P02097 (HBG_MACNE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hemoglobin subunit gamma

Alternative name(s):
Gamma-globin
Hemoglobin gamma chain

Gene names

Name:

HBG

Organism

Macaca nemestrina (Pig-tailed macaque)

Taxonomic identifier

9545 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Cercopithecoidea › Cercopithecidae › Cercopithecinae › Macaca

Protein attributes

Sequence length	146 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.
Subunit structure	Heterotetramer of two alpha chains and two gamma chains in fetal hemoglobin (Hb F).
Tissue specificity	Red blood cells.
Miscellaneous	The gamma-slow sequence is shown. The residues responsible for the gamma-fast sequence are not known.
Sequence similarities	Belongs to the globin family.

Ontologies

Keywords
Biological process	Oxygen transport Transport
Ligand	Heme Iron Metal-binding
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular_component	hemoglobin complex Inferred from electronic annotation. Source: InterPro
Molecular_function	heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro oxygen binding Inferred from electronic annotation. Source: InterPro oxygen transporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 146	146	Hemoglobin subunit gamma		PRO_0000053260
Sites
	Metal binding	63	1	Iron (heme distal ligand) By similarity
	Metal binding	92	1	Iron (heme proximal ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	P02097 [UniParc]. Last modified July 21, 1986. Version 1. Checksum: C180EEFEF50359C4	FASTA	146	15,989
	10 20 30 40 50 60 GHFTEEDKAT ITSLWGKVNV EDAGGETLGR LLVVYPWTQR FFDSFGNLSS ASAIMGNPKV 70 80 90 100 110 120 KAHGKKVLTS LGDAIKNLDD LKGTFAQLSE LHCDKLHVDP ENFRLLGNVL VTVLAIRFGK 130 140 EFTPEVQASW QKMVAGVASA LSSRYH

References

[1]	"Complete amino acid sequence of the gamma chain from the major fetal hemoglobin of the pig-tailed macaque, Macaca nemestrina." Nute P.E., Mahoney W.C. Biochemistry 18:467-472(1979) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases
PIR	HGMQP. A02413.
3D structure databases
ProteinModelPortal	P02097.
SMR	P02097. Positions 1-146.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
HOVERGEN	HBG009709.
Family and domain databases
Gene3D	1.10.490.10. 1 hit.
InterPro	IPR000971. Globin. IPR009050. Globin-like. IPR012292. Globin_dom. IPR002337. Haemoglobin_b. [Graphical view]
PANTHER	PTHR11442:SF7. PTHR11442:SF7. 1 hit.
Pfam	PF00042. Globin. 1 hit. [Graphical view]
PRINTS	PR00814. BETAHAEM.
SUPFAM	SSF46458. Globin_like. 1 hit.
PROSITE	PS01033. GLOBIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HBG_MACNE

Accession

Primary (citable) accession number: P02097

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	April 3, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program