P02118 (HBB_ANSIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hemoglobin subunit beta

Alternative name(s):
Beta-globin
Hemoglobin beta chain

Gene names

Name:

HBB

Organism

Anser indicus (Bar-headed goose) (Anas indica)

Taxonomic identifier

8846 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Anseriformes › Anatidae › Anser

Protein attributes

Sequence length	146 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in oxygen transport from the lung to the various peripheral tissues.
Subunit structure	Heterotetramer of two alpha chains and two beta chains.
Tissue specificity	Red blood cells.
Sequence similarities	Belongs to the globin family.

Ontologies

Keywords
Biological process	Oxygen transport Transport
Ligand	Heme Iron Metal-binding
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Cellular_component	hemoglobin complex Inferred from electronic annotation. Source: InterPro
Molecular_function	heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro oxygen binding Inferred from electronic annotation. Source: InterPro oxygen transporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 146

146

Hemoglobin subunit beta

PRO_0000052873

Sites

Metal binding

63

1

Iron (heme distal ligand)

Metal binding

92

1

Iron (heme proximal ligand)

Secondary structure

1

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146

Helix Strand Turn

Details...

Helix

5 – 15

11

Helix

20 – 34

15

Helix

36 – 45

10

Helix

51 – 55

5

Helix

58 – 76

19

Turn

77 – 79

3

Helix

81 – 94

14

Helix

101 – 118

18

Helix

119 – 121

3

Helix

124 – 141

18

Turn

143 – 145

3

Sequences

	Sequence		Length	Mass (Da)
	P02118 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: 473E9A70E5602A53	FASTA	146	16,291
	10 20 30 40 50 60 VHWSAEEKQL ITGLWGKVNV ADCGAEALAR LLIVYPWTQR FFSSFGNLSS PTAILGNPMV 70 80 90 100 110 120 RAHGKKVLTS FGDAVKNLDN IKNTFAQLSE LHCDKLHVDP ENFRLLGDIL IIVLAAHFAK 130 140 EFTPDCQAAW QKLVRVVAHA LARKYH

References

[1]	"Hemoglobins, XLVII. Hemoglobins of the bar-headed goose (Anser indicus): primary structure and physiology of respiration, systematic and evolution." Oberthur W., Braunitzer G., Wurdinger I. Hoppe-Seyler's Z. Physiol. Chem. 363:581-590(1982) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE.
[2]	"The crystal structure of a high oxygen affinity species of haemoglobin (bar-headed goose haemoglobin in the oxy form)." Zhang J., Hua Z., Tame J.R.H., Lu G., Zhang R., Gu X. J. Mol. Biol. 255:484-493(1996) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
+	Additional computationally mapped references.

Cross-references

Sequence databases

PIR

HBGSI. A02438.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1A4F	X-ray	2.00	B	1-146	[»]
1C40	X-ray	2.30	B	1-146	[»]
1HV4	X-ray	2.80	B/D/F/H	1-146	[»]

ProteinModelPortal

P02118.

SMR

P02118. Positions 1-146.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Phylogenomic databases

HOVERGEN

HBG009709.

Family and domain databases

Gene3D

1.10.490.10. 1 hit.

InterPro

IPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002337. Haemoglobin_b.
[Graphical view]

PANTHER

PTHR11442:SF7. PTHR11442:SF7. 1 hit.

Pfam

PF00042. Globin. 1 hit.
[Graphical view]

PRINTS

PR00814. BETAHAEM.

SUPFAM

SSF46458. Globin_like. 1 hit.

PROSITE

PS01033. GLOBIN. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P02118.

Entry information

Entry name

HBB_ANSIN

Accession

Primary (citable) accession number: P02118

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	April 3, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program