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P02185 (MYG_PHYCD) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myoglobin
Gene names
Name:MB
OrganismPhyseter catodon (Sperm whale) (Physeter macrocephalus)
Taxonomic identifier9755 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaCetaceaOdontocetiPhyseteridaePhyseter

Protein attributes

Sequence length154 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

Sequence similarities

Belongs to the globin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.2
Chain2 – 154153Myoglobin
PRO_0000053335

Sites

Metal binding651Iron (heme distal ligand) Ref.4
Metal binding941Iron (heme proximal ligand) Ref.4

Natural variations

Natural variant1221G → A in metmyoglobin.

Experimental info

Sequence conflict1231D → N AA sequence Ref.2

Secondary structure

....................... 154
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P02185 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: FD1D85814263E1A8

FASTA15417,331
        10         20         30         40         50         60 
MVLSEGEWQL VLHVWAKVEA DVAGHGQDIL IRLFKSHPET LEKFDRFKHL KTEAEMKASE 

        70         80         90        100        110        120 
DLKKHGVTVL TALGAILKKK GHHEAELKPL AQSHATKHKI PIKYLEFISE AIIHVLHSRH 

       130        140        150 
PGDFGADAQG AMNKALELFR KDIAAKYKEL GYQG 

« Hide

References

[1]"cDNA-derived amino acid sequences of myoglobins from nine species of whales and dolphins."
Iwanami K., Mita H., Yamamoto Y., Fujise Y., Yamada T., Suzuki T.
Comp. Biochem. Physiol. 145B:249-256(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Amino-acid sequence of sperm whale myoglobin."
Edmundson A.B.
Nature 205:883-887(1965)
Cited for: PROTEIN SEQUENCE OF 2-154.
Tissue: Heart muscle.
[3]"Residue 122 of sperm whale and horse myoglobin."
Romero-Herrera A.E., Lehmann H.
Biochim. Biophys. Acta 336:318-323(1974)
Cited for: SEQUENCE REVISION TO 123.
Tissue: Skeletal muscle.
[4]"Structure of myoglobin refined at 2.0-A resolution. I. Crystallographic refinement of metmyoglobin from sperm whale."
Takano T.
J. Mol. Biol. 110:537-568(1977) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF METMYOGLOBIN.
[5]"Structure of myoglobin refined at 2.0-A resolution. II. Structure of deoxymyoglobin from sperm whale."
Takano T.
J. Mol. Biol. 110:569-584(1977) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF DEOXYMYOGLOBIN.
[6]"Structure and refinement of oxymyoglobin at 1.6-A resolution."
Phillips S.E.V.
J. Mol. Biol. 142:531-554(1980) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF OXYMYOGLOBIN.
[7]"X-ray crystal structure of the ferric sperm whale myoglobin: imidazole complex at 2.0-A resolution."
Lionetti C., Guanziroli M.G., Frigerio F., Ascenzi P., Bolognesi M.
J. Mol. Biol. 217:409-412(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
[8]"Structural dynamics of ligand diffusion in the protein matrix: a study on a new myoglobin mutant Y(B10) Q(E7) R(E10)."
Brunori M., Cutruzzola F., Savino C., Travaglini-Allocatelli C., Vallone B., Gibson Q.H.
Biophys. J. 76:1259-1269(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS).
[9]"The role of cavities in protein dynamics: crystal structure of a photolytic intermediate of a mutant myoglobin."
Brunori M., Vallone B., Cutruzzola F., Travaglini-Allocatelli C., Berendzen J., Chu K., Sweet R.M., Schlichting I.
Proc. Natl. Acad. Sci. U.S.A. 97:2058-2063(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB271144 mRNA. Translation: BAF03579.1.
PIRMYWHP. A90591.
RefSeqNP_001277651.1. NM_001290722.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
101MX-ray2.07A1-154[»]
102MX-ray1.84A1-154[»]
103MX-ray2.07A1-154[»]
104MX-ray1.71A2-154[»]
105MX-ray2.02A2-154[»]
106MX-ray1.99A1-154[»]
107MX-ray2.09A1-154[»]
108MX-ray2.67A1-154[»]
109MX-ray1.83A1-154[»]
110MX-ray1.77A1-154[»]
111MX-ray1.88A1-154[»]
112MX-ray2.34A1-154[»]
1A6GX-ray1.15A2-152[»]
1A6KX-ray1.10A2-152[»]
1A6MX-ray1.00A2-152[»]
1A6NX-ray1.15A2-152[»]
1ABSX-ray1.50A1-154[»]
1AJGX-ray1.69A2-154[»]
1AJHX-ray1.69A2-154[»]
1BVCX-ray1.50A2-154[»]
1BVDX-ray1.40A2-154[»]
1BZ6X-ray1.20A2-154[»]
1BZPX-ray1.15A2-154[»]
1BZRX-ray1.15A2-154[»]
1CH1X-ray1.90A1-154[»]
1CH2X-ray1.80A2-154[»]
1CH3X-ray2.00A2-154[»]
1CH5X-ray2.10A2-154[»]
1CH7X-ray1.90A2-154[»]
1CH9X-ray1.80A2-154[»]
1CIKX-ray1.70A2-154[»]
1CIOX-ray1.60A2-154[»]
1CO8X-ray1.80A1-154[»]
1CO9X-ray1.60A1-154[»]
1CP0X-ray2.00A1-154[»]
1CP5X-ray2.10A1-154[»]
1CPWX-ray2.20A1-154[»]
1CQ2neutron diffraction2.00A2-154[»]
1DO1X-ray1.50A1-154[»]
1DO3X-ray1.55A1-154[»]
1DO4X-ray1.70A1-154[»]
1DO7X-ray1.85A1-154[»]
1DTIX-ray1.70A1-154[»]
1DTMX-ray2.13A2-154[»]
1DUKX-ray2.13A2-154[»]
1DUOX-ray2.00A2-154[»]
1DXCX-ray1.40A1-154[»]
1DXDX-ray1.40A1-154[»]
1EBCX-ray1.80A2-154[»]
1F63X-ray1.80A1-154[»]
1F65X-ray1.70A1-154[»]
1F6HX-ray3.31A2-154[»]
1FCSX-ray1.60A1-154[»]
1H1XX-ray1.40A2-154[»]
1HJTX-ray1.70A2-154[»]
1IOPX-ray1.90A2-154[»]
1IRCX-ray2.17A1-154[»]
1J3FX-ray1.45A1-154[»]
1J52X-ray1.90A1-154[»]
1JDOX-ray1.90A1-154[»]
1JP6X-ray2.30A2-154[»]
1JP8X-ray2.30A2-154[»]
1JP9X-ray1.70A2-154[»]
1JPBX-ray1.70A2-154[»]
1JW8X-ray1.30A1-154[»]
1L2Kneutron diffraction1.50A2-154[»]
1LTWX-ray1.70A1-154[»]
1LUEX-ray1.70A1-154[»]
1MBCX-ray1.50A2-154[»]
1MBDX-ray1.40A2-154[»]
1MBIX-ray2.00A2-154[»]
1MBNX-ray2.00A2-154[»]
1MBOX-ray1.60A2-154[»]
1MCYX-ray1.70A1-154[»]
1MGNX-ray1.90A1-154[»]
1MLFX-ray2.00A1-154[»]
1MLGX-ray2.00A1-154[»]
1MLHX-ray2.00A1-154[»]
1MLJX-ray2.00A1-154[»]
1MLKX-ray1.80A1-154[»]
1MLLX-ray1.70A1-154[»]
1MLMX-ray1.80A1-154[»]
1MLNX-ray2.00A1-154[»]
1MLOX-ray1.80A1-154[»]
1MLQX-ray2.00A1-154[»]
1MLRX-ray2.00A1-154[»]
1MLSX-ray1.70A1-154[»]
1MLUX-ray1.90A1-154[»]
1MOAX-ray1.90A1-154[»]
1MOBX-ray2.20A1-154[»]
1MOCX-ray2.00A1-154[»]
1MODX-ray2.00A1-154[»]
1MTIX-ray1.90A1-154[»]
1MTJX-ray1.70A1-154[»]
1MTKX-ray1.80A1-154[»]
1MYFNMR-A2-154[»]
1MYMX-ray1.70A1-154[»]
1MYZX-ray1.60A1-154[»]
1MZ0X-ray1.60A1-154[»]
1N9FX-ray1.80A1-154[»]
1N9HX-ray1.80A1-154[»]
1N9IX-ray1.60A1-154[»]
1N9XX-ray1.60A1-154[»]
1NAZX-ray1.04A1-154[»]
1O16X-ray1.95A1-154[»]
1OBMX-ray1.85A1-154[»]
1OFJX-ray1.80A1-154[»]
1OFKX-ray1.80A1-154[»]
1SPEX-ray2.00A2-154[»]
1SWMX-ray1.80A2-154[»]
1TESX-ray1.70A1-154[»]
1U7RX-ray1.15A2-154[»]
1U7SX-ray1.40A2-154[»]
1UFJX-ray1.60A1-154[»]
1UFPX-ray2.10A1-154[»]
1V9QX-ray1.45A1-154[»]
1VXAX-ray2.00A2-154[»]
1VXBX-ray2.00A2-154[»]
1VXCX-ray1.70A2-154[»]
1VXDX-ray1.70A2-154[»]
1VXEX-ray1.70A2-154[»]
1VXFX-ray1.70A2-154[»]
1VXGX-ray1.70A2-154[»]
1VXHX-ray1.70A2-154[»]
1WVPX-ray1.53A2-154[»]
1YOGX-ray1.65A2-154[»]
1YOHX-ray1.65A2-154[»]
1YOIX-ray1.65A2-154[»]
2BLHX-ray1.77A2-154[»]
2BLIX-ray1.70A2-154[»]
2BLJX-ray1.80M2-154[»]
2BW9X-ray1.68M2-154[»]
2BWHX-ray1.90A2-154[»]
2CMMX-ray1.80A2-154[»]
2D6CX-ray2.26A/B2-154[»]
2E2YX-ray1.60A1-154[»]
2EB8X-ray1.65A1-154[»]
2EB9X-ray1.80A1-154[»]
2EF2X-ray1.80A1-154[»]
2EKTX-ray1.10A2-154[»]
2EKUX-ray1.40A2-154[»]
2EVKX-ray1.40A2-154[»]
2EVPX-ray1.70A2-154[»]
2G0RX-ray1.95A1-154[»]
2G0SX-ray1.90A1-154[»]
2G0VX-ray1.95A1-154[»]
2G0XX-ray1.95A1-154[»]
2G0ZX-ray1.95A1-154[»]
2G10X-ray1.90A1-154[»]
2G11X-ray1.90A1-154[»]
2G12X-ray1.90A1-154[»]
2G14X-ray1.90A1-154[»]
2JHOX-ray1.40A2-154[»]
2MB5neutron diffraction1.80A2-154[»]
2MBWX-ray1.50A1-154[»]
2MGAX-ray2.20A1-154[»]
2MGBX-ray2.00A1-154[»]
2MGCX-ray1.90A1-154[»]
2MGDX-ray1.80A1-154[»]
2MGEX-ray1.70A1-154[»]
2MGFX-ray1.80A1-154[»]
2MGGX-ray1.80A1-154[»]
2MGHX-ray2.00A1-154[»]
2MGIX-ray2.00A1-154[»]
2MGJX-ray2.00A1-154[»]
2MGKX-ray2.00A1-154[»]
2MGLX-ray2.00A1-154[»]
2MGMX-ray1.90A1-154[»]
2MYAX-ray1.80A2-154[»]
2MYBX-ray1.90A2-154[»]
2MYCX-ray1.80A2-154[»]
2MYDX-ray1.80A2-154[»]
2MYEX-ray1.68A2-154[»]
2OH8X-ray1.80A1-154[»]
2OH9X-ray1.80A1-154[»]
2OHAX-ray1.80A1-154[»]
2OHBX-ray1.80A1-154[»]
2SPLX-ray1.70A1-154[»]
2SPMX-ray1.70A1-154[»]
2SPNX-ray1.70A1-154[»]
2SPOX-ray1.70A1-154[»]
2W6WX-ray1.99A1-154[»]
2W6XX-ray1.73A1-154[»]
2W6YX-ray1.60A1-154[»]
2Z6SX-ray1.25A2-154[»]
2Z6TX-ray1.20A2-154[»]
2ZSNX-ray1.21A2-154[»]
2ZSOX-ray1.21A2-154[»]
2ZSPX-ray1.21A2-154[»]
2ZSQX-ray1.21A2-154[»]
2ZSRX-ray1.21A2-154[»]
2ZSSX-ray1.21A2-154[»]
2ZSTX-ray1.21A2-154[»]
2ZSXX-ray1.21A2-154[»]
2ZSYX-ray1.21A2-154[»]
2ZSZX-ray1.21A2-154[»]
2ZT0X-ray1.21A2-154[»]
2ZT1X-ray1.21A2-154[»]
2ZT2X-ray1.21A2-154[»]
2ZT3X-ray1.21A2-154[»]
2ZT4X-ray1.21A2-154[»]
3A2GX-ray1.75A1-154[»]
3ASEX-ray1.75A1-154[»]
3E4NX-ray1.21A2-154[»]
3E55X-ray1.21A2-154[»]
3E5IX-ray1.22A2-154[»]
3E5OX-ray1.21A2-154[»]
3ECLX-ray1.21A2-154[»]
3ECXX-ray1.21A2-154[»]
3ECZX-ray1.21A2-154[»]
3ED9X-ray1.21A2-154[»]
3EDAX-ray1.21A2-154[»]
3EDBX-ray1.21A2-154[»]
3H57X-ray1.70A1-154[»]
3H58X-ray1.80A1-154[»]
3K9ZX-ray1.72A2-154[»]
3M38X-ray1.42A2-154[»]
3M39X-ray1.65A2-154[»]
3M3AX-ray1.37A2-154[»]
3M3BX-ray1.60A2-154[»]
3MN0X-ray1.65A2-154[»]
3NMLX-ray1.68A1-154[»]
3O89X-ray1.10A2-154[»]
3OGBX-ray1.60A1-154[»]
3SDNX-ray1.50A1-154[»]
3U3EX-ray1.21A1-154[»]
4FWXX-ray1.90A2-154[»]
4FWYX-ray1.80A2-154[»]
4FWZX-ray1.90A2-154[»]
4H07X-ray1.14A1-154[»]
4H0BX-ray1.26A1-154[»]
4IT8X-ray1.50A1-154[»]
4MBNX-ray2.00A2-154[»]
4MXKX-ray1.52A2-154[»]
4MXLX-ray1.50A2-154[»]
5MBNX-ray2.00A2-154[»]
DisProtDP00303.
ProteinModelPortalP02185.
SMRP02185. Positions 1-154.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID102975021.

Phylogenomic databases

HOVERGENHBG107340.

Family and domain databases

Gene3D1.10.490.10. 1 hit.
InterProIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002335. Myoglobin.
[Graphical view]
PANTHERPTHR11442:SF5. PTHR11442:SF5. 1 hit.
PfamPF00042. Globin. 1 hit.
[Graphical view]
PRINTSPR00613. MYOGLOBIN.
SUPFAMSSF46458. SSF46458. 1 hit.
PROSITEPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP02185.

Entry information

Entry nameMYG_PHYCD
AccessionPrimary (citable) accession number: P02185
Secondary accession number(s): Q0KIY8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references