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Protein

Hemoglobin subunit beta-2

Gene

Hbb-b2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Miscellaneous

The D-minor sequence is shown. See also the entry for the beta D-major chain and the S allele.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi64Iron (heme distal ligand)1
Metal bindingi93Iron (heme proximal ligand)1

GO - Molecular functioni

  • heme binding Source: InterPro
  • iron ion binding Source: InterPro
  • oxygen binding Source: MGI
  • oxygen transporter activity Source: UniProtKB-KW

GO - Biological processi

  • erythrocyte development Source: MGI
  • positive regulation of myeloid cell differentiation Source: MGI
  • regulation of erythrocyte differentiation Source: MGI

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit beta-2
Alternative name(s):
Beta-2-globin
Hemoglobin beta-2 chain
Hemoglobin beta-minor chain
Gene namesi
Name:Hbb-b2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:96022. Hbb-b2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4007.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000530252 – 147Hemoglobin subunit beta-2Add BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylvalineBy similarity1
Modified residuei18N6-succinyllysineCombined sources1
Modified residuei42PhosphotyrosineCombined sources1
Modified residuei45PhosphoserineCombined sources1
Modified residuei51PhosphoserineBy similarity1
Modified residuei53PhosphoserineCombined sources1
Modified residuei60N6-succinyllysineCombined sources1
Modified residuei105Asymmetric dimethylarginineCombined sources1
Modified residuei124PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PeptideAtlasiP02089.
PRIDEiP02089.

PTM databases

iPTMnetiP02089.
PhosphoSitePlusiP02089.

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Protein-protein interaction databases

BioGridi200220. 2 interactors.
IntActiP02089. 11 interactors.
MINTiMINT-4097249.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FNEX-ray1.90B/D65-77[»]
1FNGX-ray1.90B/D65-77[»]
1I3RX-ray2.40B/D/F/H65-77[»]
ProteinModelPortaliP02089.
SMRiP02089.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02089.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709.
InParanoidiP02089.
KOiK13823.

Family and domain databases

CDDicd08925. Hb-beta_like. 1 hit.
InterProiView protein in InterPro
IPR000971. Globin.
IPR009050. Globin-like.
IPR002337. Haemoglobin_b.
PfamiView protein in Pfam
PF00042. Globin. 1 hit.
PRINTSiPR00814. BETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiView protein in PROSITE
PS01033. GLOBIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02089-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHLTDAEKS AVSCLWAKVN PDEVGGEALG RLLVVYPWTQ RYFDSFGDLS
60 70 80 90 100
SASAIMGNPK VKAHGKKVIT AFNEGLKNLD NLKGTFASLS ELHCDKLHVD
110 120 130 140
PENFRLLGNA IVIVLGHHLG KDFTPAAQAA FQKVVAGVAT ALAHKYH
Length:147
Mass (Da):15,878
Last modified:January 23, 2007 - v2
Checksum:i1FABBDC2D0ABC4FD
GO

Polymorphismi

Inbred mouse strains possess 1 of 3 alleles at the HBB locus: D (diffuse), S (single), and P. The D and P alleles are actually closely linked doublets that coordinately express a major and a minor chain, the minor chain being slightly different in the two alleles. The S allele produces only 1 chain, it is characteristic of North American wild mice.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti23 – 24EV → AI in allele P. 1 Publication2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00722 Genomic DNA. Translation: CAA24101.1.
X14061 Genomic DNA. Translation: CAA32225.1. Sequence problems.
BC027434 mRNA. Translation: AAH27434.1.
BC032264 mRNA. Translation: AAH32264.1.
PIRiB90790. HBMSN1.
RefSeqiNP_058652.1. NM_016956.3.
UniGeneiMm.288567.
Mm.467412.

Genome annotation databases

GeneIDi15130.
KEGGimmu:15130.
UCSCiuc009iup.1. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHBB2_MOUSE
AccessioniPrimary (citable) accession number: P02089
Secondary accession number(s): Q5D0E8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families