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P02104 (HBE_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hemoglobin subunit epsilon-Y2
Alternative name(s):
Epsilon-Y2-globin
Hemoglobin epsilon-Y2 chain
Gene names
Name:Hbb-y
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length147 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Hemoglobin epsilon chain is a beta-type chain found in early embryos.

Tissue specificity

High expression in yolk sac blood islands, fetal liver, and embryonic erythrocytes. Very low levels in adult liver and spleen.

Sequence similarities

Belongs to the globin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.5
Chain2 – 147146Hemoglobin subunit epsilon-Y2
PRO_0000053219

Sites

Metal binding641Iron (heme distal ligand) By similarity
Metal binding931Iron (heme proximal ligand) By similarity

Natural variations

Natural variant22 – 232EE → GK.
Natural variant401Q → H.
Natural variant941Missing.
Natural variant1241Missing.

Sequences

Sequence LengthMass (Da)Tools
P02104 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: BAA84E91B8864C88

FASTA14716,137
        10         20         30         40         50         60 
MVNFTAEEKT LINGLWSKVN VEEVGGEALG RLLVVYPWTQ RFFDSFGNLS SASAIMGNPR 

        70         80         90        100        110        120 
VKAHGKKVLT AFGESIKNLD NLKSALAKLS ELHCDKLHVD PENFKLLGNV LVIVLASHFG 

       130        140 
NEFTAEMQAA WQKLVAGVAT ALSHKYH 

« Hide

References

[1]"Nucleotide sequence of the BALB/c mouse beta-globin complex."
Shehee W.R., Loeb D.D., Adey N.B., Burton F.H., Casavant N.C., Cole P., Davies C.J., McGraw R.A., Schichman S.A., Severynse D.M., Voliva C.F., Weyter F.W., Wisely G.B., Edgell M.H., Hutchison C.A. III
J. Mol. Biol. 205:41-62(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BALB/c.
[2]"The sequence of a mouse embryonic beta-globin gene. Evolution of the gene and its signal region."
Hansen J.N., Konkel D.A., Leder P.
J. Biol. Chem. 257:1048-1052(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: BALB/c.
[3]Josifovska O., Gilman J.G.
Submitted (JUN-1992) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[4]"A molecular analysis of mouse development from 8 to 10 days post coitum detects changes only in embryonic globin expression."
Wilkinson D.G., Bailes J.A., Champion J.E., McMahon A.P.
Development 99:493-500(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: CBA/Ca.
Tissue: Embryo.
[5]"Mouse haemoglobin beta chains. Sequence data on embryonic y chain and genetic linkage of the Y-chain locus to the adult beta-chain locus Hbb."
Gilman J.G.
Biochem. J. 155:231-241(1976) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-40.
[6]"The nucleotide sequence of the mouse embryonic beta-like y-globin messenger RNA as determined from cloned cDNA."
Vanin E.F., Farace M.G., Gambari R., Fantoni A.
Gene 16:141-148(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 22-147.
[7]"DNA sequence organization of the beta-globin complex in the BALB/c mouse."
Jahn C.L., Hutchison C.A. III, Phillips S.J., Weaver S., Haigwood N.L., Voliva C.F., Edgell M.H.
Cell 21:159-168(1980) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 32-105.
Strain: BALB/c.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X14061 Genomic DNA. Translation: CAA32219.1.
V00726 Genomic DNA. Translation: CAA24104.1.
M95676 Genomic DNA. Translation: AAA40575.1.
M26897 mRNA. Translation: AAA37701.1.
V00857 mRNA. Translation: CAA24225.1.
V00742 Genomic DNA. Translation: CAA24117.1.
PIRHEMSY2. A92342.
RefSeqNP_032247.1. NM_008221.4.
UniGeneMm.440164.

3D structure databases

ProteinModelPortalP02104.
SMRP02104. Positions 2-146.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP02104.

Proteomic databases

PaxDbP02104.
PRIDEP02104.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID15135.
KEGGmmu:15135.

Organism-specific databases

CTD15135.
MGIMGI:96027. Hbb-y.

Phylogenomic databases

eggNOGNOG325823.
HOGENOMHOG000036868.
HOVERGENHBG009709.
InParanoidP02104.
KOK13825.
PhylomeDBP02104.

Gene expression databases

CleanExMM_HBB-Y.
GenevestigatorP02104.

Family and domain databases

Gene3D1.10.490.10. 1 hit.
InterProIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002337. Haemoglobin_b.
[Graphical view]
PANTHERPTHR11442:SF7. PTHR11442:SF7. 1 hit.
PfamPF00042. Globin. 1 hit.
[Graphical view]
PRINTSPR00814. BETAHAEM.
SUPFAMSSF46458. SSF46458. 1 hit.
PROSITEPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHbb-y. mouse.
NextBio287598.
PROP02104.
SOURCESearch...

Entry information

Entry nameHBE_MOUSE
AccessionPrimary (citable) accession number: P02104
Secondary accession number(s): Q62480, Q64358
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot