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Protein

Hemoglobin subunit beta-1

Gene

Hbb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi64Iron (heme distal ligand)1
Metal bindingi93Iron (heme proximal ligand)1

GO - Molecular functioni

  • heme binding Source: InterPro
  • hemoglobin alpha binding Source: RGD
  • hemoglobin beta binding Source: RGD
  • iron ion binding Source: InterPro
  • oxygen binding Source: InterPro
  • oxygen transporter activity Source: UniProtKB-KW

GO - Biological processi

  • glutathione metabolic process Source: RGD
  • oxygen transport Source: RGD
  • protein heterooligomerization Source: RGD
Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit beta-1
Alternative name(s):
Beta-1-globin
Hemoglobin beta chain, major-form
Hemoglobin beta-1 chain
Gene namesi
Name:Hbb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2783. Hbb.

Subcellular locationi

GO - Cellular componenti

  • hemoglobin complex Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity3 Publications
ChainiPRO_00000530902 – 147Hemoglobin subunit beta-1Add BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylvalineBy similarity1
Modified residuei18N6-succinyllysineBy similarity1
Modified residuei45PhosphoserineCombined sources1
Modified residuei51PhosphoserineCombined sources1
Modified residuei53PhosphoserineCombined sources1
Modified residuei60N6-acetyllysine; alternateBy similarity1
Modified residuei60N6-succinyllysine; alternateBy similarity1
Modified residuei83N6-acetyllysineBy similarity1
Modified residuei94S-nitrosocysteineBy similarity1
Modified residuei105Asymmetric dimethylarginineBy similarity1
Modified residuei124PhosphothreonineBy similarity1
Modified residuei145N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein, S-nitrosylation

Proteomic databases

PaxDbiP02091.
PRIDEiP02091.

PTM databases

iPTMnetiP02091.
PhosphoSitePlusiP02091.

Expressioni

Tissue specificityi

Red blood cells.

Gene expression databases

BgeeiENSRNOG00000049424.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Protein-protein interaction databases

BioGridi246605. 2 interactors.
STRINGi10116.ENSRNOP00000048250.

Structurei

Secondary structure

1147
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 16Combined sources11
Helixi21 – 35Combined sources15
Helixi37 – 42Combined sources6
Helixi44 – 46Combined sources3
Helixi52 – 57Combined sources6
Helixi59 – 77Combined sources19
Helixi79 – 81Combined sources3
Helixi82 – 85Combined sources4
Helixi87 – 95Combined sources9
Helixi102 – 119Combined sources18
Helixi120 – 122Combined sources3
Helixi125 – 142Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DHTX-ray2.98B2-147[»]
3HF4X-ray2.70B/F2-147[»]
ProteinModelPortaliP02091.
SMRiP02091.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02091.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
HOGENOMiHOG000036868.
HOVERGENiHBG009709.
InParanoidiP02091.
KOiK13823.
PhylomeDBiP02091.
TreeFamiTF333268.

Family and domain databases

CDDicd08925. Hb-beta_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002337. Haemoglobin_b.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00814. BETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02091-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHLTDAEKA AVNGLWGKVN PDDVGGEALG RLLVVYPWTQ RYFDSFGDLS
60 70 80 90 100
SASAIMGNPK VKAHGKKVIN AFNDGLKHLD NLKGTFAHLS ELHCDKLHVD
110 120 130 140
PENFRLLGNM IVIVLGHHLG KEFTPCAQAA FQKVVAGVAS ALAHKYH
Length:147
Mass (Da):15,979
Last modified:January 23, 2007 - v3
Checksum:i77A715901BC44D26
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti14G → A in AAA41309 (PubMed:3619896).Curated1

Polymorphismi

In rats there are two non-allelic alpha chains and two non-allelic beta chains.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti59P → A.1
Natural varianti88H → N.1
Natural varianti90S → T.1
Natural varianti124T → S.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16417 mRNA. Translation: CAA34439.1.
X15009 Genomic DNA. Translation: CAA33114.1.
M17084 mRNA. Translation: AAA41309.1.
X67613 Genomic DNA. Translation: CAA47873.1.
BC058448 mRNA. Translation: AAH58448.1.
PIRiS04588.
S06748. HBRT.
RefSeqiNP_150237.1. NM_033234.1.
UniGeneiRn.202945.
Rn.216394.

Genome annotation databases

GeneIDi24440.
KEGGirno:24440.
UCSCiRGD:2783. rat.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16417 mRNA. Translation: CAA34439.1.
X15009 Genomic DNA. Translation: CAA33114.1.
M17084 mRNA. Translation: AAA41309.1.
X67613 Genomic DNA. Translation: CAA47873.1.
BC058448 mRNA. Translation: AAH58448.1.
PIRiS04588.
S06748. HBRT.
RefSeqiNP_150237.1. NM_033234.1.
UniGeneiRn.202945.
Rn.216394.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DHTX-ray2.98B2-147[»]
3HF4X-ray2.70B/F2-147[»]
ProteinModelPortaliP02091.
SMRiP02091.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi246605. 2 interactors.
STRINGi10116.ENSRNOP00000048250.

PTM databases

iPTMnetiP02091.
PhosphoSitePlusiP02091.

Proteomic databases

PaxDbiP02091.
PRIDEiP02091.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi24440.
KEGGirno:24440.
UCSCiRGD:2783. rat.

Organism-specific databases

CTDi3043.
RGDi2783. Hbb.

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
HOGENOMiHOG000036868.
HOVERGENiHBG009709.
InParanoidiP02091.
KOiK13823.
PhylomeDBiP02091.
TreeFamiTF333268.

Miscellaneous databases

EvolutionaryTraceiP02091.
PROiP02091.

Gene expression databases

BgeeiENSRNOG00000049424.

Family and domain databases

CDDicd08925. Hb-beta_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002337. Haemoglobin_b.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00814. BETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHBB1_RAT
AccessioniPrimary (citable) accession number: P02091
Secondary accession number(s): P33584
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 148 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

PubMed:8334153 incorrectly assigned their sequence fragment as a fatty acid-binding protein.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.