ID   HBE_MOUSE               Reviewed;         147 AA.
AC   P02104; Q62480; Q64358;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   08-NOV-2023, entry version 157.
DE   RecName: Full=Hemoglobin subunit epsilon-Y2;
DE   AltName: Full=Epsilon-Y2-globin;
DE   AltName: Full=Hemoglobin epsilon-Y2 chain;
GN   Name=Hbb-y;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BALB/cJ;
RX   PubMed=2926808; DOI=10.1016/0022-2836(89)90363-x;
RA   Shehee W.R., Loeb D.D., Adey N.B., Burton F.H., Casavant N.C., Cole P.,
RA   Davies C.J., McGraw R.A., Schichman S.A., Severynse D.M., Voliva C.F.,
RA   Weyter F.W., Wisely G.B., Edgell M.H., Hutchison C.A. III;
RT   "Nucleotide sequence of the BALB/c mouse beta-globin complex.";
RL   J. Mol. Biol. 205:41-62(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BALB/cJ;
RX   PubMed=6274852; DOI=10.1016/s0021-9258(19)68306-7;
RA   Hansen J.N., Konkel D.A., Leder P.;
RT   "The sequence of a mouse embryonic beta-globin gene. Evolution of the gene
RT   and its signal region.";
RL   J. Biol. Chem. 257:1048-1052(1982).
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RA   Josifovska O., Gilman J.G.;
RL   Submitted (JUN-1992) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CBA/CaJ; TISSUE=Embryo;
RX   PubMed=2444404; DOI=10.1242/dev.99.4.493;
RA   Wilkinson D.G., Bailes J.A., Champion J.E., McMahon A.P.;
RT   "A molecular analysis of mouse development from 8 to 10 days post coitum
RT   detects changes only in embryonic globin expression.";
RL   Development 99:493-500(1987).
RN   [5]
RP   PROTEIN SEQUENCE OF 2-40.
RX   PubMed=938477; DOI=10.1042/bj1550231;
RA   Gilman J.G.;
RT   "Mouse haemoglobin beta chains. Sequence data on embryonic y chain and
RT   genetic linkage of the Y-chain locus to the adult beta-chain locus Hbb.";
RL   Biochem. J. 155:231-241(1976).
RN   [6]
RP   NUCLEOTIDE SEQUENCE OF 22-147.
RX   PubMed=6177582; DOI=10.1016/0378-1119(81)90070-6;
RA   Vanin E.F., Farace M.G., Gambari R., Fantoni A.;
RT   "The nucleotide sequence of the mouse embryonic beta-like y-globin
RT   messenger RNA as determined from cloned cDNA.";
RL   Gene 16:141-148(1981).
RN   [7]
RP   NUCLEOTIDE SEQUENCE OF 32-105.
RC   STRAIN=BALB/cJ; TISSUE=Embryo;
RX   PubMed=6250710; DOI=10.1016/0092-8674(80)90123-3;
RA   Jahn C.L., Hutchison C.A. III, Phillips S.J., Weaver S., Haigwood N.L.,
RA   Voliva C.F., Edgell M.H.;
RT   "DNA sequence organization of the beta-globin complex in the BALB/c
RT   mouse.";
RL   Cell 21:159-168(1980).
CC   -!- FUNCTION: Hemoglobin epsilon chain is a beta-type chain found in early
CC       embryos.
CC   -!- TISSUE SPECIFICITY: High expression in yolk sac blood islands, fetal
CC       liver, and embryonic erythrocytes. Very low levels in adult liver and
CC       spleen.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   EMBL; X14061; CAA32219.1; -; Genomic_DNA.
DR   EMBL; V00726; CAA24104.1; -; Genomic_DNA.
DR   EMBL; M95676; AAA40575.1; -; Genomic_DNA.
DR   EMBL; M26897; AAA37701.1; -; mRNA.
DR   EMBL; V00857; CAA24225.1; -; mRNA.
DR   EMBL; V00742; CAA24117.1; -; Genomic_DNA.
DR   CCDS; CCDS21593.1; -.
DR   PIR; A92342; HEMSY2.
DR   RefSeq; NP_032247.1; NM_008221.4.
DR   AlphaFoldDB; P02104; -.
DR   SMR; P02104; -.
DR   BioGRID; 200224; 2.
DR   ComplexPortal; CPX-2939; Embryonic hemoglobin complex.
DR   STRING; 10090.ENSMUSP00000033229; -.
DR   iPTMnet; P02104; -.
DR   PhosphoSitePlus; P02104; -.
DR   jPOST; P02104; -.
DR   MaxQB; P02104; -.
DR   PaxDb; 10090-ENSMUSP00000033229; -.
DR   PeptideAtlas; P02104; -.
DR   ProteomicsDB; 271493; -.
DR   DNASU; 15135; -.
DR   GeneID; 15135; -.
DR   KEGG; mmu:15135; -.
DR   AGR; MGI:96027; -.
DR   CTD; 15135; -.
DR   MGI; MGI:96027; Hbb-y.
DR   eggNOG; KOG3378; Eukaryota.
DR   InParanoid; P02104; -.
DR   OrthoDB; 5356926at2759; -.
DR   PhylomeDB; P02104; -.
DR   BioGRID-ORCS; 15135; 0 hits in 78 CRISPR screens.
DR   ChiTaRS; Hbb-y; mouse.
DR   PRO; PR:P02104; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; P02104; Protein.
DR   GO; GO:0031838; C:haptoglobin-hemoglobin complex; IBA:GO_Central.
DR   GO; GO:0005833; C:hemoglobin complex; ISO:MGI.
DR   GO; GO:0020037; F:heme binding; IBA:GO_Central.
DR   GO; GO:0031721; F:hemoglobin alpha binding; ISO:MGI.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0043177; F:organic acid binding; IBA:GO_Central.
DR   GO; GO:0019825; F:oxygen binding; IBA:GO_Central.
DR   GO; GO:0005344; F:oxygen carrier activity; ISO:MGI.
DR   GO; GO:0044877; F:protein-containing complex binding; ISO:MGI.
DR   GO; GO:0015670; P:carbon dioxide transport; NAS:ComplexPortal.
DR   GO; GO:0098869; P:cellular oxidant detoxification; IEA:GOC.
DR   GO; GO:0042744; P:hydrogen peroxide catabolic process; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:MGI.
DR   GO; GO:0015671; P:oxygen transport; NAS:ComplexPortal.
DR   CDD; cd08925; Hb-beta-like; 1.
DR   Gene3D; 1.10.490.10; Globins; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   InterPro; IPR002337; Hemoglobin_b.
DR   PANTHER; PTHR11442; HEMOGLOBIN FAMILY MEMBER; 1.
DR   PANTHER; PTHR11442:SF84; HEMOGLOBIN SUBUNIT EPSILON-Y2; 1.
DR   Pfam; PF00042; Globin; 1.
DR   PRINTS; PR00814; BETAHAEM.
DR   SUPFAM; SSF46458; Globin-like; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Heme; Iron; Metal-binding; Oxygen transport;
KW   Phosphoprotein; Reference proteome; Transport.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:938477"
FT   CHAIN           2..147
FT                   /note="Hemoglobin subunit epsilon-Y2"
FT                   /id="PRO_0000053219"
FT   BINDING         64
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT   BINDING         93
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT   MOD_RES         51
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P02100"
FT   VARIANT         22..23
FT                   /note="EE -> GK"
FT   VARIANT         40
FT                   /note="Q -> H"
FT   VARIANT         94
FT                   /note="Missing"
FT   VARIANT         124
FT                   /note="Missing"
SQ   SEQUENCE   147 AA;  16137 MW;  BAA84E91B8864C88 CRC64;
     MVNFTAEEKT LINGLWSKVN VEEVGGEALG RLLVVYPWTQ RFFDSFGNLS SASAIMGNPR
     VKAHGKKVLT AFGESIKNLD NLKSALAKLS ELHCDKLHVD PENFKLLGNV LVIVLASHFG
     NEFTAEMQAA WQKLVAGVAT ALSHKYH
//