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Protein

Hemoglobin subunit epsilon-Y2

Gene

Hbb-y

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Hemoglobin epsilon chain is a beta-type chain found in early embryos.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi64 – 641Iron (heme distal ligand)PROSITE-ProRule annotation
Metal bindingi93 – 931Iron (heme proximal ligand)PROSITE-ProRule annotation

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. oxygen binding Source: InterPro
  4. oxygen transporter activity Source: UniProtKB-KW

GO - Biological processi

  1. negative regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit epsilon-Y2
Alternative name(s):
Epsilon-Y2-globin
Hemoglobin epsilon-Y2 chain
Gene namesi
Name:Hbb-y
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:96027. Hbb-y.

Subcellular locationi

GO - Cellular componenti

  1. blood microparticle Source: MGI
  2. hemoglobin complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 147146Hemoglobin subunit epsilon-Y2PRO_0000053219Add
BLAST

Proteomic databases

MaxQBiP02104.
PaxDbiP02104.
PRIDEiP02104.

PTM databases

PhosphoSiteiP02104.

Expressioni

Tissue specificityi

High expression in yolk sac blood islands, fetal liver, and embryonic erythrocytes. Very low levels in adult liver and spleen.

Gene expression databases

CleanExiMM_HBB-Y.
GenevestigatoriP02104.

Interactioni

Protein-protein interaction databases

BioGridi200224. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP02104.
SMRiP02104. Positions 2-146.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG325823.
HOGENOMiHOG000036868.
HOVERGENiHBG009709.
InParanoidiP02104.
KOiK13825.
PhylomeDBiP02104.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002337. Haemoglobin_b.
[Graphical view]
PANTHERiPTHR11442:SF7. PTHR11442:SF7. 1 hit.
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00814. BETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02104-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNFTAEEKT LINGLWSKVN VEEVGGEALG RLLVVYPWTQ RFFDSFGNLS
60 70 80 90 100
SASAIMGNPR VKAHGKKVLT AFGESIKNLD NLKSALAKLS ELHCDKLHVD
110 120 130 140
PENFKLLGNV LVIVLASHFG NEFTAEMQAA WQKLVAGVAT ALSHKYH
Length:147
Mass (Da):16,137
Last modified:January 23, 2007 - v2
Checksum:iBAA84E91B8864C88
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti22 – 232EE → GK.
Natural varianti40 – 401Q → H.
Natural varianti94 – 941Missing .
Natural varianti124 – 1241Missing .

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14061 Genomic DNA. Translation: CAA32219.1.
V00726 Genomic DNA. Translation: CAA24104.1.
M95676 Genomic DNA. Translation: AAA40575.1.
M26897 mRNA. Translation: AAA37701.1.
V00857 mRNA. Translation: CAA24225.1.
V00742 Genomic DNA. Translation: CAA24117.1.
CCDSiCCDS21593.1.
PIRiA92342. HEMSY2.
RefSeqiNP_032247.1. NM_008221.4.
UniGeneiMm.440164.

Genome annotation databases

GeneIDi15135.
KEGGimmu:15135.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14061 Genomic DNA. Translation: CAA32219.1.
V00726 Genomic DNA. Translation: CAA24104.1.
M95676 Genomic DNA. Translation: AAA40575.1.
M26897 mRNA. Translation: AAA37701.1.
V00857 mRNA. Translation: CAA24225.1.
V00742 Genomic DNA. Translation: CAA24117.1.
CCDSiCCDS21593.1.
PIRiA92342. HEMSY2.
RefSeqiNP_032247.1. NM_008221.4.
UniGeneiMm.440164.

3D structure databases

ProteinModelPortaliP02104.
SMRiP02104. Positions 2-146.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200224. 1 interaction.

PTM databases

PhosphoSiteiP02104.

Proteomic databases

MaxQBiP02104.
PaxDbiP02104.
PRIDEiP02104.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi15135.
KEGGimmu:15135.

Organism-specific databases

CTDi15135.
MGIiMGI:96027. Hbb-y.

Phylogenomic databases

eggNOGiNOG325823.
HOGENOMiHOG000036868.
HOVERGENiHBG009709.
InParanoidiP02104.
KOiK13825.
PhylomeDBiP02104.

Miscellaneous databases

ChiTaRSiHbb-y. mouse.
NextBioi287598.
PROiP02104.
SOURCEiSearch...

Gene expression databases

CleanExiMM_HBB-Y.
GenevestigatoriP02104.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002337. Haemoglobin_b.
[Graphical view]
PANTHERiPTHR11442:SF7. PTHR11442:SF7. 1 hit.
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00814. BETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/c.
  2. "The sequence of a mouse embryonic beta-globin gene. Evolution of the gene and its signal region."
    Hansen J.N., Konkel D.A., Leder P.
    J. Biol. Chem. 257:1048-1052(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/c.
  3. Josifovska O., Gilman J.G.
    Submitted (JUN-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. "A molecular analysis of mouse development from 8 to 10 days post coitum detects changes only in embryonic globin expression."
    Wilkinson D.G., Bailes J.A., Champion J.E., McMahon A.P.
    Development 99:493-500(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: CBA/Ca.
    Tissue: Embryo.
  5. "Mouse haemoglobin beta chains. Sequence data on embryonic y chain and genetic linkage of the Y-chain locus to the adult beta-chain locus Hbb."
    Gilman J.G.
    Biochem. J. 155:231-241(1976) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-40.
  6. "The nucleotide sequence of the mouse embryonic beta-like y-globin messenger RNA as determined from cloned cDNA."
    Vanin E.F., Farace M.G., Gambari R., Fantoni A.
    Gene 16:141-148(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 22-147.
  7. "DNA sequence organization of the beta-globin complex in the BALB/c mouse."
    Jahn C.L., Hutchison C.A. III, Phillips S.J., Weaver S., Haigwood N.L., Voliva C.F., Edgell M.H.
    Cell 21:159-168(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 32-105.
    Strain: BALB/c.
    Tissue: Embryo.

Entry informationi

Entry nameiHBE_MOUSE
AccessioniPrimary (citable) accession number: P02104
Secondary accession number(s): Q62480, Q64358
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: February 4, 2015
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.