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P02134

- HBB_RANES

UniProt

P02134 - HBB_RANES

Protein

Hemoglobin subunit beta

Gene

HBB

Organism
Rana esculenta (Edible frog) (Pelophylax esculentus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Involved in oxygen transport from the lung to the various peripheral tissues.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi57 – 571Iron (heme distal ligand)
    Metal bindingi86 – 861Iron (heme proximal ligand)

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. oxygen binding Source: InterPro
    4. oxygen transporter activity Source: UniProtKB-KW

    Keywords - Biological processi

    Oxygen transport, Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hemoglobin subunit beta
    Alternative name(s):
    Beta-globin
    Hemoglobin beta chain
    Gene namesi
    Name:HBB
    OrganismiRana esculenta (Edible frog) (Pelophylax esculentus)
    Taxonomic identifieri8401 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaRanoideaRanidaePelophylax

    Subcellular locationi

    GO - Cellular componenti

    1. hemoglobin complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 140140Hemoglobin subunit betaPRO_0000053088Add
    BLAST

    Proteomic databases

    PRIDEiP02134.

    Expressioni

    Tissue specificityi

    Red blood cells.

    Interactioni

    Subunit structurei

    Heterotetramer of two alpha chains and two beta chains.

    Structurei

    3D structure databases

    ProteinModelPortaliP02134.
    SMRiP02134. Positions 5-125.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the globin family.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG009709.

    Family and domain databases

    Gene3Di1.10.490.10. 1 hit.
    InterProiIPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    IPR002337. Haemoglobin_b.
    [Graphical view]
    PANTHERiPTHR11442:SF7. PTHR11442:SF7. 1 hit.
    PfamiPF00042. Globin. 1 hit.
    [Graphical view]
    PRINTSiPR00814. BETAHAEM.
    SUPFAMiSSF46458. SSF46458. 1 hit.
    PROSITEiPS01033. GLOBIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P02134-1 [UniParc]FASTAAdd to Basket

    « Hide

    GSDLVSGFWG KVDAHKIGGE ALARLLVVYP WTQRYFTTFG NLGSADAICH    50
    NAKVLAHGEK VLAAIGEGLK HPENLKAHYA KLSEYHSNKL HVDPANFRLL 100
    GNVFITVLAR HFQHEFTPEL QHALEAHFCA VGDALAKAYH 140
    Length:140
    Mass (Da):15,424
    Last modified:July 21, 1986 - v1
    Checksum:i151F75CF7076AAB0
    GO

    Sequence databases

    PIRiA02454. HBFGRE.

    Cross-referencesi

    Sequence databases

    PIRi A02454. HBFGRE.

    3D structure databases

    ProteinModelPortali P02134.
    SMRi P02134. Positions 5-125.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P02134.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG009709.

    Family and domain databases

    Gene3Di 1.10.490.10. 1 hit.
    InterProi IPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    IPR002337. Haemoglobin_b.
    [Graphical view ]
    PANTHERi PTHR11442:SF7. PTHR11442:SF7. 1 hit.
    Pfami PF00042. Globin. 1 hit.
    [Graphical view ]
    PRINTSi PR00814. BETAHAEM.
    SUPFAMi SSF46458. SSF46458. 1 hit.
    PROSITEi PS01033. GLOBIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Phylogeny of hemoglobins. Beta chain of frog (Rana esculenta) hemoglobin."
      Chauvet J.-P., Acher R.
      Biochemistry 11:916-927(1972) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.

    Entry informationi

    Entry nameiHBB_RANES
    AccessioniPrimary (citable) accession number: P02134
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3