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Protein

Hemoglobin subunit beta

Gene

HBB

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi64Iron (heme distal ligand)By similarity1
Metal bindingi93Iron (heme proximal ligand)PROSITE-ProRule annotationCombined sources2 Publications1

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit beta
Alternative name(s):
Beta-globin
Hemoglobin beta chain
Gene namesi
Name:HBB
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4006.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity1 Publication
ChainiPRO_00000530712 – 147Hemoglobin subunit betaAdd BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylvalineBy similarity1
Modified residuei45PhosphoserineBy similarity1
Modified residuei60N6-acetyllysineBy similarity1
Modified residuei83N6-acetyllysineBy similarity1
Modified residuei94S-nitrosocysteineBy similarity1
Modified residuei145N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein, S-nitrosylation

Proteomic databases

PaxDbiP02067.
PeptideAtlasiP02067.
PRIDEiP02067.

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Protein-protein interaction databases

DIPiDIP-59910N.
STRINGi9823.ENSSSCP00000015647.

Structurei

Secondary structure

1147
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 16Combined sources11
Helixi21 – 35Combined sources15
Helixi37 – 46Combined sources10
Helixi52 – 55Combined sources4
Helixi59 – 75Combined sources17
Helixi79 – 81Combined sources3
Helixi82 – 95Combined sources14
Helixi102 – 119Combined sources18
Helixi120 – 122Combined sources3
Helixi125 – 142Combined sources18
Turni143 – 145Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QPWX-ray1.80B/D2-147[»]
2PGHX-ray2.80B/D2-147[»]
4F4OX-ray2.90B/E/H/K2-147[»]
ProteinModelPortaliP02067.
SMRiP02067.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02067.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
HOGENOMiHOG000036868.
HOVERGENiHBG009709.
InParanoidiP02067.
KOiK13823.

Family and domain databases

CDDicd08925. Hb-beta_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002337. Haemoglobin_b.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00814. BETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P02067-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHLSAEEKE AVLGLWGKVN VDEVGGEALG RLLVVYPWTQ RFFESFGDLS
60 70 80 90 100
NADAVMGNPK VKAHGKKVLQ SFSDGLKHLD NLKGTFAKLS ELHCDQLHVD
110 120 130 140
PENFRLLGNV IVVVLARRLG HDFNPNVQAA FQKVVAGVAN ALAHKYH
Length:147
Mass (Da):16,166
Last modified:January 23, 2007 - v3
Checksum:iFC96A95FE14CEC93
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti126N → D AA sequence (PubMed:565742).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86791 Genomic DNA. Translation: CAA60490.1.
PIRiS54269. HBPG.
RefSeqiNP_001138313.1. NM_001144841.1.
UniGeneiSsc.2867.

Genome annotation databases

GeneIDi407066.
KEGGissc:407066.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86791 Genomic DNA. Translation: CAA60490.1.
PIRiS54269. HBPG.
RefSeqiNP_001138313.1. NM_001144841.1.
UniGeneiSsc.2867.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QPWX-ray1.80B/D2-147[»]
2PGHX-ray2.80B/D2-147[»]
4F4OX-ray2.90B/E/H/K2-147[»]
ProteinModelPortaliP02067.
SMRiP02067.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-59910N.
STRINGi9823.ENSSSCP00000015647.

Chemistry databases

ChEMBLiCHEMBL4006.

Proteomic databases

PaxDbiP02067.
PeptideAtlasiP02067.
PRIDEiP02067.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi407066.
KEGGissc:407066.

Organism-specific databases

CTDi3043.

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
HOGENOMiHOG000036868.
HOVERGENiHBG009709.
InParanoidiP02067.
KOiK13823.

Miscellaneous databases

EvolutionaryTraceiP02067.

Family and domain databases

CDDicd08925. Hb-beta_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002337. Haemoglobin_b.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00814. BETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHBB_PIG
AccessioniPrimary (citable) accession number: P02067
Secondary accession number(s): Q29025
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 119 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.