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Protein

Hemoglobin subunit beta

Gene

HBB

Organism
Equus caballus (Horse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in oxygen transport from the lung to the various peripheral tissues.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi63Iron (heme distal ligand)By similarity1
Metal bindingi92Iron (heme proximal ligand)Combined sources1 Publication1

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hemoglobin subunit beta
Alternative name(s):
Beta-globin
Hemoglobin beta chain
Gene namesi
Name:HBB
OrganismiEquus caballus (Horse)
Taxonomic identifieri9796 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaPerissodactylaEquidaeEquus
Proteomesi
  • UP000002281 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000529751 – 146Hemoglobin subunit betaAdd BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylvalineBy similarity1
Modified residuei44PhosphoserineBy similarity1
Modified residuei59N6-acetyllysineBy similarity1
Modified residuei82N6-acetyllysineBy similarity1
Modified residuei93S-nitrosocysteineBy similarity1
Modified residuei144N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein, S-nitrosylation

Proteomic databases

PaxDbiP02062.
PeptideAtlasiP02062.
PRIDEiP02062.

Expressioni

Tissue specificityi

Red blood cells.

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.

Protein-protein interaction databases

MINTiMINT-242194.
STRINGi9796.ENSECAP00000008056.

Structurei

Secondary structure

1146
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi5 – 15Combined sources11
Helixi20 – 34Combined sources15
Helixi36 – 45Combined sources10
Helixi51 – 56Combined sources6
Helixi58 – 75Combined sources18
Helixi76 – 80Combined sources5
Helixi81 – 94Combined sources14
Helixi101 – 118Combined sources18
Helixi119 – 121Combined sources3
Helixi124 – 141Combined sources18
Helixi143 – 145Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G0BX-ray1.90B1-146[»]
1IBEX-ray1.80B1-146[»]
1IWHX-ray1.55B1-146[»]
1NS6X-ray2.05B1-146[»]
1NS9X-ray1.60B1-146[»]
1Y8HX-ray3.10B/D1-146[»]
1Y8IX-ray2.60B/D1-146[»]
1Y8KX-ray2.30B/D1-146[»]
2D5XX-ray1.45B1-146[»]
2DHBX-ray2.80B1-146[»]
2MHBX-ray2.00B1-146[»]
2ZLTX-ray1.90B1-146[»]
2ZLUX-ray2.00B1-146[»]
2ZLVX-ray2.00B1-146[»]
2ZLWX-ray2.90B/D1-146[»]
2ZLXX-ray2.80B/D1-146[»]
5C6EOther1.70B1-146[»]
ProteinModelPortaliP02062.
SMRiP02062.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP02062.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
HOGENOMiHOG000036868.
HOVERGENiHBG009709.
InParanoidiP02062.
OMAiWTRRFFE.

Family and domain databases

CDDicd08925. Hb-beta_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002337. Haemoglobin_b.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00814. BETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P02062-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
VQLSGEEKAA VLALWDKVNE EEVGGEALGR LLVVYPWTQR FFDSFGDLSN
60 70 80 90 100
PGAVMGNPKV KAHGKKVLHS FGEGVHHLDN LKGTFAALSE LHCDKLHVDP
110 120 130 140
ENFRLLGNVL VVVLARHFGK DFTPELQASY QKVVAGVANA LAHKYH
Length:146
Mass (Da):16,008
Last modified:July 21, 1986 - v1
Checksum:i734664793DA642EE
GO

Sequence databases

PIRiB91688. HBHO.
UniGeneiEca.16920.

Cross-referencesi

Web resourcesi

Protein Spotlight

The man behind the molecular lung - Issue 21 of April 2002

Sequence databases

PIRiB91688. HBHO.
UniGeneiEca.16920.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G0BX-ray1.90B1-146[»]
1IBEX-ray1.80B1-146[»]
1IWHX-ray1.55B1-146[»]
1NS6X-ray2.05B1-146[»]
1NS9X-ray1.60B1-146[»]
1Y8HX-ray3.10B/D1-146[»]
1Y8IX-ray2.60B/D1-146[»]
1Y8KX-ray2.30B/D1-146[»]
2D5XX-ray1.45B1-146[»]
2DHBX-ray2.80B1-146[»]
2MHBX-ray2.00B1-146[»]
2ZLTX-ray1.90B1-146[»]
2ZLUX-ray2.00B1-146[»]
2ZLVX-ray2.00B1-146[»]
2ZLWX-ray2.90B/D1-146[»]
2ZLXX-ray2.80B/D1-146[»]
5C6EOther1.70B1-146[»]
ProteinModelPortaliP02062.
SMRiP02062.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-242194.
STRINGi9796.ENSECAP00000008056.

Proteomic databases

PaxDbiP02062.
PeptideAtlasiP02062.
PRIDEiP02062.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

CTDi3043.

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
HOGENOMiHOG000036868.
HOVERGENiHBG009709.
InParanoidiP02062.
OMAiWTRRFFE.

Miscellaneous databases

EvolutionaryTraceiP02062.

Family and domain databases

CDDicd08925. Hb-beta_like. 1 hit.
Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002337. Haemoglobin_b.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00814. BETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHBB_HORSE
AccessioniPrimary (citable) accession number: P02062
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: July 21, 1986
Last modified: November 30, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.