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Protein

Myoglobin

Gene

MB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi65Iron (heme distal ligand)1 Publication1
Metal bindingi94Iron (heme proximal ligand)Combined sources1 Publication1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Muscle protein

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:G66-30927-MONOMER.

Protein family/group databases

TCDBi1.A.107.1.3. the pore-forming globin (globin) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Myoglobin
Gene namesi
Name:MB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:6915. MB.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi4151.
OpenTargetsiENSG00000198125.
PharmGKBiPA30658.

Chemistry databases

ChEMBLiCHEMBL2406892.
DrugBankiDB03404. Hemin.

Polymorphism and mutation databases

BioMutaiMB.
DMDMi127661.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00000533032 – 154MyoglobinAdd BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei4PhosphoserineBy similarity1
Modified residuei68PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP02144.
MaxQBiP02144.
PaxDbiP02144.
PeptideAtlasiP02144.
PRIDEiP02144.

2D gel databases

UCD-2DPAGEP02144.

PTM databases

iPTMnetiP02144.
PhosphoSitePlusiP02144.

Expressioni

Gene expression databases

BgeeiENSG00000198125.
CleanExiHS_MB.
ExpressionAtlasiP02144. baseline and differential.
GenevisibleiP02144. HS.

Organism-specific databases

HPAiCAB000060.
HPA003123.

Interactioni

Protein-protein interaction databases

BioGridi110321. 5 interactors.
STRINGi9606.ENSP00000352835.

Chemistry databases

BindingDBiP02144.

Structurei

Secondary structure

1154
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 18Combined sources14
Helixi19 – 21Combined sources3
Helixi22 – 36Combined sources15
Helixi38 – 43Combined sources6
Helixi45 – 47Combined sources3
Helixi53 – 57Combined sources5
Helixi60 – 77Combined sources18
Turni78 – 81Combined sources4
Helixi84 – 96Combined sources13
Helixi102 – 119Combined sources18
Turni121 – 123Combined sources3
Helixi126 – 149Combined sources24

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RGKX-ray1.65A2-154[»]
ProteinModelPortaliP02144.
SMRiP02144.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
GeneTreeiENSGT00730000110844.
HOGENOMiHOG000070111.
HOVERGENiHBG107340.
InParanoidiP02144.
OMAiKKKGQHE.
OrthoDBiEOG091G0OAO.
PhylomeDBiP02144.
TreeFamiTF332967.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002335. Myoglobin.
[Graphical view]
PANTHERiPTHR11442:SF5. PTHR11442:SF5. 1 hit.
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00613. MYOGLOBIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02144-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLSDGEWQL VLNVWGKVEA DIPGHGQEVL IRLFKGHPET LEKFDKFKHL
60 70 80 90 100
KSEDEMKASE DLKKHGATVL TALGGILKKK GHHEAEIKPL AQSHATKHKI
110 120 130 140 150
PVKYLEFISE CIIQVLQSKH PGDFGADAQG AMNKALELFR KDMASNYKEL

GFQG
Length:154
Mass (Da):17,184
Last modified:January 23, 2007 - v2
Checksum:iF6A41F19A525F09C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti106E → Q in AAX84516 (Ref. 5) Curated1
Sequence conflicti129Q → E in AAA59595 (PubMed:2989088).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00318055E → K.1 PublicationCorresponds to variant rs145465287dbSNPEnsembl.1
Natural variantiVAR_003181134K → N.1 PublicationCorresponds to variant rs766095327dbSNPEnsembl.1
Natural variantiVAR_003182140R → Q.1 PublicationCorresponds to variant rs142225854dbSNPEnsembl.1
Natural variantiVAR_003183140R → W.1 PublicationCorresponds to variant rs767663245dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00371, X00372, X00373 Genomic DNA. Translation: CAA25109.1.
M14603, M10090, M14602 Genomic DNA. Translation: AAA59595.1.
CR456516 mRNA. Translation: CAG30402.1.
CR541949 mRNA. Translation: CAG46747.1.
DQ003030 Genomic DNA. Translation: AAX84516.1.
AL022334, AL049747 Genomic DNA. Translation: CAI21837.1.
BC014547 mRNA. Translation: AAH14547.1.
CCDSiCCDS13917.1.
PIRiI53991. MYHU.
RefSeqiNP_005359.1. NM_005368.2.
NP_976311.1. NM_203377.1.
NP_976312.1. NM_203378.1.
XP_005261662.1. XM_005261605.2.
UniGeneiHs.517586.

Genome annotation databases

EnsembliENST00000359787; ENSP00000352835; ENSG00000198125.
ENST00000397326; ENSP00000380489; ENSG00000198125.
ENST00000397328; ENSP00000380491; ENSG00000198125.
ENST00000406324; ENSP00000384239; ENSG00000198125.
GeneIDi4151.
KEGGihsa:4151.
UCSCiuc003anz.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00371, X00372, X00373 Genomic DNA. Translation: CAA25109.1.
M14603, M10090, M14602 Genomic DNA. Translation: AAA59595.1.
CR456516 mRNA. Translation: CAG30402.1.
CR541949 mRNA. Translation: CAG46747.1.
DQ003030 Genomic DNA. Translation: AAX84516.1.
AL022334, AL049747 Genomic DNA. Translation: CAI21837.1.
BC014547 mRNA. Translation: AAH14547.1.
CCDSiCCDS13917.1.
PIRiI53991. MYHU.
RefSeqiNP_005359.1. NM_005368.2.
NP_976311.1. NM_203377.1.
NP_976312.1. NM_203378.1.
XP_005261662.1. XM_005261605.2.
UniGeneiHs.517586.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RGKX-ray1.65A2-154[»]
ProteinModelPortaliP02144.
SMRiP02144.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110321. 5 interactors.
STRINGi9606.ENSP00000352835.

Chemistry databases

BindingDBiP02144.
ChEMBLiCHEMBL2406892.
DrugBankiDB03404. Hemin.

Protein family/group databases

TCDBi1.A.107.1.3. the pore-forming globin (globin) family.

PTM databases

iPTMnetiP02144.
PhosphoSitePlusiP02144.

Polymorphism and mutation databases

BioMutaiMB.
DMDMi127661.

2D gel databases

UCD-2DPAGEP02144.

Proteomic databases

EPDiP02144.
MaxQBiP02144.
PaxDbiP02144.
PeptideAtlasiP02144.
PRIDEiP02144.

Protocols and materials databases

DNASUi4151.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000359787; ENSP00000352835; ENSG00000198125.
ENST00000397326; ENSP00000380489; ENSG00000198125.
ENST00000397328; ENSP00000380491; ENSG00000198125.
ENST00000406324; ENSP00000384239; ENSG00000198125.
GeneIDi4151.
KEGGihsa:4151.
UCSCiuc003anz.4. human.

Organism-specific databases

CTDi4151.
DisGeNETi4151.
GeneCardsiMB.
HGNCiHGNC:6915. MB.
HPAiCAB000060.
HPA003123.
MIMi160000. gene.
neXtProtiNX_P02144.
OpenTargetsiENSG00000198125.
PharmGKBiPA30658.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
GeneTreeiENSGT00730000110844.
HOGENOMiHOG000070111.
HOVERGENiHBG107340.
InParanoidiP02144.
OMAiKKKGQHE.
OrthoDBiEOG091G0OAO.
PhylomeDBiP02144.
TreeFamiTF332967.

Enzyme and pathway databases

BioCyciZFISH:G66-30927-MONOMER.

Miscellaneous databases

ChiTaRSiMB. human.
GeneWikiiMyoglobin.
GenomeRNAii4151.
PROiP02144.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198125.
CleanExiHS_MB.
ExpressionAtlasiP02144. baseline and differential.
GenevisibleiP02144. HS.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002335. Myoglobin.
[Graphical view]
PANTHERiPTHR11442:SF5. PTHR11442:SF5. 1 hit.
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00613. MYOGLOBIN.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYG_HUMAN
AccessioniPrimary (citable) accession number: P02144
Secondary accession number(s): Q52H51, Q5THY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 167 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.