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P02062

- HBB_HORSE

UniProt

P02062 - HBB_HORSE

Protein

Hemoglobin subunit beta

Gene

HBB

Organism
Equus caballus (Horse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Involved in oxygen transport from the lung to the various peripheral tissues.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi63 – 631Iron (heme distal ligand)
    Metal bindingi92 – 921Iron (heme proximal ligand)

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. oxygen binding Source: InterPro
    4. oxygen transporter activity Source: UniProtKB-KW

    Keywords - Biological processi

    Oxygen transport, Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hemoglobin subunit beta
    Alternative name(s):
    Beta-globin
    Hemoglobin beta chain
    Gene namesi
    Name:HBB
    OrganismiEquus caballus (Horse)
    Taxonomic identifieri9796 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
    ProteomesiUP000002281: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. hemoglobin complex Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 146146Hemoglobin subunit betaPRO_0000052975Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylvalineBy similarity
    Modified residuei59 – 591N6-acetyllysineBy similarity
    Modified residuei82 – 821N6-acetyllysineBy similarity
    Modified residuei93 – 931S-nitrosocysteineBy similarity
    Modified residuei144 – 1441N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation, S-nitrosylation

    Proteomic databases

    PRIDEiP02062.

    Expressioni

    Tissue specificityi

    Red blood cells.

    Interactioni

    Subunit structurei

    Heterotetramer of two alpha chains and two beta chains.

    Protein-protein interaction databases

    MINTiMINT-242194.
    STRINGi9796.ENSECAP00000008056.

    Structurei

    Secondary structure

    1
    146
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi5 – 1511
    Helixi20 – 3415
    Helixi36 – 4510
    Helixi51 – 566
    Helixi58 – 7518
    Helixi76 – 805
    Helixi81 – 9414
    Helixi101 – 11818
    Helixi119 – 1213
    Helixi124 – 14118
    Helixi143 – 1453

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1G0BX-ray1.90B1-146[»]
    1IBEX-ray1.80B1-146[»]
    1IWHX-ray1.55B1-146[»]
    1NS6X-ray2.05B1-146[»]
    1NS9X-ray1.60B1-146[»]
    1Y8HX-ray3.10B/D1-146[»]
    1Y8IX-ray2.60B/D1-146[»]
    1Y8KX-ray2.30B/D1-146[»]
    2D5XX-ray1.45B1-146[»]
    2DHBX-ray2.80B1-146[»]
    2MHBX-ray2.00B1-146[»]
    2ZLTX-ray1.90B1-146[»]
    2ZLUX-ray2.00B1-146[»]
    2ZLVX-ray2.00B1-146[»]
    2ZLWX-ray2.90B/D1-146[»]
    2ZLXX-ray2.80B/D1-146[»]
    ProteinModelPortaliP02062.
    SMRiP02062. Positions 1-146.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP02062.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the globin family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG269316.
    HOGENOMiHOG000036868.
    HOVERGENiHBG009709.
    InParanoidiP02062.
    KOiK13823.
    OMAiAVMNNPK.

    Family and domain databases

    Gene3Di1.10.490.10. 1 hit.
    InterProiIPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    IPR002337. Haemoglobin_b.
    [Graphical view]
    PfamiPF00042. Globin. 1 hit.
    [Graphical view]
    PRINTSiPR00814. BETAHAEM.
    SUPFAMiSSF46458. SSF46458. 1 hit.
    PROSITEiPS01033. GLOBIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P02062-1 [UniParc]FASTAAdd to Basket

    « Hide

    VQLSGEEKAA VLALWDKVNE EEVGGEALGR LLVVYPWTQR FFDSFGDLSN    50
    PGAVMGNPKV KAHGKKVLHS FGEGVHHLDN LKGTFAALSE LHCDKLHVDP 100
    ENFRLLGNVL VVVLARHFGK DFTPELQASY QKVVAGVANA LAHKYH 146
    Length:146
    Mass (Da):16,008
    Last modified:July 21, 1986 - v1
    Checksum:i734664793DA642EE
    GO

    Sequence databases

    PIRiB91688. HBHO.
    RefSeqiNP_001157490.1. NM_001164018.1.
    UniGeneiEca.16920.

    Genome annotation databases

    GeneIDi100054109.
    KEGGiecb:100054109.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    The man behind the molecular lung - Issue 21 of April 2002

    Sequence databases

    PIRi B91688. HBHO.
    RefSeqi NP_001157490.1. NM_001164018.1.
    UniGenei Eca.16920.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1G0B X-ray 1.90 B 1-146 [» ]
    1IBE X-ray 1.80 B 1-146 [» ]
    1IWH X-ray 1.55 B 1-146 [» ]
    1NS6 X-ray 2.05 B 1-146 [» ]
    1NS9 X-ray 1.60 B 1-146 [» ]
    1Y8H X-ray 3.10 B/D 1-146 [» ]
    1Y8I X-ray 2.60 B/D 1-146 [» ]
    1Y8K X-ray 2.30 B/D 1-146 [» ]
    2D5X X-ray 1.45 B 1-146 [» ]
    2DHB X-ray 2.80 B 1-146 [» ]
    2MHB X-ray 2.00 B 1-146 [» ]
    2ZLT X-ray 1.90 B 1-146 [» ]
    2ZLU X-ray 2.00 B 1-146 [» ]
    2ZLV X-ray 2.00 B 1-146 [» ]
    2ZLW X-ray 2.90 B/D 1-146 [» ]
    2ZLX X-ray 2.80 B/D 1-146 [» ]
    ProteinModelPortali P02062.
    SMRi P02062. Positions 1-146.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-242194.
    STRINGi 9796.ENSECAP00000008056.

    Proteomic databases

    PRIDEi P02062.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100054109.
    KEGGi ecb:100054109.

    Organism-specific databases

    CTDi 3043.

    Phylogenomic databases

    eggNOGi NOG269316.
    HOGENOMi HOG000036868.
    HOVERGENi HBG009709.
    InParanoidi P02062.
    KOi K13823.
    OMAi AVMNNPK.

    Miscellaneous databases

    EvolutionaryTracei P02062.

    Family and domain databases

    Gene3Di 1.10.490.10. 1 hit.
    InterProi IPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    IPR002337. Haemoglobin_b.
    [Graphical view ]
    Pfami PF00042. Globin. 1 hit.
    [Graphical view ]
    PRINTSi PR00814. BETAHAEM.
    SUPFAMi SSF46458. SSF46458. 1 hit.
    PROSITEi PS01033. GLOBIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Hemoglobins, XXXIII. Note on the sequence of the hemoglobins of the horse."
      Matsuda G., Maita T., Braunitzer G., Schrank B.
      Hoppe-Seyler's Z. Physiol. Chem. 361:1107-1116(1980) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
    2. "Amino acid sequences of some tryptic peptides from the beta-chain of horse hemoglobin."
      Smith D.B.
      Can. J. Biochem. 46:825-843(1968) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-82 AND 117-146.
    3. "Amide groups of some tryptic peptides from the beta-chain of horse hemoglobin."
      Smith D.B., Chung W.P.
      Can. J. Biochem. 48:1160-1164(1970) [PubMed] [Europe PMC] [Abstract]
      Cited for: DETERMINATION OF AMIDES, PROTEIN SEQUENCE OF 52-54.
    4. "Three-dimensional Fourier synthesis of horse oxyhaemoglobin at 2.8-A resolution: (1) X-ray analysis."
      Perutz M.F., Miurhead H., Cox J.M., Goaman L.C., Mathews F.S., McGandy E.L., Webb L.E.
      Nature 219:29-32(1968) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
    5. "Three-dimensional Fourier synthesis of horse oxyhaemoglobin at 2.8 A resolution: the atomic model."
      Perutz M.F., Muirhead H., Cox J.M., Goaman L.C.
      Nature 219:131-139(1968) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
    6. "The structure of horse methaemoglobin at 2.0-A resolution."
      Ladner R.C., Heidner E.J., Perutz M.F.
      J. Mol. Biol. 114:385-414(1977) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).

    Entry informationi

    Entry nameiHBB_HORSE
    AccessioniPrimary (citable) accession number: P02062
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 21, 1986
    Last sequence update: July 21, 1986
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3