P02104 (HBE_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hemoglobin subunit epsilon-Y2

Alternative name(s):
Epsilon-Y2-globin
Hemoglobin epsilon-Y2 chain

Gene names

Name:

Hbb-y

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	147 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Hemoglobin epsilon chain is a beta-type chain found in early embryos.
Tissue specificity	High expression in yolk sac blood islands, fetal liver, and embryonic erythrocytes. Very low levels in adult liver and spleen.
Sequence similarities	Belongs to the globin family.

Ontologies

Keywords
Biological process	Oxygen transport Transport
Ligand	Heme Iron Metal-binding
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of transcription from RNA polymerase II promoter Inferred from mutant phenotype PubMed 17077320. Source: MGI
Cellular_component	hemoglobin complex Inferred from electronic annotation. Source: InterPro
Molecular_function	heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro oxygen binding Inferred from electronic annotation. Source: InterPro oxygen transporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.5
	Chain	2 – 147	146	Hemoglobin subunit epsilon-Y2		PRO_0000053219
Sites
	Metal binding	64	1	Iron (heme distal ligand) By similarity
	Metal binding	93	1	Iron (heme proximal ligand) By similarity
Natural variations
	Natural variant	22 – 23	2	EE → GK.
	Natural variant	40	1	Q → H.
	Natural variant	94	1	Missing.
	Natural variant	124	1	Missing.

Sequences

	Sequence		Length	Mass (Da)
	P02104 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: BAA84E91B8864C88	FASTA	147	16,137
	10 20 30 40 50 60 MVNFTAEEKT LINGLWSKVN VEEVGGEALG RLLVVYPWTQ RFFDSFGNLS SASAIMGNPR 70 80 90 100 110 120 VKAHGKKVLT AFGESIKNLD NLKSALAKLS ELHCDKLHVD PENFKLLGNV LVIVLASHFG 130 140 NEFTAEMQAA WQKLVAGVAT ALSHKYH

References

[1]	"Nucleotide sequence of the BALB/c mouse beta-globin complex." Shehee W.R., Loeb D.D., Adey N.B., Burton F.H., Casavant N.C., Cole P., Davies C.J., McGraw R.A., Schichman S.A., Severynse D.M., Voliva C.F., Weyter F.W., Wisely G.B., Edgell M.H., Hutchison C.A. III J. Mol. Biol. 205:41-62(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BALB/c.
[2]	"The sequence of a mouse embryonic beta-globin gene. Evolution of the gene and its signal region." Hansen J.N., Konkel D.A., Leder P. J. Biol. Chem. 257:1048-1052(1982) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BALB/c.
[3]	Josifovska O., Gilman J.G. Submitted (JUN-1992) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[4]	"A molecular analysis of mouse development from 8 to 10 days post coitum detects changes only in embryonic globin expression." Wilkinson D.G., Bailes J.A., Champion J.E., McMahon A.P. Development 99:493-500(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: CBA/Ca. Tissue: Embryo.
[5]	"Mouse haemoglobin beta chains. Sequence data on embryonic y chain and genetic linkage of the Y-chain locus to the adult beta-chain locus Hbb." Gilman J.G. Biochem. J. 155:231-241(1976) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-40.
[6]	"The nucleotide sequence of the mouse embryonic beta-like y-globin messenger RNA as determined from cloned cDNA." Vanin E.F., Farace M.G., Gambari R., Fantoni A. Gene 16:141-148(1981) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 22-147.
[7]	"DNA sequence organization of the beta-globin complex in the BALB/c mouse." Jahn C.L., Hutchison C.A. III, Phillips S.J., Weaver S., Haigwood N.L., Voliva C.F., Edgell M.H. Cell 21:159-168(1980) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 32-105. Strain: BALB/c. Tissue: Embryo.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X14061 Genomic DNA. Translation: CAA32219.1. V00726 Genomic DNA. Translation: CAA24104.1. M95676 Genomic DNA. Translation: AAA40575.1. M26897 mRNA. Translation: AAA37701.1. V00857 mRNA. Translation: CAA24225.1. V00742 Genomic DNA. Translation: CAA24117.1.
IPI	IPI00555131.
PIR	HEMSY2. A92342.
RefSeq	NP_032247.1. NM_008221.4.
UniGene	Mm.440164.
3D structure databases
ProteinModelPortal	P02104.
SMR	P02104. Positions 2-146.
ModBase	Search...
PTM databases
PhosphoSite	P02104.
Proteomic databases
PaxDb	P02104.
PRIDE	P02104.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	15135.
KEGG	mmu:15135.
Organism-specific databases
CTD	15135.
MGI	MGI:96027. Hbb-y.
Phylogenomic databases
eggNOG	NOG325823.
HOGENOM	HOG000036868.
HOVERGEN	HBG009709.
InParanoid	P02104.
KO	K13825.
OrthoDB	EOG4THVVF.
Gene expression databases
CleanEx	MM_HBB-Y.
Genevestigator	P02104.
GermOnline	ENSMUSG00000052187. Mus musculus.
Family and domain databases
Gene3D	1.10.490.10. 1 hit.
InterPro	IPR000971. Globin. IPR009050. Globin-like. IPR012292. Globin_dom. IPR002337. Haemoglobin_b. [Graphical view]
PANTHER	PTHR11442:SF7. PTHR11442:SF7. 1 hit.
Pfam	PF00042. Globin. 1 hit. [Graphical view]
PRINTS	PR00814. BETAHAEM.
SUPFAM	SSF46458. Globin_like. 1 hit.
PROSITE	PS01033. GLOBIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	Hbb-y. mouse.
NextBio	287598.
SOURCE	Search...

Entry information

Entry name

HBE_MOUSE

Accession

Primary (citable) accession number: P02104
Secondary accession number(s): Q62480, Q64358

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	January 23, 2007
Last modified:	April 3, 2013
This is version 106 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program