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P02097 (HBG_MACNE) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Hemoglobin subunit gamma
Alternative name(s):
Gamma-globin
Hemoglobin gamma chain
Gene names
Name:HBG
OrganismMacaca nemestrina (Pig-tailed macaque)
Taxonomic identifier9545 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Protein attributes

Sequence length146 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.

Subunit structure

Heterotetramer of two alpha chains and two gamma chains in fetal hemoglobin (Hb F).

Tissue specificity

Red blood cells.

Miscellaneous

The gamma-slow sequence is shown. The residues responsible for the gamma-fast sequence are not known.

Sequence similarities

Belongs to the globin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 146146Hemoglobin subunit gamma
PRO_0000053260

Sites

Metal binding631Iron (heme distal ligand) By similarity
Metal binding921Iron (heme proximal ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
P02097 [UniParc].

Last modified July 21, 1986. Version 1.
Checksum: C180EEFEF50359C4

FASTA14615,989
        10         20         30         40         50         60 
GHFTEEDKAT ITSLWGKVNV EDAGGETLGR LLVVYPWTQR FFDSFGNLSS ASAIMGNPKV 

        70         80         90        100        110        120 
KAHGKKVLTS LGDAIKNLDD LKGTFAQLSE LHCDKLHVDP ENFRLLGNVL VTVLAIRFGK 

       130        140 
EFTPEVQASW QKMVAGVASA LSSRYH 

« Hide

References

[1]"Complete amino acid sequence of the gamma chain from the major fetal hemoglobin of the pig-tailed macaque, Macaca nemestrina."
Nute P.E., Mahoney W.C.
Biochemistry 18:467-472(1979) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE.

Cross-references

Sequence databases

PIRHGMQP. A02413.

3D structure databases

ProteinModelPortalP02097.
SMRP02097. Positions 1-146.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG009709.

Family and domain databases

Gene3D1.10.490.10. 1 hit.
InterProIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002337. Haemoglobin_b.
[Graphical view]
PANTHERPTHR11442:SF7. PTHR11442:SF7. 1 hit.
PfamPF00042. Globin. 1 hit.
[Graphical view]
PRINTSPR00814. BETAHAEM.
SUPFAMSSF46458. SSF46458. 1 hit.
PROSITEPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHBG_MACNE
AccessionPrimary (citable) accession number: P02097
Entry history
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: October 16, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families