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P02100

- HBE_HUMAN

UniProt

P02100 - HBE_HUMAN

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Protein

Hemoglobin subunit epsilon

Gene

HBE1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi64 – 641Iron (heme distal ligand)
Metal bindingi93 – 931Iron (heme proximal ligand)

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. oxygen binding Source: InterPro
  4. oxygen transporter activity Source: ProtInc

GO - Biological processi

  1. blood coagulation Source: Reactome
  2. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  3. protein heterooligomerization Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_24970. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit epsilon
Alternative name(s):
Epsilon-globin
Hemoglobin epsilon chain
Gene namesi
Name:HBE1
Synonyms:HBE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:4830. HBE1.

Subcellular locationi

GO - Cellular componenti

  1. blood microparticle Source: UniProt
  2. cytosol Source: Reactome
  3. hemoglobin complex Source: ProtInc
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29205.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 147146Hemoglobin subunit epsilonPRO_0000053212Add
BLAST

Proteomic databases

MaxQBiP02100.
PaxDbiP02100.
PeptideAtlasiP02100.
PRIDEiP02100.

PTM databases

PhosphoSiteiP02100.

Expressioni

Tissue specificityi

Red blood cells.

Gene expression databases

BgeeiP02100.
CleanExiHS_HBE1.
ExpressionAtlasiP02100. baseline and differential.
GenevestigatoriP02100.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two epsilon chains in early embryonic hemoglobin Gower-2; two zeta chains and two epsilon chains in early embryonic hemoglobin Gower-1.1 Publication

Protein-protein interaction databases

BioGridi109296. 2 interactions.
IntActiP02100. 4 interactions.
STRINGi9606.ENSP00000292896.

Structurei

Secondary structure

1
147
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 1813Combined sources
Turni21 – 233Combined sources
Helixi24 – 3512Combined sources
Helixi37 – 415Combined sources
Helixi44 – 463Combined sources
Helixi52 – 576Combined sources
Helixi59 – 7618Combined sources
Beta strandi79 – 813Combined sources
Turni83 – 864Combined sources
Helixi87 – 948Combined sources
Turni95 – 973Combined sources
Helixi102 – 11918Combined sources
Helixi120 – 1223Combined sources
Helixi125 – 14218Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1A9WX-ray2.90E/F2-147[»]
ProteinModelPortaliP02100.
SMRiP02100. Positions 2-146.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02100.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG325823.
GeneTreeiENSGT00760000119197.
HOGENOMiHOG000036868.
HOVERGENiHBG009709.
InParanoidiP02100.
KOiK13825.
OMAiMDNLKGA.
OrthoDBiEOG7B8S5H.
PhylomeDBiP02100.
TreeFamiTF333268.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002337. Haemoglobin_b.
[Graphical view]
PANTHERiPTHR11442:SF7. PTHR11442:SF7. 1 hit.
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00814. BETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02100-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVHFTAEEKA AVTSLWSKMN VEEAGGEALG RLLVVYPWTQ RFFDSFGNLS
60 70 80 90 100
SPSAILGNPK VKAHGKKVLT SFGDAIKNMD NLKPAFAKLS ELHCDKLHVD
110 120 130 140
PENFKLLGNV MVIILATHFG KEFTPEVQAA WQKLVSAVAI ALAHKYH
Length:147
Mass (Da):16,203
Last modified:January 23, 2007 - v2
Checksum:i223388816EDDE8D5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti143 – 1431A → G AA sequence (PubMed:6172865)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01317 Genomic DNA. Translation: AAA16330.1.
V00508 Genomic DNA. Translation: CAA23766.1.
CR541912 mRNA. Translation: CAG46710.1.
CH471064 Genomic DNA. Translation: EAW68802.1.
BC015537 mRNA. Translation: AAH15537.1.
CCDSiCCDS7756.1.
PIRiA90802. HEHU.
RefSeqiNP_005321.1. NM_005330.3.
UniGeneiHs.655195.

Genome annotation databases

EnsembliENST00000292896; ENSP00000292896; ENSG00000213931.
ENST00000380237; ENSP00000369586; ENSG00000213931.
GeneIDi3046.
KEGGihsa:3046.
UCSCiuc001mal.1. human.

Polymorphism databases

DMDMi122726.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01317 Genomic DNA. Translation: AAA16330.1 .
V00508 Genomic DNA. Translation: CAA23766.1 .
CR541912 mRNA. Translation: CAG46710.1 .
CH471064 Genomic DNA. Translation: EAW68802.1 .
BC015537 mRNA. Translation: AAH15537.1 .
CCDSi CCDS7756.1.
PIRi A90802. HEHU.
RefSeqi NP_005321.1. NM_005330.3.
UniGenei Hs.655195.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1A9W X-ray 2.90 E/F 2-147 [» ]
ProteinModelPortali P02100.
SMRi P02100. Positions 2-146.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109296. 2 interactions.
IntActi P02100. 4 interactions.
STRINGi 9606.ENSP00000292896.

PTM databases

PhosphoSitei P02100.

Polymorphism databases

DMDMi 122726.

Proteomic databases

MaxQBi P02100.
PaxDbi P02100.
PeptideAtlasi P02100.
PRIDEi P02100.

Protocols and materials databases

DNASUi 3046.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000292896 ; ENSP00000292896 ; ENSG00000213931 .
ENST00000380237 ; ENSP00000369586 ; ENSG00000213931 .
GeneIDi 3046.
KEGGi hsa:3046.
UCSCi uc001mal.1. human.

Organism-specific databases

CTDi 3046.
GeneCardsi GC11M005289.
HGNCi HGNC:4830. HBE1.
MIMi 142100. gene.
neXtProti NX_P02100.
PharmGKBi PA29205.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG325823.
GeneTreei ENSGT00760000119197.
HOGENOMi HOG000036868.
HOVERGENi HBG009709.
InParanoidi P02100.
KOi K13825.
OMAi MDNLKGA.
OrthoDBi EOG7B8S5H.
PhylomeDBi P02100.
TreeFami TF333268.

Enzyme and pathway databases

Reactomei REACT_24970. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

EvolutionaryTracei P02100.
GeneWikii HBE1.
GenomeRNAii 3046.
NextBioi 12059.
PROi P02100.
SOURCEi Search...

Gene expression databases

Bgeei P02100.
CleanExi HS_HBE1.
ExpressionAtlasi P02100. baseline and differential.
Genevestigatori P02100.

Family and domain databases

Gene3Di 1.10.490.10. 1 hit.
InterProi IPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002337. Haemoglobin_b.
[Graphical view ]
PANTHERi PTHR11442:SF7. PTHR11442:SF7. 1 hit.
Pfami PF00042. Globin. 1 hit.
[Graphical view ]
PRINTSi PR00814. BETAHAEM.
SUPFAMi SSF46458. SSF46458. 1 hit.
PROSITEi PS01033. GLOBIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The primary structure of the human epsilon-globin gene."
    Baralle F.E., Shoulders C.C., Proudfoot N.J.
    Cell 21:621-626(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  5. "Embryonic hemoglobin: sequence of the epsilon and zeta chains."
    Clegg J.B.
    Tex. Rep. Biol. Med. 40:23-28(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-147.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Crystal structure of a human embryonic haemoglobin: the carbonmonoxy form of Gower II (alpha2 epsilon2) haemoglobin at 2.9-A resolution."
    Sutherland-Smith A.J., Baker H.M., Hofmann O.M., Brittain T., Baker E.N.
    J. Mol. Biol. 280:475-484(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF HB GOWER-2, SUBUNIT.

Entry informationi

Entry nameiHBE_HUMAN
AccessioniPrimary (citable) accession number: P02100
Secondary accession number(s): Q6FH44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 149 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3