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P02100 (HBE_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 143. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hemoglobin subunit epsilon
Alternative name(s):
Epsilon-globin
Hemoglobin epsilon chain
Gene names
Name:HBE1
Synonyms:HBE
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length147 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The epsilon chain is a beta-type chain of early mammalian embryonic hemoglobin.

Subunit structure

Heterotetramer of two alpha chains and two epsilon chains in early embryonic hemoglobin Gower-2; two zeta chains and two epsilon chains in early embryonic hemoglobin Gower-1. Ref.7

Tissue specificity

Red blood cells.

Sequence similarities

Belongs to the globin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.5
Chain2 – 147146Hemoglobin subunit epsilon
PRO_0000053212

Sites

Metal binding641Iron (heme distal ligand)
Metal binding931Iron (heme proximal ligand)

Experimental info

Sequence conflict1431A → G AA sequence Ref.5

Secondary structure

......................... 147
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P02100 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 223388816EDDE8D5

FASTA14716,203
        10         20         30         40         50         60 
MVHFTAEEKA AVTSLWSKMN VEEAGGEALG RLLVVYPWTQ RFFDSFGNLS SPSAILGNPK 

        70         80         90        100        110        120 
VKAHGKKVLT SFGDAIKNMD NLKPAFAKLS ELHCDKLHVD PENFKLLGNV MVIILATHFG 

       130        140 
KEFTPEVQAA WQKLVSAVAI ALAHKYH 

« Hide

References

« Hide 'large scale' references
[1]"The primary structure of the human epsilon-globin gene."
Baralle F.E., Shoulders C.C., Proudfoot N.J.
Cell 21:621-626(1980) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[5]"Embryonic hemoglobin: sequence of the epsilon and zeta chains."
Clegg J.B.
Tex. Rep. Biol. Med. 40:23-28(1980) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-147.
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"Crystal structure of a human embryonic haemoglobin: the carbonmonoxy form of Gower II (alpha2 epsilon2) haemoglobin at 2.9-A resolution."
Sutherland-Smith A.J., Baker H.M., Hofmann O.M., Brittain T., Baker E.N.
J. Mol. Biol. 280:475-484(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF HB GOWER-2, SUBUNIT.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U01317 Genomic DNA. Translation: AAA16330.1.
V00508 Genomic DNA. Translation: CAA23766.1.
CR541912 mRNA. Translation: CAG46710.1.
CH471064 Genomic DNA. Translation: EAW68802.1.
BC015537 mRNA. Translation: AAH15537.1.
PIRHEHU. A90802.
RefSeqNP_005321.1. NM_005330.3.
UniGeneHs.655195.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1A9WX-ray2.90E/F2-147[»]
ProteinModelPortalP02100.
SMRP02100. Positions 2-146.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109296. 2 interactions.
IntActP02100. 4 interactions.
STRING9606.ENSP00000292896.

PTM databases

PhosphoSiteP02100.

Polymorphism databases

DMDM122726.

Proteomic databases

PaxDbP02100.
PeptideAtlasP02100.
PRIDEP02100.

Protocols and materials databases

DNASU3046.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000292896; ENSP00000292896; ENSG00000213931.
ENST00000380237; ENSP00000369586; ENSG00000213931.
GeneID3046.
KEGGhsa:3046.
UCSCuc001mal.1. human.

Organism-specific databases

CTD3046.
GeneCardsGC11M005289.
HGNCHGNC:4830. HBE1.
MIM142100. gene.
neXtProtNX_P02100.
PharmGKBPA29205.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG325823.
HOGENOMHOG000036868.
HOVERGENHBG009709.
InParanoidP02100.
KOK13825.
OMAMDNLKGA.
OrthoDBEOG7B8S5H.
PhylomeDBP02100.
TreeFamTF333268.

Enzyme and pathway databases

ReactomeREACT_604. Hemostasis.

Gene expression databases

ArrayExpressP02100.
BgeeP02100.
CleanExHS_HBE1.
GenevestigatorP02100.

Family and domain databases

Gene3D1.10.490.10. 1 hit.
InterProIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002337. Haemoglobin_b.
[Graphical view]
PANTHERPTHR11442:SF7. PTHR11442:SF7. 1 hit.
PfamPF00042. Globin. 1 hit.
[Graphical view]
PRINTSPR00814. BETAHAEM.
SUPFAMSSF46458. SSF46458. 1 hit.
PROSITEPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP02100.
GeneWikiHBE1.
GenomeRNAi3046.
NextBio12059.
PROP02100.
SOURCESearch...

Entry information

Entry nameHBE_HUMAN
AccessionPrimary (citable) accession number: P02100
Secondary accession number(s): Q6FH44
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: April 16, 2014
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM