P02134 (HBB_RANES) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hemoglobin subunit beta

Alternative name(s):
Beta-globin
Hemoglobin beta chain

Gene names

Name:

HBB

Organism

Rana esculenta (Edible frog) (Pelophylax esculentus)

Taxonomic identifier

8401 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Neobatrachia › Ranoidea › Ranidae › Pelophylax

Protein attributes

Sequence length	140 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in oxygen transport from the lung to the various peripheral tissues.
Subunit structure	Heterotetramer of two alpha chains and two beta chains.
Tissue specificity	Red blood cells.
Sequence similarities	Belongs to the globin family.

Ontologies

Keywords
Biological process	Oxygen transport Transport
Ligand	Heme Iron Metal-binding
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular_component	hemoglobin complex Inferred from electronic annotation. Source: InterPro
Molecular_function	heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro oxygen binding Inferred from electronic annotation. Source: InterPro oxygen transporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 140	140	Hemoglobin subunit beta		PRO_0000053088
Sites
	Metal binding	57	1	Iron (heme distal ligand)
	Metal binding	86	1	Iron (heme proximal ligand)

Sequences

	Sequence		Length	Mass (Da)
	P02134 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 151F75CF7076AAB0	FASTA	140	15,424
	10 20 30 40 50 60 GSDLVSGFWG KVDAHKIGGE ALARLLVVYP WTQRYFTTFG NLGSADAICH NAKVLAHGEK 70 80 90 100 110 120 VLAAIGEGLK HPENLKAHYA KLSEYHSNKL HVDPANFRLL GNVFITVLAR HFQHEFTPEL 130 140 QHALEAHFCA VGDALAKAYH

References

[1]	"Phylogeny of hemoglobins. Beta chain of frog (Rana esculenta) hemoglobin." Chauvet J.-P., Acher R. Biochemistry 11:916-927(1972) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases
PIR	HBFGRE. A02454.
3D structure databases
ProteinModelPortal	P02134.
SMR	P02134. Positions 5-125.
ModBase	Search...
Proteomic databases
PRIDE	P02134.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG009709.
Family and domain databases
Gene3D	1.10.490.10. 1 hit.
InterPro	IPR000971. Globin. IPR009050. Globin-like. IPR012292. Globin_dom. IPR002337. Haemoglobin_b. [Graphical view]
PANTHER	PTHR11442:SF7. PTHR11442:SF7. 1 hit.
Pfam	PF00042. Globin. 1 hit. [Graphical view]
PRINTS	PR00814. BETAHAEM.
SUPFAM	SSF46458. Globin_like. 1 hit.
PROSITE	PS01033. GLOBIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HBB_RANES

Accession

Primary (citable) accession number: P02134

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	April 3, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program