HBB

Functionⁱ

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Metal bindingⁱ	63	Iron (heme distal ligand)By similarity		1
Metal bindingⁱ	92	Iron (heme proximal ligand)Combined sources1 Publication		1

GO - Molecular functionⁱ

heme binding Source: InterPro
iron ion binding Source: InterPro
oxygen binding Source: InterPro
oxygen carrier activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Oxygen transport, Transport
Ligand	Heme, Iron, Metal-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Hemoglobin subunit beta Alternative name(s): Beta-globin Hemoglobin beta chain
Gene namesⁱ	Name:HBB
Organismⁱ	Equus caballus (Horse)
Taxonomic identifierⁱ	9796 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › Equus
Proteomesⁱ	UP000002281 Componentⁱ: Unplaced

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000052975	1 – 146	Hemoglobin subunit betaAdd BLAST		146

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylvalineBy similarity	1
Modified residueⁱ	44	PhosphoserineBy similarity	1
Modified residueⁱ	59	N6-acetyllysineBy similarity	1
Modified residueⁱ	82	N6-acetyllysineBy similarity	1
Modified residueⁱ	93	S-nitrosocysteineBy similarity	1
Modified residueⁱ	144	N6-acetyllysineBy similarity	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein, S-nitrosylation

Proteomic databases

PaxDbⁱ	P02062
PeptideAtlas More...PeptideAtlasⁱ	P02062
PRIDEⁱ	P02062

Expressionⁱ

Tissue specificityⁱ

Red blood cells.

Interactionⁱ

Subunit structureⁱ

Heterotetramer of two alpha chains and two beta chains.

Protein-protein interaction databases

IntActⁱ	P02062, 2 interactors
Molecular INTeraction database More...MINTⁱ	P02062
STRINGⁱ	9796.ENSECAP00000008056

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	5 – 15	Combined sources	11
Helixⁱ	20 – 34	Combined sources	15
Helixⁱ	36 – 45	Combined sources	10
Helixⁱ	51 – 56	Combined sources	6
Helixⁱ	58 – 75	Combined sources	18
Helixⁱ	76 – 80	Combined sources	5
Helixⁱ	81 – 94	Combined sources	14
Helixⁱ	101 – 118	Combined sources	18
Helixⁱ	119 – 121	Combined sources	3
Helixⁱ	124 – 141	Combined sources	18
Helixⁱ	143 – 145	Combined sources	3

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1G0B	X-ray	1.90	B	1-146	[»]
	1IBE	X-ray	1.80	B	1-146	[»]
	1IWH	X-ray	1.55	B	1-146	[»]
	1NS6	X-ray	2.05	B	1-146	[»]
	1NS9	X-ray	1.60	B	1-146	[»]
	1Y8H	X-ray	3.10	B/D	1-146	[»]
	1Y8I	X-ray	2.60	B/D	1-146	[»]
	1Y8K	X-ray	2.30	B/D	1-146	[»]
	2D5X	X-ray	1.45	B	1-146	[»]
	2DHB	X-ray	2.80	B	1-146	[»]
	2MHB	X-ray	2.00	B	1-146	[»]
	2ZLT	X-ray	1.90	B	1-146	[»]
	2ZLU	X-ray	2.00	B	1-146	[»]
	2ZLV	X-ray	2.00	B	1-146	[»]
	2ZLW	X-ray	2.90	B/D	1-146	[»]
	2ZLX	X-ray	2.80	B/D	1-146	[»]
	5C6E	Other	1.70	B	1-146	[»]
ProteinModelPortalⁱ	P02062
SMRⁱ	P02062
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P02062

EvolutionaryTraceⁱ

P02062

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG3378 Eukaryota COG1018 LUCA
HOGENOMⁱ	HOG000036868
HOVERGENⁱ	HBG009709
InParanoidⁱ	P02062
OMAⁱ	WTRRFFE

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08925 Hb-beta_like, 1 hit
Gene3Dⁱ	1.10.490.10, 1 hit
InterProⁱ	View protein in InterPro IPR000971 Globin IPR009050 Globin-like_sf IPR012292 Globin/Proto IPR002337 Haemoglobin_b
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00042 Globin, 1 hit
PRINTSⁱ	PR00814 BETAHAEM
SUPFAMⁱ	SSF46458 SSF46458, 1 hit
PROSITEⁱ	View protein in PROSITE PS01033 GLOBIN, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P02062-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
VQLSGEEKAA VLALWDKVNE EEVGGEALGR LLVVYPWTQR FFDSFGDLSN 
        60         70         80         90        100
PGAVMGNPKV KAHGKKVLHS FGEGVHHLDN LKGTFAALSE LHCDKLHVDP 
       110        120        130        140 
ENFRLLGNVL VVVLARHFGK DFTPELQASY QKVVAGVANA LAHKYH

Length:146

Mass (Da):16,008

Last modified:July 21, 1986 - v1

Checksum:ⁱ734664793DA642EE

GO

Sequence databases

PIRⁱ	B91688 HBHO
UniGeneⁱ	Eca.16920

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P02062	D1MPT0 F6RDD3	Equus asinus (Donkey) (Equus africanus asinus) Equus caballus (Horse)	146	UniRef100_P02062	Cluster: Hemoglobin subunit beta	3

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P02062	D1MPT0 F6RDD3 UPI0002C62FBC UPI0002C688D2 P67823 P67824 UPI00071A0F07 P02066 UPI0000110FDB	Equus asinus (Donkey) (Equus africanus asinus) Equus caballus (Horse) Ceratotherium simum simum (southern white rhinoceros) Equus hemionus kulan (Turkmenian kulan) (Equus onager kulan) Equus zebra (Mountain zebra) Ceratotherium simum (White rhinoceros) (Square-lipped rhinoceros)	146	UniRef90_P02062	Cluster: Hemoglobin subunit beta	10

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P02062	P69892 P62742 P61921 D9YZU9 A0A0P5WXU3 A0A2J8P6N7 Q9UNL6 UPI00001F9BB0 Q9UJ01 E7CYP2 +804	Homo sapiens (Human) Gorilla gorilla gorilla (Western lowland gorilla) Pan troglodytes (Chimpanzee) Daphnia magna Pan paniscus (Pygmy chimpanzee) (Bonobo) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Pongo pygmaeus (Bornean orangutan) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Papio anubis (Olive baboon) Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys) And more	147	UniRef50_P69892	Cluster: Hemoglobin subunit gamma-2	815

Cross-referencesⁱ

Web resourcesⁱ

Protein Spotlight

The man behind the molecular lung - Issue 21 of April 2002

Sequence databases

PIRⁱ	B91688 HBHO
UniGeneⁱ	Eca.16920

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1G0B	X-ray	1.90	B	1-146	[»]
	1IBE	X-ray	1.80	B	1-146	[»]
	1IWH	X-ray	1.55	B	1-146	[»]
	1NS6	X-ray	2.05	B	1-146	[»]
	1NS9	X-ray	1.60	B	1-146	[»]
	1Y8H	X-ray	3.10	B/D	1-146	[»]
	1Y8I	X-ray	2.60	B/D	1-146	[»]
	1Y8K	X-ray	2.30	B/D	1-146	[»]
	2D5X	X-ray	1.45	B	1-146	[»]
	2DHB	X-ray	2.80	B	1-146	[»]
	2MHB	X-ray	2.00	B	1-146	[»]
	2ZLT	X-ray	1.90	B	1-146	[»]
	2ZLU	X-ray	2.00	B	1-146	[»]
	2ZLV	X-ray	2.00	B	1-146	[»]
	2ZLW	X-ray	2.90	B/D	1-146	[»]
	2ZLX	X-ray	2.80	B/D	1-146	[»]
	5C6E	Other	1.70	B	1-146	[»]
ProteinModelPortalⁱ	P02062
SMRⁱ	P02062
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	P02062, 2 interactors
Molecular INTeraction database More...MINTⁱ	P02062
STRINGⁱ	9796.ENSECAP00000008056

Proteomic databases

PaxDbⁱ	P02062
PeptideAtlas More...PeptideAtlasⁱ	P02062
PRIDEⁱ	P02062

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Phylogenomic databases

eggNOGⁱ	KOG3378 Eukaryota COG1018 LUCA
HOGENOMⁱ	HOG000036868
HOVERGENⁱ	HBG009709
InParanoidⁱ	P02062
OMAⁱ	WTRRFFE

Miscellaneous databases

EvolutionaryTraceⁱ	P02062

EvolutionaryTraceⁱ

P02062

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd08925 Hb-beta_like, 1 hit
Gene3Dⁱ	1.10.490.10, 1 hit
InterProⁱ	View protein in InterPro IPR000971 Globin IPR009050 Globin-like_sf IPR012292 Globin/Proto IPR002337 Haemoglobin_b
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00042 Globin, 1 hit
PRINTSⁱ	PR00814 BETAHAEM
SUPFAMⁱ	SSF46458 SSF46458, 1 hit
PROSITEⁱ	View protein in PROSITE PS01033 GLOBIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HBB_HORSE
Accessionⁱ	P02062Primary (citable) accession number: P02062
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
	Last sequence update:	July 21, 1986
	Last modified:	April 25, 2018
	This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

UniProtKB

UniParc

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UniRef

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Annotation systems

Supporting data

UniProtKB - P02062 (HBB_HORSE)

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Hemoglobin subunit beta

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

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<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ