Globin-like.
IPR002335. Myoglobin.
PANTHERiPTHR11442:SF57. PTHR11442:SF57. 1 hit.
PfamiView protein in Pfam
PF00042. Globin. 1 hit.
PRINTSiPR00613. MYOGLOBIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiView protein in PROSITE
PS01033. GLOBIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02185-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLSEGEWQL VLHVWAKVEA DVAGHGQDIL IRLFKSHPET LEKFDRFKHL
60 70 80 90 100
KTEAEMKASE DLKKHGVTVL TALGAILKKK GHHEAELKPL AQSHATKHKI
110 120 130 140 150
PIKYLEFISE AIIHVLHSRH PGDFGADAQG AMNKALELFR KDIAAKYKEL

GYQG
Length:154
Mass (Da):17,331
Last modified:January 23, 2007 - v2
Checksum:iFD1D85814263E1A8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti123D → N AA sequence (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti122G → A in metmyoglobin. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB271144 mRNA. Translation: BAF03579.1.
PIRiA90591. MYWHP.
RefSeqiNP_001277651.1. NM_001290722.1.

Genome annotation databases

GeneIDi102975021.

Similar proteinsi

Entry informationi

Entry nameiMYG_PHYCD
AccessioniPrimary (citable) accession number: P02185
Secondary accession number(s): Q0KIY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families