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P02134

- HBB_PELES

UniProt

P02134 - HBB_PELES

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Protein

Hemoglobin subunit beta

Gene

HBB

Organism
Pelophylax esculentus (Edible frog) (Rana esculenta)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi57 – 571Iron (heme distal ligand)
Metal bindingi86 – 861Iron (heme proximal ligand)

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. oxygen binding Source: InterPro
  4. oxygen transporter activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit beta
Alternative name(s):
Beta-globin
Hemoglobin beta chain
Gene namesi
Name:HBB
OrganismiPelophylax esculentus (Edible frog) (Rana esculenta)
Taxonomic identifieri8401 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraNeobatrachiaRanoideaRanidaePelophylax

Subcellular locationi

GO - Cellular componenti

  1. hemoglobin complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 140140Hemoglobin subunit betaPRO_0000053088Add
BLAST

Proteomic databases

PRIDEiP02134.

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Structurei

3D structure databases

ProteinModelPortaliP02134.
SMRiP02134. Positions 5-125.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002337. Haemoglobin_b.
[Graphical view]
PANTHERiPTHR11442:SF7. PTHR11442:SF7. 1 hit.
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00814. BETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P02134-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
GSDLVSGFWG KVDAHKIGGE ALARLLVVYP WTQRYFTTFG NLGSADAICH
60 70 80 90 100
NAKVLAHGEK VLAAIGEGLK HPENLKAHYA KLSEYHSNKL HVDPANFRLL
110 120 130 140
GNVFITVLAR HFQHEFTPEL QHALEAHFCA VGDALAKAYH
Length:140
Mass (Da):15,424
Last modified:July 21, 1986 - v1
Checksum:i151F75CF7076AAB0
GO

Sequence databases

PIRiA02454. HBFGRE.

Cross-referencesi

Sequence databases

PIRi A02454. HBFGRE.

3D structure databases

ProteinModelPortali P02134.
SMRi P02134. Positions 5-125.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P02134.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG009709.

Family and domain databases

Gene3Di 1.10.490.10. 1 hit.
InterProi IPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002337. Haemoglobin_b.
[Graphical view ]
PANTHERi PTHR11442:SF7. PTHR11442:SF7. 1 hit.
Pfami PF00042. Globin. 1 hit.
[Graphical view ]
PRINTSi PR00814. BETAHAEM.
SUPFAMi SSF46458. SSF46458. 1 hit.
PROSITEi PS01033. GLOBIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Phylogeny of hemoglobins. Beta chain of frog (Rana esculenta) hemoglobin."
    Chauvet J.-P., Acher R.
    Biochemistry 11:916-927(1972) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE.

Entry informationi

Entry nameiHBB_PELES
AccessioniPrimary (citable) accession number: P02134
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 26, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3