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Protein

Hemoglobin subunit beta-1

Gene

Hbb-b1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi64 – 641Iron (heme distal ligand)By similarity
Metal bindingi93 – 931Iron (heme proximal ligand)Combined sources1 Publication

GO - Molecular functioni

  • heme binding Source: InterPro
  • iron ion binding Source: InterPro
  • oxygen binding Source: InterPro
  • oxygen transporter activity Source: MGI

GO - Biological processi

  • erythrocyte development Source: MGI
  • hemopoiesis Source: MGI
  • oxygen transport Source: MGI
  • regulation of eIF2 alpha phosphorylation by heme Source: MGI
Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit beta-1
Alternative name(s):
Beta-1-globin
Hemoglobin beta-1 chain
Hemoglobin beta-major chain
Gene namesi
Name:Hbb-b1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:96021. Hbb-b1.

Subcellular locationi

GO - Cellular componenti

  • hemoglobin complex Source: MGI
  • myelin sheath Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 147146Hemoglobin subunit beta-1PRO_0000053024Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei18 – 181N6-succinyllysineCombined sources
Modified residuei21 – 211PhosphoserineCombined sources
Modified residuei45 – 451PhosphoserineBy similarity
Modified residuei51 – 511PhosphoserineBy similarity
Modified residuei60 – 601N6-acetyllysineBy similarity
Modified residuei83 – 831N6-acetyllysineBy similarity
Modified residuei94 – 941S-nitrosocysteineBy similarity
Modified residuei145 – 1451N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein, S-nitrosylation

Proteomic databases

MaxQBiP02088.
PaxDbiP02088.
PeptideAtlasiP02088.
PRIDEiP02088.

2D gel databases

REPRODUCTION-2DPAGEIPI00553333.
P02088.
SWISS-2DPAGEP02088.

PTM databases

iPTMnetiP02088.
PhosphoSiteiP02088.
SwissPalmiP02088.

Expressioni

Tissue specificityi

Red blood cells.

Gene expression databases

CleanExiMM_HBB-B1.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Protein-protein interaction databases

BioGridi200219. 4 interactions.
IntActiP02088. 11 interactions.
MINTiMINT-4097231.
STRINGi10090.ENSMUSP00000095794.

Structurei

Secondary structure

1
147
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi6 – 1813Combined sources
Helixi21 – 3515Combined sources
Helixi37 – 426Combined sources
Helixi52 – 565Combined sources
Helixi59 – 7719Combined sources
Helixi82 – 9413Combined sources
Turni95 – 973Combined sources
Helixi102 – 11918Combined sources
Helixi120 – 1223Combined sources
Helixi125 – 14319Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JEBX-ray2.10B/D2-147[»]
3HRWX-ray2.80B/D2-147[»]
ProteinModelPortaliP02088.
SMRiP02088. Positions 2-147.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02088.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
HOVERGENiHBG009709.
InParanoidiP02088.
KOiK13823.
PhylomeDBiP02088.

Family and domain databases

CDDicd08925. Hb-beta_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002337. Haemoglobin_b.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00814. BETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02088-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHLTDAEKA AVSCLWGKVN SDEVGGEALG RLLVVYPWTQ RYFDSFGDLS
60 70 80 90 100
SASAIMGNAK VKAHGKKVIT AFNDGLNHLD SLKGTFASLS ELHCDKLHVD
110 120 130 140
PENFRLLGNM IVIVLGHHLG KDFTPAAQAA FQKVVAGVAT ALAHKYH
Length:147
Mass (Da):15,840
Last modified:January 23, 2007 - v2
Checksum:i8190EAEEFD9036A3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 151L → Q in BAB27362 (PubMed:16141072).Curated
Sequence conflicti39 – 391T → A in BAB29299 (PubMed:16141072).Curated
Sequence conflicti63 – 631A → T in BAB27237 (PubMed:16141072).Curated
Sequence conflicti91 – 911E → Q (PubMed:482942).Curated
Sequence conflicti109 – 1091N → S in BAB29299 (PubMed:16141072).Curated

Polymorphismi

Inbred mouse strains possess 1 of 4 alleles at the HBB locus: D (diffuse), S (single), P and W1. The D and P alleles are actually closely linked doublets that coordinately express a major and a minor chain, the minor chain being slightly different in the two alleles. The S allele produces only 1 chain, it is characteristic of North American wild mice. The W1 allele is observed mainly in Northwestern China.3 Publications

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti14 – 141C → G in allele S and allele W1. 3 Publications
Natural varianti21 – 211S → A in allele S. 2 Publications
Natural varianti74 – 741D → E in allele W1. 2 Publications
Natural varianti135 – 1351V → M in allele W1. 2 Publications
Natural varianti140 – 1401T → A in allele S. 2 Publications

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14061 Genomic DNA. Translation: CAA32224.1.
J00413 Genomic DNA. Translation: AAA37791.1.
AB020013 mRNA. Translation: BAA77353.1.
AB020015 mRNA. Translation: BAA77355.1.
AK002258 mRNA. Translation: BAB21971.1.
AK002394 mRNA. Translation: BAB22067.1.
AK003096 mRNA. Translation: BAB22562.1.
AK003472 mRNA. Translation: BAB22806.1.
AK005442 mRNA. Translation: BAB24036.1.
AK005490 mRNA. Translation: BAB24075.1.
AK005496 mRNA. Translation: BAB24080.1.
AK010873 mRNA. Translation: BAB27237.1.
AK010902 mRNA. Translation: BAB27255.1.
AK010980 mRNA. Translation: BAB27302.1.
AK010981 mRNA. Translation: BAB27303.1.
AK010991 mRNA. Translation: BAB27310.1.
AK010993 mRNA. Translation: BAB27312.1.
AK011006 mRNA. Translation: BAB27325.1.
AK011013 mRNA. Translation: BAB27331.1.
AK011016 mRNA. Translation: BAB27334.1.
AK011027 mRNA. Translation: BAB27343.1.
AK011033 mRNA. Translation: BAB27347.1.
AK011050 mRNA. Translation: BAB27360.1.
AK011052 mRNA. Translation: BAB27361.1.
AK011053 mRNA. Translation: BAB27362.1.
AK011057 mRNA. Translation: BAB27365.1.
AK011067 mRNA. Translation: BAB27374.1.
AK011069 mRNA. Translation: BAB27376.1.
AK011075 mRNA. Translation: BAB27380.1.
AK011077 mRNA. Translation: BAB27382.1.
AK011083 mRNA. Translation: BAB27387.1.
AK011102 mRNA. Translation: BAB27399.1.
AK012551 mRNA. Translation: BAB28311.1.
AK014364 mRNA. Translation: BAB29299.1.
AK027903 mRNA. Translation: BAC25655.1.
AK027904 mRNA. Translation: BAC25656.1.
AK028067 mRNA. Translation: BAC25734.1.
AK088149 mRNA. Translation: BAC40173.1.
AK133714 mRNA. Translation: BAE21794.1.
AK147001 mRNA. Translation: BAE27598.1.
AK160629 mRNA. Translation: BAE35926.1.
AK161021 mRNA. Translation: BAE36152.1.
AK165490 mRNA. Translation: BAE38217.1.
AK167615 mRNA. Translation: BAE39668.1.
AK168412 mRNA. Translation: BAE40327.1.
AK168477 mRNA. Translation: BAE40366.1.
AK168562 mRNA. Translation: BAE40435.1.
AK168584 mRNA. Translation: BAE40453.1.
AK168819 mRNA. Translation: BAE40646.1.
AK168826 mRNA. Translation: BAE40653.1.
AK168846 mRNA. Translation: BAE40669.1.
M19236 mRNA. Translation: AAA37788.1.
M10828 Genomic DNA. Translation: AAA37786.1.
M10830, M10829 Genomic DNA. Translation: AAA37787.1.
M10688 Genomic DNA. Translation: AAA37790.1.
PIRiA90790. HBMS.
RefSeqiNP_001188320.1. NM_001201391.1.
NP_001265090.1. NM_001278161.1.
NP_032246.2. NM_008220.5.
UniGeneiMm.288567.
Mm.467412.

Genome annotation databases

GeneIDi100503605.
101488143.
15129.
KEGGimmu:100503605.
mmu:101488143.
mmu:15129.
UCSCiuc009iuq.3. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X14061 Genomic DNA. Translation: CAA32224.1.
J00413 Genomic DNA. Translation: AAA37791.1.
AB020013 mRNA. Translation: BAA77353.1.
AB020015 mRNA. Translation: BAA77355.1.
AK002258 mRNA. Translation: BAB21971.1.
AK002394 mRNA. Translation: BAB22067.1.
AK003096 mRNA. Translation: BAB22562.1.
AK003472 mRNA. Translation: BAB22806.1.
AK005442 mRNA. Translation: BAB24036.1.
AK005490 mRNA. Translation: BAB24075.1.
AK005496 mRNA. Translation: BAB24080.1.
AK010873 mRNA. Translation: BAB27237.1.
AK010902 mRNA. Translation: BAB27255.1.
AK010980 mRNA. Translation: BAB27302.1.
AK010981 mRNA. Translation: BAB27303.1.
AK010991 mRNA. Translation: BAB27310.1.
AK010993 mRNA. Translation: BAB27312.1.
AK011006 mRNA. Translation: BAB27325.1.
AK011013 mRNA. Translation: BAB27331.1.
AK011016 mRNA. Translation: BAB27334.1.
AK011027 mRNA. Translation: BAB27343.1.
AK011033 mRNA. Translation: BAB27347.1.
AK011050 mRNA. Translation: BAB27360.1.
AK011052 mRNA. Translation: BAB27361.1.
AK011053 mRNA. Translation: BAB27362.1.
AK011057 mRNA. Translation: BAB27365.1.
AK011067 mRNA. Translation: BAB27374.1.
AK011069 mRNA. Translation: BAB27376.1.
AK011075 mRNA. Translation: BAB27380.1.
AK011077 mRNA. Translation: BAB27382.1.
AK011083 mRNA. Translation: BAB27387.1.
AK011102 mRNA. Translation: BAB27399.1.
AK012551 mRNA. Translation: BAB28311.1.
AK014364 mRNA. Translation: BAB29299.1.
AK027903 mRNA. Translation: BAC25655.1.
AK027904 mRNA. Translation: BAC25656.1.
AK028067 mRNA. Translation: BAC25734.1.
AK088149 mRNA. Translation: BAC40173.1.
AK133714 mRNA. Translation: BAE21794.1.
AK147001 mRNA. Translation: BAE27598.1.
AK160629 mRNA. Translation: BAE35926.1.
AK161021 mRNA. Translation: BAE36152.1.
AK165490 mRNA. Translation: BAE38217.1.
AK167615 mRNA. Translation: BAE39668.1.
AK168412 mRNA. Translation: BAE40327.1.
AK168477 mRNA. Translation: BAE40366.1.
AK168562 mRNA. Translation: BAE40435.1.
AK168584 mRNA. Translation: BAE40453.1.
AK168819 mRNA. Translation: BAE40646.1.
AK168826 mRNA. Translation: BAE40653.1.
AK168846 mRNA. Translation: BAE40669.1.
M19236 mRNA. Translation: AAA37788.1.
M10828 Genomic DNA. Translation: AAA37786.1.
M10830, M10829 Genomic DNA. Translation: AAA37787.1.
M10688 Genomic DNA. Translation: AAA37790.1.
PIRiA90790. HBMS.
RefSeqiNP_001188320.1. NM_001201391.1.
NP_001265090.1. NM_001278161.1.
NP_032246.2. NM_008220.5.
UniGeneiMm.288567.
Mm.467412.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JEBX-ray2.10B/D2-147[»]
3HRWX-ray2.80B/D2-147[»]
ProteinModelPortaliP02088.
SMRiP02088. Positions 2-147.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200219. 4 interactions.
IntActiP02088. 11 interactions.
MINTiMINT-4097231.
STRINGi10090.ENSMUSP00000095794.

PTM databases

iPTMnetiP02088.
PhosphoSiteiP02088.
SwissPalmiP02088.

2D gel databases

REPRODUCTION-2DPAGEIPI00553333.
P02088.
SWISS-2DPAGEP02088.

Proteomic databases

MaxQBiP02088.
PaxDbiP02088.
PeptideAtlasiP02088.
PRIDEiP02088.

Protocols and materials databases

DNASUi15129.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100503605.
101488143.
15129.
KEGGimmu:100503605.
mmu:101488143.
mmu:15129.
UCSCiuc009iuq.3. mouse.

Organism-specific databases

CTDi100503605.
101488143.
15129.
MGIiMGI:96021. Hbb-b1.

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
HOVERGENiHBG009709.
InParanoidiP02088.
KOiK13823.
PhylomeDBiP02088.

Miscellaneous databases

ChiTaRSiHbb-b1. mouse.
EvolutionaryTraceiP02088.
PROiP02088.
SOURCEiSearch...

Gene expression databases

CleanExiMM_HBB-B1.

Family and domain databases

CDDicd08925. Hb-beta_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002337. Haemoglobin_b.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00814. BETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHBB1_MOUSE
AccessioniPrimary (citable) accession number: P02088
Secondary accession number(s): Q54AI0
, Q91V86, Q9CRZ2, Q9CXH5, Q9CY12, Q9CY54, Q9R0S6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 163 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The D-major sequence is shown. See also the entry for the beta D and P-minor chain.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.