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Protein

Hemoglobin subunit beta-2

Gene

Hbb-b2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi64 – 641Iron (heme distal ligand)
Metal bindingi93 – 931Iron (heme proximal ligand)

GO - Molecular functioni

  • heme binding Source: InterPro
  • iron ion binding Source: InterPro
  • oxygen binding Source: MGI
  • oxygen transporter activity Source: UniProtKB-KW

GO - Biological processi

  • erythrocyte development Source: MGI
  • positive regulation of myeloid cell differentiation Source: MGI
  • regulation of erythrocyte differentiation Source: MGI
Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit beta-2
Alternative name(s):
Beta-2-globin
Hemoglobin beta-2 chain
Hemoglobin beta-minor chain
Gene namesi
Name:Hbb-b2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:96022. Hbb-b2.

Subcellular locationi

GO - Cellular componenti

  • hemoglobin complex Source: MGI
Complete GO annotation...

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL4007.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 147146Hemoglobin subunit beta-2PRO_0000053025Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei18 – 181N6-succinyllysineCombined sources
Modified residuei42 – 421PhosphotyrosineCombined sources
Modified residuei45 – 451PhosphoserineCombined sources
Modified residuei51 – 511PhosphoserineBy similarity
Modified residuei53 – 531PhosphoserineCombined sources
Modified residuei60 – 601N6-acetyllysine; alternateBy similarity
Modified residuei60 – 601N6-succinyllysine; alternateCombined sources
Modified residuei83 – 831N6-acetyllysineBy similarity
Modified residuei94 – 941S-nitrosocysteineBy similarity
Modified residuei124 – 1241PhosphothreonineBy similarity
Modified residuei145 – 1451N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein, S-nitrosylation

Proteomic databases

PeptideAtlasiP02089.
PRIDEiP02089.

PTM databases

iPTMnetiP02089.
PhosphoSiteiP02089.

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Protein-protein interaction databases

BioGridi200220. 2 interactions.
IntActiP02089. 11 interactions.
MINTiMINT-4097249.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FNEX-ray1.90B/D65-77[»]
1FNGX-ray1.90B/D65-77[»]
1I3RX-ray2.40B/D/F/H65-77[»]
ProteinModelPortaliP02089.
SMRiP02089. Positions 2-147.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02089.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG009709.
InParanoidiP02089.
KOiK13823.

Family and domain databases

CDDicd08925. Hb-beta_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002337. Haemoglobin_b.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00814. BETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02089-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHLTDAEKS AVSCLWAKVN PDEVGGEALG RLLVVYPWTQ RYFDSFGDLS
60 70 80 90 100
SASAIMGNPK VKAHGKKVIT AFNEGLKNLD NLKGTFASLS ELHCDKLHVD
110 120 130 140
PENFRLLGNA IVIVLGHHLG KDFTPAAQAA FQKVVAGVAT ALAHKYH
Length:147
Mass (Da):15,878
Last modified:January 23, 2007 - v2
Checksum:i1FABBDC2D0ABC4FD
GO

Polymorphismi

Inbred mouse strains possess 1 of 3 alleles at the HBB locus: D (diffuse), S (single), and P. The D and P alleles are actually closely linked doublets that coordinately express a major and a minor chain, the minor chain being slightly different in the two alleles. The S allele produces only 1 chain, it is characteristic of North American wild mice.1 Publication

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti23 – 242EV → AI in allele P. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00722 Genomic DNA. Translation: CAA24101.1.
X14061 Genomic DNA. Translation: CAA32225.1. Sequence problems.
BC027434 mRNA. Translation: AAH27434.1.
BC032264 mRNA. Translation: AAH32264.1.
PIRiB90790. HBMSN1.
RefSeqiNP_058652.1. NM_016956.3.
UniGeneiMm.288567.
Mm.467412.

Genome annotation databases

GeneIDi15130.
KEGGimmu:15130.
UCSCiuc009iup.1. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
V00722 Genomic DNA. Translation: CAA24101.1.
X14061 Genomic DNA. Translation: CAA32225.1. Sequence problems.
BC027434 mRNA. Translation: AAH27434.1.
BC032264 mRNA. Translation: AAH32264.1.
PIRiB90790. HBMSN1.
RefSeqiNP_058652.1. NM_016956.3.
UniGeneiMm.288567.
Mm.467412.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FNEX-ray1.90B/D65-77[»]
1FNGX-ray1.90B/D65-77[»]
1I3RX-ray2.40B/D/F/H65-77[»]
ProteinModelPortaliP02089.
SMRiP02089. Positions 2-147.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200220. 2 interactions.
IntActiP02089. 11 interactions.
MINTiMINT-4097249.

Chemistry

ChEMBLiCHEMBL4007.

PTM databases

iPTMnetiP02089.
PhosphoSiteiP02089.

Proteomic databases

PeptideAtlasiP02089.
PRIDEiP02089.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi15130.
KEGGimmu:15130.
UCSCiuc009iup.1. mouse.

Organism-specific databases

CTDi15130.
MGIiMGI:96022. Hbb-b2.

Phylogenomic databases

HOVERGENiHBG009709.
InParanoidiP02089.
KOiK13823.

Miscellaneous databases

EvolutionaryTraceiP02089.
PROiP02089.
SOURCEiSearch...

Family and domain databases

CDDicd08925. Hb-beta_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002337. Haemoglobin_b.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00814. BETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHBB2_MOUSE
AccessioniPrimary (citable) accession number: P02089
Secondary accession number(s): Q5D0E8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 144 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The D-minor sequence is shown. See also the entry for the beta D-major chain and the S allele.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.