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Protein

Hemoglobin subunit epsilon

Gene

HBE1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi64Iron (heme distal ligand)By similarity1
Metal bindingi93Iron (heme proximal ligand)Combined sources1 Publication1

GO - Molecular functioni

  • heme binding Source: InterPro
  • hemoglobin alpha binding Source: Ensembl
  • iron ion binding Source: InterPro
  • oxygen binding Source: InterPro
  • oxygen transporter activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171924-MONOMER.
ReactomeiR-HSA-983231. Factors involved in megakaryocyte development and platelet production.

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit epsilon
Alternative name(s):
Epsilon-globin
Hemoglobin epsilon chain
Gene namesi
Name:HBE1
Synonyms:HBE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:4830. HBE1.

Subcellular locationi

GO - Cellular componenti

  • blood microparticle Source: UniProtKB
  • cytosol Source: Reactome
  • hemoglobin complex Source: ProtInc
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi3046.
OpenTargetsiENSG00000213931.
PharmGKBiPA29205.

Polymorphism and mutation databases

BioMutaiHBE1.
DMDMi122726.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000532122 – 147Hemoglobin subunit epsilonAdd BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineCombined sources1
Modified residuei51PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP02100.
MaxQBiP02100.
PaxDbiP02100.
PeptideAtlasiP02100.
PRIDEiP02100.

PTM databases

iPTMnetiP02100.
PhosphoSitePlusiP02100.

Expressioni

Tissue specificityi

Red blood cells.

Gene expression databases

BgeeiENSG00000213931.
CleanExiHS_HBE1.
ExpressionAtlasiP02100. baseline and differential.
GenevisibleiP02100. HS.

Organism-specific databases

HPAiHPA043234.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two epsilon chains in early embryonic hemoglobin Gower-2; two zeta chains and two epsilon chains in early embryonic hemoglobin Gower-1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
HBZP020083EBI-6190240,EBI-719843

Protein-protein interaction databases

BioGridi109296. 5 interactors.
IntActiP02100. 5 interactors.
STRINGi9606.ENSP00000292896.

Structurei

Secondary structure

1147
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 18Combined sources13
Turni21 – 23Combined sources3
Helixi24 – 35Combined sources12
Helixi37 – 41Combined sources5
Helixi44 – 46Combined sources3
Helixi52 – 57Combined sources6
Helixi59 – 76Combined sources18
Beta strandi79 – 81Combined sources3
Turni83 – 86Combined sources4
Helixi87 – 94Combined sources8
Turni95 – 97Combined sources3
Helixi102 – 119Combined sources18
Helixi120 – 122Combined sources3
Helixi125 – 142Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A9WX-ray2.90E/F2-147[»]
ProteinModelPortaliP02100.
SMRiP02100.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02100.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
GeneTreeiENSGT00760000119197.
HOGENOMiHOG000036868.
HOVERGENiHBG009709.
InParanoidiP02100.
KOiK13825.
OMAiPTAIIGN.
OrthoDBiEOG091G0R7W.
PhylomeDBiP02100.
TreeFamiTF333268.

Family and domain databases

CDDicd08925. Hb-beta_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002337. Haemoglobin_b.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00814. BETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02100-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHFTAEEKA AVTSLWSKMN VEEAGGEALG RLLVVYPWTQ RFFDSFGNLS
60 70 80 90 100
SPSAILGNPK VKAHGKKVLT SFGDAIKNMD NLKPAFAKLS ELHCDKLHVD
110 120 130 140
PENFKLLGNV MVIILATHFG KEFTPEVQAA WQKLVSAVAI ALAHKYH
Length:147
Mass (Da):16,203
Last modified:January 23, 2007 - v2
Checksum:i223388816EDDE8D5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti143A → G AA sequence (PubMed:6172865).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01317 Genomic DNA. Translation: AAA16330.1.
V00508 Genomic DNA. Translation: CAA23766.1.
CR541912 mRNA. Translation: CAG46710.1.
CH471064 Genomic DNA. Translation: EAW68802.1.
BC015537 mRNA. Translation: AAH15537.1.
CCDSiCCDS7756.1.
PIRiA90802. HEHU.
RefSeqiNP_005321.1. NM_005330.3.
UniGeneiHs.655195.

Genome annotation databases

EnsembliENST00000292896; ENSP00000292896; ENSG00000213931.
ENST00000380237; ENSP00000369586; ENSG00000213931.
GeneIDi3046.
KEGGihsa:3046.
UCSCiuc001mal.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01317 Genomic DNA. Translation: AAA16330.1.
V00508 Genomic DNA. Translation: CAA23766.1.
CR541912 mRNA. Translation: CAG46710.1.
CH471064 Genomic DNA. Translation: EAW68802.1.
BC015537 mRNA. Translation: AAH15537.1.
CCDSiCCDS7756.1.
PIRiA90802. HEHU.
RefSeqiNP_005321.1. NM_005330.3.
UniGeneiHs.655195.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1A9WX-ray2.90E/F2-147[»]
ProteinModelPortaliP02100.
SMRiP02100.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109296. 5 interactors.
IntActiP02100. 5 interactors.
STRINGi9606.ENSP00000292896.

PTM databases

iPTMnetiP02100.
PhosphoSitePlusiP02100.

Polymorphism and mutation databases

BioMutaiHBE1.
DMDMi122726.

Proteomic databases

EPDiP02100.
MaxQBiP02100.
PaxDbiP02100.
PeptideAtlasiP02100.
PRIDEiP02100.

Protocols and materials databases

DNASUi3046.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000292896; ENSP00000292896; ENSG00000213931.
ENST00000380237; ENSP00000369586; ENSG00000213931.
GeneIDi3046.
KEGGihsa:3046.
UCSCiuc001mal.2. human.

Organism-specific databases

CTDi3046.
DisGeNETi3046.
GeneCardsiHBE1.
HGNCiHGNC:4830. HBE1.
HPAiHPA043234.
MIMi142100. gene.
neXtProtiNX_P02100.
OpenTargetsiENSG00000213931.
PharmGKBiPA29205.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
GeneTreeiENSGT00760000119197.
HOGENOMiHOG000036868.
HOVERGENiHBG009709.
InParanoidiP02100.
KOiK13825.
OMAiPTAIIGN.
OrthoDBiEOG091G0R7W.
PhylomeDBiP02100.
TreeFamiTF333268.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000171924-MONOMER.
ReactomeiR-HSA-983231. Factors involved in megakaryocyte development and platelet production.

Miscellaneous databases

EvolutionaryTraceiP02100.
GeneWikiiHBE1.
GenomeRNAii3046.
PROiP02100.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000213931.
CleanExiHS_HBE1.
ExpressionAtlasiP02100. baseline and differential.
GenevisibleiP02100. HS.

Family and domain databases

CDDicd08925. Hb-beta_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002337. Haemoglobin_b.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00814. BETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHBE_HUMAN
AccessioniPrimary (citable) accession number: P02100
Secondary accession number(s): Q6FH44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 168 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.