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P02104

- HBE_MOUSE

UniProt

P02104 - HBE_MOUSE

Protein

Hemoglobin subunit epsilon-Y2

Gene

Hbb-y

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Hemoglobin epsilon chain is a beta-type chain found in early embryos.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi64 – 641Iron (heme distal ligand)PROSITE-ProRule annotation
    Metal bindingi93 – 931Iron (heme proximal ligand)PROSITE-ProRule annotation

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. oxygen binding Source: InterPro
    4. oxygen transporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. negative regulation of transcription from RNA polymerase II promoter Source: MGI

    Keywords - Biological processi

    Oxygen transport, Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hemoglobin subunit epsilon-Y2
    Alternative name(s):
    Epsilon-Y2-globin
    Hemoglobin epsilon-Y2 chain
    Gene namesi
    Name:Hbb-y
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:96027. Hbb-y.

    Subcellular locationi

    GO - Cellular componenti

    1. hemoglobin complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 147146Hemoglobin subunit epsilon-Y2PRO_0000053219Add
    BLAST

    Proteomic databases

    MaxQBiP02104.
    PaxDbiP02104.
    PRIDEiP02104.

    PTM databases

    PhosphoSiteiP02104.

    Expressioni

    Tissue specificityi

    High expression in yolk sac blood islands, fetal liver, and embryonic erythrocytes. Very low levels in adult liver and spleen.

    Gene expression databases

    CleanExiMM_HBB-Y.
    GenevestigatoriP02104.

    Interactioni

    Protein-protein interaction databases

    BioGridi200224. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP02104.
    SMRiP02104. Positions 2-146.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the globin family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG325823.
    HOGENOMiHOG000036868.
    HOVERGENiHBG009709.
    InParanoidiP02104.
    KOiK13825.
    PhylomeDBiP02104.

    Family and domain databases

    Gene3Di1.10.490.10. 1 hit.
    InterProiIPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    IPR002337. Haemoglobin_b.
    [Graphical view]
    PANTHERiPTHR11442:SF7. PTHR11442:SF7. 1 hit.
    PfamiPF00042. Globin. 1 hit.
    [Graphical view]
    PRINTSiPR00814. BETAHAEM.
    SUPFAMiSSF46458. SSF46458. 1 hit.
    PROSITEiPS01033. GLOBIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P02104-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVNFTAEEKT LINGLWSKVN VEEVGGEALG RLLVVYPWTQ RFFDSFGNLS    50
    SASAIMGNPR VKAHGKKVLT AFGESIKNLD NLKSALAKLS ELHCDKLHVD 100
    PENFKLLGNV LVIVLASHFG NEFTAEMQAA WQKLVAGVAT ALSHKYH 147
    Length:147
    Mass (Da):16,137
    Last modified:January 23, 2007 - v2
    Checksum:iBAA84E91B8864C88
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti22 – 232EE → GK.
    Natural varianti40 – 401Q → H.
    Natural varianti94 – 941Missing.
    Natural varianti124 – 1241Missing.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14061 Genomic DNA. Translation: CAA32219.1.
    V00726 Genomic DNA. Translation: CAA24104.1.
    M95676 Genomic DNA. Translation: AAA40575.1.
    M26897 mRNA. Translation: AAA37701.1.
    V00857 mRNA. Translation: CAA24225.1.
    V00742 Genomic DNA. Translation: CAA24117.1.
    CCDSiCCDS21593.1.
    PIRiA92342. HEMSY2.
    RefSeqiNP_032247.1. NM_008221.4.
    UniGeneiMm.440164.

    Genome annotation databases

    GeneIDi15135.
    KEGGimmu:15135.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X14061 Genomic DNA. Translation: CAA32219.1 .
    V00726 Genomic DNA. Translation: CAA24104.1 .
    M95676 Genomic DNA. Translation: AAA40575.1 .
    M26897 mRNA. Translation: AAA37701.1 .
    V00857 mRNA. Translation: CAA24225.1 .
    V00742 Genomic DNA. Translation: CAA24117.1 .
    CCDSi CCDS21593.1.
    PIRi A92342. HEMSY2.
    RefSeqi NP_032247.1. NM_008221.4.
    UniGenei Mm.440164.

    3D structure databases

    ProteinModelPortali P02104.
    SMRi P02104. Positions 2-146.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200224. 1 interaction.

    PTM databases

    PhosphoSitei P02104.

    Proteomic databases

    MaxQBi P02104.
    PaxDbi P02104.
    PRIDEi P02104.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 15135.
    KEGGi mmu:15135.

    Organism-specific databases

    CTDi 15135.
    MGIi MGI:96027. Hbb-y.

    Phylogenomic databases

    eggNOGi NOG325823.
    HOGENOMi HOG000036868.
    HOVERGENi HBG009709.
    InParanoidi P02104.
    KOi K13825.
    PhylomeDBi P02104.

    Miscellaneous databases

    ChiTaRSi Hbb-y. mouse.
    NextBioi 287598.
    PROi P02104.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_HBB-Y.
    Genevestigatori P02104.

    Family and domain databases

    Gene3Di 1.10.490.10. 1 hit.
    InterProi IPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    IPR002337. Haemoglobin_b.
    [Graphical view ]
    PANTHERi PTHR11442:SF7. PTHR11442:SF7. 1 hit.
    Pfami PF00042. Globin. 1 hit.
    [Graphical view ]
    PRINTSi PR00814. BETAHAEM.
    SUPFAMi SSF46458. SSF46458. 1 hit.
    PROSITEi PS01033. GLOBIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BALB/c.
    2. "The sequence of a mouse embryonic beta-globin gene. Evolution of the gene and its signal region."
      Hansen J.N., Konkel D.A., Leder P.
      J. Biol. Chem. 257:1048-1052(1982) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: BALB/c.
    3. Josifovska O., Gilman J.G.
      Submitted (JUN-1992) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    4. "A molecular analysis of mouse development from 8 to 10 days post coitum detects changes only in embryonic globin expression."
      Wilkinson D.G., Bailes J.A., Champion J.E., McMahon A.P.
      Development 99:493-500(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: CBA/Ca.
      Tissue: Embryo.
    5. "Mouse haemoglobin beta chains. Sequence data on embryonic y chain and genetic linkage of the Y-chain locus to the adult beta-chain locus Hbb."
      Gilman J.G.
      Biochem. J. 155:231-241(1976) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-40.
    6. "The nucleotide sequence of the mouse embryonic beta-like y-globin messenger RNA as determined from cloned cDNA."
      Vanin E.F., Farace M.G., Gambari R., Fantoni A.
      Gene 16:141-148(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 22-147.
    7. "DNA sequence organization of the beta-globin complex in the BALB/c mouse."
      Jahn C.L., Hutchison C.A. III, Phillips S.J., Weaver S., Haigwood N.L., Voliva C.F., Edgell M.H.
      Cell 21:159-168(1980) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 32-105.
      Strain: BALB/c.
      Tissue: Embryo.

    Entry informationi

    Entry nameiHBE_MOUSE
    AccessioniPrimary (citable) accession number: P02104
    Secondary accession number(s): Q62480, Q64358
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3