Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P02089

- HBB2_MOUSE

UniProt

P02089 - HBB2_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Hemoglobin subunit beta-2

Gene

Hbb-b2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi64 – 641Iron (heme distal ligand)
Metal bindingi93 – 931Iron (heme proximal ligand)

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. oxygen binding Source: MGI
  4. oxygen transporter activity Source: UniProtKB-KW

GO - Biological processi

  1. erythrocyte development Source: MGI
  2. positive regulation of myeloid cell differentiation Source: MGI
  3. regulation of erythrocyte differentiation Source: MGI
Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit beta-2
Alternative name(s):
Beta-2-globin
Hemoglobin beta-2 chain
Hemoglobin beta-minor chain
Gene namesi
Name:Hbb-b2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:96022. Hbb-b2.

Subcellular locationi

GO - Cellular componenti

  1. hemoglobin complex Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 147146Hemoglobin subunit beta-2PRO_0000053025Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei18 – 181N6-succinyllysine1 Publication
Modified residuei60 – 601N6-succinyllysine1 Publication

Proteomic databases

MaxQBiP02089.
PRIDEiP02089.

PTM databases

PhosphoSiteiP02089.

Expressioni

Tissue specificityi

Red blood cells.

Gene expression databases

GenevestigatoriP02089.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Protein-protein interaction databases

BioGridi200220. 1 interaction.
IntActiP02089. 11 interactions.
MINTiMINT-4097249.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FNEX-ray1.90B/D65-77[»]
1FNGX-ray1.90B/D65-77[»]
1I3RX-ray2.40B/D/F/H65-77[»]
ProteinModelPortaliP02089.
SMRiP02089. Positions 2-147.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02089.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709.
InParanoidiP02089.
KOiK13823.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002337. Haemoglobin_b.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00814. BETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02089-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVHLTDAEKS AVSCLWAKVN PDEVGGEALG RLLVVYPWTQ RYFDSFGDLS
60 70 80 90 100
SASAIMGNPK VKAHGKKVIT AFNEGLKNLD NLKGTFASLS ELHCDKLHVD
110 120 130 140
PENFRLLGNA IVIVLGHHLG KDFTPAAQAA FQKVVAGVAT ALAHKYH
Length:147
Mass (Da):15,878
Last modified:January 23, 2007 - v2
Checksum:i1FABBDC2D0ABC4FD
GO

Polymorphismi

Inbred mouse strains possess 1 of 3 alleles at the HBB locus: D (diffuse), S (single), and P. The D and P alleles are actually closely linked doublets that coordinately express a major and a minor chain, the minor chain being slightly different in the two alleles. The S allele produces only 1 chain, it is characteristic of North American wild mice.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti23 – 242EV → AI in allele P.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00722 Genomic DNA. Translation: CAA24101.1.
X14061 Genomic DNA. Translation: CAA32225.1. Sequence problems.
BC027434 mRNA. Translation: AAH27434.1.
BC032264 mRNA. Translation: AAH32264.1.
PIRiB90790. HBMSN1.
RefSeqiNP_058652.1. NM_016956.3.
UniGeneiMm.288567.
Mm.467412.

Genome annotation databases

GeneIDi15130.
KEGGimmu:15130.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00722 Genomic DNA. Translation: CAA24101.1 .
X14061 Genomic DNA. Translation: CAA32225.1 . Sequence problems.
BC027434 mRNA. Translation: AAH27434.1 .
BC032264 mRNA. Translation: AAH32264.1 .
PIRi B90790. HBMSN1.
RefSeqi NP_058652.1. NM_016956.3.
UniGenei Mm.288567.
Mm.467412.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1FNE X-ray 1.90 B/D 65-77 [» ]
1FNG X-ray 1.90 B/D 65-77 [» ]
1I3R X-ray 2.40 B/D/F/H 65-77 [» ]
ProteinModelPortali P02089.
SMRi P02089. Positions 2-147.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200220. 1 interaction.
IntActi P02089. 11 interactions.
MINTi MINT-4097249.

Chemistry

ChEMBLi CHEMBL4007.

PTM databases

PhosphoSitei P02089.

Proteomic databases

MaxQBi P02089.
PRIDEi P02089.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 15130.
KEGGi mmu:15130.

Organism-specific databases

CTDi 15130.
MGIi MGI:96022. Hbb-b2.

Phylogenomic databases

HOVERGENi HBG009709.
InParanoidi P02089.
KOi K13823.

Miscellaneous databases

EvolutionaryTracei P02089.
NextBioi 287586.
PROi P02089.
SOURCEi Search...

Gene expression databases

Genevestigatori P02089.

Family and domain databases

Gene3Di 1.10.490.10. 1 hit.
InterProi IPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
IPR002337. Haemoglobin_b.
[Graphical view ]
Pfami PF00042. Globin. 1 hit.
[Graphical view ]
PRINTSi PR00814. BETAHAEM.
SUPFAMi SSF46458. SSF46458. 1 hit.
PROSITEi PS01033. GLOBIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE.
  2. "The evolution and sequence comparison of two recently diverged mouse chromosomal beta-globin genes."
    Konkel D.A., Maizel J.V. Jr., Leder P.
    Cell 18:865-873(1979) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: BALB/c.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT 24-ALA--ILE-25.
    Strain: Czech II and FVB/N.
    Tissue: Mammary gland and Salivary gland.
  4. "Mouse haemoglobin beta chains. Comparative sequence data on adult major and minor beta chains from two species, Mus musculus and Mus cervicolor."
    Gilman J.G.
    Biochem. J. 159:43-53(1976) [PubMed] [Europe PMC] [Abstract]
    Cited for: POLYMORPHISM, VARIANT 23-ALA-ILE-24.
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUCCINYLATION [LARGE SCALE ANALYSIS] AT LYS-18 AND LYS-60, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiHBB2_MOUSE
AccessioniPrimary (citable) accession number: P02089
Secondary accession number(s): Q5D0E8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The D-minor sequence is shown. See also the entry for the beta D-major chain and the S allele.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3