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Protein

Hemoglobin subunit gamma

Gene

HBG

Organism
Macaca nemestrina (Pig-tailed macaque)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Gamma chains make up the fetal hemoglobin F, in combination with alpha chains.

Miscellaneous

The gamma-slow sequence is shown. The residues responsible for the gamma-fast sequence are not known.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi63Iron (heme distal ligand)PROSITE-ProRule annotation1
Metal bindingi92Iron (heme proximal ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit gamma
Alternative name(s):
Gamma-globin
Hemoglobin gamma chain
Gene namesi
Name:HBG
OrganismiMacaca nemestrina (Pig-tailed macaque)
Taxonomic identifieri9545 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca
Proteomesi
  • UP000233120 Componenti: Whole Genome Shotgun Assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000532601 – 146Hemoglobin subunit gammaAdd BLAST146

Proteomic databases

PRIDEiP02097.

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two gamma chains in fetal hemoglobin (Hb F).

Structurei

3D structure databases

ProteinModelPortaliP02097.
SMRiP02097.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709.
OrthoDBiEOG091G0R7W.

Family and domain databases

CDDicd08925. Hb-beta_like. 1 hit.
InterProiView protein in InterPro
IPR000971. Globin.
IPR009050. Globin-like_sf.
IPR002337. Haemoglobin_b.
PfamiView protein in Pfam
PF00042. Globin. 1 hit.
PRINTSiPR00814. BETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiView protein in PROSITE
PS01033. GLOBIN. 1 hit.

Sequencei

Sequence statusi: Complete.

P02097-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GHFTEEDKAT ITSLWGKVNV EDAGGETLGR LLVVYPWTQR FFDSFGNLSS
60 70 80 90 100
ASAIMGNPKV KAHGKKVLTS LGDAIKNLDD LKGTFAQLSE LHCDKLHVDP
110 120 130 140
ENFRLLGNVL VTVLAIRFGK EFTPEVQASW QKMVAGVASA LSSRYH
Length:146
Mass (Da):15,989
Last modified:July 21, 1986 - v1
Checksum:iC180EEFEF50359C4
GO

Sequence databases

PIRiA02413. HGMQP.

Similar proteinsi

Entry informationi

Entry nameiHBG_MACNE
AccessioniPrimary (citable) accession number: P02097
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: March 28, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing