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Protein

Hemoglobin subunit beta

Gene

HBB

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.1 Publication
Spinorphin: functions as an endogenous inhibitor of enkephalin-degrading enzymes such as DPP3, and may thereby play a role as a regulator of pain and inflammation.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi62Iron (heme distal ligand)1
Metal bindingi91Iron (heme proximal ligand)1

GO - Molecular functioni

Keywordsi

Biological processOxygen transport, Transport
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

ReactomeiR-BTA-1237044 Erythrocytes take up carbon dioxide and release oxygen
R-BTA-1247673 Erythrocytes take up oxygen and release carbon dioxide
R-BTA-2168880 Scavenging of heme from plasma
R-BTA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit beta
Alternative name(s):
Beta-globin
Hemoglobin beta chain
Cleaved into the following chain:
Gene namesi
Name:HBB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Protein family/group databases

Allergomei8242 Bos d HG

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000528921 – 145Hemoglobin subunit betaAdd BLAST145
PeptideiPRO_000042422531 – 37Spinorphin7

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11PhosphothreonineBy similarity1
Modified residuei43PhosphoserineBy similarity1
Modified residuei58N6-acetyllysineBy similarity1
Modified residuei81N6-acetyllysineBy similarity1
Modified residuei92S-nitrosocysteineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein, S-nitrosylation

Proteomic databases

PaxDbiP02070
PeptideAtlasiP02070
PRIDEiP02070

Miscellaneous databases

PMAP-CutDBP02070

Expressioni

Tissue specificityi

Red blood cells.

Gene expression databases

BgeeiENSBTAG00000038748
ExpressionAtlasiP02070 baseline and differential

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000043063

Structurei

Secondary structure

1145
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 14Combined sources11
Helixi21 – 33Combined sources13
Helixi35 – 44Combined sources10
Helixi50 – 55Combined sources6
Helixi57 – 73Combined sources17
Helixi77 – 79Combined sources3
Helixi80 – 83Combined sources4
Helixi85 – 93Combined sources9
Helixi100 – 117Combined sources18
Helixi118 – 120Combined sources3
Helixi123 – 140Combined sources18
Helixi141 – 144Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FSXX-ray2.10B/D1-145[»]
1G08X-ray1.90B/D1-145[»]
1G09X-ray2.04B/D1-145[»]
1G0AX-ray2.04B/D1-145[»]
1HDAX-ray2.20B/D1-145[»]
2QSPX-ray1.85B/D1-145[»]
2QSSX-ray1.75B/D1-145[»]
3CIUX-ray3.50B/D1-145[»]
3PI8X-ray2.20B/D1-145[»]
3PI9X-ray2.90B/D1-145[»]
3PIAX-ray2.10B/D1-145[»]
ProteinModelPortaliP02070
SMRiP02070
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02070

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378 Eukaryota
COG1018 LUCA
GeneTreeiENSGT00760000119197
HOGENOMiHOG000036868
HOVERGENiHBG009709
InParanoidiP02070
KOiK13823
OMAiWTRRFFE
OrthoDBiEOG091G0R7W
TreeFamiTF333268

Family and domain databases

CDDicd08925 Hb-beta_like, 1 hit
Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971 Globin
IPR009050 Globin-like_sf
IPR012292 Globin/Proto
IPR002337 Haemoglobin_b
PfamiView protein in Pfam
PF00042 Globin, 1 hit
PRINTSiPR00814 BETAHAEM
SUPFAMiSSF46458 SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033 GLOBIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02070-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTAEEKAAV TAFWGKVKVD EVGGEALGRL LVVYPWTQRF FESFGDLSTA
60 70 80 90 100
DAVMNNPKVK AHGKKVLDSF SNGMKHLDDL KGTFAALSEL HCDKLHVDPE
110 120 130 140
NFKLLGNVLV VVLARNFGKE FTPVLQADFQ KVVAGVANAL AHRYH
Length:145
Mass (Da):15,954
Last modified:July 21, 1986 - v1
Checksum:iFD62217E8477CFD4
GO

Polymorphismi

Four allelic beta chains have been found in bovine hemoglobins. A and B alleles were found in Jersey cattle and C and D alleles were found in Angoni cattle (East African short-horn zebu). The sequence shown is that of the allele A.3 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti15G → S in allele B. 1 Publication1
Natural varianti18K → H in allele B. 1 Publication1
Natural varianti20D → G in allele D-Zambia. 1 Publication1
Natural varianti43S → T in allele D-Zambia. 1 Publication1
Natural varianti119K → N in allele B. 1
Natural varianti131K → Q in allele C-Rhodesia. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X00376 Genomic DNA Translation: CAA25111.1
M63453 Genomic DNA Translation: AAA30408.1
PIRiB93504 HBBOB
RefSeqiNP_776342.1, NM_173917.2
UniGeneiBt.23726

Genome annotation databases

EnsembliENSBTAT00000045694; ENSBTAP00000043063; ENSBTAG00000038748
GeneIDi280813
KEGGibta:280813

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHBB_BOVIN
AccessioniPrimary (citable) accession number: P02070
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: May 23, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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