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P02097

- HBG_MACNE

UniProt

P02097 - HBG_MACNE

Protein

Hemoglobin subunit gamma

Gene

HBG

Organism
Macaca nemestrina (Pig-tailed macaque)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi63 – 631Iron (heme distal ligand)PROSITE-ProRule annotation
    Metal bindingi92 – 921Iron (heme proximal ligand)PROSITE-ProRule annotation

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. oxygen binding Source: InterPro
    4. oxygen transporter activity Source: UniProtKB-KW

    Keywords - Biological processi

    Oxygen transport, Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hemoglobin subunit gamma
    Alternative name(s):
    Gamma-globin
    Hemoglobin gamma chain
    Gene namesi
    Name:HBG
    OrganismiMacaca nemestrina (Pig-tailed macaque)
    Taxonomic identifieri9545 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

    Subcellular locationi

    GO - Cellular componenti

    1. hemoglobin complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 146146Hemoglobin subunit gammaPRO_0000053260Add
    BLAST

    Expressioni

    Tissue specificityi

    Red blood cells.

    Interactioni

    Subunit structurei

    Heterotetramer of two alpha chains and two gamma chains in fetal hemoglobin (Hb F).

    Structurei

    3D structure databases

    ProteinModelPortaliP02097.
    SMRiP02097. Positions 1-146.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the globin family.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG009709.

    Family and domain databases

    Gene3Di1.10.490.10. 1 hit.
    InterProiIPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    IPR002337. Haemoglobin_b.
    [Graphical view]
    PfamiPF00042. Globin. 1 hit.
    [Graphical view]
    PRINTSiPR00814. BETAHAEM.
    SUPFAMiSSF46458. SSF46458. 1 hit.
    PROSITEiPS01033. GLOBIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P02097-1 [UniParc]FASTAAdd to Basket

    « Hide

    GHFTEEDKAT ITSLWGKVNV EDAGGETLGR LLVVYPWTQR FFDSFGNLSS    50
    ASAIMGNPKV KAHGKKVLTS LGDAIKNLDD LKGTFAQLSE LHCDKLHVDP 100
    ENFRLLGNVL VTVLAIRFGK EFTPEVQASW QKMVAGVASA LSSRYH 146
    Length:146
    Mass (Da):15,989
    Last modified:July 21, 1986 - v1
    Checksum:iC180EEFEF50359C4
    GO

    Sequence databases

    PIRiA02413. HGMQP.

    Cross-referencesi

    Sequence databases

    PIRi A02413. HGMQP.

    3D structure databases

    ProteinModelPortali P02097.
    SMRi P02097. Positions 1-146.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG009709.

    Family and domain databases

    Gene3Di 1.10.490.10. 1 hit.
    InterProi IPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    IPR002337. Haemoglobin_b.
    [Graphical view ]
    Pfami PF00042. Globin. 1 hit.
    [Graphical view ]
    PRINTSi PR00814. BETAHAEM.
    SUPFAMi SSF46458. SSF46458. 1 hit.
    PROSITEi PS01033. GLOBIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete amino acid sequence of the gamma chain from the major fetal hemoglobin of the pig-tailed macaque, Macaca nemestrina."
      Nute P.E., Mahoney W.C.
      Biochemistry 18:467-472(1979) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.

    Entry informationi

    Entry nameiHBG_MACNE
    AccessioniPrimary (citable) accession number: P02097
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The gamma-slow sequence is shown. The residues responsible for the gamma-fast sequence are not known.

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3