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Protein

Hemoglobin subunit beta

Gene

HBB

Organism
Pelophylax esculentus (Edible frog) (Rana esculenta)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi57Iron (heme distal ligand)1
Metal bindingi86Iron (heme proximal ligand)1

GO - Molecular functioni

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit beta
Alternative name(s):
Beta-globin
Hemoglobin beta chain
Gene namesi
Name:HBB
OrganismiPelophylax esculentus (Edible frog) (Rana esculenta)
Taxonomic identifieri8401 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaRanoideaRanidaePelophylax

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000530881 – 140Hemoglobin subunit betaAdd BLAST140

Proteomic databases

PRIDEiP02134

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Structurei

3D structure databases

ProteinModelPortaliP02134
SMRiP02134
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709

Family and domain databases

CDDicd08925 Hb-beta_like, 1 hit
Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002337 Haemoglobin_b
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00814 BETAHAEM
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequencei

Sequence statusi: Complete.

P02134-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GSDLVSGFWG KVDAHKIGGE ALARLLVVYP WTQRYFTTFG NLGSADAICH
60 70 80 90 100
NAKVLAHGEK VLAAIGEGLK HPENLKAHYA KLSEYHSNKL HVDPANFRLL
110 120 130 140
GNVFITVLAR HFQHEFTPEL QHALEAHFCA VGDALAKAYH
Length:140
Mass (Da):15,424
Last modified:July 21, 1986 - v1
Checksum:i151F75CF7076AAB0
GO

Sequence databases

PIRiA02454 HBFGRE

Similar proteinsi

Entry informationi

Entry nameiHBB_PELES
AccessioniPrimary (citable) accession number: P02134
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: April 25, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
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Main funding by: National Institutes of Health