P02170 (MYG_RABIT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Myoglobin

Gene names

Name:

MB

Organism

Oryctolagus cuniculus (Rabbit) [Reference proteome]

Taxonomic identifier

9986 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Lagomorpha › Leporidae › Oryctolagus

Protein attributes

Sequence length	154 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.
Sequence similarities	Belongs to the globin family.

Ontologies

Keywords
Biological process	Oxygen transport Transport
Ligand	Heme Iron Metal-binding
Molecular function	Muscle protein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	brown fat cell differentiation Inferred from electronic annotation. Source: Compara enucleate erythrocyte differentiation Inferred from electronic annotation. Source: Compara heart development Inferred from electronic annotation. Source: Compara response to hypoxia Inferred from electronic annotation. Source: Compara
Molecular_function	heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro oxygen binding Inferred from electronic annotation. Source: InterPro oxygen transporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.1
	Chain	2 – 154	153	Myoglobin		PRO_0000053340
Sites
	Metal binding	65	1	Iron (heme distal ligand)
	Metal binding	94	1	Iron (heme proximal ligand)

Sequences

	Sequence		Length	Mass (Da)
	P02170 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: 7E5C5CED36F4EB56	FASTA	154	17,221
	10 20 30 40 50 60 MGLSDAEWQL VLNVWGKVEA DLAGHGQEVL IRLFHTHPET LEKFDKFKHL KSEDEMKASE 70 80 90 100 110 120 DLKKHGNTVL TALGAILKKK GHHEAEIKPL AQSHATKHKI PVKYLEFISE AIIHVLHSKH 130 140 150 PGDFGADAQA AMSKALELFR NDIAAQYKEL GFQG

References

[1]	"The primary structure of the myoglobin of rabbit (Oryctolagus cuniculus)." Romero-Herrera A.E., Lehmann H., Castillo O. Biochim. Biophys. Acta 439:51-54(1976) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-154.

Cross-references

Sequence databases
PIR	MYRB. A02492.
3D structure databases
ProteinModelPortal	P02170.
SMR	P02170. Positions 2-154.
ModBase	Search...
Protein-protein interaction databases
STRING	9986.ENSOCUP00000023254.
Proteomic databases
PRIDE	P02170.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	NOG276460.
HOGENOM	HOG000070111.
HOVERGEN	HBG107340.
OrthoDB	EOG4Z8XXZ.
Family and domain databases
Gene3D	1.10.490.10. 1 hit.
InterPro	IPR000971. Globin. IPR009050. Globin-like. IPR012292. Globin_dom. IPR002335. Myoglobin. [Graphical view]
PANTHER	PTHR11442:SF5. PTHR11442:SF5. 1 hit.
Pfam	PF00042. Globin. 1 hit. [Graphical view]
PRINTS	PR00613. MYOGLOBIN.
SUPFAM	SSF46458. Globin_like. 1 hit.
PROSITE	PS01033. GLOBIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MYG_RABIT

Accession

Primary (citable) accession number: P02170

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 71 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program