Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Hemoglobin subunit beta-4

Gene

hbb4

Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from gills to the various peripheral tissues.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi64Iron (heme distal ligand)1
Metal bindingi93Iron (heme proximal ligand)1

GO - Molecular functioni

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit beta-4
Alternative name(s):
Beta-4-globin
Hemoglobin beta-4 chain
Hemoglobin beta-IV chain
Gene namesi
Name:hbb4
OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Taxonomic identifieri8022 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiProtacanthopterygiiSalmoniformesSalmonidaeSalmoninaeOncorhynchus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved2 Publications
ChainiPRO_00000531012 – 148Hemoglobin subunit beta-4Add BLAST147

Proteomic databases

PRIDEiP02141

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Structurei

Secondary structure

1148
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 18Combined sources13
Helixi21 – 35Combined sources15
Helixi37 – 42Combined sources6
Helixi44 – 46Combined sources3
Helixi52 – 56Combined sources5
Helixi59 – 77Combined sources19
Turni78 – 80Combined sources3
Helixi82 – 85Combined sources4
Helixi87 – 95Combined sources9
Helixi102 – 123Combined sources22
Helixi126 – 144Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2R1HX-ray1.90B/D2-148[»]
3BOMX-ray1.35B/D2-148[»]
ProteinModelPortaliP02141
SMRiP02141
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02141

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709

Family and domain databases

CDDicd08925 Hb-beta_like, 1 hit
Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002337 Haemoglobin_b
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00814 BETAHAEM
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02141-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVDWTDPERS AIVGLWGKIS VDEIGPQALA RLLIVSPWTQ RHFSTFGNLS
60 70 80 90 100
TPAAIMGNPA VAKHGKTVMH GLDRAVQNLD DIKNTYTALS VMHSEKLHVD
110 120 130 140
PDNFRLLADC ITVCVAAKLG PAVFSADTQE AFQKFLAVVV SALGRQYH
Length:148
Mass (Da):16,140
Last modified:January 23, 2007 - v3
Checksum:iB8F24E8618DEB936
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7P → A AA sequence (Ref. 2) Curated1
Sequence conflicti78 – 81NLDD → DLBB AA sequence (PubMed:1269767).Curated4
Sequence conflicti87 – 88TA → AT AA sequence (Ref. 2) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D82926 mRNA Translation: BAA11632.1
PIRiA02461 HBTR4
RefSeqiNP_001118017.1, NM_001124545.1
UniGeneiOmy.29996

Genome annotation databases

GeneIDi100136291

Similar proteinsi

Entry informationi

Entry nameiHBB4_ONCMY
AccessioniPrimary (citable) accession number: P02141
Secondary accession number(s): Q91199
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 96 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health