UniProtKB - P02062 (HBB_HORSE)
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Protein
Hemoglobin subunit beta
Gene
HBB
Organism
Equus caballus (Horse)
Status
Functioni
Involved in oxygen transport from the lung to the various peripheral tissues.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 63 | Iron (heme distal ligand)By similarity | 1 | |
Metal bindingi | 92 | Iron (heme proximal ligand)Combined sources1 Publication | 1 |
GO - Molecular functioni
- heme binding Source: InterPro
- iron ion binding Source: InterPro
- oxygen binding Source: InterPro
- oxygen carrier activity Source: UniProtKB-KW
Keywordsi
Biological process | Oxygen transport, Transport |
Ligand | Heme, Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Hemoglobin subunit betaAlternative name(s): Beta-globin Hemoglobin beta chain |
Gene namesi | Name:HBB |
Organismi | Equus caballus (Horse) |
Taxonomic identifieri | 9796 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › |
Proteomesi |
|
Subcellular locationi
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000052975 | 1 – 146 | Hemoglobin subunit betaAdd BLAST | 146 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylvalineBy similarity | 1 | |
Modified residuei | 44 | PhosphoserineBy similarity | 1 | |
Modified residuei | 59 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 82 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 93 | S-nitrosocysteineBy similarity | 1 | |
Modified residuei | 144 | N6-acetyllysineBy similarity | 1 |
Keywords - PTMi
Acetylation, Phosphoprotein, S-nitrosylationProteomic databases
PaxDbi | P02062. |
PeptideAtlasi | P02062. |
PRIDEi | P02062. |
Expressioni
Tissue specificityi
Red blood cells.
Interactioni
Subunit structurei
Heterotetramer of two alpha chains and two beta chains.
Protein-protein interaction databases
IntActi | P02062. 2 interactors. |
MINTi | P02062. |
STRINGi | 9796.ENSECAP00000008056. |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more detailsFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Helixi | 5 – 15 | Combined sources | 11 | |
Helixi | 20 – 34 | Combined sources | 15 | |
Helixi | 36 – 45 | Combined sources | 10 | |
Helixi | 51 – 56 | Combined sources | 6 | |
Helixi | 58 – 75 | Combined sources | 18 | |
Helixi | 76 – 80 | Combined sources | 5 | |
Helixi | 81 – 94 | Combined sources | 14 | |
Helixi | 101 – 118 | Combined sources | 18 | |
Helixi | 119 – 121 | Combined sources | 3 | |
Helixi | 124 – 141 | Combined sources | 18 | |
Helixi | 143 – 145 | Combined sources | 3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1G0B | X-ray | 1.90 | B | 1-146 | [»] | |
1IBE | X-ray | 1.80 | B | 1-146 | [»] | |
1IWH | X-ray | 1.55 | B | 1-146 | [»] | |
1NS6 | X-ray | 2.05 | B | 1-146 | [»] | |
1NS9 | X-ray | 1.60 | B | 1-146 | [»] | |
1Y8H | X-ray | 3.10 | B/D | 1-146 | [»] | |
1Y8I | X-ray | 2.60 | B/D | 1-146 | [»] | |
1Y8K | X-ray | 2.30 | B/D | 1-146 | [»] | |
2D5X | X-ray | 1.45 | B | 1-146 | [»] | |
2DHB | X-ray | 2.80 | B | 1-146 | [»] | |
2MHB | X-ray | 2.00 | B | 1-146 | [»] | |
2ZLT | X-ray | 1.90 | B | 1-146 | [»] | |
2ZLU | X-ray | 2.00 | B | 1-146 | [»] | |
2ZLV | X-ray | 2.00 | B | 1-146 | [»] | |
2ZLW | X-ray | 2.90 | B/D | 1-146 | [»] | |
2ZLX | X-ray | 2.80 | B/D | 1-146 | [»] | |
5C6E | Other | 1.70 | B | 1-146 | [»] | |
ProteinModelPortali | P02062. | |||||
SMRi | P02062. | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P02062. |
Family & Domainsi
Sequence similaritiesi
Belongs to the globin family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG3378. Eukaryota. COG1018. LUCA. |
HOGENOMi | HOG000036868. |
HOVERGENi | HBG009709. |
InParanoidi | P02062. |
OMAi | WTRRFFE. |
Family and domain databases
CDDi | cd08925. Hb-beta_like. 1 hit. |
InterProi | View protein in InterPro IPR000971. Globin. IPR009050. Globin-like_sf. IPR002337. Haemoglobin_b. |
Pfami | View protein in Pfam PF00042. Globin. 1 hit. |
PRINTSi | PR00814. BETAHAEM. |
SUPFAMi | SSF46458. SSF46458. 1 hit. |
PROSITEi | View protein in PROSITE PS01033. GLOBIN. 1 hit. |
i Sequence
Sequence statusi: Complete.
P02062-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
VQLSGEEKAA VLALWDKVNE EEVGGEALGR LLVVYPWTQR FFDSFGDLSN
60 70 80 90 100
PGAVMGNPKV KAHGKKVLHS FGEGVHHLDN LKGTFAALSE LHCDKLHVDP
110 120 130 140
ENFRLLGNVL VVVLARHFGK DFTPELQASY QKVVAGVANA LAHKYH
Sequence databases
PIRi | B91688. HBHO. |
UniGenei | Eca.16920. |
Similar proteinsi
Entry informationi
Entry namei | HBB_HORSE | |
Accessioni | P02062Primary (citable) accession number: P02062 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 21, 1986 |
Last sequence update: | July 21, 1986 | |
Last modified: | March 28, 2018 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |