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P02089

- HBB2_MOUSE

UniProt

P02089 - HBB2_MOUSE

Protein

Hemoglobin subunit beta-2

Gene

Hbb-b2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Involved in oxygen transport from the lung to the various peripheral tissues.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi64 – 641Iron (heme distal ligand)
    Metal bindingi93 – 931Iron (heme proximal ligand)

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. oxygen binding Source: MGI
    4. oxygen transporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. erythrocyte development Source: MGI
    2. positive regulation of myeloid cell differentiation Source: MGI
    3. regulation of erythrocyte differentiation Source: MGI

    Keywords - Biological processi

    Oxygen transport, Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hemoglobin subunit beta-2
    Alternative name(s):
    Beta-2-globin
    Hemoglobin beta-2 chain
    Hemoglobin beta-minor chain
    Gene namesi
    Name:Hbb-b2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:96022. Hbb-b2.

    Subcellular locationi

    GO - Cellular componenti

    1. hemoglobin complex Source: MGI

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 147146Hemoglobin subunit beta-2PRO_0000053025Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei18 – 181N6-succinyllysine1 Publication
    Modified residuei60 – 601N6-succinyllysine1 Publication

    Proteomic databases

    MaxQBiP02089.
    PRIDEiP02089.

    PTM databases

    PhosphoSiteiP02089.

    Expressioni

    Tissue specificityi

    Red blood cells.

    Gene expression databases

    GenevestigatoriP02089.

    Interactioni

    Subunit structurei

    Heterotetramer of two alpha chains and two beta chains.

    Protein-protein interaction databases

    BioGridi200220. 1 interaction.
    IntActiP02089. 11 interactions.
    MINTiMINT-4097249.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1FNEX-ray1.90B/D65-77[»]
    1FNGX-ray1.90B/D65-77[»]
    1I3RX-ray2.40B/D/F/H65-77[»]
    ProteinModelPortaliP02089.
    SMRiP02089. Positions 2-147.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP02089.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the globin family.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG009709.
    InParanoidiQ5D0E8.
    KOiK13823.

    Family and domain databases

    Gene3Di1.10.490.10. 1 hit.
    InterProiIPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    IPR002337. Haemoglobin_b.
    [Graphical view]
    PfamiPF00042. Globin. 1 hit.
    [Graphical view]
    PRINTSiPR00814. BETAHAEM.
    SUPFAMiSSF46458. SSF46458. 1 hit.
    PROSITEiPS01033. GLOBIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P02089-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVHLTDAEKS AVSCLWAKVN PDEVGGEALG RLLVVYPWTQ RYFDSFGDLS    50
    SASAIMGNPK VKAHGKKVIT AFNEGLKNLD NLKGTFASLS ELHCDKLHVD 100
    PENFRLLGNA IVIVLGHHLG KDFTPAAQAA FQKVVAGVAT ALAHKYH 147
    Length:147
    Mass (Da):15,878
    Last modified:January 23, 2007 - v2
    Checksum:i1FABBDC2D0ABC4FD
    GO

    Polymorphismi

    Inbred mouse strains possess 1 of 3 alleles at the HBB locus: D (diffuse), S (single), and P. The D and P alleles are actually closely linked doublets that coordinately express a major and a minor chain, the minor chain being slightly different in the two alleles. The S allele produces only 1 chain, it is characteristic of North American wild mice.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti23 – 242EV → AI in allele P.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V00722 Genomic DNA. Translation: CAA24101.1.
    X14061 Genomic DNA. Translation: CAA32225.1. Sequence problems.
    BC027434 mRNA. Translation: AAH27434.1.
    BC032264 mRNA. Translation: AAH32264.1.
    PIRiB90790. HBMSN1.
    RefSeqiNP_058652.1. NM_016956.3.
    UniGeneiMm.288567.
    Mm.467412.

    Genome annotation databases

    GeneIDi15130.
    KEGGimmu:15130.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    V00722 Genomic DNA. Translation: CAA24101.1 .
    X14061 Genomic DNA. Translation: CAA32225.1 . Sequence problems.
    BC027434 mRNA. Translation: AAH27434.1 .
    BC032264 mRNA. Translation: AAH32264.1 .
    PIRi B90790. HBMSN1.
    RefSeqi NP_058652.1. NM_016956.3.
    UniGenei Mm.288567.
    Mm.467412.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1FNE X-ray 1.90 B/D 65-77 [» ]
    1FNG X-ray 1.90 B/D 65-77 [» ]
    1I3R X-ray 2.40 B/D/F/H 65-77 [» ]
    ProteinModelPortali P02089.
    SMRi P02089. Positions 2-147.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200220. 1 interaction.
    IntActi P02089. 11 interactions.
    MINTi MINT-4097249.

    Chemistry

    ChEMBLi CHEMBL4007.

    PTM databases

    PhosphoSitei P02089.

    Proteomic databases

    MaxQBi P02089.
    PRIDEi P02089.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 15130.
    KEGGi mmu:15130.

    Organism-specific databases

    CTDi 15130.
    MGIi MGI:96022. Hbb-b2.

    Phylogenomic databases

    HOVERGENi HBG009709.
    InParanoidi Q5D0E8.
    KOi K13823.

    Miscellaneous databases

    EvolutionaryTracei P02089.
    NextBioi 287586.
    PROi P02089.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori P02089.

    Family and domain databases

    Gene3Di 1.10.490.10. 1 hit.
    InterProi IPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    IPR002337. Haemoglobin_b.
    [Graphical view ]
    Pfami PF00042. Globin. 1 hit.
    [Graphical view ]
    PRINTSi PR00814. BETAHAEM.
    SUPFAMi SSF46458. SSF46458. 1 hit.
    PROSITEi PS01033. GLOBIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.
    2. "The evolution and sequence comparison of two recently diverged mouse chromosomal beta-globin genes."
      Konkel D.A., Maizel J.V. Jr., Leder P.
      Cell 18:865-873(1979) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: BALB/c.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT 24-ALA--ILE-25.
      Strain: Czech II and FVB/N.
      Tissue: Mammary gland and Salivary gland.
    4. "Mouse haemoglobin beta chains. Comparative sequence data on adult major and minor beta chains from two species, Mus musculus and Mus cervicolor."
      Gilman J.G.
      Biochem. J. 159:43-53(1976) [PubMed] [Europe PMC] [Abstract]
      Cited for: POLYMORPHISM, VARIANT 23-ALA-ILE-24.
    5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-18 AND LYS-60, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiHBB2_MOUSE
    AccessioniPrimary (citable) accession number: P02089
    Secondary accession number(s): Q5D0E8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 129 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The D-minor sequence is shown. See also the entry for the beta D-major chain and the S allele.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3