HBB

Functionⁱ

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Metal bindingⁱ	63 – 63	1	Iron (heme distal ligand)By similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:P80044 (HBB_TREBE)
Metal bindingⁱ	92 – 92	1	Iron (heme proximal ligand)Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:1G0B PDB:1IBE PDB:1IWH PDB:1NS6 PDB:1NS9 PDB:1Y8H PDB:1Y8I PDB:1Y8K PDB:2D5X PDB:2DHB PDB:2MHB PDB:2ZLT PDB:2ZLU PDB:2ZLV PDB:2ZLW PDB:2ZLX 1 Publication Manual assertion based on experiment inⁱ Ref.6 "The structure of horse methaemoglobin at 2.0-A resolution." Ladner R.C., Heidner E.J., Perutz M.F. J. Mol. Biol. 114:385-414(1977) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH HEME.

GO - Molecular functionⁱ

heme binding Source: InterPro
iron ion binding Source: InterPro
oxygen binding Source: InterPro
oxygen transporter activity Source: UniProtKB-KW

Complete GO annotation...

Keywords - Biological processⁱ

Oxygen transport, Transport

Keywords - Ligandⁱ

Heme, Iron, Metal-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Hemoglobin subunit beta Alternative name(s): Beta-globin Hemoglobin beta chain
Gene namesⁱ	Name:HBB
Organismⁱ	Equus caballus (Horse)
Taxonomic identifierⁱ	9796 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Laurasiatheria › Perissodactyla › Equidae › Equus › Equus
Proteomesⁱ	UP000002281 Componentⁱ: Unplaced

Subcellular locationⁱ

GO - Cellular componentⁱ

hemoglobin complex Source: InterPro

Complete GO annotation...

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	Length	Description	Graphical view	Feature identifier	Actions
Chainⁱ	1 – 146	146	Hemoglobin subunit beta		PRO_0000052975	Add BLAST

Amino acid modifications

Feature key	Position(s)	Length	Description
Modified residueⁱ	1 – 1	1	N-acetylvalineBy similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:P02086 (HBB_PROHA)
Modified residueⁱ	44 – 44	1	PhosphoserineBy similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:P68871 (HBB_HUMAN)
Modified residueⁱ	59 – 59	1	N6-acetyllysineBy similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:P68871 (HBB_HUMAN)
Modified residueⁱ	82 – 82	1	N6-acetyllysineBy similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:P68871 (HBB_HUMAN)
Modified residueⁱ	93 – 93	1	S-nitrosocysteineBy similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:P68871 (HBB_HUMAN)
Modified residueⁱ	144 – 144	1	N6-acetyllysineBy similarity Manual assertion inferred from sequence similarity toⁱ UniProtKB:P68871 (HBB_HUMAN)

Keywords - PTMⁱ

Acetylation, Phosphoprotein, S-nitrosylation

Proteomic databases

PaxDbⁱ	P02062.
PeptideAtlasⁱ	P02062.
PRIDEⁱ	P02062.

Expressionⁱ

Tissue specificityⁱ

Red blood cells.

Interactionⁱ

Subunit structureⁱ

Heterotetramer of two alpha chains and two beta chains.

Protein-protein interaction databases

MINTⁱ	MINT-242194.
STRINGⁱ	9796.ENSECAP00000008056.

Structureⁱ

Secondary structure

1

146

Legend: HelixTurnBeta strand

Show more details

Feature key	Position(s)	Length	Description
Helixⁱ	5 – 15	11	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:2D5X
Helixⁱ	20 – 34	15	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:2D5X
Helixⁱ	36 – 45	10	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:2D5X
Helixⁱ	51 – 56	6	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:2D5X
Helixⁱ	58 – 75	18	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:2D5X
Helixⁱ	76 – 80	5	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:2D5X
Helixⁱ	81 – 94	14	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:2D5X
Helixⁱ	101 – 118	18	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:2D5X
Helixⁱ	119 – 121	3	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:2D5X
Helixⁱ	124 – 141	18	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:2D5X
Helixⁱ	143 – 145	3	Combined sources Manual assertion inferred from combination of experimental and computational evidenceⁱ PDB:2D5X

3D structure databases

Select the link destinations:
PDBeⁱ
RCSB PDBⁱ
PDBjⁱ

Links Updated

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1G0B	X-ray	1.90	B	1-146	[»]
1IBE	X-ray	1.80	B	1-146	[»]
1IWH	X-ray	1.55	B	1-146	[»]
1NS6	X-ray	2.05	B	1-146	[»]
1NS9	X-ray	1.60	B	1-146	[»]
1Y8H	X-ray	3.10	B/D	1-146	[»]
1Y8I	X-ray	2.60	B/D	1-146	[»]
1Y8K	X-ray	2.30	B/D	1-146	[»]
2D5X	X-ray	1.45	B	1-146	[»]
2DHB	X-ray	2.80	B	1-146	[»]
2MHB	X-ray	2.00	B	1-146	[»]
2ZLT	X-ray	1.90	B	1-146	[»]
2ZLU	X-ray	2.00	B	1-146	[»]
2ZLV	X-ray	2.00	B	1-146	[»]
2ZLW	X-ray	2.90	B/D	1-146	[»]
2ZLX	X-ray	2.80	B/D	1-146	[»]
5C6E	Other	1.70	B	1-146	[»]

ProteinModelPortalⁱ

P02062.

SMRⁱ

P02062. Positions 1-146.

ModBaseⁱ

Search...

MobiDBⁱ

Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P02062.

EvolutionaryTraceⁱ

P02062.

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGⁱ	KOG3378. Eukaryota. COG1018. LUCA.
HOGENOMⁱ	HOG000036868.
HOVERGENⁱ	HBG009709.
InParanoidⁱ	P02062.
KOⁱ	K13823.
OMAⁱ	WTRRFFE.

Family and domain databases

CDDⁱ	cd08925. Hb-beta_like. 1 hit.
Gene3Dⁱ	1.10.490.10. 1 hit.
InterProⁱ	IPR000971. Globin. IPR009050. Globin-like. IPR012292. Globin/Proto. IPR002337. Haemoglobin_b. [Graphical view]
Pfamⁱ	PF00042. Globin. 1 hit. [Graphical view]
PRINTSⁱ	PR00814. BETAHAEM.
SUPFAMⁱ	SSF46458. SSF46458. 1 hit.
PROSITEⁱ	PS01033. GLOBIN. 1 hit. [Graphical view]

Sequenceⁱ

Sequence statusⁱ: Complete.

P02062-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
VQLSGEEKAA VLALWDKVNE EEVGGEALGR LLVVYPWTQR FFDSFGDLSN 
        60         70         80         90        100
PGAVMGNPKV KAHGKKVLHS FGEGVHHLDN LKGTFAALSE LHCDKLHVDP 
       110        120        130        140 
ENFRLLGNVL VVVLARHFGK DFTPELQASY QKVVAGVANA LAHKYH

Length:146

Mass (Da):16,008

Last modified:July 21, 1986 - v1

Checksum:ⁱ734664793DA642EE

GO

Sequence databases

PIRⁱ	B91688. HBHO.
UniGeneⁱ	Eca.16920.

Genome annotation databases

KEGGⁱ	ecb:100054109.

KEGGⁱ

ecb:100054109.

Cross-referencesⁱ

Web resourcesⁱ

Protein Spotlight

The man behind the molecular lung - Issue 21 of April 2002

Sequence databases

PIRⁱ	B91688. HBHO.
UniGeneⁱ	Eca.16920.

3D structure databases

Select the link destinations:
PDBeⁱ
RCSB PDBⁱ
PDBjⁱ

Links Updated

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1G0B	X-ray	1.90	B	1-146	[»]
1IBE	X-ray	1.80	B	1-146	[»]
1IWH	X-ray	1.55	B	1-146	[»]
1NS6	X-ray	2.05	B	1-146	[»]
1NS9	X-ray	1.60	B	1-146	[»]
1Y8H	X-ray	3.10	B/D	1-146	[»]
1Y8I	X-ray	2.60	B/D	1-146	[»]
1Y8K	X-ray	2.30	B/D	1-146	[»]
2D5X	X-ray	1.45	B	1-146	[»]
2DHB	X-ray	2.80	B	1-146	[»]
2MHB	X-ray	2.00	B	1-146	[»]
2ZLT	X-ray	1.90	B	1-146	[»]
2ZLU	X-ray	2.00	B	1-146	[»]
2ZLV	X-ray	2.00	B	1-146	[»]
2ZLW	X-ray	2.90	B/D	1-146	[»]
2ZLX	X-ray	2.80	B/D	1-146	[»]
5C6E	Other	1.70	B	1-146	[»]

ProteinModelPortalⁱ

P02062.

SMRⁱ

P02062. Positions 1-146.

ModBaseⁱ

Search...

MobiDBⁱ

Search...

Protein-protein interaction databases

MINTⁱ	MINT-242194.
STRINGⁱ	9796.ENSECAP00000008056.

Proteomic databases

PaxDbⁱ	P02062.
PeptideAtlasⁱ	P02062.
PRIDEⁱ	P02062.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

KEGGⁱ	ecb:100054109.

KEGGⁱ

ecb:100054109.

Organism-specific databases

CTDⁱ	3043.

CTDⁱ

3043.

Phylogenomic databases

eggNOGⁱ	KOG3378. Eukaryota. COG1018. LUCA.
HOGENOMⁱ	HOG000036868.
HOVERGENⁱ	HBG009709.
InParanoidⁱ	P02062.
KOⁱ	K13823.
OMAⁱ	WTRRFFE.

Miscellaneous databases

EvolutionaryTraceⁱ	P02062.

EvolutionaryTraceⁱ

P02062.

Family and domain databases

CDDⁱ	cd08925. Hb-beta_like. 1 hit.
Gene3Dⁱ	1.10.490.10. 1 hit.
InterProⁱ	IPR000971. Globin. IPR009050. Globin-like. IPR012292. Globin/Proto. IPR002337. Haemoglobin_b. [Graphical view]
Pfamⁱ	PF00042. Globin. 1 hit. [Graphical view]
PRINTSⁱ	PR00814. BETAHAEM.
SUPFAMⁱ	SSF46458. SSF46458. 1 hit.
PROSITEⁱ	PS01033. GLOBIN. 1 hit. [Graphical view]
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ

HBB_HORSE

Accessionⁱ

Primary (citable) accession number: P02062

Entry historyⁱ

Integrated into UniProtKB/Swiss-Prot:	July 21, 1986
Last sequence update:	July 21, 1986
Last modified:	September 7, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]

Entry statusⁱ

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Protein Spotlight
Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P02062 (HBB_HORSE)

UniProt

P02062 - HBB_HORSE

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Hemoglobin subunit beta

Select a section on the left to see content.

<p>Provides any useful information about the protein, mostly biological knowledge.</p><p><a href='../manual/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>Provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.</p><p><a href='../manual/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>Provides information on the location and the topology of the mature protein in the cell.</p><p><a href='../manual/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:</p><p><a href='../manual/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>Describes post-translational modifications (PTMs) and/or processing events.</p><p><a href='../manual/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>Provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.</p><p><a href='../manual/expression_section' target='_top'>More...</a></p>Expressioni

<p>Provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.</p><p><a href='../manual/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>Provides information on the tertiary and secondary structure of a protein.</p><p><a href='../manual/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>Provides information on sequence similarities with other proteins and the domain(s) present in a protein.</p><p><a href='../manual/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>Provides information about the sequence similarity with other proteins.</p><p><a href='../manual/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>Displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.</p><p><a href='../manual/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>Is used to point to information related to entries and found in data collections other than UniProtKB.</p><p><a href='../manual/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>Provides links to various web resources that are relevant for a specific protein.</p><p><a href='../manual/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Family and domain databases

<p>Provides general information on the entry.</p><p><a href='../manual/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>Contains any relevant information that doesn’t fit in any other defined sections</p><p><a href='../manual/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ