Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Myoglobin

Gene

MB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi65Iron (heme distal ligand)1 Publication1
Metal bindingi94Iron (heme proximal ligand)Combined sources1 Publication1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMuscle protein
Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-8981607 Intracellular oxygen transport

Protein family/group databases

TCDBi1.A.107.1.3 the pore-forming globin (globin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Myoglobin
Gene namesi
Name:MB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000198125.12
HGNCiHGNC:6915 MB
MIMi160000 gene
neXtProtiNX_P02144

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi4151
OpenTargetsiENSG00000198125
PharmGKBiPA30658

Chemistry databases

ChEMBLiCHEMBL2406892
DrugBankiDB02671 1-Methylimidazole
DB03385 4-Methylimidazole
DB02379 Beta-D-Glucose
DB02073 Biliverdine Ix Alpha
DB03399 Ethyl Isocyanide
DB04337 Methyl Isocyanide
DB02396 Methylethylamine
DB01826 N-Butyl Isocyanide
DB04050 N-Propyl Isocyanide
DB02646 Nitrosoethane
DB01710 Porphyrin Fe(Iii)
DB02528 Tetrazolyl Histidine

Polymorphism and mutation databases

BioMutaiMB
DMDMi127661

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00000533032 – 154MyoglobinAdd BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphoserineBy similarity1
Modified residuei68PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP02144
PaxDbiP02144
PeptideAtlasiP02144
PRIDEiP02144

2D gel databases

UCD-2DPAGEiP02144

PTM databases

CarbonylDBiP02144
iPTMnetiP02144
PhosphoSitePlusiP02144

Expressioni

Gene expression databases

BgeeiENSG00000198125
CleanExiHS_MB
ExpressionAtlasiP02144 baseline and differential
GenevisibleiP02144 HS

Organism-specific databases

HPAiCAB000060
HPA003123

Interactioni

Protein-protein interaction databases

BioGridi110321, 7 interactors
IntActiP02144, 2 interactors
STRINGi9606.ENSP00000352835

Chemistry databases

BindingDBiP02144

Structurei

Secondary structure

1154
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 18Combined sources14
Helixi19 – 21Combined sources3
Helixi22 – 36Combined sources15
Helixi38 – 43Combined sources6
Helixi45 – 47Combined sources3
Helixi53 – 57Combined sources5
Helixi60 – 77Combined sources18
Turni78 – 81Combined sources4
Helixi84 – 96Combined sources13
Helixi102 – 119Combined sources18
Turni121 – 123Combined sources3
Helixi126 – 149Combined sources24

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RGKX-ray1.65A2-154[»]
ProteinModelPortaliP02144
SMRiP02144
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378 Eukaryota
COG1018 LUCA
GeneTreeiENSGT00730000110844
HOGENOMiHOG000070111
HOVERGENiHBG107340
InParanoidiP02144
KOiK21892
OMAiLFRNDIA
OrthoDBiEOG091G0OAO
PhylomeDBiP02144
TreeFamiTF332967

Family and domain databases

Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002335 Myoglobin
PANTHERiPTHR11442:SF5 PTHR11442:SF5, 1 hit
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00613 MYOGLOBIN
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02144-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLSDGEWQL VLNVWGKVEA DIPGHGQEVL IRLFKGHPET LEKFDKFKHL
60 70 80 90 100
KSEDEMKASE DLKKHGATVL TALGGILKKK GHHEAEIKPL AQSHATKHKI
110 120 130 140 150
PVKYLEFISE CIIQVLQSKH PGDFGADAQG AMNKALELFR KDMASNYKEL

GFQG
Length:154
Mass (Da):17,184
Last modified:January 23, 2007 - v2
Checksum:iF6A41F19A525F09C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti106E → Q in AAX84516 (Ref. 5) Curated1
Sequence conflicti129Q → E in AAA59595 (PubMed:2989088).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00318055E → K1 PublicationCorresponds to variant dbSNP:rs145465287Ensembl.1
Natural variantiVAR_003181134K → N1 PublicationCorresponds to variant dbSNP:rs766095327Ensembl.1
Natural variantiVAR_003182140R → Q1 PublicationCorresponds to variant dbSNP:rs142225854Ensembl.1
Natural variantiVAR_003183140R → W1 PublicationCorresponds to variant dbSNP:rs767663245Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00371, X00372, X00373 Genomic DNA Translation: CAA25109.1
M14603, M10090, M14602 Genomic DNA Translation: AAA59595.1
CR456516 mRNA Translation: CAG30402.1
CR541949 mRNA Translation: CAG46747.1
DQ003030 Genomic DNA Translation: AAX84516.1
AL022334, AL049747 Genomic DNA Translation: CAI21837.1
BC014547 mRNA Translation: AAH14547.1
CCDSiCCDS13917.1
PIRiI53991 MYHU
RefSeqiNP_005359.1, NM_005368.2
NP_976311.1, NM_203377.1
NP_976312.1, NM_203378.1
XP_005261662.1, XM_005261605.2
UniGeneiHs.517586

Genome annotation databases

EnsembliENST00000359787; ENSP00000352835; ENSG00000198125
ENST00000397326; ENSP00000380489; ENSG00000198125
ENST00000397328; ENSP00000380491; ENSG00000198125
ENST00000406324; ENSP00000384239; ENSG00000198125
GeneIDi4151
KEGGihsa:4151
UCSCiuc003anz.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiMYG_HUMAN
AccessioniPrimary (citable) accession number: P02144
Secondary accession number(s): Q52H51, Q5THY7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 178 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health