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P02134 (HBB_RANES) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Hemoglobin subunit beta
Alternative name(s):
Beta-globin
Hemoglobin beta chain
Gene names
Name:HBB
OrganismRana esculenta (Edible frog) (Pelophylax esculentus)
Taxonomic identifier8401 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaRanoideaRanidaePelophylax

Protein attributes

Sequence length140 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in oxygen transport from the lung to the various peripheral tissues.

Subunit structure

Heterotetramer of two alpha chains and two beta chains.

Tissue specificity

Red blood cells.

Sequence similarities

Belongs to the globin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 140140Hemoglobin subunit beta
PRO_0000053088

Sites

Metal binding571Iron (heme distal ligand)
Metal binding861Iron (heme proximal ligand)

Sequences

Sequence LengthMass (Da)Tools
P02134 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: 151F75CF7076AAB0

FASTA14015,424
        10         20         30         40         50         60 
GSDLVSGFWG KVDAHKIGGE ALARLLVVYP WTQRYFTTFG NLGSADAICH NAKVLAHGEK 

        70         80         90        100        110        120 
VLAAIGEGLK HPENLKAHYA KLSEYHSNKL HVDPANFRLL GNVFITVLAR HFQHEFTPEL 

       130        140 
QHALEAHFCA VGDALAKAYH 

« Hide

References

[1]"Phylogeny of hemoglobins. Beta chain of frog (Rana esculenta) hemoglobin."
Chauvet J.-P., Acher R.
Biochemistry 11:916-927(1972) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases

PIRHBFGRE. A02454.

3D structure databases

ProteinModelPortalP02134.
SMRP02134. Positions 5-125.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP02134.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG009709.

Family and domain databases

Gene3D1.10.490.10. 1 hit.
InterProIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002337. Haemoglobin_b.
[Graphical view]
PANTHERPTHR11442:SF7. PTHR11442:SF7. 1 hit.
PfamPF00042. Globin. 1 hit.
[Graphical view]
PRINTSPR00814. BETAHAEM.
SUPFAMSSF46458. SSF46458. 1 hit.
PROSITEPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHBB_RANES
AccessionPrimary (citable) accession number: P02134
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 16, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families